Effects of energy balance on appetite and physiologic mediators of appetite during strenuous physical activity: secondary analysis of a randomized crossover trial

2021 ◽  
pp. 1-40
Author(s):  
J. Philip Karl ◽  
Adrienne Hatch-McChesney ◽  
Jillian T. Allen ◽  
Heather S. Fagnant ◽  
Patrick N. Radcliffe ◽  
...  
Keyword(s):  
Physical Activity ◽  
Gastric Emptying ◽  
Energy Balance ◽  
Secondary Analysis ◽  
Energy Deficit ◽  
Military Operations ◽  
Appetite Suppression ◽  
Balanced Diet ◽  
Strenuous Physical Activity ◽  
Prospective Consumption

Abstract Energy deficit is common during prolonged periods of strenuous physical activity and limited sleep, but the extent to which appetite suppression contributes is unclear. The aim of this randomized crossover study was to determine the effects of energy balance on appetite and physiologic mediators of appetite during a 72-hr period of high physical activity energy expenditure (PAEE, ˜2300kcal/d) and limited sleep designed to simulate military operations (SUSOPS). Ten men consumed an energy-balanced diet while sedentary for 1d (REST) followed by energy balanced (BAL) and energy deficient (DEF) controlled diets during SUSOPS. Appetite ratings, gastric emptying time (GET), and appetite-mediating hormone concentrations were measured. Energy balance was positive during BAL (18±20%) and negative during DEF (-43±9%). Relative to REST, hunger, desire to eat and prospective consumption ratings were all higher during DEF (26±40%, 56±71%, 28±34%, respectively), and lower during BAL (-55±25%, -52±27%, -54±21%, respectively; Pcondition<0.05). Fullness ratings did not differ from REST during DEF, but were 65±61% higher during BAL (Pcondition<0.05). Regression analyses predicted hunger and prospective consumption would be reduced and fullness increased if energy balance were maintained during SUSOPS, and energy deficits of ≥25% would be required to elicit increases in appetite. Between-condition differences in GET and appetite-mediating hormones identified slowed gastric emptying, increased anorexigenic hormone concentrations, and decreased fasting acylated ghrelin concentrations as potential mechanisms of appetite suppression. Findings suggest that physiologic responses that suppress appetite may deter energy balance from being achieved during prolonged periods of strenuous activity and limited sleep.

Energy flux, more so than energy balance, protein intake, or fitness level, influences insulin-like growth factor-I system responses during 7 days of increased physical activity

2007 ◽  
Vol 103 (5) ◽  
pp. 1613-1621 ◽  
Author(s):  
Kevin R. Rarick ◽  
Matthew A. Pikosky ◽  
Ann Grediagin ◽  
Tracey J. Smith ◽  
Ellen L. Glickman ◽  
...  
Keyword(s):  
Physical Activity ◽  
Energy Balance ◽  
Energy Intake ◽  
Energy Flux ◽  
Protein Intake ◽  
Activity Level ◽  
Protein Diet ◽  
Energy Deficit ◽  
Fitness Level ◽  
Igf I

The purpose of this study was to determine the impact of dietary factors and exercise-associated factors on the response of IGF-I and its binding proteins (IGFBPs) during a period of increased physical activity. Twenty-nine men completed a 4-day ( days 1–4) baseline period of a controlled energy balanced diet while maintaining their normal physical activity level followed by 7 days ( days 5–11) of a 1,000 kcal/day increase in physical activity above their normal activity levels. Two subject groups, one sedentary (Sed, mean V̇o2peak: 39 ml·kg−1·min−1, n = 7) and one fit (FIT1, mean V̇o2peak: 56 ml·kg−1·min−1, n = 8) increased energy intake to maintain energy balance throughout the 7-day intervention. In two other fit subject groups (FIT2, n = 7 and FIT3, n = 7), energy intake remained at baseline resulting in a 1,000 kcal/day exercise-induced energy deficit. Of these, FIT2 received an adequate protein diet (0.9 g/kg), and FIT3 received a high-protein diet (1.8 g/kg). For all four groups, IGF-I, IGFBP-3, and the acid labile subunit (ALS) were significantly decreased by day 11 (27 ± 4%, 10 ± 2%, and 19 ± 4%, respectively) and IGFBP-2 significantly increased by 49 ± 21% following day 3. IGFBP-1 significantly increased only in the two negative energy balance groups, FIT2 (38 ± 6%) and FIT3 (46 ± 8%). Differences in initial fitness level and dietary protein intake did not alter the IGF-I system response to an acute increase in physical activity. Decreases in IGF-I were observed during a moderate increase in physical activity despite maintaining energy balance, suggesting that currently unexplained exercise-associated mechanisms, such as increased energy flux, regulate IGF-I independent of energy deficit.

scholarly journals Declines in Dietary Iron Absorption Following Simulated Military Operations Are Exacerbated by Energy Deficit

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1807-1807
Author(s):  
Stephen Hennigar ◽  
Adrienne Hatch-McChesney ◽  
Jillian Allen ◽  
Christopher Carrigan ◽  
Nancy Murphy ◽  
...  
Keyword(s):  
Energy Balance ◽  
Iron Absorption ◽  
Iron Status ◽  
Military Training ◽  
Energy Deficit ◽  
Dietary Iron ◽  
Daily Energy Expenditure ◽  
Military Operations ◽  
Daily Energy ◽  
Total Daily Energy Expenditure

Abstract Objectives Iron status declines with military training; however, the reason for the decline is not known. The objective of this study was to determine whether dietary iron absorption is reduced following military training and whether energy deficit during training modifies the effect. Methods This was a randomized, cross-over, controlled-feeding trial in healthy, active duty military males (n = 10, age 22.4 ± 5.4 y, weight 87.3 ± 10.9 kg) with normal iron status (serum ferritin 77.0 ± 36.7 ng/mL). Following a rest day (no exercise), participants completed a 72-h simulated sustained military operations (SUSOPS) followed by a 7-d recovery period. SUSOPS was comprised of military tasks designed to elicit high energy expenditures, muscle damage, and sleep deprivation. During SUSOPS, participants were randomized to consume ± 10% of estimated total daily energy expenditure (BAL) or 45% of total daily energy expenditure to induce severe negative energy balance (NEG BAL), but an equivalent amount of dietary iron. Two hours after rest, BAL, and NEG BAL participants consumed a beverage containing 3.8 mg of a stable iron isotope and plasma isotope appearance and hepcidin were determined 0, 20, 40, 60, 120, 240, and 360 min later. Results BAL maintained weight (−0.03 ± 0.8 kg) and muscle glycogen (4.1 ± 68.1% change), while NEG BAL lost weight (−2.38 ± 1.7 kg, P &lt; 0.01) and muscle glycogen (−47.6 ± 17.8% change, P = 0.08) during SUSOPS. C-reactive protein (rest 1.2 ± 0.9, BAL 4.7 ± 3.6, NEG BAL 4.8 ± 3.5 mg/L, Pphase &lt; 0.001) increased with SUSOPS compared to rest regardless of energy balance. Peak plasma isotope appearance at 120 min was 49% lower with BAL (116.9 ± 81.4% change from 0 min) and 74% lower with NEG BAL (58.9 ± 38.1%) compared to rest (229.7 ± 97.3%, P &lt; 0.01 for all comparisons). Plasma hepcidin was not different at 0 min (rest 7.2 ± 1.6, BAL 6.7 ± 2.4, NEG BAL 6.8 ± 1.7 ng/mL, P = 0.79) and peaked at 360 min (rest 19.4 ± 9.5, BAL 9.5 ± 4.7, NEG BAL 13.7 ± 8.9 ng/mL, P = 0.03). Conclusions Dietary iron absorption is reduced following SUSOPS in healthy males with normal iron status and the reduction is exacerbated with energy deficit. Circulating concentrations of hepcidin following 72-h SUSOPS do not appear to mediate the reduction in dietary iron absorption. Funding Sources The views expressed are those of the authors and do not reflect official policy of the Army, DoD, or US Government. Supported by MRDC.

scholarly journals Energy deficit increases hepcidin and exacerbates declines in dietary iron absorption following strenuous physical activity: a randomized-controlled cross-over trial

2020 ◽  
Author(s):  
Stephen R Hennigar ◽  
James P McClung ◽  
Adrienne Hatch-McChesney ◽  
Jillian T Allen ◽  
Marques A Wilson ◽  
...  
Keyword(s):  
Physical Activity ◽  
Energy Expenditure ◽  
Iron Absorption ◽  
Iron Status ◽  
Energy Deficit ◽  
Dietary Iron ◽  
Daily Energy Expenditure ◽  
Daily Energy ◽  
Total Daily Energy Expenditure ◽  
Strenuous Physical Activity

ABSTRACT Background Strenuous physical activity promotes inflammation and depletes muscle glycogen, which may increase the iron regulatory hormone hepcidin. Hepcidin reduces dietary iron absorption and may contribute to declines in iron status frequently observed following strenuous physical activity. Objectives To determine the effects of strenuous physical activity on hepcidin and dietary iron absorption and whether energy deficit compared with energy balance modifies those effects. Methods This was a randomized, cross-over, controlled-feeding trial in healthy male subjects (n = 10, mean ± SD age: 22.4 ± 5.4 y, weight: 87.3 ± 10.9 kg) with sufficient iron status (serum ferritin 77.0 ± 36.7 ng/mL). Rest measurements were collected before participants began a 72-h simulated sustained military operation (SUSOPS), designed to elicit high energy expenditure, glycogen depletion, and inflammation, followed by a 7-d recovery period. Two 72-h SUSOPS trials were performed where participants were randomly assigned to consume either energy matched (±10%) to their individual estimated total daily energy expenditure (BAL) or energy at 45% of total daily energy expenditure to induce energy deficit (DEF). On the rest day and at the completion of BAL and DEF, participants consumed a beverage containing 3.8 mg of a stable iron isotope, and plasma isotope appearance was measured over 6 h. Results Muscle glycogen declined during DEF and was preserved during BAL (−188 ± 179 mmol/kg, P-adjusted &lt; 0.01). Despite similar increases in interleukin-6, plasma hepcidin increased during DEF but not BAL, such that hepcidin was 108% greater during DEF compared with BAL (7.8 ± 12.2 ng/mL, P-adjusted &lt; 0.0001). Peak plasma isotope appearance at 120 min was 74% lower with DEF (59 ± 38% change from 0 min) and 49% lower with BAL (117 ± 81%) compared with rest (230 ± 97%, P-adjusted &lt; 0.01 for all comparisons). Conclusions Strenuous physical activity decreases dietary iron absorption compared with rest. Energy deficit exacerbates both the hepcidin response to physical activity and declines in dietary iron absorption compared with energy balance. This trial was registered at clinicaltrials.gov as NCT03524690.

scholarly journals Influence of intense physical activity on energy balance and body fatness

1999 ◽  
Vol 58 (1) ◽  
pp. 99-105 ◽  
Author(s):  
Angelo Tremblay
Keyword(s):  
Physical Activity ◽  
Energy Balance ◽  
Energy Expenditure ◽  
Energy Deficit ◽  
Surgical Approaches ◽  
Post Exercise ◽  
Exercise Energy Expenditure ◽  
Prevalence Of Obesity ◽  
Intense Physical Activity ◽  
Free Living Conditions

The reduced contribution of physical activity to daily energy expenditure and the accessibility to high-fat foods have put an excessive burden on energy balance, resulting in an increase in the prevalence of obesity throughout the world. In this context, fat gain can be seen as a natural adaptation to deal with a fattening lifestyle, since the hormonal adaptations that accompany fat gain favour the readjustment of energy expenditure to energy intake. Intense physical activity would also seem to facilitate the regulation of energy balance, since it increases the energy cost of exercise, increases post-exercise energy expenditure and the potential of skeletal muscles to utilize lipids, and also favours a decrease in post-exercise intake. Moreover, the effects of intense exercise seem to be mediated by an activation of sympathetic nervous system activity that seems to be specific to skeletal muscle. It is also important to manipulate macronutrient composition in order to reduce fat intake, because unhealthy food habits can favour overfeeding and thus overcome the energy deficit caused by regular physical activity. Under free-living conditions, the combination of vigorous activity and healthy food practices can amount to a substantial weight loss which is comparable with that of other non-surgical approaches to treat obesity.

scholarly journals The Impact of Prescribed Exercise and Short-Term Caloric Restriction on Moderate-to-Vigorous Physical Activity (P08-011-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Alexandra Martin ◽  
Birgit Wallmann-Sperlich ◽  
Billy Sperlich ◽  
Karsten Koehler
Keyword(s):  
Physical Activity ◽  
Weight Loss ◽  
Energy Balance ◽  
Caloric Restriction ◽  
Repeated Measures ◽  
Vigorous Physical Activity ◽  
Energy Deficit ◽  
Short Term ◽  
Food And Agriculture ◽  
The Impact

Abstract Objectives Weight loss, especially when achieved by caloric restriction (CR), reduces total daily energy expenditure (EE), which can attenuate further weight loss. Although exercise is a common countermeasure to the decline in EE, it is unknown whether prescribed exercise leads to compensatory changes in moderate-to-vigorous physical activities (MVPA) during non-exercise periods in the context of CR. The present study sought to quantify changes in MVPA in response to an energetically-matched energy deficit induced by CR alone or combined with exercise. We hypothesized that MVPA outside of prescribed exercise would be greater during non-exercise conditions, regardless of energy balance. Methods In a repeated-measures crossover design, active men (n = 6, 25 ± 1.0 y) underwent four 4-day conditions: CR with exercise (CR + X), CR without exercise (CR–X), energy-balanced control (CON) with exercise (CON + X) and without exercise (CON–X). Dietary intake was manipulated such that energy availability (EA) was 15 kcal·kg FFM−1·day−1 (CR) or 40 kcal·kg FFM−1·day−1 (CON). Prescribed exercise EE was 15 kcal·kg FFM−1·day−1. Physical activity was assessed using the SenseWear Pro3 armband (Bodymedia, Pittsburgh, USA) to quantify time spent in MVPA and light activities (sleep, lying down without sleep, and non-lying light activities) as % of total wear time. Results EA did not differ between CR (P = 0.87) nor CON (P = 0.42). As expected, weight loss was significant (P < 0.001) in CR + EX (–1.8 ± 0.4 kg) and CR-EX (–2.4 ± 0.3 kg). After deducting prescribed exercise, there was a significant effect of exercise on time spent in MVPA (P = 0.02), in that MVPA was lower during CON-EX vs. CON + EX (11.4 ± 2.0% vs. 17.9 ± 2.1%, P = 0.03) and trended lower during CR-EX vs. CR + EX (13.6 ± 1.5% vs. 15.5 ± 1.6%, P = 0.08). In exercise conditions, MVPA was lower during CR + EX when compared to CON + EX (P = 0.03). Conclusions Independent of energy balance, engaging in short-term exercise led to more, not less, time spent in non-exercise MVPA. These findings indicate the prevention of reductions in non-exercise activity as an additional benefit of incorporating exercise into weight loss interventions. Funding Sources The study was supported in part by the USDA National Institute of Food and Agriculture and institutional funding from the University of Nebraska-Lincoln.

Weight and Physical Activity: a 12-month follow-up of a digital diabetes prevention program (VP Transform for Prediabetes) in adults with prediabetes (Preprint)

2020 ◽  
Author(s):  
Ryan Batten ◽  
Meshari F Alwashmi ◽  
Gerald Mugford ◽  
Misa Muccio ◽  
Angele Besner ◽  
...  
Keyword(s):  
Physical Activity ◽  
Type 2 Diabetes ◽  
Prevention Program ◽  
Diabetes Prevention ◽  
Secondary Analysis ◽  
Diabetes Prevention Program ◽  
Global Scale ◽  
Lifestyle Modifications ◽  
Behavior Tracking

BACKGROUND The prevalence of diabetes increasingly rapidly. Previous research has demonstrated the efficacy of a diabetes prevention program (DPP) in lifestyle modifications which can prevent or delay the onset of type 2 diabetes among individuals at-risk. Digital DPPs have the potential to utilize technology, in conjunction with behavior change science, to prevent prediabetes on a national and global scale OBJECTIVE The aim of this study was to investigate the effects of a digital DPP (VP Transform for Prediabetes) on weight loss and physical activity among participants who had completed twelve months of the program. METHODS This study was a secondary analysis of retrospective data of adults with prediabetes who were enrolled in VP Transform for Prediabetes for 12 months of the program. The program incorporates interactive mobile computing, remote monitoring, an evidence-based curriculum, behavior tracking tools, health coaching and online peer support to prevent or delay the onset of type 2 diabetes. Analysis included data that were collected at baseline and after 12 months of the VP Transform for Prediabetes DPP. RESULTS The sample (N=1,095) comprised people with prediabetes who completed 12 months of the VP Transform for Prediabetes program. Participants included 67.7% female, with a mean age of 53.6 (SD 9.75). On average, participants decreased their weight by 10.9 pounds (5.5%) and increased their physical activity by 91.2 minutes per week. CONCLUSIONS These results suggest that VP Transform for Prediabetes is effective at preventing type 2 diabetes through significant reduction in body weight and increase of physical activity. Furthermore, these results suggest that the DPP remains effective 12 months after beginning the program. A prospective, controlled clinical study is warranted to validate these findings.

scholarly journals The EnergyKids Pilot Study: Comparing Energy Balance of Primary School Children during School and Summer Camp

Nutrients ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 92
Author(s):  
Cinzia Franchini ◽  
Alice Rosi ◽  
Cristian Ricci ◽  
Francesca Scazzina
Keyword(s):  
Physical Activity ◽  
Energy Balance ◽  
Weight Status ◽  
Summer Camp ◽  
Negative Energy ◽  
Primary School Children ◽  
Food Diary ◽  
Activity Tracker ◽  
School Time ◽  
Study Participants

Children’s energy requirements may vary during school and summer camp days. To evaluate energy balance during these two periods, seventy-eight children (45% females, 8–10 years) living in Parma, Italy, were enrolled in this observational study. Participants completed a 3-day food diary and wore an activity tracker for three consecutive days during a school- and a summer camp-week to estimate energy intake (EI) and energy expenditure (TEE). Height and body weight were measured at the beginning of each period to define children’s weight status. BMI and EI (school: 1692 ± 265 kcal/day; summer camp: 1738 ± 262 kcal/day) were similar during both periods. Both physical activity and TEE (summer camp: 1948 ± 312; school: 1704 ± 263 kcal/day) were higher during summer camp compared to school time. Therefore, energy balance was more negative during summer camp (−209 ± 366 kcal/day) compared to school time (−12 ± 331 kcal/day). Similar results were observed when males and females were analyzed separately but, comparing the sexes, males had a higher TEE and a more negative energy balance than females, during both periods. The results strongly suggest that an accurate evaluation of children’s energy balance, that considers both diet and physical activity, is needed when planning adequate diets for different situations.

Association of Behavioral Phenotypes With Changes in Sleep During a Workplace Wellness Program

2021 ◽  
pp. 089011712110150
Author(s):  
Kimberly J. Waddell ◽  
Sujatha Changolkar ◽  
Gregory Szwartz ◽  
Sarah Godby ◽  
Mitesh S. Patel
Keyword(s):  
Physical Activity ◽  
Sleep Duration ◽  
Physical Activity Intervention ◽  
Secondary Analysis ◽  
The United States ◽  
Behavioral Phenotype ◽  
Workplace Wellness ◽  
Wellness Program ◽  
Behavioral Phenotypes ◽  
Physically Active

Purpose: Examine changes in sleep duration by 3 behavioral phenotypes during a workplace wellness program with overweight and obese adults. Design: Secondary analysis of a randomized clinical trial Setting: Remotely monitored intervention conducted across the United States Subjects: 553 participants with a body mass index ≥25 Intervention: Participants were randomized to 1 of 4 study arms: control, gamification with support, gamification with collaboration, and gamification with competition to increase their physical activity. All participants were issued a wrist-worn wearable device to record their daily physical activity and sleep duration. Measures: The primary outcome was change in daily sleep duration from baseline during the 24 week intervention and follow-up period by study arm within behavioral phenotype class. Analysis: Linear mixed effects regression. Results: Participants who had a phenotype of less physically active and less social at baseline, in the gamification with collaboration arm, significantly increased their sleep duration during the intervention period (30.2 minutes [95% CI 6.9, 53.5], P = 0.01), compared to the control arm. There were no changes in sleep duration among participants who were more extroverted and motivated or participants who were less motivated and at-risk. Conclusions: Changes in sleep during a physical activity intervention varied by behavioral phenotype. Behavioral phenotypes may help to precisely identify who is likely to improve sleep duration during a physical activity intervention.

scholarly journals Systematic review of interventions in the childcare setting with direct parental involvement: effectiveness on child weight status and energy balance-related behaviours

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
I. van de Kolk ◽  
S. R. B. Verjans-Janssen ◽  
J. S. Gubbels ◽  
S. P. J. Kremers ◽  
S. M. P. L. Gerards
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Energy Balance ◽  
Parental Involvement ◽  
Sedentary Behaviour ◽  
Weight Status ◽  
Overweight And Obesity ◽  
Early Years ◽  
Effect Sizes ◽  
Intervention Effectiveness

Abstract Background The early years are a crucial period to promote healthy energy balance-related behaviours in children and prevent overweight and obesity. The childcare setting is important for health-promoting interventions. Increasingly, attention has been paid to parental involvement in childcare-based interventions. The aim of this systematic review is to evaluate the effectiveness of these interventions with direct parental involvement on the children’s weight status and behavioural outcomes. Methods A systematic search was conducted in four electronic databases to include studies up until January 2019. Studies written in English, describing results on relevant outcomes (weight status, physical activity, sedentary behaviour and/or nutrition-related behaviour) of childcare-based interventions with direct parental involvement were included. Studies not adopting a pre-post-test design or reporting on pilot studies were excluded. To improve comparability, effect sizes (Cohen’s d) were calculated. Information on different types of environment targeted (e.g., social, physical, political and economic) was extracted in order to narratively examine potential working principles of effective interventions. Results A total of 22 studies, describing 17 different interventions, were included. With regard to the intervention group, 61.1% found some favourable results on weight status, 73.3% on physical activity, 88.9% on sedentary behaviour, and all on nutrition-related behaviour. There were studies that also showed unfavourable results. Only a small number of studies was able to show significant differences between the intervention and control group (22.2% weight status, 60.0% physical activity, 66.6% sedentary behaviour, 76.9% nutrition behaviour). Effect sizes, if available, were predominantly small to moderate, with some exceptions with large effect sizes. The interventions predominantly targeted the socio-cultural and physical environments in both the childcare and home settings. Including changes in the political environment in the intervention and a higher level of intensity of parental involvement appeared to positively impact intervention effectiveness. Conclusion Childcare-based interventions with direct parental involvement show promising effects on the children’s energy balance-related behaviours. However, evidence on effectiveness is limited, particularly for weight-related outcomes. Better understanding of how to reach and involve parents may be essential for strengthening intervention effectiveness.

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