scholarly journals The proportion of lycopene isomers in human plasma is modulated by lycopene isomer profile in the meal but not by lycopene preparation

2011 ◽  
Vol 107 (10) ◽  
pp. 1482-1488 ◽  
Author(s):  
Myriam Richelle ◽  
Pierre Lambelet ◽  
Andreas Rytz ◽  
Isabelle Tavazzi ◽  
Anne-France Mermoud ◽  
...  
Keyword(s):  
Intestinal Absorption ◽  
Human Plasma ◽  
Health Benefits ◽  
Healthy Men ◽  
Low Level

Dietary lycopene consists mostly of the (all-E) isomer. Upon absorption, (all-E) lycopene undergoes isomerisation into various (Z)-isomers. Because these isomers offer potentially better health benefits than the (all-E) isomer, the aim of the present study was to investigate if the profile of lycopene isomers in intestinal lipoproteins is affected by the profile of lycopene isomers in the meal and by the tomato preparation. Six postprandial, crossover tests were performed in healthy men. Three meals provided about 70 % of the lycopene as (Z)-isomers, either mainly as 5-(Z) or 13-(Z), or as a mixture of 9-(Z) and 13-(Z) lycopene, while three tomato preparations provided lycopene mainly as the (all-E) isomer. Consumption of the 5-(Z) lycopene-rich meal led to a high (60 %) proportion of this isomer in TAG-rich lipoproteins (TRL), indicating a good absorption and/or a low intestinal conversion of this isomer. By contrast, consumption of meals rich in 9-(Z) and 13-(Z) lycopene isomers resulted in a low level of these isomers but high amounts of the 5-(Z) and (all-E) isomers in TRL. This indicates that the 9-(Z) and 13-(Z) isomers were less absorbed or were converted into 5-(Z) and (all-E) isomers. Dietary (Z)-lycopene isomers were, therefore, differently isomerised and released in TRL during their intestinal absorption in men. Consuming the three meals rich in (all-E) lycopene resulted in similar proportions of lycopene isomers in TRL: 60 % (all-E), 20 % 5-(Z), 9 % 13-(Z), 2 % 9-(Z) and 9 % unidentified (Z)-isomers. These results show that the tomato preparation has no impact on the lycopene isomerisation occurring during absorption in humans.

DOSAGE DE L'HORMONE LUTEINISANTE DANS LE PLASMA HUMAIN. RESULTATS CHEZ LES SUJETS NORMAUX DES DEUX SEXES

1965 ◽  
Vol 49 (2) ◽  
pp. 293-298 ◽  
Author(s):  
Jean Louchart ◽  
Jacqueline Truffert ◽  
Jacques Decourt
Keyword(s):  
Luteinizing Hormone ◽  
Human Plasma ◽  
Assay Method ◽  
Men And Women ◽  
Healthy Men ◽  
Low Level ◽  
Plasma Humain

ABSTRACT An assay method for luteinizing hormone in human plasma is described. The results in healthy men and women are reported: in ten men, a significant level is constantly found, varying from 5 to 14 μg/2.5 ml of plasma. In three women with normal menses, a very low level is found during the preovulatory period, rising significantly at mid-cycle to return afterwards to lower levels, these remaining higher than preovulatory ones.

MALABSORPTION OF FOOD IN RURAL COMMUNITIES

PEDIATRICS ◽  
1978 ◽  
Vol 62 (1) ◽  
pp. 53-53
Keyword(s):  
Drinking Water ◽  
Rural Communities ◽  
Intestinal Absorption ◽  
Rural Areas ◽  
Healthy Men ◽  
Adult Men ◽  
Definite Improvement ◽  
Experimental Introduction ◽  
Cash Cost ◽  
Better Than

The survey on malabsorption of food in rural communities of Guatemala indicated that the experimental introduction of drinking water in a community resulted in a definite decline in the incidence of diarrhoea in children from 3 to 7 years of age. Longitudinal evaluation of the capacity of healthy men to absorb d-xylose revealed malabsorption in 30% of individuals living under poor sanitation conditions, as compared with 9% among those living under sanitation conditions which were better than those in rural areas. A definite improvement in d-xylose absorption was observed in the community where drinking water was introduced. Findings of longitudinal studies on intestinal absorption indicated that between 50 and 60 per cent of all the adult men were losing about 350 calories per day, a loss which, expressed in economic terms, is equivalent to 5-7 per cent of the cash cost of the diet.

Targeted Proteomics of Low-Level Proteins in Human Plasma by LC/MSn:  Using Human Growth Hormone as a Model System

2002 ◽  
Vol 1 (5) ◽  
pp. 459-465 ◽  
Author(s):  
Shiaw-Lin Wu ◽  
Heidi Amato ◽  
Roger Biringer ◽  
Gargi Choudhary ◽  
Paul Shieh ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Human Plasma ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Model System ◽  
Targeted Proteomics ◽  
Low Level

scholarly journals Bioavailability of astaxanthin stereoisomers from wild (Oncorhynchusspp.) and aquacultured (Salmo salar) salmon in healthy men: a randomised, double-blind study

2008 ◽  
Vol 99 (5) ◽  
pp. 1048-1054 ◽  
Author(s):  
Corinna E. Rüfer ◽  
Jutta Moeseneder ◽  
Karlis Briviba ◽  
Gerhard Rechkemmer ◽  
Achim Bub
Keyword(s):  
Human Plasma ◽  
Salmo Salar ◽  
Chiral Stationary Phase ◽  
Relative Proportion ◽  
Double Blind Study ◽  
Double Blind ◽  
Wild Salmon ◽  
Healthy Men ◽  
Isomer Distribution ◽  
Selective Process

The objective of the present study was to investigate the bioavailability and the configurational isomer distribution of the carotenoid astaxanthin (AST) in human plasma after ingestion of wild (Oncorhynchusspp.) and aquacultured (Salmo salar) salmon. In a randomised and double-blind trial, twenty-eight healthy men consumed 250 g wild or aquacultured salmon daily for 4 weeks which provided 5 μg AST/g salmon flesh. The plasma AST concentrations as well as the isomer distribution were measured by HPLC using a reversed and a chiral stationary phase. After 6 d of intervention with salmon, plasma AST concentrations reached a plateau of 39 nmol/l after consumption of wild salmon and of 52 nmol/l after administration of aquacultured salmon. At days 3, 6, 10 and 14 – but not at day 28 – the AST concentrations in human plasma were significantly greater after ingestion of aquacultured salmon. After administration of wild salmon, the (3S,3′S) isomer predominated in plasma (80 %), whereas after intake of aquacultured salmon themesoform (3R,3′S) prevailed (48 %). Therefore, the AST isomer pattern in human plasma resembles that of the ingested salmon. However, after consumption of both wild and aquacultured salmon for 28 d the relative proportion of the (3S,3′S) isomer was slightly higher and the (3R,3′R) form lower in human plasma compared with the isomer distribution in salmon flesh. A selective process of isomer absorption could be responsible for the observed differences in the relative proportions of the (3S,3′S) and (3R,3′R) isomers in human plasma compared with salmon flesh.

scholarly journals Lipid-Based Nanocarrier System for the Effective Delivery of Nutraceuticals

Molecules ◽  
2021 ◽  
Vol 26 (18) ◽  
pp. 5510
Author(s):  
Parthasarathi Subramanian
Keyword(s):  
Intestinal Absorption ◽  
Health Benefits ◽  
Lipid Nanoparticles ◽  
Lymphatic Transport ◽  
Mass Ratio ◽  
Carrier System ◽  
Current Limitation ◽  
Effective Delivery ◽  
Critical Overview

Nutraceuticals possess several health benefits and functions; however, most nutraceuticals are prone to degradation in the gastrointestinal environment and have poor bioavailability. Application of a novel carrier system is of increasing importance to overcome obstacles and provide efficient applicability. Lipid-based nanocarriers provide a large surface-to-mass ratio, enhanced intestinal absorption by solubilization in the intestinal milieu, intestinal lymphatic transport, and altering enterocyte-based transport. A critical overview of the current limitation, preparation, and application of lipid-based nanocarriers (liposomes and niosomes) and lipid nanoparticles (SLNs and NLCs) is discussed. Physical and gastrointestinal stability and bioavailability of nanoencapsulated nutraceuticals are considered as well.

scholarly journals Demographic variability indicators of somatically healthy men from different administrative and territorial regions of Ukraine

2016 ◽  
Vol 29 (2) ◽  
pp. 90-93 ◽  
Author(s):  
Volodymyr Mishalov ◽  
Larisa Klimas ◽  
Valery Gunas
Keyword(s):  
Cultural Differences ◽  
Healthy Men ◽  
Low Level ◽  
The North ◽  
Quantitative Characteristics ◽  
Central Regions ◽  
North And South ◽  
Territorial Division

Abstract Our work has revealed a rather low level of similarity in regard to the finger dermatoglyphics of somatically healthy men, 19-35 years old, between Ukraine’s north and west, north and south, center and west, center and south, as well as the palmar dermatoglyphics between central regions and the east, center and west, center and south. The obtained finger/palmar dermatoglyphics did not differentiate administrative-territorial local groups of men between the north and the center, south and west (quantitative characteristics); or palmar – between the north and west, north and east, south and west, south and east, north and center. The differences between the administrative and territorial division of dermatoglyphic signs are a reflection of the historical and cultural differences induced by migration, as well as the intensive process of mixing, in addition to the isolation of particular groups.

scholarly journals Enhancing sulforaphane absorption and excretion in healthy men through the combined consumption of fresh broccoli sprouts and a glucoraphanin-rich powder

2011 ◽  
Vol 107 (9) ◽  
pp. 1333-1338 ◽  
Author(s):  
Jenna M. Cramer ◽  
Margarita Teran-Garcia ◽  
Elizabeth H. Jeffery
Keyword(s):  
Health Benefits ◽  
Human Diet ◽  
Healthy Men ◽  
Broccoli Sprouts ◽  
Early Appearance ◽  
Broccoli Sprout ◽  
Insight Into

Sulforaphane (SF) is a chemopreventive isothiocyanate (ITC) derived from glucoraphanin (GRP) hydrolysis by myrosinase, a thioglucoside present in broccoli. The ability of broccoli powders sold as supplements to provide dietary SF is often of concern as many supplements contain GRP, but lack myrosinase. In a previous study, biomarkers of SF bioavailability from a powder rich in GRP, but lacking myrosinase, were enhanced by co-consumption of a myrosinase-containing air-dried broccoli sprout powder. Here, we studied the absorption of SF from the GRP-rich powder used in the previous study, but in combination with fresh broccoli sprouts, which are commercially available and more applicable to the human diet than air-dried sprout powder. A total of four participants each consumed four meals (separated by 1 week) consisting of dry cereal and yogurt with sprouts equivalent to 70 μmol SF, GRP powder equivalent to 120 μmol SF, both or neither. Metabolites of SF were analysed in blood and urine. The 24 h urinary SF-N-acetylcysteine recovery was 65, 60 and 24 % of the dose ingested from combination, broccoli sprout and GRP powder meals, respectively. In urine and plasma, ITC appearance was delayed following the GRP powder meal compared with the sprout and combination meals. Compared with the GRP powder or sprouts alone, combining broccoli sprouts with the GRP powder synergistically enhanced the early appearance of SF, offering insight into the combination of foods for improved health benefits of foods that reduce the risk for cancer.

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