scholarly journals Excessive adiposity is associated with an inflammation induced elevation in serum hepcidin, serum ferritin and increased risk of iron overload

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Aoibhín Moore Heslin ◽  
Aisling O' Donnell ◽  
Maria Buffini ◽  
Anne Nugent ◽  
Janette Walton ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Iron Overload ◽  
Body Fat ◽  
Serum Ferritin ◽  
Linear Regression Analysis ◽  
Elevated Serum ◽  
Metabolic Effects ◽  
Serum Hepcidin ◽  
Excessive Adiposity

AbstractExcess body fat is associated with the production of pro-inflammatory molecules from dysfunctional adipose tissue resulting in systemic inflammation. Inflammation stimulates expression of the iron regulatory hormone hepcidin, resulting in elevated serum ferritin and iron overload in metabolic tissues. Hepcidin driven iron maldistribution may be implicated in the development of metabolic diseases such as Type 2 diabetes and CVD. The aim of this study was to investigate the effect of body fat and the associated inflammation on markers of iron homeostasis.Analyses were based on data from the cross-sectional National Adult Nutrition Survey (2008–2010) (www.iuna.net). Percentage body fat (BF%) of participants (n = 1211) was measured by a Tanita BC420MA device. Participants were classified as healthy, overweight or obese based on age and gender-specific BF% ranges. Serum ferritin and serum hepcidin were measured using immunoturbidimetric immunoassays. ANCOVA with Bonferroni post hoc (p < 0.05) was used to compare anthropometric parameters, biochemical markers of iron status and inflammation and nutrient intakes between BF% groups. Predictors of serum hepcidin and serum ferritin were determined using linear regression analysis.In the population 42% were classified as healthy, 33% as overfat and 25% as obese. Serum hepcidin was significantly elevated in obese participants (8.42ng/ml ± 4.2) compared to their healthy counterparts (6.49ng/ml ± 3.9)(p < 0.001). Significantly higher serum ferritin was observed in obese (223ng/ml ± 170) and overfat males (166ng/ml ± 120) compared to healthy males (135ng/ml ± 91)(p < 0.001). A significant percentage of overweight (20%) and obese (32%) participants were at severe risk of iron overload compared to healthy participants (8%)(p < 0.001). No significant differences in dietary iron intakes were observed between BF% groups. Linear regression analysis indicated that BF% was a significant (p < 0.001) predictor of hepcidin in males (β = 0.327) and females (β = 0.226). IL-6 (β = 0.317,p < 0.001) and TNFα (β = 0.229,p < 0.001) were the strongest inflammatory predictors of hepcidin in females only. In males, leptin was a positive predictor (β = 0.159,p = 0.003) of hepcidin, while adiponectin displayed a negative predictive relationship (β = -0.145,p = 0.001)Our results indicate that excessive adiposity is associated with elevated serum ferritin and hepcidin independent of dietary intake. Cytokines are a potential driver of hepcidin in females, with adipose-derived hormones seeming to have the greater effect in males. These results may help to elucidate the relationship between obesity and dysregulated iron metabolism. Further research is required to investigate the metabolic effects of hepcidin-induced iron overload in those with excess body fat.

scholarly journals Risk of Iron Overload in Obesity and Implications in Metabolic Health

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1539
Author(s):  
Aoibhín Moore Heslin ◽  
Aisling O’Donnell ◽  
Maria Buffini ◽  
Anne P. Nugent ◽  
Janette Walton ◽  
...  
Keyword(s):  
Iron Overload ◽  
Body Fat ◽  
Serum Ferritin ◽  
Iron Homeostasis ◽  
Iron Status ◽  
Elevated Serum ◽  
Metabolic Health ◽  
Nutrition Survey ◽  
Increased Risk ◽  
Serum Hepcidin

Excessive adiposity is associated with several metabolic perturbations including disturbances in iron homeostasis. Increased systemic inflammation in obesity stimulates expression of the iron regulatory hormone hepcidin, which can result in a maldistribution of bodily iron, which may be implicated in metabolic dysfunction. This study aimed to investigate the effect of adiposity and any associated inflammation on iron homeostasis and the potential implications of dysregulated iron metabolism on metabolic health. Analyses are based on a subsample from the cross-sectional Irish National Adult Nutrition Survey (2008–2010) (n = 1120). Ferritin status and risk of iron overload were determined based on established WHO ferritin ranges. Participants were classed as having a healthy % body fat or as having overfat or obesity based on age- and gender-specific % body fat ranges as determined by bioelectrical impedance. Biomarkers of iron status were examined in association with measures of body composition, serum adipocytokines and markers of metabolic health. Excessive % body fat was significantly associated with increased serum hepcidin and ferritin and an increased prevalence of severe risk of iron overload amongst males independent of dietary iron intake. Elevated serum ferritin displayed significant positive associations with serum triglycerides and markers of glucose metabolism, with an increased but non-significant presentation of metabolic risk factors amongst participants with overfat and obesity at severe risk of iron overload. Increased adiposity is associated with dysregulations in iron homeostasis, presenting as increased serum hepcidin, elevated serum ferritin and an increased risk of iron overload, with potential implications in impairments in metabolic health.

scholarly journals Utility of Transient Elastography (Fibroscan) in Estimating Hepatic Iron Concentration in Comparison to MRI in Patients with Transfusion Dependent Hemoglobinopathies

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 4888-4888
Author(s):  
Hatoon Ezzat
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Iron Overload ◽  
Serum Ferritin ◽  
Transient Elastography ◽  
Linear Regression Analysis ◽  
Iron Concentration ◽  
Thalassemia Major ◽  
Hepatic Iron ◽  
Hepatic Iron Concentration

Abstract Background Patients with severe hereditary anemias (e.g. β-Thalassemia Major) are transfusion-dependent for survival. Current guidelines suggest monitoring serum ferritin every three months and annual MRI to assess hepatic and cardiac iron load1. However, MRI, particularly the R2 sequence (FerriScan) which has high specificity and sensitivity in estimating the liver iron concentration, is expensive and not always readily available. Transient elastography (FibroScan) measures liver's stiffness and predicts fibrosis. Previous studies have suggested its utility in other conditions that increase liver stiffness, such as amyloidosis2and perhaps iron overload. Aim To determine if FibroScan value correlates with hepatic iron concentration estimated using R2 MRI (FerriScan), and/or serum ferritin level. Methods A prospective cross-sectional study was conducted at a university-affiliated tertiary care center (St. Paul’s Hospital, Vancouver, BC) in 2013 and 2014. Inclusion criteria: Age ≥ 19 years with transfusion-dependent hereditary anemias. Exclusion criteria: liver cirrhosis, primary liver disease (e.g. Wilson’s disease, hereditary hemochromatosis), and chronic viral hepatitis (e.g. Hepatitis B, C and HIV). In addition to having annual MRI and ferritin levels monitored every three months, subjects underwent FibroScan within six months of MRI in 2013. In 2014, participants were invited to undergo repeat FibroScan within three months of the annual MRI. Linear regression analysis was used to determine if there is any correlation/linear fit between FibroScan result, MRI result, and ferritin levels. This study was approved by the University of British Columbia Research Ethics Board. Results 20 subjects have been recruited as of August 1, 2014, with 35 and 33 complete FibroScan and MRI results, respectively. 14 (70%) were female. Mean age was 30.7±9.8 years. Most common primary diagnosis was transfusion-dependent beta-thalassemia (Major and intermedia) (n=17). Linear regression analysis showed a weakly positive correlation between hepatic iron concentrations estimated with R2 MRI (FerriScan) and ferritin levels (R2=0.29; p=0.004), when they are performed within four weeks apart. The correlation remained statistically significant when all subjects were included regardless of time lapse between the two investigations (R2=0.30; p=0.001). However, FibroScan values did not appear to correlate with MRI, regardless of whether the scans are performed within six months (R2=0.011; p=0.58) or three months apart (R2=0.035; p=0.44). Similarly, there was no correlation between FibroScan and Ferritin (R2=0.022; p=0.49) when the investigations were performed within 4 weeks part. Conclusion Interim analysis did not demonstrate any correlation between FibroScan result and MRI-estimated hepatic iron concentration. A final analysis will be performed upon complete formal evaluation of the remaining MRI and FibroScan data. References Remacha A, Sanz C, Contreras E, et al. Guidelines on haemovigilance of post-transfusional iron overload. Blood Transfus. 2013; 11(1): 128-139Loustaud-Ratti V, Cypierre A, Rousseau A, et al. Non-invasive detection of hepatic amyloidosis: Fibroscan, a new tool. Amyloid 2013; 18(1): 19-24 Disclosures No relevant conflicts of interest to declare.

scholarly journals Haptoglobin 2-2 Genotype Is Associated with TNF-αand IL-6 Levels in Subjects with Obesity

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Brissia Lazalde ◽  
Héctor M. Huerta-Guerrero ◽  
Luis E. Simental-Mendía ◽  
Martha Rodríguez-Morán ◽  
Fernando Guerrero-Romero
Keyword(s):  
Regression Analysis ◽  
Waist Circumference ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Body Fat ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Total Body Fat ◽  
Obese Subjects ◽  
Total Body

Objective. To evaluate the association between Haptoglobin (HP) gene polymorphisms with inflammatory status in obese subjects.Materials and Methods. A cross-sectional study was carried out. A total of 276 apparently healthy men and nonpregnant obese women were enrolled and allocated according to theHPgenotype into theHP1/HP1,HP2/HP1, andHP2/HP2groups. Distribution ofHPgenotypes was 49, 87, and 140 for theHP1/HP1,HP2/HP1, andHP2/HP2, respectively. TheHPgenotype was determined using the polymerase chain reaction method. A multiple linear regression analysis adjusted by age, sex, waist circumference, and total body fat was used to determine the association betweenHPgenotypes with TNF-α, IL-6, and high-sensitivity C-reactive protein (hsCRP) levels.Results. A multiple linear regression analysis adjusted by sex, waist circumference, and total body fat was performed showing a significant association between theHP2/HP2genotype and TNF-α(β= 0.180; 95% CI 14.41–159.64,P= 0.01) and IL-6 (β= 0.188; 95% CI 1.53–12.72,P= 0.01) levels, but not with hsCRP (β= −0.008; 95% CI −1.64–1.47,P= 0.914) levels, whereas theHP2/HP1genotype showed no association compared with theHP1/HP1genotype (control group).Conclusion. Results of our study show that theHP2/HP2genotype is associated with elevated TNF-αand IL-6, but not with hsCRP, levels in obese subjects.

Elevated serum preptin concentrations in patients with diabetic nephropathy

2019 ◽  
Vol 67 (7) ◽  
pp. 1048-1052 ◽  
Author(s):  
Rui Wang ◽  
Aili Xue ◽  
Wenjian Zheng ◽  
Linchuan Wang ◽  
Fei Yan ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Diabetic Nephropathy ◽  
Linear Regression ◽  
Linear Regression Analysis ◽  
Elevated Serum ◽  
Multiple Linear Regression Analysis ◽  
Urine Albumin ◽  
Acarbose Treatment ◽  
And Gender

Preptin is a peptide synthesized and secreted accompanied with insulin from pancreatic β cells. Here, we tested the hypothesis that serum preptin concentrations are correlated with diabetic nephropathy (DN). Our study was performed in a population of 234 patients with type 2 diabetes mellitus (T2DM) and 78 healthy subjects. Patients with T2DM were divided into three groups: normoalbuminuria group (DN0, n=106), microalbuminuria group (DN1, n=90), and macroalbuminuria group (DN2, n=38) according to urine albumin to creatinine ratio (ACR). Serum preptin concentrations were significantly increased in the three T2DM subgroups than those in the controls. DN2 group showed significantly higher serum preptin concentrations compared with DN0 and DN1 groups. Moreover, DN1 group had higher serum preptin concentrations than DN0 group. Serum preptin was correlated with a higher risk of T2DM and DN after logistic regression analysis. Simply linear regression analysis demonstrated a positive correlation between serum preptin and gender, body mass index (BMI), blood urea nitrogen, creatinine, ACR, and a negative correlation between serum preptin and glomerular filtration rate, metformin, acarbose treatment. Gender, BMI, and ACR were still positively correlated with serum preptin after multiple linear regression analysis. Our findings indicate that serum preptin concentrations are associated with renal function and DN.

scholarly journals Associations between serum hepcidin, ferritin and Hb concentrations and type 2 diabetes risks in a Han Chinese population

2013 ◽  
Vol 110 (12) ◽  
pp. 2180-2185 ◽  
Author(s):  
Xin Guo ◽  
Daizhan Zhou ◽  
Peng An ◽  
Qian Wu ◽  
Hao Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Regression Analysis ◽  
Serum Ferritin ◽  
Linear Regression Analysis ◽  
Han Chinese ◽  
Control Group ◽  
Abnormal Glucose Metabolism ◽  
Serum Hepcidin

Systemic Fe overload can contribute to abnormal glucose metabolism and the onset of type 2 diabetes (T2D). Although hepcidin is the master regulator of systemic Fe homeostasis, few studies have systematically evaluated the associations of serum hepcidin concentrations with Fe metabolism parameters and risks for the development of T2D. In this regard, whether hepcidin concentrations are associated with T2D remains controversial. We measured serum hepcidin and ferritin concentrations in a case–control study of 1259 Han Chinese participants to evaluate the possible associations of serum hepcidin concentrations with Fe metabolism parameters and risks of T2D. Individuals with diabetes (n 555) and control participants (n 704) were recruited and serum hepcidin and ferritin concentrations were quantified. Additionally, selected biochemical and anthropometric variables were determined. A logistic regression analysis was performed to evaluate the association of serum hepcidin and ferritin concentrations with T2D. A linear regression analysis was used to test for associations between serum hepcidin and ferritin concentrations and a number of clinical, demographic and diabetes-associated variables. We found that serum hepcidin concentrations correlated with Hb and serum ferritin concentrations. No differences in hepcidin concentrations were found between the group with diabetes and the control group. Hepcidin concentrations were not significantly correlated with T2D risk factors. We also found that serum ferritin concentrations were elevated in individuals with diabetes and were positively correlated with both Hb concentrations and T2D risk factors. The present findings suggest that serum ferritin concentrations correlate with T2D risk factors, while serum hepcidin concentrations are positively associated with Hb and serum ferritin concentrations, but do not correlate with T2D.

Correlates of Hepcidin and NTBI according to HFE Status in Patients Referred to a Liver Centre

2014 ◽  
Vol 133 (2) ◽  
pp. 155-161 ◽  
Author(s):  
Eleanor Ryan ◽  
John D. Ryan ◽  
Jennifer Russell ◽  
Barbara Coughlan ◽  
Harold Tjalsma ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Iron Overload ◽  
Serum Ferritin ◽  
Transferrin Saturation ◽  
Hereditary Haemochromatosis ◽  
The Matrix ◽  
Serum Hepcidin ◽  
Obese Male ◽  
Compound Heterozygotes ◽  
Genotypic Risk

Background/Aims: Innately low hepcidin levels lead to iron overload in HFE-associated hereditary haemochromatosis. Methods: This study compared hepcidin and non-transferrin bound iron (NTBI) levels in untreated iron-loaded and non-iron-loaded C282Y homozygotes to levels in C282Y/H63D compound heterozygotes and individuals with other HFE genotypes associated with less risk of iron overload. Results: As the genotypic risk for iron overload increased, transferrin saturation and serum NTBI levels increased while serum hepcidin levels decreased. Overweight and obese male C282Y homozygotes had significantly higher hepcidin levels than male C282Y homozygotes with a normal BMI. Pearson product-moment analysis showed that serum hepcidin levels significantly correlated with HFE status, serum ferritin, age, NTBI, transferrin saturation, gender and BMI. Subsequent multiple regression analysis showed that HFE status and serum ferritin were significant independent correlates of serum hepcidin levels. Conclusions: In summary, this study has shown that while serum ferritin and HFE status are the most important determinants of hepcidin levels, factors such age, gender, BMI, transferrin saturation and NTBI all interact closely in the matrix of homeostatic iron balance. © 2014 S. Karger AG, Basel

Anthropometric variations in different BMI and adiposity levels among children, adolescents and young adults in Kolkata, India

2018 ◽  
Vol 51 (4) ◽  
pp. 603-618 ◽  
Author(s):  
Łukasz Kryst ◽  
Magdalena Żegleń ◽  
Iwona Wronka ◽  
Agnieszka Woronkowicz ◽  
Inez Bilińska-Pawlak ◽  
...  
Keyword(s):  
Young Adults ◽  
Regression Analysis ◽  
Linear Regression ◽  
Body Fat ◽  
Statistical Significance ◽  
Linear Regression Analysis ◽  
Body Height ◽  
Adolescents And Young Adults ◽  
Anthropometric Features ◽  
Study Population

AbstractThe objective of the study was to analyse selected anthropometric features of children, adolescents and young adults from middle-class families in Kolkata, India, by BMI and adiposity categories. Standardized anthropometric measurements of 4194 individuals (1999 male and 2195 female) aged 7–21 were carried out between the years 2005 and 2011. The results were compared by BMI and adiposity categories. Statistical significance was assessed using two-way-ANOVA and linear regression analysis was performed. The study population could be differentiated in terms of BMI and adiposity categories for all examined anthropometric characteristics (p≤ 0.001). After taking age into consideration, differences were observed for males in the case of body height and humerus breadth in BMI and adiposity categories, and for femur breadth in the case of adiposity categories. For females, differences were noted in body height measurements in BMI and adiposity categories, a sum of skinfold thicknesses in BMI categories, and upper-arm and calf circumferences in adiposity categories. The patterns of differences in the BMI categories were found to be similar to those in adiposity categories. The linear regression analysis results showed that there was a significant relationship between BMI and body fat ratio in the examined population. Underweight individuals, and those with low adiposity, were characterized by lower extremity circumferences and skeletal breadths. These features reached highest values in overweight/obese persons, characterized by high body fat. However, the differences observed between each BMI and adiposity category, in most cases, were only present in early childhood.

scholarly journals Relation of Serum Hepcidin Levels and Restless Legs Syndrome in Patients Undergoing Peritoneal Dialysis

2021 ◽  
Vol 8 ◽  
Author(s):  
Yanhong Guo ◽  
Yuan Sang ◽  
Tian Pu ◽  
Xiaodan Li ◽  
Yulin Wang ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Peritoneal Dialysis ◽  
Linear Regression ◽  
Restless Legs Syndrome ◽  
Linear Regression Analysis ◽  
Multivariate Linear Regression Analysis ◽  
Hepcidin Level ◽  
Restless Legs ◽  
Determinant Factors ◽  
Serum Hepcidin

Introduction: Restless legs syndrome is a common and severe complication in patients undergoing peritoneal dialysis (PD), which seriously affects the life quality and prognosis of patients undergoing PD. Unfortunately, there are still no effective prevention and treatment measures. Serum hepcidin was demonstrated to be related to primary restless legs syndrome (RLS), whereas there are no studies on the relationship between serum hepcidin and RLS in patients undergoing PD. We aimed to evaluate the role and function of serum hepcidin in patients undergoing PD with RLS.Methods: A total of 51 patients undergoing PD with RLS and 102 age-and gender-matched patients undergoing PD without RLS were included. We collected the clinical data including serum hepcidin of those patients undergoing PD. We scored the severity of RLS according to the International restless leg Syndrome Research Group rating scale (IRLS). We compared the clinical characteristics of the two groups and evaluated the determinant factors of RLS by Logistic regression analysis. In addition, we evaluated the diagnostic value of serum hepcidin in patients undergoing PD with RLS by receiver operating characteristic (ROC) curve. We also analyzed the influencing factors of IRLS by multivariate linear regression analysis.Results: The duration of PD, serum hepcidin, and calcium were found to be significantly higher in patients undergoing PD with RLS than those patients undergoing PD without RLS (P &lt; 0.001, P &lt; 0.001, and P = 0.002, respectively). The level of hemoglobin, albumin, and RKF were significantly lower in patients undergoing PD with RLS (P = 0.002, P = 0.042, and P &lt; 0.001, respectively). The duration of PD [odds ratio (OR) 1.038, 95% CI: 1.017, 1.060, P &lt; 0.001], hemoglobulin level (OR 0.969, 95% CI: 0.944, 0.995, P = 0.019), calcium level (OR 9.224, 95% CI: 1.261, 67.450, P = 0.029), albumin level (OR 0.835, 95% CI: 0.757, 0.921, P &lt; 0.001), hepcidin level (OR 1.023, 95% CI: 1.009, 1.038, P = 0.001), and RKF (OR 0.65, 95% CI: 0.495, 0.856, P = 0.002) are independent determinant factors of RLS in patients undergoing PD. Multivariate linear regression analysis revealed that, in addition to albumin, they were also independently associated with the severity of RLS.Conclusion: A significant relation was detected between serum hepcidin level and RLS in patients undergoing PD.

ANALISIS PENGARUH INFLASI, KURS DAN IHSG TERHADAP RETURN REKSA DANA SAHAM PT NIKKO SECURITIES INDONESIA PERIODE 2014-2017

2019 ◽  
Vol 2 (2) ◽  
pp. 103
Author(s):  
Muhammad Rois Rois ◽  
Manarotul Fatati Fatati ◽  
Winda Ihda Magfiroh
Keyword(s):  
Regression Analysis ◽  
Exchange Rate ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Stock Price ◽  
Price Index ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Equity Fund ◽  
Stock Price Index

This study aims to determine the effect of Inflation, Exchange Rate and Composite Stock Price Index (IHSG) to Return of PT Nikko Securities Indonesia Stock Fund period 2014-2017. The study used secondary data obtained through documentation in the form of PT Nikko Securities Indonesia Monthly Net Asset (NAB) report. Data analysis is used with quantitative analysis, multiple linear regression analysis using eviews 9. Population and sample in this research are PT Nikko Securities Indonesia. The result of multiple linear regression analysis was the coefficient of determination (R2) showed the result of 0.123819 or 12%. This means that the Inflation, Exchange Rate and Composite Stock Price Index (IHSG) variables can influence the return of PT Nikko Securities Indonesia's equity fund of 12% and 88% is influenced by other variables. Based on the result of the research, the variables of inflation and exchange rate have a negative and significant effect toward the return of PT Nikko Securities Indonesia's equity fund. While the variable of Composite Stock Price Index (IHSG) has a negative but not significant effect toward Return of Equity Fund of PT Nikko Securities Indonesia

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