P.2.a.009 Low lipid levels are risk factors for suicidal behaviour in patients with depression

2012 ◽  
Vol 22 ◽  
pp. S229
Author(s):  
B. Aini-yet ◽  
J. Rybakowski
Keyword(s):  
Risk Factors ◽  
Suicidal Behaviour ◽  
Lipid Levels

The Relation of Body Mass Index to Biochemical Parameters and Profile of Heart Failure

2018 ◽  
Vol 69 (7) ◽  
pp. 1673-1677
Author(s):  
Viviana Aursulesei ◽  
Andrei Manta ◽  
Razan Al Namat ◽  
Monica Hugianu ◽  
Angela Maria Moloce ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Failure ◽  
Body Mass Index ◽  
Body Mass ◽  
Patient Selection ◽  
Biochemical Parameters ◽  
Obesity Paradox ◽  
Lipid Levels ◽  
Randomized Control ◽  
Selection Parameters

The bidirectional relation between body mass index (BMI) and heart failure (HF) is complex and not fully understood. The obesity paradox phenomena is controversial and related to patient selection, parameters used for defining abnormal weight, characteristics of HF. Our study sustain the importance of controlling risk factors, in particular plasma glucose, lipid levels, as well as hypertension in patients with HF and BMI over 25 kg/m2. Also, in contrast to the randomized control studies our results can only partially support data related to obesity paradox phenomena.

Correlates of Youth Suicide Attempters in Australian Community and Clinical Samples

2003 ◽  
Vol 37 (3) ◽  
pp. 286-293 ◽  
Author(s):  
Gregory L. Carter ◽  
Cathy Issakidis ◽  
Kerrie Clover
Keyword(s):  
Mental Health ◽  
Risk Factors ◽  
Substance Use ◽  
Substance Use Disorder ◽  
Suicidal Behaviour ◽  
Clinical Sample ◽  
Community Sample ◽  
Community Control ◽  
Clinical Group ◽  
Health Related

Objective: This study (i) explores differences between a clinical sample of deliberate selfpoisoning (DSP) patients and a community sample who reported previous attempted suicide (AS); and (ii) examines correlates of suicidal behaviour in these groups compared with a community control group (CC) with no suicidal behaviour. Method: The study design was: case–case, case–control and cross-sectional population studies. A clinical sample of DSP (n = 51), a community sample of AS (n = 31) and a community sample with no suicidal behaviour (n = 842) were used, all aged 18–24 years. The DSP and AS groups were compared on several variables and two logistic regression models were developed for risk of (i) DSP and (ii) AS compared to community controls. Results: The adjusted odds ratios for DSP were: female gender (OR = 5.7, CI = 1.7–19.4), anxiety (OR = 7.4, CI = 2.2–25.1), affective (OR = 23.0, CI = 6.9–76.5), or substance-use disorder (OR = 19.2, CI = 5.6–65.4) and greater mental health related disability (OR = 0.5, CI = 0.3–0.7 for 1 SD decrease). For AS the results were: anxiety (OR = 9.4, CI = 1.7–52.8) or substance-use disorder (OR = 3.0, CI = 1.1–8.7) and greater mental health disability (OR = 0.5, CI = 0.4–0.7). Affective disorder was close to significant for the AS group (OR = 4.0, CI = 0.9–17.1). Conclusions: Correlates of DSP/AS were usually more powerful in the clinical group, but showed a similar pattern of psychiatric disorder and disability factors in both groups, supporting a continuum of risk factors across these groups. Interventions based on modifiable risk factors could target the same factors for public health, primary care or hospital populations: anxiety, depression and substance use disorders and mental health related disability.

scholarly journals Increased midlife triglycerides predict brain β-amyloid and tau pathology 20 years later

Neurology ◽  
2017 ◽  
Vol 90 (1) ◽  
pp. e73-e81 ◽  
Author(s):  
Katarina Nägga ◽  
Anna-Märta Gustavsson ◽  
Erik Stomrud ◽  
Daniel Lindqvist ◽  
Danielle van Westen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Healthy Population ◽  
Lipid Levels ◽  
Tau Pathology ◽  
Lipoprotein Subfractions ◽  
Cognitively Normal ◽  
Normal Individuals ◽  
Β Amyloid

ObjectiveTo evaluate the effect of midlife lipid levels on Alzheimer brain pathology 20 years later in cognitively normal elderly individuals.MethodsThis is a longitudinal cohort study of 318 cognitively normal individuals with data on fasting lipid levels at midlife (mean age 54 years). Presence of β-amyloid (Aβ) and tau pathologies 20 years later (mean age 73 years) were detected by quantifying Alzheimer disease (AD) biomarkers in CSF. In a subset (n = 134), Aβ (18F-flutemetamol) PET was also performed.ResultsCSF Aβ42 and Aβ PET revealed Aβ pathology in approximately 20% of the cognitively healthy population and CSF Aβ42/phosphorylated tau (p-tau) ratio indicated both Aβ and tau pathology in 16%. Higher levels of triglycerides in midlife were independently associated with abnormal CSF Aβ42 (odds ratio [OR] 1.34, 95% confidence interval [CI] 1.03–1.75, p = 0.029) and abnormal Aβ42/p-tau ratio (OR 1.46, 95% CI 1.10–1.93; p = 0.009) adjusting for age, sex, APOE ε4, education, and multiple vascular risk factors. Triglycerides were also associated with abnormal Aβ PET in multivariable regression models, but the association was attenuated in the fully adjusted model. Increased levels of medium and large low-density lipoprotein subfractions were significantly associated with abnormal Aβ PET and large high-density lipoprotein particles were associated with decreased risk of abnormal Aβ PET.ConclusionsIncreased levels of triglycerides at midlife predict brain Aβ and tau pathology 20 years later in cognitively healthy individuals. Certain lipoprotein subfractions may also be risk factors for Aβ pathology. These findings further support an involvement of lipids in the very early stages of AD development.

scholarly journals Socio-demographic, mental health and childhood adversity risk factors for self-harm and suicidal behaviour in College students in Northern Ireland

2018 ◽  
Vol 239 ◽  
pp. 58-65 ◽  
Author(s):  
Siobhan O'Neill ◽  
Margaret McLafferty ◽  
Edel Ennis ◽  
Coral Lapsley ◽  
Tony Bjourson ◽  
...  
Keyword(s):  
Mental Health ◽  
Risk Factors ◽  
College Students ◽  
Northern Ireland ◽  
Suicidal Behaviour ◽  
Childhood Adversity ◽  
Self Harm

Abstract P555: Plasma Lipids And The Risk For Stroke In The Reasons For Geographic And Racial Differences In Stroke Study (regards).

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Neil Zakai ◽  
Jessica Minnier ◽  
Monika M Safford ◽  
Lisandro Colantonio ◽  
Marguerite M Irvin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Racial Differences ◽  
Stroke Risk ◽  
Plasma Lipids ◽  
Cox Regression ◽  
Strong Association ◽  
Plasma Lipid ◽  
Lipid Levels ◽  
Cvd Risk ◽  
Stroke Incidence

Introduction: Whether plasma lipid levels are associated with stroke risk remains controversial, with even less data for American blacks versus whites. Hypothesis: We hypothesized that abnormal lipid levels are not associated with stroke incidence in either blacks or whites. Methods: The REasons for Geographic And Racial Differences in Stroke (REGARDS) study recruited 30,283 black and white individuals aged 45+ from the contiguous U.S. between 2003 to 2007, participants with a history of stroke at baseline were excluded. Participants were followed until 2018 for stroke events following the WHO definition and confirmed by review of medical records. The association of lipid measures with stroke were assessed using Cox regression models adjusted for traditional CVD risk factors and an age-x-race interaction term. Results: With 27,714 participants (mean age 64.85± 9.43, 59.5% white and 55.4% female), over a median of 11 years of follow up, 1,415 stroke events occurred, of which 599 among blacks. After adjusting for traditional stroke risk factors, there were modest associations between higher total cholesterol and higher LDL, but not higher triglycerides, with stroke risk. There was no evidence of a race interaction. Overall, HDL levels were not associated with stroke risk. However, when stratified by race, whites had a reduced risk of stroke with higher HDL-C, whereas no association was seen among blacks (p-interaction 0.09). Conclusion: In REGARDs, there was a modest association of cholesterol measures with stroke risk. The association for HDL with stroke may be influenced by race, with a less strong association among blacks than among whites.

scholarly journals Lipidomic profiling of plasma in a healthy Singaporean population to identify ethnic specific differences in lipid levels and associations with disease risk factors

2017 ◽  
Vol 6 ◽  
pp. 25-31 ◽  
Author(s):  
Husna Begum ◽  
Federico Torta ◽  
Pradeep Narayanaswamy ◽  
Piyushkumar A. Mundra ◽  
Shanshan Ji ◽  
...  
Keyword(s):  
Risk Factors ◽  
Disease Risk ◽  
Lipid Levels

scholarly journals Suicide following discharge from in-patient psychiatric care

2004 ◽  
Vol 10 (6) ◽  
pp. 434-438 ◽  
Author(s):  
Mike J. Crawford
Keyword(s):  
Risk Factors ◽  
Social Support ◽  
Patient Care ◽  
Hospital Discharge ◽  
Continuity Of Care ◽  
Suicidal Behaviour ◽  
Psychiatric Care ◽  
Epidemiological Studies ◽  
Clinical Risk Factors ◽  
Service Organisation

The risk of suicide is higher during the period immediately following discharge from in-patient psychiatric care than at any other time in a service user's life. Demographic and clinical risk factors for suicide in this period are similar to those for suicide at other times and may not be specific enough to enable identification of those at greatest risk. Epidemiological studies suggest that factors related to service organisation and delivery (e.g. social support and continuity of care) are also important in the aetiology of suicide following hospital discharge. Interventions aimed at helping people in the period immediately following discharge from in-patient care have been developed. Although the effect of these interventions on suicidal behaviour has not been examined, available evidence suggests that efforts to increase patients' confidence and level of social support may be of value.

A Longitudinal Survey of the Evolution of Some Cardiovascular Risk Factors during the Careers of Male Firefighters Retiring from Strathclyde Fire Brigade from 1985–1994

2000 ◽  
Vol 45 (3) ◽  
pp. 79-83 ◽  
Author(s):  
C.W. Ide
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Hdl Cholesterol ◽  
Tobacco Consumption ◽  
Longitudinal Survey ◽  
Lipid Levels ◽  
Retrospective Survey ◽  
Fire Brigade ◽  
Medical Examinations ◽  
Electrocardiographic Abnormalities

This paper is based on a retrospective survey of the cardiovascular risk factor records of 526 wholetime male firefighters retiring from Strathclyde Fire Brigade during the decade beginning 1 January 1985 who had accumulated 14,022 man-years of service. Changes in body mass index (BMI) and systolic & diastolic blood pressure (S&DBP) were observed from enlistment and through the triennial routine medical examinations (RME) which took place from age 40 to retirement, usually occuring after age 50. Tobacco consumption, electrocardiographic abnormalities, and fasting lipid levels were checked at each RME. The findings were then subdivided into quinquennia. Mean BMI (+/-1 SD) increased from 23.4(2.6) at enlistment to 26.6(3.2) at retirement with the proportion of those obese (BMI>=30) changing from 1.8% to 17.2% respectively. Systolic and diastolic BP also rose throughout the study from 126(7.14) and 77(7.1 1) to 137(16.9) and 87(10,9). No subjects had BP > 160 or > 110 at enlistment but, on retirement, this had been attained by 7.2 and 2.1%. Mean cholesterol and triglyceride levels rose from 5.23(.70) to 6.21(1.09) and 1.65(0.67) to 1.93(1.32). HDL cholesterol fell from 1.71(0.35) to 1.37(0.46). The proportion of non-smokers rose from 35.9 to 48.9%. When the results were analysed by quinquennia, statistically significant differences at retirement were found for BMI, S&DBP, and triglycerides. This would suggest that health education activities have not been effective in this workforce.

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