Assessment of nasal functions and their relationship with cholesteatoma formation in patients with unilateral chronic otitis media

2018 ◽  
Vol 132 (11) ◽  
pp. 974-977
Author(s):  
F Arslan ◽  
M Binar ◽  
U Aydin
Keyword(s):  
Otitis Media ◽  
Airway Resistance ◽  
Chronic Otitis Media ◽  
Control Group ◽  
Nasal Airway ◽  
Mucociliary Transport ◽  
Nasal Airway Resistance ◽  
And Control ◽  
Larger Sample ◽  
Active Anterior Rhinomanometry

AbstractObjectivesTo evaluate the nasal functions of patients with unilateral chronic otitis media using rhinomanometry, comparing chronic otitis media sides with healthy sides, chronic otitis media patients with cholesteatoma and without cholesteatoma, and patients with healthy individuals.MethodsThis prospective study included 102 patients with unilateral chronic otitis media (48 with and 54 without cholesteatoma). The control group comprised 40 individuals without any ear or nasal pathologies. All patients underwent active anterior rhinomanometry to measure nasal airway resistance and a saccharin test to measure mucociliary transport times.ResultsThere were no significant differences in nasal airway resistance and mucociliary transport time between the chronic otitis media sides and unaffected sides in the 102 patients (p = 0.72 and p = 0.28, respectively), between the non-suppurative chronic otitis media patients (without cholesteatoma) and chronic otitis media with cholesteatoma patients (p > 0.05), or between the study and control groups (p > 0.05).ConclusionThe present study, with a larger sample size compared to previously published literature, supports the conclusion that unilateral nasal obstruction is unlikely to lead to chronic otitis media on the same side. The results also suggest that nasal functions do not contribute to the development of cholesteatoma.

Objective assessment of nasal resistance among electronic cigarette users

2021 ◽  
pp. 1-4
Author(s):  
S W Lim ◽  
AB Zulkiflee
Keyword(s):  
Tobacco Smoking ◽  
Repeated Measures ◽  
Airway Resistance ◽  
Electronic Cigarettes ◽  
Objective Assessment ◽  
Control Group ◽  
Nasal Airway ◽  
Nasal Resistance ◽  
Short Term ◽  
Nasal Airway Resistance

Abstract Background Electronic cigarettes have been a popular alternative to tobacco smoking. The effect of tobacco smoking on nasal airway resistance has been investigated before; however, the effect of the aerosol generated by electronic cigarettes is still unknown. This study aimed to evaluate the short-term effects of e-cigarettes on nasal airway resistance. Methods Sixty-one participants were recruited into a vapers group and a control group. The vapers group was instructed to smoke for 5 minutes, and their nasal resistance was measured pre-procedure and at 1 and 5 minutes post-procedure. The results were compared between both groups. Results Repeated measures analysis of variance demonstrated that vaping has no statistically significant effect on total nasal airway resistance. Conclusion Although the differences between both groups were not statistically significant overall, the vapers group showed a reduction in nasal airway resistance in the short term.

Location of the middle cranial fossa dural plate in patients with chronic otitis media

2014 ◽  
Vol 128 (1) ◽  
pp. 60-63 ◽  
Author(s):  
S Genc ◽  
M G Genc ◽  
I B Arslan ◽  
A Selcuk
Keyword(s):  
Otitis Media ◽  
Chronic Otitis Media ◽  
Middle Cranial Fossa ◽  
Control Group ◽  
Adjacent Structures ◽  
Cranial Fossa ◽  
The Mean ◽  
Bone Scans ◽  
The Right ◽  
And Control

AbstractAim:This study aimed to determine whether or not the middle cranial fossa dural plate is located lower (i.e. more caudally) in patients with chronic otitis media, relative to adjacent structures.Methods:The authors retrospectively investigated computed tomography temporal bone scans of 267 ears of 206 patients who had undergone surgery with a diagnosis of chronic otitis media, together with scans of 222 ears of 111 patients without chronic otitis media. The depth of the middle cranial fossa dural plates was recorded.Results:The mean depth of the middle cranial fossa dural plate was 4.59 mm in the study group and 2.71 mm in the control group (p < 0.001). The middle cranial fossa dural plate was located lower in the right ear in both the study and control groups.Conclusion:The middle cranial fossa dural plate was located lower in patients with chronic otitis media, and in the right ears of both patients and controls. Surgeons should take this low location into consideration, and take extra care, during relevant surgery on patients with chronic otitis media.

scholarly journals EFFECT OF PUGUNTANO LEAF EXTRACT (CURANGAFEL-TERRAE MERR) ON INTERLEUKIN-1α EXPRESSION OF CHOLESTEATOMA MATRIX CULTURES WITH ATTICOANTRAL CHRONIC SUPURATIVE OTITIS MEDIA

2020 ◽  
pp. 1-2
Author(s):  
Elvien Dwi Saleh ◽  
Harry Agustaf Asroel* ◽  
Adlin Adnan ◽  
Restu Syamsul Hadi
Keyword(s):  
Otitis Media ◽  
Chronic Otitis Media ◽  
Ethanol Extract ◽  
Expression Level ◽  
Control Group ◽  
Anti Cancer ◽  
Interleukin 1Α ◽  
And Control ◽  
Hepatoprotective Drug

Chronic otitis media (COM) with or without cholesteatoma is a major global health problem, especially in developing countries. Until today, there is no other treatment for COM with cholesteatoma (COMch) other than surgery. Puguntano (Curanganfel-terrae Merr) is a plant from Scrophulariaceae family. It can be found in Asia, especially in China, India, Philippines, Myanmar, Malaysia and Indonesia. This plant has traditionally used as stimulant, antidiuretic, treatment for malaria, hepatoprotective drug, antipyretic, antiherpetic drug, anti-cancer, antihyperglycemic, antioxidant and anti-inammatory. The objective of this study is to evaluate the effect of ethanol extract from Puguntano leaves on Interleukin-1α expression level in cholesteatoma matrix cultures with atticoantral type chronic supurative otitis media. This study is an in vitro experimental research comparing two groups, a keratinocyte cholesteatoma culture with and without Puguntano extract. A group without extract Puguntano was divided into 4 different groups: group with Puguntano extract 1 mg/ml, 2 mg/ml, 4 mg/ml and control group.Interleukin-1α level in cholesteatoma culture is inversely proportional to Puguntano extract. Interleukin-1α expression level in group with Puguntano extract 1 mg/ml is 4,335 pg/ml; 2 mg/ml is 3,83 pg/ml; and 4 mg/ml is 2,74 pg/ml. Those results showed the decreasing level of Interleukin-1α expression compared to control group, which is 8,2889 pg/ml.

Scintigraphic evaluation of nasal mucociliary activity in unilateral chronic otitis media

2005 ◽  
Vol 119 (6) ◽  
pp. 443-447 ◽  
Author(s):  
Cemal Cingi ◽  
Fazilet Altin ◽  
Hamdi Cakli ◽  
Ernre Entok ◽  
Kezban Gurbuz ◽  
...  
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Mucociliary Clearance ◽  
Chronic Otitis Media ◽  
Control Group ◽  
Ciliary Activity ◽  
Mucociliary Transport ◽  
Defence Mechanism ◽  
Lower Airways ◽  
The Difference

Mucociliary clearance is a key defence mechanism in human upper and lower airways. Although mucociliary activity is present in both ears of the patients, most cases of chronic otitis media are unilateral.In this study, we aim to evaluate the difference between nasal mucociliary activity of the affected and non-affected sides in patients with unilateral chronic otitis media. Both nasal transport times of 36 patients with unilateral chronic otitis media were compared statistically with each other and with the control group by independent samples t-test. The nasal mucociliary transport times of the nasal cavity at the same side as the affected ear and as the non-affected ear are significantly different, in the same patients.Our study shows that impaired or decreased nasal mucociliary activity may result in dysfunction of the eustachian tube and middle-ear ciliary activity, which plays an important role in the aetiopathogenesis of chronic otitis media.

Genetic polymorphisms affecting antioxidant enzymes are present in tympanosclerosis patients

2016 ◽  
Vol 130 (10) ◽  
pp. 928-933 ◽  
Author(s):  
A Akyigit ◽  
Ş Yalcin ◽  
E Ö Etem ◽  
İ Kaygusuz ◽  
T Karlidag ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Otitis Media ◽  
Venous Blood ◽  
Chronic Otitis Media ◽  
Study Groups ◽  
Control Group ◽  
Genotype Distribution ◽  
Control Groups ◽  
Significant Difference ◽  
And Control

AbstractBackground:This study investigated genetic polymorphisms affecting the inducible nitric oxide synthase, superoxide dismutase and catalase enzymes in chronic otitis media patients with and without tympanosclerosis, and the role of genetic susceptibility in the disease aetiology.Methods:A total of 162 patients who underwent surgery for chronic otitis media were divided into two study groups: a tympanosclerosis group and a chronic otitis media group. A third, the control, group comprised 188 healthy volunteers. Venous blood samples were evaluated using reverse transcriptase polymerase chain reaction.Results:There was a significant difference in GG genotype distribution of the −277A>G polymorphism in the NOS2 gene between the tympanosclerosis and control groups (p < 0.05). However, there were no significant between-group differences in the CC genotype distribution of the p.Ala16Val (C>T) polymorphism in the SOD2 gene (p > 0.05). There were significant differences in the TT genotype distribution of the −21A>T polymorphism in the CAT gene between the tympanosclerosis and control groups, and between the chronic otitis media and control groups (p < 0.05).Conclusion:These results suggest that genetic predisposition may play a role in the aetiopathogenesis of tympanosclerosis.

An Evaluation of Active Anterior and Posterior Rhinomanometry in British Adults

1996 ◽  
Vol 10 (1) ◽  
pp. 33-38 ◽  
Author(s):  
Ercan I. Canbay ◽  
Suren N. Bhatia
Keyword(s):  
Airway Resistance ◽  
Repeated Measurements ◽  
Nasal Airway ◽  
Mean Values ◽  
Nasal Decongestant ◽  
Nasal Airway Resistance ◽  
On Line ◽  
The Mean ◽  
Reference Pressure ◽  
Active Anterior Rhinomanometry

In this study, active Anterior Rhinomanometry (ARM) and Posterior Rhinomanometry (PRM) were performed sequentially by 56 normal British Caucasian adults using an on-line Mercury Electronics NR6D Rhinomanometer. Xylometazoline nasal spray was used as a nasal decongestant before the test. In addition, repeated measurements were made on a randomly selected 13 subjects to evaluate the error of the methods. The mean total nasal airway resistance by the anterior method was found to be 0.182 Pa/cm3/s at a reference pressure of 150 Pascals, and by the posterior method 0.166 Pa/cm3/s at a reference pressure of 75 Pascals. These mean values are similar to those reported by other authors for Caucasians. The errors of the methods were found to be smaller than previously reported (Coefficient of variation, ARM = 6.9%; PRM = 7.7%). The total nasal airway resistance was higher during expiration than inspiration, and higher in women than in men. The ARM values were on an average 9% higher than those of the PRM, and the association between the two values was found to be moderate (r = 0.48). The higher ARM mean values could be attributed to inappropriateness of the conventional Ohm's law used in their calculation. For a number of reasons, PRM is considered to be more suitable than ARM for measuring nasal resistance.

Active anterior rhinomanometry analysis in normal adult Malays

2003 ◽  
Vol 117 (8) ◽  
pp. 605-608 ◽  
Author(s):  
A. H. Suzina ◽  
M. Hamzah ◽  
A. R. Samsudin
Keyword(s):  
Airway Resistance ◽  
Objective Assessment ◽  
Nasal Airway ◽  
Nasal Resistance ◽  
Clinical Method ◽  
Pressure Point ◽  
Nasal Airway Resistance ◽  
The Mean ◽  
Reference Pressure ◽  
Active Anterior Rhinomanometry

The differences in facial anatomical structures of the major ethnic groups,may also be reflected in nasal resistance. Active anterior rhinomanometry (AAR) is the recommended technique for the objective assessment of nasal airway resistance (NAR). This study comprised of 85 adult Malay subjects. All the subjects had to undergo a primary assessment of relevantsymptoms of nasal disease and nasal examination before undergoing AAR assessment. The mean value of total nasal airway resistance (NAR) was 0.19 Pa/cm3/s (ranged from 0.09 to 0.55Pa/cm3/s) at 75 Pa pressure point and 0.24 Pa/cm3/s ranged from 0.12 to 0.52 Pa/cm3/s) at 150 Pa pressure point. The mean unilateral NARwas 0.46 Pa/cm3/s at a reference pressure of 75 Pa and 0.51 Pa/cm3/s at a reference pressure of 150 Pa. In this study we presented normal values for NAR in healthy Malay adult subjects. AARproves to be a valuable clinical method for recording and quantitating nasal resistance.

scholarly journals Treatment with a topical glucocorticoid, budesonide, reduced the variability of rhinomanometric nasal airway resistance

2014 ◽  
Vol 52 (1) ◽  
pp. 19-24
Author(s):  
H.L. Thulesius ◽  
A. Cervin ◽  
M. Jessen
Keyword(s):  
Visual Analogue Scale ◽  
Healthy Volunteers ◽  
Nasal Obstruction ◽  
Analogue Scale ◽  
Airway Resistance ◽  
Nasal Airway ◽  
Nasal Airway Resistance ◽  
The Mean ◽  
Active Anterior Rhinomanometry

Background: Previous rhinomanometry studies have shown significant long-term variability of the nasal airway resistance and questioned the clinical validity of rhinomanometry. Research question: Could treatment with a topical glucocorticoid, budesonide, influence the long-term variability of active anterior rhinomanometry? Methods: Eight healthy volunteers participated in an unblinded controlled trial without, and later with, nasal budesonide once a day for 5 months. Their nasal airway resistance was measured every two weeks with active anterior rhinomanometry before and after decongestion with xylometazoline hydrochloride. In addition, subjective nasal obstruction was evaluated on a Visual Analogue Scale before each measurement. The participants had a year earlier been investigated with rhinomanometry every two weeks during 5 months but without budesonide treatment. We compared the variability of nasal airway resistance during the two periods with and without treatment with topical budesonide. Results: Budesonide significantly reduced mean nasal airway resistance and the standard deviation of the mean after decongestion for 6 of 8 participants. The mean reduction of the nasal airway resistance was 40% for the decongested nasal cavity compared to the period without treatment with nasal budesonide. Subjective nasal obstruction assessed by Visual Analogue Scale was reduced in 3 of the 8 participants. Conclusion: The variability of nasal airway resistance was significantly reduced by treatment with topical budesonide for 6 out of 8 healthy volunteers participating in an unblinded repeated 5 month trial where the participants served as their own controls.

Factors associated with the development of paediatric chronic otitis media by age nine: a prospective longitudinal cohort study of 6560 children

2020 ◽  
pp. 1-12
Author(s):  
P J Clamp ◽  
K De-Loyde ◽  
A R Maw ◽  
S Gregory ◽  
J Golding ◽  
...  
Keyword(s):  
Cohort Study ◽  
Otitis Media ◽  
Maternal Education ◽  
Univariate Analysis ◽  
Chronic Otitis Media ◽  
Birth Cohort Study ◽  
Control Group ◽  
Factors Associated ◽  
Prospective Longitudinal

Abstract Objective This study aimed to analyse social, health and environmental factors associated with the development of chronic otitis media by age nine. Method This was a prospective, longitudinal, birth cohort study of 6560 children, reviewed at age nine. Chronic otitis media defined as previous surgical history or video-otoscopic changes of tympanic membrane retraction, perforation or cholesteatoma. Non-affected children were used as the control group. Results Univariate analysis demonstrated an association between chronic otitis media and otorrhoea, snoring, grommet insertion, adenoidectomy, tonsillectomy, hearing loss, abnormal tympanograms and preterm birth. Multivariate analysis suggests many of these factors may be interrelated. Conclusion The association between chronic otitis media and otorrhoea, abnormal tympanograms and grommets supports the role of the Eustachian tube and otitis media (with effusion or acute) in the pathogenesis of chronic otitis media. The role of snoring, adenoidectomy and tonsillectomy is unclear. Associations suggested by previous studies (sex, socioeconomic group, parental smoking, maternal education, childcare, crowding and siblings) were not found to be significant predictors in this analysis.

Evaluation of Nasal Passage Patency after Antigen and Histamine Challenge in Guinea Pigs by Acoustic Rhinometry

1997 ◽  
Vol 11 (1) ◽  
pp. 85-90 ◽  
Author(s):  
Setsuo Nakamoto ◽  
Yasuo Sakakura ◽  
Ole F. Pedersen ◽  
Kotaro Ukai
Keyword(s):  
Nasal Cavity ◽  
Guinea Pigs ◽  
Airway Resistance ◽  
Cross Sectional Area ◽  
Nasal Passage ◽  
Nasal Airway ◽  
Sectional Area ◽  
Cross Sectional ◽  
Percent Change ◽  
Nasal Airway Resistance

We investigated the effects of antigen and histamine on the nasal passage patency in guinea pigs with or without nasal allergy. The change of nasal patency was measured by acoustic rhinometry and nasal airway resistance. Acoustic reflections have been used in adult humans to determine nasal cavity dimensions in terms of cross-sectional areas as a function of the distance from the nostril. In order to measure nasal cavity dimensions in guinea pigs, we modified equipment for use in humans by decreasing sound tube dimensions, increasing sampling frequency, and applying a special nosepiece. The percent change of volume, minimum cross-sectional area, and nasal airway resistance showed the largest changes at 10 minutes after antigen challenge in sensitized guinea pigs. There was a significant correlation between the individual percent change of nasal airway resistance and volume or minimum cross-sectional area. Histamine, 102 to 105 μg/mL, caused a dose-dependent reduction in percent change of volume in the challenged side of nonsensitized guinea pigs, but not in the opposite side. These results indicate that the noninvasive acoustic reflections technique is useful in small experimental animals, especially to assess the effect of nasal cavity dimensions after the challenge of antigen or nonspecific stimuli.

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