Systemically administered human umbilical cord perivascular cells (HUCPVC) prevent tumor growth in a human melanoma tumor-bearing mouse model

Cytotherapy ◽  
2021 ◽  
Vol 23 (5) ◽  
pp. S59
Author(s):  
L. Lopez ◽  
H. Shuster Hyman ◽  
A. Gasner ◽  
H. Khan ◽  
E. Marco ◽  
...  
Keyword(s):  
Mouse Model ◽  
Tumor Growth ◽  
Umbilical Cord ◽  
Human Melanoma ◽  
Human Umbilical Cord ◽  
Tumor Bearing Mouse ◽  
Perivascular Cells ◽  
Melanoma Tumor ◽  
Tumor Bearing ◽  
Prevent Tumor Growth

scholarly journals Effects of Oral Administration of Fucoidan Extracted from Cladosiphon okamuranus on Tumor Growth and Survival Time in a Tumor-Bearing Mouse Model

Marine Drugs ◽  
2012 ◽  
Vol 10 (12) ◽  
pp. 2337-2348 ◽  
Author(s):  
Kazuo Azuma ◽  
Toshitsugu Ishihara ◽  
Hiroyuki Nakamoto ◽  
Takao Amaha ◽  
Tomohiro Osaki ◽  
...  
Keyword(s):  
Mouse Model ◽  
Oral Administration ◽  
Tumor Growth ◽  
Survival Time ◽  
Tumor Bearing Mouse ◽  
Growth And Survival ◽  
Tumor Bearing ◽  
Cladosiphon Okamuranus

scholarly journals Effects of photodynamic hyperthermal therapy with indocyanine green on tumor growth in a colon 26 tumor-bearing mouse model

2014 ◽  
Vol 7 (4) ◽  
pp. 1147-1150 ◽  
Author(s):  
MASAKI ONOYAMA ◽  
KAZUO AZUMA ◽  
TAKESHI TSUKA ◽  
TOMOHIRO IMAGAWA ◽  
TOMOHIRO OSAKI ◽  
...  
Keyword(s):  
Mouse Model ◽  
Tumor Growth ◽  
Indocyanine Green ◽  
Tumor Bearing Mouse ◽  
Colon 26 ◽  
Tumor Bearing

scholarly journals Effects of orlistat combined with enzalutamide and castration through inhibition of fatty acid synthase in a PC3 tumor-bearing mouse model

2021 ◽  
Author(s):  
Yeu-Sheng Tyan ◽  
Yen-Po Lee ◽  
Hui-Yen Chuang ◽  
Wei-Hsun Wang ◽  
Jeng-Jong Hwang
Keyword(s):  
Prostate Cancer ◽  
Cell Cycle ◽  
Fatty Acid ◽  
Mouse Model ◽  
Tumor Growth ◽  
Fatty Acid Synthase ◽  
Synergistic Effects ◽  
Growth Delay ◽  
Tumor Bearing Mouse ◽  
Tumor Bearing

Androgen deprivation therapy (ADT) is one of the typical treatments used for patients with prostate cancer (PCa). ADT, however, may fail when PCa develops castration-resistance. Fatty acid synthase (FASN), a critical enzyme involved in fatty acid synthesis, is found to be upregulated in PCa. Since enzalutamide and ADT are frequently used for the treatment of PCa, this study aimed to unravel the underlying mechanism of combination of orlistat, a FASN inhibitor, and enzalutamide using PC3 cell line; and orlistat and castration in PC3 tumor-bearing animal model. Cytotoxicity was determined by AlamarBlue assay. Drug effects on the cell cycle and protein expressions were assayed by the flow cytometry and Western blot. Electromobility shift assay was used to evaluate the NF-κB activity. The tumor growth delay, expressions of the signaling–related proteins, and histopathology post treatments of orlistat and castration were evaluated in PC3 tumor-bearing mouse model. The results showed that orlistat arrested the PC3 cells at the G1 phase of the cell cycle and enhanced the cytotoxic effects of enzalutamide synergistically. Pretreatment with orlistat combined with castration inhibited the tumor growth significantly compared with those of castration and orlistat treatments alone in PC3 tumor-bearing mice. Combination treatment reduced both fatty acid synthase and NF-κB activities and their downstream effector proteins. The present study demonstrated the synergistic effects of orlistat combined with enzalutamide in vitro and castration in vivo on human prostate cancer.

scholarly journals Radiation-induced lung fibrosis in a tumor-bearing mouse model is associated with enhanced Type-2 immunity

2015 ◽  
Vol 57 (2) ◽  
pp. 133-141 ◽  
Author(s):  
Jing Chen ◽  
Yacheng Wang ◽  
Zijie Mei ◽  
Shimin Zhang ◽  
Jie Yang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Lung Fibrosis ◽  
Tumor Bearing Mouse ◽  
Tumor Bearing ◽  
Type 2 Immunity ◽  
Radiation Induced
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