The First Five Years of the Budapest Twin Register, 1970–1974

1979 ◽  
Vol 28 (1) ◽  
pp. 73-76 ◽  
Author(s):  
A. Czeizel ◽  
I. Pazonyi ◽  
J. Métneki ◽  
M. Tomka

The Budapest Twin Register recorded 88.6% of the 1739 multiple births that occurred between 1970 and 1974. Of these, 31.2% were male-female pairs. Based on the examination of the placenta (19.8% monochorial) and of genetic markers, 406 pairs proved to be monozygotic and 645 dizygotic. Sex ratio of twins at birth showed a female preponderance (1000 F: 1009 M) in comparison to singletons (1000 F: 1071 M). Average birth weight of the twins was 2101 g. The frequency of stillbirths was about four times higher in twins than in singletons, twice as high in monozygotic than in dizygotic twins, and 2.4 times higher among second than first-born twins.

1950 ◽  
Vol 1 (1) ◽  
pp. 76 ◽  
Author(s):  
JF Kennedy ◽  
RA Bettenay

Merino ewes, 1278 in all, representing 3 age groups, were pen-mated in 32 lots to individual rams, and a further 200 similar ewes were mated in one lot to 8 rams. The layout of the yards, the techniques employed, and the ration fed to the sheep are described. The reaction by the ewes to the unusual conditions of restraint imposed upon them during both mating and lambing were observed, and it was demonstrated that with care and attention large flocks of Merino sheep are suitable subjects for intense investigations. Data relating to incidence and duration of oestrus, the length of oestrous cycles, and performance of individual rams were recorded in detail for all animals. Extensive information on all aspects of lambing is examined. It was found that the age of the dam, within the range under observation, was associated with lamb losses, birth weight of progeny, and occurrence of multiple births, but was not associated with incidence of oestrus, conception, length of gestation, or sex ratio of progeny. Length of gestation was found to be associated with sex and birth weight of progeny but was not significantly associated with the incidence of single or multiple births.


1976 ◽  
Vol 22 (3) ◽  
pp. 99-102 ◽  
Author(s):  
M. GEBRE-MEDHIN ◽  
S. GUROVSKY ◽  
L. BONDESTAM

1971 ◽  
Vol 20 (3) ◽  
pp. 301-314 ◽  
Author(s):  
Andrew Czeizel ◽  
George Acsádi

SummaryIn Hungary the frequency of multiple births has been decreasing. In 1920 the rate of multiple births was 23-5‰; by 1968 this rate decreased to 18.2‰, i.e., only 77% of the 1920 data. The male preponderance in twin births is lower than in single births, and in triplets actually a female excess can be observed. Furthermore, it can be observed that there are more boys than girls among the first-born of multiple births. The average birth weight of liveborn and stillborn twins, and of liveborn triplets is 2101 g, 1458 g, and 1723 g respectively. The ratio of MZ to DZ twins is about 30:70 in 1968. The frequency of DZ twin births increases with maternal age (the peak is now over 40 years) and birth order. According to the 1959, i960, and 1968 figures, both DZ and MZ twin births were significantly more frequent in mothers aged 16 or less than in mothers aged 17-19 years.This demographic survey belonged to preparatory works connected with the setting up of the Budapest Twin Register which came into force on January 1st, 1970.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Duah Dwomoh

Abstract Background Ghana did not meet the Millennium Development Goal 4 of reducing child mortality by two-thirds and may not meet SDG (2030). There is a need to direct scarce resources to mitigate the impact of the most important risk factors influencing high neonatal deaths. This study applied both spatial and non-spatial regression models to explore the differential impact of environmental, maternal, and child associated risk factors on neonatal deaths in Ghana. Methods The study relied on data from the Ghana Demographic and Health Surveys (GDHS) and the Ghana Maternal Health Survey (GMHS) conducted between 1998 and 2017 among 49,908 women of reproductive age and 31,367 children under five (GDHS-1998 = 3298, GDHS-2003 = 3844, GDHS-2008 = 2992, GDHS-2014 = 5884, GMHS-2017 = 15,349). Spatial Autoregressive Models that account for spatial autocorrelation in the data at the cluster-level and non-spatial statistical models with appropriate sampling weight adjustment were used to study factors associated with neonatal deaths, and a p-value less than 0.05 was considered statistically significant. Results Population density, multiple births, smaller household sizes, high parity, and low birth weight significantly increased the risk of neonatal deaths over the years. Among mothers who had multiple births, the risk of having neonatal deaths was approximately four times as high as the risk of neonatal deaths among mothers who had only single birth [aRR = 3.42, 95% CI: 1.63–7.17, p < 0.05]. Neonates who were perceived by their mothers to be small were at a higher risk of neonatal death compared to very large neonates [aRR = 2.08, 95% CI: 1.19–3.63, p < 0.05]. A unit increase in the number of children born to a woman of reproductive age was associated with a 49% increased risk in neonatal deaths [aRR = 1.49, 95% CI: 1.30–1.69, p < 0.05]. Conclusion Neonatal mortality in Ghana remains relatively high, and the factors that predisposed children to neonatal death were birth size that were perceived to be small, low birth weight, higher parity, and multiple births. Improving pregnant women’s nutritional patterns and providing special support to women who have multiple deliveries will reduce neonatal mortality in Ghana.


Author(s):  
Ane Bungum Kofoed ◽  
Laura Deen ◽  
Karin Sørig Hougaard ◽  
Kajsa Ugelvig Petersen ◽  
Harald William Meyer ◽  
...  

AbstractHuman health effects of airborne lower-chlorinated polychlorinated biphenyls (LC-PCBs) are largely unexplored. Since PCBs may cross the placenta, maternal exposure could potentially have negative consequences for fetal development. We aimed to determine if exposure to airborne PCB during pregnancy was associated with adverse birth outcomes. In this cohort study, exposed women had lived in PCB contaminated apartments at least one year during the 3.6 years before conception or the entire first trimester of pregnancy. The women and their children were followed for birth outcomes in Danish health registers. Logistic regression was performed to estimate odds ratios (OR) for changes in secondary sex ratio, preterm birth, major congenital malformations, cryptorchidism, and being born small for gestational age. We performed linear regression to estimate difference in birth weight among children of exposed and unexposed mothers. All models were adjusted for maternal age, educational level, ethnicity, and calendar time. We identified 885 exposed pregnancies and 3327 unexposed pregnancies. Relative to unexposed women, exposed women had OR 0.97 (95% CI 0.82, 1.15) for secondary sex ratio, OR 1.13 (95% CI 0.76, 1.67) for preterm birth, OR 1.28 (95% CI 0.81, 2.01) for having a child with major malformations, OR 1.73 (95% CI 1.01, 2.95) for cryptorchidism and OR 1.23 (95% CI 0.88, 1.72) for giving birth to a child born small for gestational age. The difference in birth weight for children of exposed compared to unexposed women was − 32 g (95% CI—79, 14). We observed an increased risk of cryptorchidism among boys after maternal airborne LC-PCB exposure, but due to the proxy measure of exposure, inability to perform dose–response analyses, and the lack of comparable literature, larger cohort studies with direct measures of exposure are needed to investigate the safety of airborne LC-PCB exposure during pregnancy


Author(s):  
Irma Seriana ◽  
Yusrawati Yusrawati ◽  
Gustina Lubis

Objective: To determine the relationship between serum zinc level at term pregnancy and newborn anthropometry. Methods: This study is an observational study with cross-sectional design. Serum zinc level at term pregnancy was measured and then anthropometric measurement was done to the newborn, including birth weight, birth length and head circumference at birth. The data were statistically analyzed using regression correlation test. Results: Mean serum zinc level at term pregnancy is 36.01 μg/dl (SD=18.34 μg/dl), the average birth weight is 3158 gr (SD=480.4 gr), the average birth length is 48.42 cm (SD=1.75 cm) and the average head circumference at birth is 33.13 cm (SD=1.14 cm). There was no statistically significant relationship between serum zinc levels at term pregnancy and birth weight (p-value=0.152). Meanwhile, there are statistically significant relationships between serum zinc level at term pregnancy with birth length and head circumference with pvalue 0.026 and 0.012, respectively. Conclusion: Serum zinc level at term pregnancy is correlated with birth length and head circumference, but is not correlated with birth weight. [Indones J Obstet Gynecol 2015; 3-4: 190-195] Keywords: birth length, birth weight, head circumference at birth, serum zinc level, term pregnancy


2015 ◽  
Vol 6 (4) ◽  
pp. 263-267 ◽  
Author(s):  
S. Sandboge ◽  
J. Fellman ◽  
P. M. Nilsson ◽  
A. W. Eriksson ◽  
C. Osmond ◽  
...  

The Åland Islands were recently ranked as Finland’s healthiest region with lower prevalence of several non-communicable diseases compared with the national mean. We have compared birth characteristics of 1697 individuals born on the Åland Islands between 1937 and 1944 with contemporaneous data from the Helsinki Birth Cohort Study (HBCS;n=11,808). This is a first step towards a potential future analysis of Ålandic health from a life-course perspective. Mean birth weight and length were calculated for both cohorts. Birth weight was entered into a multiple linear regression model with sex, maternal age, marital status and birth year as predictors. Mean birth weight in the Åland cohort was 3499 g, 87 g (95% CI 62; 111) higher compared with the HBCS. Sex and maternal marital status were the strongest predictors of birth weight. More detailed studies are needed to explore the potential effects of this difference in average birth weight between cohorts.


1968 ◽  
Vol 48 (2) ◽  
pp. 155-161 ◽  
Author(s):  
W. A. Jordan ◽  
E. E. Lister ◽  
G. J. Rowlands

For 4 consecutive years, calf production was compared for Shorthorn cows fed at four levels during winter pregnancy and barn-nursing: (I) ad libitum corn silage plus 1.0 kg mixed hay/100 kg initial body weight daily; (II), (III) and (IV) approximately 80, 60 and 40%, respectively, of level-I intake. Half of the cows on each level received 0.45 kg linseed oilmeal (LOM) per head, daily, and half of both the LOM and no-LOM cows received supplemental vitamin A (84,000 IU per head, weekly).Neither the 4-year average birth weight (32.8, 32.3, 34.8, 32.4 kg for levels I to IV, respectively) nor the 4-year average daily gain to weaning (0.85, 0.89, 0.89, 0.89 kg for levels I to IV, respectively) were significantly different (P > 0.05). The 4-year average wither height and body depth at birth were similarly not different for the four levels. Supplementing the dam’s ration with LOM and/or vitamin A had no significant (P > 0.05) effect on either weight and body measurements at birth or gain to weaning. It was only during year 3, when level-IV cows’ (non-LOM-supplemented) daily intake was 0.033 kg digestible protein and 0.36 kg total digestible nutrients per 100 kg initial weight, that protein supplementation significantly (P < 0.05) increased birth weight and body measurements of their calves. There was little difference in survival of calves from cows fed at different levels or fed LOM versus no LOM. Contrary to expectations, vitamin A-supplemented cows appeared to produce calves with poorer survival.


PEDIATRICS ◽  
1965 ◽  
Vol 36 (1) ◽  
pp. 138-140
Author(s):  
PAUL W. K. WONG ◽  
RICHARD C. BURNSTINE ◽  
DAVID YI-YUNG HSIA

The familial nature of "neonatal hepatitis" has been known far some years. The present paper reports on the occurrence of this condition in one of dizygotic twins. Case Report A.B., a white female, was first admitted to the Children's Memorial Hospital at the age of 2 months with a history of persistent jaundice. She was the first born of a twin pregnancy with a birth weight of 5 lb (2.3 kg). Jaundice was first noted within a few hours after birth and increased in intensity as the child grew older. The stools were light and the urine dark. Despite a good appetite, the weight gain had been poor.


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