Metabolic syndrome in schizophrenia -impact of antipsychotic medication

2011 ◽  
Vol 26 (S2) ◽  
pp. 1255-1255
Author(s):  
T.M.-S. Maria-Silvia
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Family History ◽  
Antipsychotic Medication ◽  
Paranoid Schizophrenia ◽  
Personal Hygiene ◽  
Psychotic Symptoms ◽  
Psychotic Behavior ◽  
Diet And Lifestyle ◽  
Almost Continuous

Metabolic syndrome generally includes some or all of the following: elevated blood pressure, abdominal obesity, diabetes or “prediabetes” (impaired glucose tolerance, impaired fasting glucose or insulin resistance), dyslipidemia (high levels of triglycerides and/or HDL), and inflammatory markersP.S. a 34 year old, diagnosed with Paranoid schizophrenia. The patient comes from a disorganised family. The disease started at 18 years with psychotic symptoms - delirious, psychotic behavior, aggression, neglect of personal hygiene. He received almost continuous antipsychotic medication. In recent years received the second generation antipsychotic medication. Under this medication increased weight reaching 160 kg in weight. The most significant weight gain occurred in recent years under neuroleptic medication with clozapinum. Hypertension (max 200/120) appeared as a complication of increased weight, requiring antihypertensive medication. Has not other endocrine problems. Laboratory values increased cholesterol, triglyceride, and lipid. Glycemia remained normal. In the last six months patient received amisulpiridum 800 mg/day. In same conditions of life the patient has lost 40 kg in weight reaching 140 kg. Family history- mother obesity and HTA;Weight and (BMI) initially 160kg/180 cm then 120 kg/180 cm;Waist circumference 140 cm;Blood pressure initially 200/120 mm Hg then160 /110 mmhg;Fasting lipids increased,glucose normal Conclusion: Assessment of risk factors is necessary before prescription of antipsychotics. Especially weight, BMI, family history for obesity, and ethnicity should be evaluated. People taking antipsychotics that increase the risk of MetS should be educated on this subject. They should be advised about their diet and lifestyle, about how to recognize symptoms of MetS and its consequences.

scholarly journals Riwayat Hipertensi Keluarga Sebagai Faktor Dominan Hipertensi pada Remaja Kelas XI SMA Sejahtera 1 Depok Tahun 2017

2018 ◽  
Vol 46 (1) ◽  
pp. 1-10
Author(s):  
Annisa Nursita Angesti ◽  
Triyanti Triyanti ◽  
Ratu Ayu Dewi Sartika
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Family History ◽  
Fruits And Vegetables ◽  
Dominant Factor ◽  
Cross Sectional ◽  
Include Blood Pressure ◽  
History Of ◽  
Family History Of Hypertension ◽  
Diet And Lifestyle

AbstractNutritional status changes, diet, and lifestyle are risk factors adolescent’s hypertension. This study isa cross sectional research to determine the most dominant factor of hypertension among adolescentsat SMA Sejahtera 1 Depok 2017. Collected data include blood pressure, nutritional status (BMI forage), intake nutrients (sodium, potassium, calcium, fat, fruits and vegetables consumption), lifestyle(sleep duration, stress, and physical activity), and adolescent characteristics (sex and family historyof hypertension). Blood pressure was measured using mercury sphygmomanometer, nutritional statuswith anthropometry, nutrient intake with Semi Quantitative FFQ, lifestyle and characteristics withquestionnaire. The study showed that 42.4% of adolescents had hypertension (≥95 percentile). Factorsassociated with hypertension were BMI for age and family history of hypertension. The most dominantfactor associated with hypertension was family history of hypertension. Education on genetic relatedrisk factors of hypertension such as genetic counseling through Health School Program was needed forprevent adolescent’s hypertension, so that students with a family history of hypertension may be moreconcerned about other risk factors such as nutritional status.Keywords : adolescent, family history of hypertension, hypertension   AbstrakPerubahan status gizi, pola makan dan gaya hidup pada remaja merupakan faktor risiko hipertensi remaja.Penelitian ini merupakan penelitian cross sectional untuk mengetahui faktor dominan hipertensi padaremaja di SMA Sejahtera 1 Depok tahun 2017. Data yang dikumpulkan meliputi tekanan darah, statusgizi (IMT/U), asupan zat gizi (natrium, kalium, kalsium, lemak, konsumsi buah dan sayur), pola hidup(durasi tidur, stres, aktivitas fisik), dan karakteristik remaja (jenis kelamin dan riwayat hipertensi keluarga).Tekanan darah diukur menggunakan sfigmomanometer air raksa, status gizi dengan antropometri,asupan zat gizidengan Semi Quantitative FFQ, pola hidup dan karakteristik dengan kuesioner. Hasilpenelitian menunjukkan bahwa sebanyak 42,4% remaja SMA Sejahtera 1 Depok mengalami hipertensi(≥95 persentil). Terdapat hubungan IMT/U dan riwayat hipertensi keluarga pada hipertensi remajanya.Faktor dominan yang paling berhubungan dengan hipertensi pada remaja di SMA Sejahtera 1 Depoktahun 2017 adalah riwayat hipertensi keluarga. Diperlukan edukasi seperti kegiatan konseling genetikmelalui UKS (Usaha Kesehatan Sekolah) tentang faktor risiko riwayat hipertensi keluarga sebagaipencegahan hipertensi remaja, sehingga bagi siswa yang memiliki riwayat hipertensi keluarga dapat lebihmemperhatikan faktor risiko lainnya seperti status gizi.Kata kunci: hipertensi, remaja, riwayat hipertensi keluarga

scholarly journals Audit of monitoring of the parameters of metabolic syndrome in patients on clozapine

2012 ◽  
Vol 36 (12) ◽  
pp. 466-469 ◽  
Author(s):  
John Tully ◽  
Christina Sim ◽  
Razi Hemani ◽  
Malik Munir ◽  
Nasir Khalil ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Blood Glucose ◽  
Waist Circumference ◽  
Lipid Profile ◽  
Antipsychotic Medication ◽  
Marked Improvement ◽  
Fasting Blood Glucose ◽  
Therapeutic Interventions ◽  
Clinical Implications

Aims and MethodHigh rates of metabolic syndrome exist among patients on clozapine. Monitoring its parameters facilitates interventions which may alleviate negative health consequences. We completed an audit of the monitoring of the parameters of metabolic syndrome in patients on clozapine. The results were compared with the Maudsley Guidelines for monitoring in patients on any antipsychotic medication.ResultsInitial audit showed high overall rates of concordance with guidelines for the frequency of measurement of blood pressure (91.8%), but much lower rates for measuring fasting blood glucose (43.2%) and lipid profile (52.7%), and no record of analysis of waist circumference. This prompted development of a formal protocol for measuring parameters. Repeat audit after 1 year showed marked improvement in rates of measurement.Clinical implicationsImplementation of relatively straightforward measures, such as the introduction of a one-page form on which to record parameters, can lead to a much improved rate of monitoring for metabolic syndrome. This should in turn prompt therapeutic interventions, which are discussed.

scholarly journals Prevalence of Metabolic Syndrome in Local Population of Patan.

2013 ◽  
Vol 11 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Babu Raja Maharjan ◽  
Shital Bhandary ◽  
Ira Shrestha ◽  
Laxmi Sunuwar ◽  
Sanjjit Shrestha
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Family History ◽  
Local Population ◽  
Positive Family History ◽  
International Diabetes Federation ◽  
Family History Of Diabetes ◽  
The Metabolic Syndrome ◽  
Low Hdl ◽  
History Of

Introduction: The metabolic syndrome (MS) is a cluster of complex interrelated risk factors for diabetes and cardiovascular disease which includes central obesity, glucose intolerance, hypertension, high triglyceride and low HDL-C. The prevalence of MS in Asian Indian is 49.2%. There is evidence of increasing prevalence of MS in the world. Therefore, we intended to find the prevalence of the metabolic syndrome in the local population of Patan, a major urban center in Nepal. Methods: It was a cross-sectional study which was carried out in one of the urban clusters (or wards) of the Lalitpur Sub- Metropolitan (or Patan) City. Measurements of waist circumference, height, weight; blood parameters like lipid profile, fasting blood sugar (FBS) were done. Measurement of blood pressure was done. The prevalence of MS was obtained by using three different criteria Joint Interim Statement 2009 criteria, International diabetes federation (IDF) 2005 criteria and National cholesterol education program adult treatment Panel (NCEP ATP) III 2001 criteria. Results: There were 205 participants among which 34.6% were male and 65.4% were female. The prevalence of MS as per the Joint Interim Statement 2009, IDF 2005 and NCEP ATP III 2001 criteria was 61.7%, 52.7% and 43.4% respectively. There was significantly high total cholesterol (TC), triglyceride (TAG), FBS, systolic blood pressure (SBP) and diastolic blood pressure (DBP) and significantly low HDL-C in the individuals with MS compared to the normal individuals. The logistic regression revealed the increasing prevalence of MS with increasing age, BMI and positive family history of diabetes. Conclusions: There is high prevalence of MS in the study population. Age, BMI and family history of diabetes are found to be the main predictors for metabolic syndrome. Medical Journal of Shree Birendra Hospital; Jan-June 2012/vol.11/Issue1/27-31 DOI: http://dx.doi.org/10.3126/mjsbh.v11i1.7764

METABOLIC SYNDROME IN DIALYSIS PATIENTS

2016 ◽  
pp. 7-11
Author(s):  
Vinh Phu Hoang ◽  
Tam Vo ◽  
Van Tien Le ◽  
Thi Hoai Huong Vo
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Artificial Kidney ◽  
Dialysis Patients ◽  
Cross Sectional ◽  
Average Value ◽  
The Metabolic Syndrome ◽  
End Stage

Objective: To review disorders elements of the metabolic syndrome in patients with end-stage chronic renal failure on dialysis cycle. Materials and methods: A cross sectional descriptive study of 85 patients including end-stage chronic renal failure in dialysis cycle from 5/2015 - 9/2016 at the Department of Artificial Kidney, Hue Central Hospital. Results: The prevalence of metabolic syndrome in dialysis patients was 37.65%. The prevalence of abdominal obesity was 30.6%; The prevalence of hypertension was 72.9%, the average value systolic blood pressure and diastolic blood pressure were 142.24 ± 27.53, 80.35 ± 12.48 mmHg; The prevalence of hyperglycemia was 28%, the average value blood glucose was 4.9 ± 1.19 mmol/l; The prevalence of triglyceride increase was 34.1%, the average value triglyceride was 1.59 ± 0.84 mmol/l. The prevalence of HDL-C increase was 47.1%, the average value HDL-C was 1.24 ± 0.33 mmol/l. Conclusion: The prevalence of metabolic syndrome in dialysis patients is very high, in which hypertension and HDL disturbances are the highest. Key words: chronic renal failure, dialysis, metabolic syndrome

Comparative Effect of Telmisartan vs Lisinopril on Blood Pressure in Patients of Metabolic Syndrome

2015 ◽  
Vol 15 (1) ◽  
pp. 64-70 ◽  
Author(s):  
Pradip N. Gore ◽  
Vandana A. Badar ◽  
Mrunalini M. Hardas ◽  
Varsha J. Bansode
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Comparative Effect

scholarly journals Association between polymorphism at IGF-1 rs35767 gene locus and long-term decline in renal function: a Japanese retrospective longitudinal cohort study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Kosuke Honda ◽  
Satoru Kuriyama ◽  
Kimiyoshi Ichida ◽  
Tomoko Nakano ◽  
Naoki Sugano ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Renal Function ◽  
Uric Acid ◽  
Cohort Study ◽  
Serum Uric Acid Level ◽  
Human Growth ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort

Abstract Background Insulin-like growth factor-1 (IGF-1) acts on glucose and protein metabolism and human growth and also influences blood pressure and renal function. This study investigated whether the single-nucleotide polymorphism of IGF-1, rs35767, plays a role in metabolic syndrome indicators, including blood pressure, glucose metabolism, uric acid levels, and renal function. Methods In this retrospective longitudinal cohort study, blood samples from 1506 Japanese individuals were collected and used for genotyping for variant rs35767: T > C in the IGF-1 upstream promoter. Data were analyzed to identify associations between IGF-1 genotypes and patient biochemical parameters, including the components of metabolic syndrome and the long-term change in renal function. Results The cohort rs35767 genotypes included 650 CC carriers (43.2%), 687 TC carriers (45.6%), and 169 TT carriers (11.2%). Multiple regression analysis revealed no association between IGF-1 genotype and blood pressure, glycated hemoglobin level, and serum uric acid level. However, in females, blood pressure was negatively correlated with the TT genotype. Longitudinal observation revealed that the decline in eGFR over 10 years was greater in TT (− 18.51 ± 1.04 mL/min/1.73m2) than in CC carriers (− 16.38 ± 0.52 mL/min/1.73m2; P < 0.05). Conclusion The present study suggests that renal function declines faster in individuals with the TT genotype at the IGF-1 rs35767 locus than in those with the CC genotype, suggesting that the TT genotype is associated with the long-term chronological decline in renal function.

scholarly journals Metabolic Syndrome Features and Excess Weight Were Inversely Associated with Nut Consumption after 1-Year Follow-Up in the PREDIMED-Plus Study

2020 ◽  
Vol 150 (12) ◽  
pp. 3161-3170
Author(s):  
Alicia Julibert ◽  
Maria del Mar Bibiloni ◽  
Laura Gallardo-Alfaro ◽  
Manuela Abbate ◽  
Miguel Á Martínez-González ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Energy Intake ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Virgin Olive Oil ◽  
Hdl Cholesterol ◽  
Excess Weight ◽  
Study Cohort

ABSTRACT Background High nut consumption has been previously associated with decreased prevalence of metabolic syndrome (MetS) regardless of race and dietary patterns. Objectives The aim of this study was to assess whether changes in nut consumption over a 1-y follow-up are associated with changes in features of MetS in a middle-aged and older Spanish population at high cardiovascular disease risk. Methods This prospective 1-y follow-up cohort study, conducted in the framework of the PREvención con DIeta MEDiterránea (PREDIMED)-Plus randomized trial, included 5800 men and women (55–75 y old) with overweight/obesity [BMI (in kg/m2) ≥27 and &lt;40] and MetS. Nut consumption (almonds, pistachios, walnuts, and other nuts) was assessed using data from a validated FFQ. The primary outcome was the change from baseline to 1 y in features of MetS [waist circumference (WC), glycemia, HDL cholesterol, triglyceride (TG), and systolic and diastolic blood pressure] and excess weight (body weight and BMI) according to tertiles of change in nut consumption. Secondary outcomes included changes in dietary and lifestyle characteristics. A generalized linear model was used to compare 1-y changes in features of MetS, weight, dietary intakes, and lifestyle characteristics across tertiles of change in nut consumption. Results As nut consumption increased, between each tertile there was a significant decrease in WC, TG, systolic blood pressure, weight, and BMI (P &lt; 0.05), and a significant increase in HDL cholesterol (only in women, P = 0.044). The interaction effect between time and group was significant for total energy intake (P &lt; 0.001), adherence to the Mediterranean diet (MedDiet) (P &lt; 0.001), and nut consumption (P &lt; 0.001). Across tertiles of increasing nut consumption there was a significant increase in extra virgin olive oil intake and adherence to the MedDiet; change in energy intake, on the other hand, was inversely related to consumption of nuts. Conclusions Features of MetS and excess weight were inversely associated with nut consumption after a 1-y follow-up in the PREDIMED-Plus study cohort. This trial was registered at isrctn.com as ISRCTN89898870.

scholarly journals Dietary and lifestyle inflammatory scores are associated with increased risk of metabolic syndrome in Iranian adults

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Hossein Farhadnejad ◽  
Karim Parastouei ◽  
Hosein Rostami ◽  
Parvin Mirmiran ◽  
Fereidoun Azizi
Keyword(s):  
Metabolic Syndrome ◽  
Positive Association ◽  
Population Based ◽  
Population Based Study ◽  
Logistic Regression Models ◽  
Increased Risk ◽  
Confounding Variables ◽  
Adjusted Model ◽  
Diet And Lifestyle

Abstract Background In the current study, we aimed to investigate the association of dietary inflammation scores (DIS) and lifestyle inflammation scores (LIS) with the risk of metabolic syndrome (MetS) in a prospective population-based study. Methods A total of 1625 participants without MetS were recruited from among participants of the Tehran Lipid and Glucose Study(2006–2008) and followed a mean of 6.1 years. Dietary data of subjects were collected using a food frequency questionnaire at baseline to determine LIS and DIS. Multivariable logistic regression models, were used to calculate the odds ratio (ORs) and 95 % confidence interval (CI) of MetS across tertiles of DIS and LIS. Results Mean ± SD age of individuals (45.8 % men) was 37.5 ± 13.4 years. Median (25–75 interquartile range) DIS and LIS for all participants was 0.80 (− 2.94, 3.64) and 0.48 (− 0.18, − 0.89), respectively. During the study follow-up, 291 (17.9 %) new cases of MetS were identified. Based on the age and sex-adjusted model, a positive association was found between LIS (OR = 7.56; 95% CI 5.10–11.22, P for trend < 0.001) and risk of MetS, however, the association of DIS and risk of MetS development was not statistically significant (OR = 1.30;95% CI 0.93–1.80, P for trend = 0.127). In the multivariable model, after adjustment for confounding variables, including age, sex, body mass index, physical activity, smoking, and energy intake, the risk of MetS is increased across tertiles of DIS (OR = 1.59; 95% CI 1.09–2.33, P for trend = 0.015) and LIS(OR = 8.38; 95% CI 5.51–12.7, P for trend < 0.001). Conclusions The findings of the current study showed that greater adherence to LIS and DIS, determined to indicate the inflammatory potential of diet and lifestyle, are associated with increased the risk of MetS.

Sign in / Sign up

Export Citation Format

Share Document