scholarly journals Inhibitory effects of an aqueous extract of Clitoria ternatea flower on α-glucosidase during in-vitro wheat starch digestion

2019 ◽  
Vol 78 (OCE2) ◽  
Author(s):  
C. Ronald ◽  
B.S. Chu
2021 ◽  
Vol 7 ◽  
Author(s):  
Bowen Ma ◽  
Tao Feng ◽  
Sanfeng Zhang ◽  
Haining Zhuang ◽  
Da Chen ◽  
...  

β-glucan has attracted extensive attention due to its health promoting effects, such as lowering the blood sugar and lipids levels, and enhancing immunity. In this study, three different β-glucans (HEBG-1, HEBG-2, HEBG-3) were obtained from Hericium erinaceus by sodium hydroxide, β-1,3-glucanase and β-1,6-glucanase, respectively. The effects of the glucans on in vitro digestion of wheat starch were investigated by Englyst method. We found that addition of HEBGs significantly reduced the digestibility of starch, showing as decreased RDS and pGI, and increased SDS and RS content. In addition, the inhibitory effects positively correlated with the molecular weight of HEBG. The triple helix structure in HEBG plays important roles in inhibiting starch digestion. And β-1,3- glucan showed stronger inhibitor effects than those of β-1,6- glucan. This study unravels the mechanism of HEBG on inhibition of starch digestion and provides a theoretical understanding for the application of edible mushroom β-glucan to the development of low glycemic index starchy foods.


2019 ◽  
Vol 126 ◽  
pp. 525-530 ◽  
Author(s):  
Fang Xie ◽  
Qiang Huang ◽  
Fang Fang ◽  
Siqian Chen ◽  
Zhigang Wang ◽  
...  

2006 ◽  
Vol 95 (3) ◽  
pp. 576-581 ◽  
Author(s):  
Jacqueline N. Mathews ◽  
Peter R. Flatt ◽  
Yasser H. Abdel-Wahab

Diabetes mellitus is a complex metabolic disease characterised by glucose overproduction and under-utilisation. As the incidence of diabetes expands rapidly across the globe there is an urgent need to expand the range of effective treatments. Higher plants such as Asparagus adscendens provide therapeutic opportunities and a rich source of potential antidiabetic agents. In the present study an aqueous extract of Asparagus adscendens was shown to induce a significant non-toxic 19–248% increase in glucose-dependent insulinotropic actions (P<0·001) in the clonal pancreatic β cell line, BRIN-BD11. In addition, the extract produced an 81% (P<0·0001) increase in glucose uptake in 3T3-L1 adipocytes. Asparagus adscendens also produced a 21% (P<0·001) decrease in starch digestion in vitro. The present study has revealed the presence of insulinotropic, insulin-enhancing activity and inhibitory effects on starch digestion in Asparagus adscendens. The former actions are dependent on the active principle(s) in the plant being absorbed intact. Future work assessing its use as a dietary adjunct or as a source of active components may provide new opportunities for the treatment of diabetes


Renal Failure ◽  
2018 ◽  
Vol 40 (1) ◽  
pp. 298-305 ◽  
Author(s):  
Mahboubeh Yousefi Ghale-Salimi ◽  
Maryam Eidi ◽  
Nasser Ghaemi ◽  
Ramezan Ali Khavari-Nejad

2021 ◽  
Author(s):  
Dan Li ◽  
Yongli Yang ◽  
Xi Yang ◽  
Xiaoyu Wang ◽  
Chuo Guo ◽  
...  

To evaluate the effect of young apple polyphenols (YAP) on starch digestion and gut microbiota, complexes of native wheat starch (NWS) with YAP, and their main components chlorogenic acid (CA) and phlorizin (P) were fabricated and gelatinized.


2021 ◽  
Vol 912 (1) ◽  
pp. 012015
Author(s):  
A R M Alnaz ◽  
R Ridha ◽  
R F G Nasution ◽  
A H Nasution ◽  
M Ichwan

Abstract Clitoria ternatea (CT) or butterfly pea was one herbs used for Ayurvedic and other traditional medicines. Utilization of its roots, flowers, and leaves proposed several medical adventages with anthelmintic was one of it. Among current anthelmintic burden of resistance, this study aimed to examine the anthelmintic profile from CT flower aqueous extract on Tubifex tubifex. The study was done by conducting a pilot experimental study by extracting CT flowers to water and piping the extracts of different level of dilution to several group of pots containing Tubifex tubifex. Anthelmintic activity was determined with its paralyzing effect and was compared to negative and positive controls with levamisole. Phytochemicals substances were detected with alkaloids, flavonoids, glycosides, saponins, tannins, and triterpenoids detected. The extract exerts anthelmintic activity it 1:4, 1:40, and 1:400 dilutions and was comparable to 1mg/mL and 0.1mg/mL levamisole. Time to paralysis observed suggested a dose-response relationship of the extract on its anthelmintic activities. It was understood the phytochemicals influents the anthelmintic activity by paralysis worms and leads to death. It was concluded that CT flower aqueous extract presents anthelmintic activity, with further experimental study will needed to be conducted.


2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Sara Ouldchikh ◽  
Aicha TirTouil ◽  
Boumédiene Meddah

The mucosal surfaces of the intestinal tract harbor a complex microbiota. Bacteria enter in contact with intestinal cells and bestow important nutritional, metabolic and protective functions which benefit the host. Various factors are able to alter the balances between different intestinal bacteria. Dysbiosis has been described in various pathologies and metabolic diseases in humans, such as cancer. Colorectal cancer pathology can benefit from gut microbial imbalance. Its overgrowth may lead to acute symptoms. An alternative strategy to restore this balance is the use of plant extracts which exhibit a prebiotic activity by stimulating of probiotic bacteria and antimicrobial activity against pathogenic bacteria colonization. The present study aims to evaluate the in vitro antioxidant and antibacterial activity of phenolic extracts (Aqueous extract "AE" and Methanolic extract "ME" ) from Zizyphus lotus. It aims also to investigate the effect of this extract as a prebiotic on the aggregation of probiotic and inhibitory effects of pathogenic bacteria isolated from faeces of patients with colorectal cancer. Phytochemical analysis of different extracts from Zizyphus lotus by HPLC showed that all are rich in phenolic compounds (225.40 mgAGE/gDW for AE and 63.04 mgAGE/gDW for ME extracts). Moreover, all extracts showed an important antioxidant activity (227 µg/ml for AE and 195 µg/ml for ME). These extracts also exhibited a significant prebiotic effect and antibacterial activity. Characterization of the in vitro effect of the aqueous extract showed that the percentage of autoaggregation and adhesion of probiotic and inhibitory effects of pathogenic bacteria increased in the presence of aqueous extracts.


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