Pharmaceutical and biological characterisation of a doxorubicin-polymer conjugate (PK1) entrapped in sorbitan monostearate Span 60 niosomes

1997 ◽  
Vol 148 (2) ◽  
pp. 139-148 ◽  
Author(s):  
Elisabetta Gianasi ◽  
Fausto Cociancich ◽  
Ijeoma F. Uchegbu ◽  
Alexander T. Florence ◽  
Ruth Duncan
Keyword(s):  
Sorbitan Monostearate ◽  
Polymer Conjugate ◽  
Span 60

scholarly journals PREPARATION OF OLIVE OIL EMULSIONS IN AQUEOUS SOLUTIONS STABILIZED BY OC-20 AND SPAN-60

2020 ◽  
pp. 137-142
Author(s):  
Дарья Алексеевна Портнова ◽  
Виолетта Андреевна Веролайнен ◽  
Светлана Анатольевна Темникова
Keyword(s):  
Aqueous Solutions ◽  
Olive Oil ◽  
Phase Inversion ◽  
Sorbitan Monostearate ◽  
Ionic Surfactants ◽  
Oil In Water ◽  
Oil Emulsions ◽  
Span 60

Методом определения температуры инверсии фаз (ТИФ) получены и исследованы обратные эмульсии оливкового масла в воде с применением в качестве стабилизаторов неионогенных поверхностноактивных веществ синтанола OC-20, сорбитана моностеарата Span 60 и их смесей. Reverse emulsions of olive oil in water with the use of non-ionic surfactants syntanol OC-20, sorbitan monostearate Span 60 and their mixtures as stabilizers were obtained and studied by the method of determining the temperature of phase inversion (TIF).

Microhydration of Sorbitan Monostearate (Span 60) Investigated Using Hybrid QM/MM Calculations in the Gas Phase

2021 ◽  
pp. 121977
Author(s):  
Nikorn Shinsuphan ◽  
Sriprajak Krongsuk ◽  
Supawadee Namuangruk
Keyword(s):  
Gas Phase ◽  
Sorbitan Monostearate ◽  
Span 60

Acute and Subacute Toxicity of Sorbitan Monostearate (Span 60) Non-ionic Surfactant Vesicles (Niosomes) in Sprague Dawley Rats

2016 ◽  
Vol 14 (2) ◽  
pp. 1-9 ◽  
Author(s):  
Jankie Satish ◽  
Johnson Jenelle ◽  
Pinto-Pereira Lexley ◽  
Adebayo Amusa ◽  
Pillai Gopalakrishna
Keyword(s):  
Sorbitan Monostearate ◽  
Ionic Surfactant ◽  
Sprague Dawley ◽  
Subacute Toxicity ◽  
Surfactant Vesicles ◽  
Sprague Dawley Rats ◽  
Span 60

Improved Gas Chromatographic Determination of Sorbitan Fatty Acid Esters in Confectionery Products

1984 ◽  
Vol 67 (6) ◽  
pp. 1149-1151
Author(s):  
Taizo Tsuda ◽  
Hiroshi Nakanishi ◽  
Shigenobu Kobayashi ◽  
Takashi Morita
Keyword(s):  
Fatty Acid ◽  
Chromatographic Determination ◽  
Sorbitan Monostearate ◽  
Fatty Acid Esters ◽  
Column Temperature ◽  
Confectionery Products ◽  
Span 60 ◽  
Sorbitan Fatty Acid Esters ◽  
Acid Esters

Abstract A method is described for gas chromatographic (GC) determination of sorbitan fatty acid esters in confectionery products as sorbitan monostearate. A sample is homogenized with chloroform, filtered, dried, and saponified with 0.1N NaOH in ethanol 1 h at 80°C. The saponification mixture is acidified, washed with hexane, and dried. Isosorbide, 1,4-sorbitan, and D-sorbitol are each derivatized at 70°C with pyridine, hexamethyldisilazane, and trimethylchlorosilane. GC separation of the polyols as TMS (trimethylsilyl) derivatives was performed on a 2% Dexsil 300 column temperature-programmed from 120 to 250°C at 107 min. The sorbitan monostearate content of the sample was calculated from the polyols, using the appropriate conversion factor. The procedure was applied to ice creams, cakes, and other confectionery products. Average recoveries from samples spiked with 1.0% Span 60 (sorbitan monostearate) were 91-96% for isosorbide, 83-99% for 1,4-sorbitan, and 82-98% for D-sorbitol. The detection limit was approximately 0.01%.

Long-term toxicity study of sorbitan monostearate (Span 60) in mice

1978 ◽  
Vol 16 (6) ◽  
pp. 527-534 ◽  
Author(s):  
R.J. Hendy ◽  
K.R. Butterworth ◽  
I.F. Gaunt ◽  
I.S. Kiss ◽  
P. Grasso
Keyword(s):  
Sorbitan Monostearate ◽  
Toxicity Study ◽  
Span 60

scholarly journals Stability, Viscosity, and Tribology Properties of Polyol Ester Oil-Based Biolubricant Filled with TEMPO-Oxidized Bacterial Cellulose Nanofiber

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Dieter Rahmadiawan ◽  
Hairul Abral ◽  
N. Nasruddin ◽  
Zahrul Fuadi
Keyword(s):  
Thermal Conductivity ◽  
Wear Rate ◽  
Bacterial Cellulose ◽  
Base Fluid ◽  
Room Temperature ◽  
Sorbitan Monostearate ◽  
Cellulose Nanofiber ◽  
Polyol Ester ◽  
The Stability ◽  
Span 60

This research is aimed at studying the stability and tribology properties of the polyol ester oil- (POE-) based biolubricant mixed with various filler loadings from microparticle of TEMPO-oxidized bacterial cellulose (NDCt) as an additive and sorbitan monostearate (Span 60) as a surfactant. Morphology, rheology, and tribology tests were conducted. The addition of NDCt and Span 60 to pure POE as a base fluid showed elevated viscosity, lower value of coefficient friction (COF), and a remarkable decrease in the wear rate (WR). The presence of 0.6 wt% NDCt and 1.8 wt% Span 60 in POE (N2S4) decreased the COF value by 79% in comparison to POE. At room temperature, this N2S4 biolubricant sample showed a higher thermal conductivity by 4% and lower WR value by 49% compared to POE. This study introduced the preparation of the ecofriendly biolubricant filled with NDCt improving the tribology properties remarkably.

Optimasi Proses Pembuatan dan Karakterisasi Fisik Niosom Sinkonin

2019 ◽  
Vol 16 (2) ◽  
pp. 178
Author(s):  
Hariyanti Hariyanti ◽  
Sophi Damayanti ◽  
Sasanti Tarini
Keyword(s):  
Differential Scanning Calorimetry ◽  
Particle Size ◽  
Hair Follicle ◽  
Scanning Calorimetry ◽  
Span 60

Sinkonin praktis tidak larut dalam air, sedikit larut dalam kloroform dan alkohol. Hal ini berdampak pada rendahnya penetrasi transfollicular sinkonin, karena hanya bahan aktif hidrofilik yang mampu melewati hair follicle. Dengan demikian dibutuhkan satu sistem penghantaran yang mampu menurunkan hidrofobisitas sinkonin untuk meningkatkan penetrasi sinkonin ke follicle. Niosom merupakan vesikel ampifilik dengan struktur lapisan rangkap yang terbentuk dari hidrasi kombinasi surfaktan nonionik dan kolesterol yang mampu menurunkan hidrofobisitas sinkonin. Penelitian ini bertujuan untuk menentukan proses pembuatan niosom sinkonin yang optimum. Pembuatan niosom sinkonin diawali dengan menentukan temperatur gelasi (Tg) dari span 60 dengan Differential Scanning Calorimetry (DSC), kemudian dilanjutkan dengan optimasi proses meliputi: optimasi kecepatan rotavapor pembentukan film lapis tipis, temperatur hidrasi, kecepatan rotavapor hidrasi, waktu hidrasi, dan waktu sonikasi. Karakteristik vesikel niosom yang optimal meliputi: ukuran partikel dan indeks polidispersitas dengan menggunakan Particle Size Analized (PSA) serta efisiensi penjeratan sinkonin dengan menggunakan KCKT. Temperatur gelasi (Tg) span 60 45±2 oC, kecepatan rotavapor pembentukan film lapis tipis niosom 210 rpm, temperatur hidrasi 55±2 oC, kecepatan rotavapor hidrasi 210 rpm, waktu hidrasi 20 menit, waktu sonikasi suspensi niosom 1 menit. Ukuran vesikel yang diperoleh adalah 100–200 nm, indeks polidispersitas 0,2–0,4 dan efisiensi penjeratan niosom sinkonin 84,49±0,0025%. Proses pembuatan niosom sinkonin memiliki pengaruh besar terhadap hasil ukuran vesikel dan efisiensi penjeratan niosom sinkonin.

scholarly journals FORMULATION AND IN VITRO, IN VIVO EVALUATION OF PRONIOSOMAL GEL OF NEOMYCIN SULPHATE

2019 ◽  
pp. 156-163
Author(s):  
AMOL SHETE ◽  
PRIYANKA THORAT ◽  
RAJENDRA DOIJAD ◽  
SACHIN SAJANE
Keyword(s):  
Phase Separation ◽  
Skin Irritation ◽  
Entrapment Efficiency ◽  
Separation Method ◽  
Gelling Agent ◽  
In Vivo Evaluation ◽  
Skin Delivery ◽  
Span 60

Objective: The objectives of present investigation were to prepare and evaluate proniosomes of neomycin sulphate (NS) by coacervation phase separation method by using sorbitan monostearate (span 60) and lecithin as a surfactant to increase the penetration through the skin and study the effect of concentration of the same. Methods: Proniosomes of neomycin sulphate (NS) were prepared by coacervation phase separation method by using span 60 and lecithin. The effect of concentration of span 60 and lecithin was studied by factorial design. The prepared proniosomes were converted to gel by using carbopol as a gelling agent. The prepared formulations were evaluated for entrapment efficiency, in vitro drug diffusion, in vitro antibacterial activity and in vivo skin irritation test etc. Results: All Formulation showed the percentage entrapment efficiency in the range 38.31±0.05% to 77.96±0.06%, good homogeneity and gel was easily spreadable with minimal of shear. Optimized formulation showed enhanced rate of diffusion in vitro, increase in zone of inhibition against staphylococcus aureus, no skin irritation and showed good stability. Conclusion: The results of present study indicates that proniosomal gel formulated by using combination of span 60, Lecithin, cholesterol can be used to enhance skin delivery of NS because of excellent permeation of drug. Developed proniosomal gel formulation was promising carrier for NS

scholarly journals Synthesis and In Vitro Assessment of pH-Sensitive Human Serum Albumin Conjugates of Pirarubicin

2020 ◽  
Vol 14 (1) ◽  
pp. 22
Author(s):  
Kenji Tsukigawa ◽  
Shuhei Imoto ◽  
Keishi Yamasaki ◽  
Koji Nishi ◽  
Toshihiko Tsutsumi ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Coupling Reaction ◽  
Synthetic Polymer ◽  
Ph Sensitive ◽  
Acidic Ph ◽  
Polymer Conjugate ◽  
Acidic Conditions

In a previous study, we reported on the development of a synthetic polymer conjugate of pirarubicin (THP) that was formed via an acid-labile hydrazone bond between the polymer and the THP. However, the synthetic polymer itself was non-biodegradable, which could lead to unexpected adverse effects. Human serum albumin (HSA), which has a high biocompatibility and good biodegradability, is also a potent carrier for delivering antitumor drugs. The objective of this study was to develop pH-sensitive HSA conjugates of THP (HSA-THP), and investigate the release of THP and the cytotoxicity under acidic conditions in vitro for further clinical development. HSA-THP was synthesized by conjugating maleimide hydrazone derivatives of THP with poly-thiolated HSA using 2-iminothiolane, via a thiol-maleimide coupling reaction. We synthesized two types of HSA-THP that contained different amounts of THP (HSA-THP2 and HSA-THP4). Free THP was released from both of the HSA conjugates more rapidly at an acidic pH, and the rates of release for HSA-THP2 and HSA-THP4 were similar. Moreover, both HSA-THPs exhibited a higher cytotoxicity at acidic pH than at neutral pH, which is consistent with the effective liberation of free THP under acidic conditions. These findings suggest that these types of HSA-THPs are promising candidates for further development.

Sign in / Sign up

Export Citation Format

Share Document