How anthelmintics help us to understand helminths
Keyword(s):
Study of the mode of action of the anti-parasitic ‘hydrogenophore’, closantel, revealed that mitochondria isolated from livers of untreated rats, 13 weeks after infection with Fasciola hepatica metacercariae, were uncoupled. This uncoupling of mitochondria might be induced by a product(s) excreted by the liver fluke. The lipid extractable product(s) binds to albumin and has a molecular weight between 500 and 1000 Daltons. A second unexpected finding indicates that closantel affects the motility of Schistosoma mansoni in vitro by interferin with mitochondrial ATP synthesis. The results obtained are suggestive of a role for aerobic metabolism in the generation of energy required for motility.
1988 ◽
Vol 62
(3)
◽
pp. 257-260
◽
Keyword(s):
1968 ◽
Vol 20
(10)
◽
pp. 744-745
◽
2022 ◽
Keyword(s):
Keyword(s):
1966 ◽
Vol 28
(2)
◽
2020 ◽
Keyword(s):