scholarly journals RISK FACTORS FOR EARLY NATURAL MENOPAUSE: EVIDENCE FROM THE 1958 AND 1970 BRITISH BIRTH COHORTS

2021 ◽  
Author(s):  
Darina Peycheva ◽  
Alice Sullivan ◽  
Rebecca Hardy ◽  
Alex Bryson ◽  
Gabriella Conti ◽  
...  
Keyword(s):  
Risk Factors ◽  
Health Behaviours ◽  
Adult Health ◽  
Birth Cohorts ◽  
Early Menopause ◽  
Natural Menopause ◽  
Two Generations ◽  
Lower Social Class ◽  
Using Data ◽  
The Life Course

Using data from two generations of British women followed from birth through childhood and into adulthood, we investigate risk factors for the onset of natural menopause before the age of 45 (known as early menopause). We focus on key stages during the life course to understand when risk factors are particularly harmful. We find that earlier cessation of menstruation is influenced by circumstances at birth. Women born in lower social class families, whose mother smoked during the pregnancy or who were short-term breastfed (one month or less) were more likely to undergo menopause before 45. Early menopause is also associated with poorer cognitive ability and smoking in childhood. Adult health behaviour also matters. Smoking is positively correlated with early menopause, while regular exercise (one to several times a week) and moderate frequency of alcohol drinking (one to three times a month) in women's early thirties are associated with a reduced risk of early menopause. The occurrence of gynaecological problems by women's early thirties is also linked to early menopause. We note that some of these factors (e.g. health behaviours) are modifiable and thus the risks may be preventable.

Social Characteristics as Predictors of ADHD Labeling across the Life Course

2020 ◽  
pp. 215686932091653
Author(s):  
Melissa Thompson ◽  
Lindsey Wilkinson ◽  
Hyeyoung Woo
Keyword(s):  
Life Course ◽  
Social Characteristics ◽  
Adult Health ◽  
Adhd Symptoms ◽  
Hyperactivity Disorder ◽  
National Longitudinal Study ◽  
The Social ◽  
Using Data ◽  
The Life Course ◽  
First Time

Although originally considered to be a disorder of childhood, attention deficit/hyperactivity disorder (ADHD) is increasingly being diagnosed for the first time in adulthood. Yet we know little about the social characteristics (race, gender, and social class) of those first labeled in adulthood, how these differ from those first labeled in childhood/adolescence, and whether the ADHD label is applied proportionately across social groups given ADHD symptomology. Using data from the National Longitudinal Study of Adolescent to Adult Health, the current research considers how typifications of ADHD affect application of the ADHD label in childhood/adolescence and in adulthood. Results indicate that even after controlling for ADHD symptoms, social characteristics are important predictors of the ADHD label in childhood/adolescence but are less influential in predicting ADHD labeling in adulthood. Additionally, results indicate the importance of race in moderating the association between childhood ADHD symptoms and application of the ADHD label throughout the life course.

scholarly journals Expansion of disability across successive Mexican birth cohorts: a longitudinal modelling analysis of birth cohorts born 10 years apart

2019 ◽  
Vol 73 (10) ◽  
pp. 900-905 ◽  
Author(s):  
Collin F Payne ◽  
Rebeca Wong
Keyword(s):  
Daily Living ◽  
Adult Health ◽  
Birth Cohorts ◽  
Middle Income ◽  
Item Questionnaire ◽  
Modelling Analysis ◽  
Aging Study ◽  
Physical Limitations ◽  
Mexican Adults ◽  
Using Data

BackgroundLife expectancy (LE) in Mexico has risen rapidly since the 1950s. In high-income contexts, these increases have coincided with a compression of disability to later ages. However, little evidence on trends in disability-free LE (DFLE) exist from Mexico or elsewhere in Latin America.MethodsUsing data from the Mexican Health and Aging Study, we compare changes in LE and DFLE in ages 50–59, 60–69 and 70–79 using birth-cohort-specific multistate lifetable models across successive 10-year birth cohorts. Disability was measured using the Katz activities of daily living (ADL) index, and limitation was measured using a seven-item questionnaire on physical functioning.ResultsOverall, Mexican adults born in 1953–1962 lived 0.87 (p<0.001) fewer active years between ages 50 and 59 than individuals born in 1942–1951, a difference comprised of a 0.54-year (p<0.001) increase in physically limited LE and a 0.27-year (p<0.001) increase in ADL-disabled LE. Active LE declined by 1.13 (p<0.001) years in ages 60–69, and by 0.93 (p<0.001) years in ages 70–79, across successive 10-year birth cohorts. No substantial changes in total LE were seen in any age group, and the magnitude of the expansion of disability was larger in females than in males.ConclusionsOur results indicate that more recently born cohorts of Mexican adults are spending more years of life with physical limitations and disabilities. These results foreshadow a need to closely monitor adult health in middle-income contexts, as the epidemiological conditions under which disability has expanded in Mexico are similar to those seen in many other countries.

Intergenerational Mobility and Changes in Drug Use Across the Life Course

2017 ◽  
Vol 48 (2) ◽  
pp. 205-225 ◽  
Author(s):  
Christopher R. Dennison
Keyword(s):  
Drug Use ◽  
Life Course ◽  
Social Mobility ◽  
Intergenerational Mobility ◽  
Economic Recession ◽  
The United States ◽  
Adult Health ◽  
Downward Mobility ◽  
Using Data ◽  
The Life Course

The consequences of “falling from grace”—or experiencing downward intergenerational mobility—are indeed becoming an abrupt reality for many entering the labor force. Scholars of social mobility speculate that such life course trajectories can result in antisocial behavior, but few have examined whether these trajectories lead to drug use. Thus, with the United States in the midst of a drug epidemic, as well as recovering from an economic recession, the study of social mobility may contribute to a better understanding of what causes individuals to turn to drugs. Using data from The National Longitudinal Study of Adolescent to Adult Health (Add Health) and a series of logistic diagonal reference models, this study examines the association between intergenerational social mobility and drug use. Overall, I find evidence that downward mobility is associated with increases in drug use, with the relationship strongest among those experiencing the greatest loss in status.

scholarly journals Family Development and Residential Trajectories of Two Birth Cohorts Living in Switzerland: Between Individualization and Standardization

2019 ◽  
Vol 45 (2) ◽  
pp. 185-214
Author(s):  
Jacques-Antoine Gauthier ◽  
Gil Viry
Keyword(s):  
Residential Mobility ◽  
Spatial Proximity ◽  
Family Development ◽  
Birth Cohorts ◽  
Spatial Mobility ◽  
The Family ◽  
Residential Context ◽  
Using Data ◽  
The Life Course ◽  
Conducive Environment

Abstract In a context of increasing pluralization and individualization of family forms, families would often develop through (individual) spatial mobility. This challenges a dominant view of the family that emphasises spatial proximity and residential stability in a conducive environment for family development. Using data from the Swiss survey Family tiMes and multi-channel sequence analysis, this article examines the links between residential context, residential mobility and family development over the life course.

Is Cerebral Palsy Changing in High Resource Settings? Data From the Quebec Cerebral Palsy Registry

2019 ◽  
Vol 34 (10) ◽  
pp. 567-573
Author(s):  
Aristides Hadjinicolaou ◽  
Pamela Ng ◽  
Xun Zhang PhD ◽  
Louise Koclas ◽  
Céline Lamarre ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cerebral Palsy ◽  
Perinatal Care ◽  
Developed Countries ◽  
Birth Cohorts ◽  
Phenotypic Profile ◽  
High Resource ◽  
Using Data ◽  
Associated Risk Factors ◽  
Over Time

Advances in maternal and perinatal care in developed countries have led to improved health outcomes for children. These changes may have impacted the profile of children with a cerebral palsy (CP) and groups at risk for CP over time. Using data from the Canadian CP Registry, the objectives of this retrospective cohort study were to describe the profile of children with CP in Quebec born between 1999 and 2010 and identify possible temporal variation in CP risk factors and phenotypic profile. Our sample consisted of 662 children with CP in Quebec. No change in profile or associated risk factors was observed across the birth cohorts 1999 to 2010. Prematurity remains the largest risk factor for CP in Quebec, and children with CP have multiple comorbidities that contribute to overall CP burden. CP registries offer a unique platform to study spectrum disorders and their longitudinal changes over time.

Risk factors of early menopause in two generations of gainfully employed French women

Maturitas ◽  
1997 ◽  
Vol 26 (3) ◽  
pp. 165-174 ◽  
Author(s):  
B. Cassou ◽  
F. Derriennic ◽  
C. Monfort ◽  
P. Dell'Accio ◽  
A. Touranchet
Keyword(s):  
Risk Factors ◽  
Early Menopause ◽  
Two Generations

Association between maternal prepregnancy body mass index with offspring cardiometabolic risk factors: analysis of three Brazilian birth cohorts

2021 ◽  
pp. 1-7
Author(s):  
Mariane da Silva Dias ◽  
Alicia Matijasevich ◽  
Ana Maria B. Menezes ◽  
Fernando C. Barros ◽  
Fernando C. Wehrmeister ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Diastolic Blood Pressure ◽  
Cardiometabolic Risk ◽  
Hdl Cholesterol ◽  
Cardiometabolic Risk Factors ◽  
Birth Cohorts ◽  
Prepregnancy Bmi ◽  
Prepregnancy Body Mass Index

Abstract Evidence suggests that maternal prepregnancy body mass index (BMI) is associated with offspring cardiometabolic risk factors. This study was aimed at assessing the association of maternal prepregnancy BMI with offspring cardiometabolic risk factors in adolescence and adulthood. We also evaluated whether offspring BMI was a mediator in this association. The study included mother–offspring pairs from three Pelotas birth cohorts. Offspring cardiometabolic risk factors were collected in the last follow-up of each cohort [mean age (in years) 30.2, 22.6, 10.9]. Blood pressure was measured using an automatic device, cholesterol by using an enzymatic colorimetric method, and glucose from fingertip blood, using a portable glucose meter. In a pooled analysis of the cohorts, multiple linear regression was used to control for confounding. Mediation analysis was conducted using G-computation formula. In the adjusted model, mean systolic blood pressure of offspring from overweight and obese mothers was on average 1.25 (95% CI: 0.45; 2.05) and 2.13 (95% CI: 0.66; 3.59) mmHg higher than that of offspring from normal-weight mothers; for diastolic blood pressure, the means were 0.80 (95% CI: 0.26; 1.34) and 2.60 (95% CI: 1.62; 3.59) mmHg higher, respectively. Non-HDL cholesterol was positively associated with maternal BMI, whereas blood glucose was not associated. Mediation analyses showed that offspring BMI explained completely the association of maternal prepregnancy BMI with offspring systolic and diastolic blood pressure, and non-HDL cholesterol. Our findings suggest that maternal prepregnancy BMI is positively associated with offspring blood pressure, and blood lipids, and this association is explained by offspring BMI.

scholarly journals Risk factors for severity on admission and the disease progression during hospitalisation in a large cohort of patients with COVID-19 in Japan

BMJ Open ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. e047007
Author(s):  
Mari Terada ◽  
Hiroshi Ohtsu ◽  
Sho Saito ◽  
Kayoko Hayakawa ◽  
Shinya Tsuzuki ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mechanical Ventilation ◽  
Chronic Respiratory Disease ◽  
Major Effect ◽  
Secondary Outcome ◽  
Healthcare Facilities ◽  
Wide Range ◽  
Registration Number ◽  
Using Data ◽  
Obesity Hypertension

ObjectivesTo investigate the risk factors contributing to severity on admission. Additionally, risk factors of worst severity and fatality were studied. Moreover, factors were compared based on three points: early severity, worst severity and fatality.DesignAn observational cohort study using data entered in a Japan nationwide COVID-19 inpatient registry, COVIREGI-JP.SettingAs of 28 September 2020, 10480 cases from 802 facilities have been registered. Participating facilities cover a wide range of hospitals where patients with COVID-19 are admitted in Japan.ParticipantsParticipants who had a positive test result on any applicable SARS-CoV-2 diagnostic tests were admitted to participating healthcare facilities. A total of 3829 cases were identified from 16 January to 31 May 2020, of which 3376 cases were included in this study.Primary and secondary outcome measuresPrimary outcome was severe or nonsevere on admission, determined by the requirement of mechanical ventilation or oxygen therapy, SpO2 or respiratory rate. Secondary outcome was the worst severity during hospitalisation, judged by the requirement of oxygen and/orinvasive mechanical ventilation/extracorporeal membrane oxygenation.ResultsRisk factors for severity on admission were older age, men, cardiovascular disease, chronic respiratory disease, diabetes, obesity and hypertension. Cerebrovascular disease, liver disease, renal disease or dialysis, solid tumour and hyperlipidaemia did not influence severity on admission; however, it influenced worst severity. Fatality rates for obesity, hypertension and hyperlipidaemia were relatively lower.ConclusionsThis study segregated the comorbidities influencing severity and death. It is possible that risk factors for severity on admission, worst severity and fatality are not consistent and may be propelled by different factors. Specifically, while hypertension, hyperlipidaemia and obesity had major effect on worst severity, their impact was mild on fatality in the Japanese population. Some studies contradict our results; therefore, detailed analyses, considering in-hospital treatments, are needed for validation.Trial registration numberUMIN000039873. https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000045453

scholarly journals Association of oral contraceptives and tubal ligation with risk of early natural menopause

2021 ◽  
Author(s):  
C R Langton ◽  
B W Whitcomb ◽  
A C Purdue-Smithe ◽  
L L Sievert ◽  
S E Hankinson ◽  
...  
Keyword(s):  
Oral Contraceptives ◽  
Proportional Hazards ◽  
Reproductive Factors ◽  
Cox Proportional Hazards ◽  
Tubal Ligation ◽  
Health Study ◽  
Early Menopause ◽  
Natural Menopause ◽  
Increased Risk

Abstract STUDY QUESTION What is the association of oral contraceptives (OCs) and tubal ligation (TL) with early natural menopause? SUMMARY ANSWER We did not observe an association of OC use with risk of early natural menopause; however, TL was associated with a modestly higher risk. WHAT IS KNOWN ALREADY OCs manipulate hormone levels, prevent ovulation, and may modify the rate of follicular atresia, while TL may disrupt the blood supply to the ovaries. These mechanisms may be associated with risk of early menopause, a condition associated with increased risk of cardiovascular disease and other adverse health outcomes. STUDY DESIGN, SIZE, DURATION We examined the association of OC use and TL with natural menopause before the age of 45 years in a population-based study within the prospective Nurses’ Health Study II (NHSII) cohort. Participants were followed from 1989 to 2017 and response rates were 85-90% for each cycle. PARTICIPANTS/MATERIALS, SETTING, METHODS Participants included 106 633 NHSII members who were premenopausal and aged 25-42 years at baseline. Use, duration and type of OC, and TL were measured at baseline and every 2 years. Menopause status and age were assessed every 2 years. Follow-up continued until early menopause, age 45 years, hysterectomy, oophorectomy, death, cancer diagnosis, or loss to follow-up. We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% CIs adjusted for lifestyle, dietary, and reproductive factors. MAIN RESULTS AND THE ROLE OF CHANCE Over 1.6 million person-years, 2579 members of the analytic cohort experienced early natural menopause. In multivariable models, the duration, timing, and type of OC use were not associated with risk of early menopause. For example, compared with women who never used OCs, those reporting 120+ months of OC use had an HR for early menopause of 1.01 (95% CI, 0.87-1.17; P for trend=0.71). TL was associated with increased risk of early menopause (HR = 1.17, 95% CI, 1.06-1.28). LIMITATIONS, REASONS FOR CAUTION Our study population is homogenous with respect to race and ethnicity. Additional evaluation of these relations in more diverse populations is important. WIDER IMPLICATIONS OF THE FINDINGS To our knowledge, this is the largest study examining the association of OC use and TL with early natural menopause to date. While TL was associated with a modest higher risk of early menopause, our findings do not support any material hazard or benefit for the use of OCs. STUDY FUNDING/COMPETING INTEREST(S) The study was sponsored by UO1CA176726 and R01HD078517 from the National Institutes of Health and Department of Health and Human Services. The work was supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development. The authors have no competing interests to report. TRIAL REGISTRATION NUMBER N/A

scholarly journals Higher Handgrip Strength Is Linked to Better Cognitive Performance in Chinese Adults with Hypertension

2021 ◽  
Vol 11 (8) ◽  
pp. 985
Author(s):  
Shenghua Lu ◽  
Fabian Herold ◽  
Yanjie Zhang ◽  
Yuruo Lei ◽  
Arthur F. Kramer ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Short Term Memory ◽  
Handgrip Strength ◽  
Adult Health ◽  
Linear Regression Models ◽  
Chinese Adults ◽  
Short Term ◽  
Term Memory ◽  
Using Data ◽  
The Relationship

Objective: There is growing evidence that in adults, higher levels of handgrip strength (HGS) are linked to better cognitive performance. However, the relationship between HGS and cognitive performance has not been sufficiently investigated in special cohorts, such as individuals with hypertension who have an intrinsically higher risk of cognitive decline. Thus, the purpose of this study was to examine the relationship between HGS and cognitive performance in adults with hypertension using data from the Global Ageing and Adult Health Survey (SAGE). Methods: A total of 4486 Chinese adults with hypertension from the SAGE were included in this study. Absolute handgrip strength (aHGS in kilograms) was measured using a handheld electronic dynamometer, and cognitive performance was assessed in the domains of short-term memory, delayed memory, and language ability. Multiple linear regression models were fitted to examine the association between relative handgrip strength (rHGS; aHGS divided by body mass index) and measures of cognitive performance. Results: Overall, higher levels of rHGS were associated with higher scores in short-term memory (β = 0.20) and language (β = 0.63) compared with the lowest tertiles of rHGS. In male participants, higher HGS was associated with higher scores in short-term memory (β = 0.31), language (β = 0.64), and delayed memory (β = 0.22). There were no associations between rHGS and cognitive performance measures in females. Conclusion: We observed that a higher level of rHGS was associated with better cognitive performance among hypertensive male individuals. Further studies are needed to investigate the neurobiological mechanisms, including sex-specific differences driving the relationship between measures of HGS and cognitive performance in individuals with hypertension.

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