Secular trends in the prevalence of dementia and depression in Swedish septuagenarians 1976–2006

2013 ◽  
Vol 43 (12) ◽  
pp. 2627-2634 ◽  
Author(s):  
P. Wiberg ◽  
M. Waern ◽  
E. Billstedt ◽  
S. Östling ◽  
I. Skoog
Keyword(s):  
Major Depression ◽  
Birth Cohort ◽  
Linear Models ◽  
Response Rate ◽  
The Elderly ◽  
Population Based ◽  
Minor Depression ◽  
Birth Cohorts ◽  
Cohort Differences ◽  
Prevalence Of Dementia

BackgroundIt is not clear whether the prevalence of dementia and depression among the elderly has changed during the past 30 years.MethodPopulation-based samples from Gothenburg, Sweden were examined with identical psychiatric and neuropsychiatric examinations at age 70 years in 1976–1977 (n = 404, response rate 78.8%) and 2000–2001 (n = 579, response rate 66.4%), and at age 75 in 1976–1977 (n = 303, response rate 78%) and 2005–2006 (n = 753, response rate 63.4%). Depression was diagnosed according to DSM-IV and dementia according to Kay's criteria. General linear models (GLMs) were used to test for differences between groups.ResultsDementia was related to age but not to birth cohort or sex. Major depression was related to sex (higher in women) but not to birth cohort or age. Minor depression was related to birth cohort, sex (higher in women), age (higher at age 75) and the interaction effect of birth cohort × age; that is, the prevalence of minor depression increased with age in the 2000s but not in the 1970s. Thus, the prevalence of minor depression was higher in 2005–2006 than in 1976–1977 among 75-year-olds for both men (12.4% v. 3.7%) and women (19.1% v. 5.6%) whereas there were no birth cohort differences at age 70.ConclusionsSecular changes were observed only for minor depression, which is considered to be related more to psychosocial factors than major depression. The high prevalence of minor depression in later-born birth cohorts emphasizes the importance of detecting minor depression in the elderly.

scholarly journals Birth Cohort Differences in Multimorbidity Burden Among Aging U.S. Adults

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 257-257
Author(s):  
Nicholas Bishop ◽  
Steven Haas ◽  
Ana Quiñones
Keyword(s):  
Cognitive Impairment ◽  
Birth Cohort ◽  
Repeated Measures ◽  
Chronic Conditions ◽  
Linear Models ◽  
Birth Cohorts ◽  
Older Americans ◽  
Cohort Differences ◽  
Increased Risk ◽  
The Us

Abstract Multimorbidity is the co-occurrence of two or more chronic health conditions and affects more than half of the US population aged 65 and older. Recent trends suggest increased risk of poor self-reported health, physical disability, cognitive impairment, and mortality among later born birth cohorts, yet we are unaware of work examining cohort trends in multimorbidity among aging US adults. Observations were drawn from the Health and Retirement Study (2000–2018) and included adults aged 51 and older across 7 birth cohorts (1923 and earlier, 1924–1930, 1931–1941, 1942–1947, 1948–1953, 1954–1959, and 1960–1965). Multimorbidity was measured as a count of 9 chronic conditions including heart disease, hypertension, stroke, diabetes, arthritis, lung disease, cancer (excluding skin cancer), depression, and cognitive impairment. General linear models adjusting for repeated measures and covariates including age, sex, race/ethnicity, and education were used to identify whether trends in multimorbidity varied across birth cohort. 31,923 adults contributed 153,940 total observations, grand mean age was 68.0 (SD=10.09), and mean multimorbidity was 2.19 (SD=1.49). In analyses adjusted for age and other covariates, adults born 1948–1953 reported .34 more chronic conditions (SE=.03, p<.001), adults born 1954–1959 reported .42 more chronic conditions (SE=.03, p<.001), and adults born 1960–1965 reported .55 more chronic conditions (SE=.03, p<.001), than those born 1931–1941, respectively. Our preliminary results confirm increasing multimorbidity among later birth cohorts of older Americans and should help guide policy to manage impending health declines among older Americans.

scholarly journals Declining Incident Dementia Rates Across Four Population-Based Birth Cohorts

2018 ◽  
Vol 74 (9) ◽  
pp. 1439-1445 ◽  
Author(s):  
Kevin J Sullivan ◽  
Hiroko H Dodge ◽  
Tiffany F Hughes ◽  
Chung-Chou H Chang ◽  
Xinmei Zhu ◽  
...  
Keyword(s):  
Birth Cohort ◽  
Sex Education ◽  
Healthy Aging ◽  
Epidemiological Studies ◽  
Population Based ◽  
Incidence Rates ◽  
Birth Cohorts ◽  
Clinical Dementia Rating ◽  
Or Education ◽  
Incident Dementia

Abstract Background Incidence rates of dementia appear to be declining in high-income countries according to several large epidemiological studies. We aimed to describe declining incident dementia rates across successive birth cohorts in a U.S. population-based sample and to explore the influences of sex and education on these trends. Methods We pooled data from two community-sampled prospective cohort studies with similar study aims and contiguous sampling regions: the Monongahela Valley Independent Elders Survey (1987–2001) and the Monongahela-Youghiogheny Healthy Aging Team (2006–Ongoing). We identified four decade-long birth cohorts spanning birth years 1902–1941. In an analysis sample of 3,010 participants (61% women, mean baseline age = 75.7 years, mean follow-up = 7.1 years), we identified 257 cases of incident dementia indicated by a Clinical Dementia Rating of 1.0 or higher. We used Poisson regression to model incident dementia rates by birth cohort, age, sex, education, and interactions of Sex × Cohort and Sex × Education. We further examined whether cohort effects varied by education, testing a Cohort × Education interaction and stratifying the models by education. Results Compared to the earliest birth cohort (1902–1911), each subsequent cohort had a significantly lower incident dementia rate (1912–1921: incidence rate ratio [IRR] = 0.655, 95% confidence interval [95% CI] = 0.477–0.899; 1922–1931: IRR = 0.387, 95% CI = 0.265–0.564; 1932–1941: IRR = 0.233, 95% CI = 0.121–0.449). We observed no significant interactions of either sex or education with birth cohort. Conclusions A decline in incident dementia rates was observed across successive birth cohorts independent of sex, education, and age.

scholarly journals Prevalence of dementia according to DSM–III–R and ICD–10

2001 ◽  
Vol 179 (3) ◽  
pp. 250-254 ◽  
Author(s):  
Steffi G. Riedel-Heller ◽  
Anja Busse ◽  
Conny Aurich ◽  
Herbert Matschinger ◽  
Matthias C. Angermeyer
Keyword(s):  
Age Groups ◽  
The Elderly ◽  
Structured Interview ◽  
Population Based ◽  
Alzheimer Type ◽  
Dementia Diagnosis ◽  
Case Definitions ◽  
Diagnosis Of Dementia ◽  
Icd 10 ◽  
Prevalence Of Dementia

BackgroundThe prevalence of dementia diagnosis according to ICD–10 and DSM–III–R in population surveys remains poorly understood.AimsTo report and compare prevalence rates according to DSM–III–R and ICD–10.MethodA population-based sample (n=1692, age 75+ years) was investigated by a Structured Interview for Diagnosis of Dementia of Alzheimer Type, Multiinfarct Dementia and Dementia of other Aetiology according to DSM–III–R and ICD–10 (SIDAM).ResultsWhereas 17.4% (95% CI=15.9–19.5) of individuals aged 75+ years suffer from dementia according to DSM–III–R, only 12.4% (95% CI=10.6–14.2) are diagnosed as having dementia according to ICD–10. The results revealed lower ICD–10 rates in all investigated age groups. The largest differences appear in the oldest of the elderly.ConclusionsThe ICD–10 sets a higher threshold for dementia diagnosis. Larger differences in the eldest age groups might reflect difficulties in applying case definitions, especially in those beyond 90 years old.

scholarly journals No associations between serum concentrations of 25-hydroxyvitamin D and parathyroid hormone and depression among US adults

2010 ◽  
Vol 104 (11) ◽  
pp. 1696-1702 ◽  
Author(s):  
Guixiang Zhao ◽  
Earl S. Ford ◽  
Chaoyang Li ◽  
Lina S. Balluz
Keyword(s):  
Parathyroid Hormone ◽  
Major Depression ◽  
Severe Depression ◽  
Diagnostic Algorithm ◽  
Population Based ◽  
Minor Depression ◽  
Serum Concentrations ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Although there is evidence that vitamin D deficiency may play a role in depression, studies done on the associations have yielded mixed results. The present study aimed to examine the associations between serum concentrations of 25-hydroxyvitamin D (25(OH)D) and parathyroid hormone (PTH) and the presence of depression among US adults. A cross-sectional, population-based sample (including 3916 participants aged ≥ 20 years) from the 2005–6 National Health and Nutrition Examination Survey was used. Participants' depressive symptoms were assessed using the Patient Health Questionnaire-9 diagnostic algorithm. The associations of 25(OH)D and PTH with depression were explored using multivariate logistic regression models. For all the participants, the age-adjusted prevalence was 5·3  (95 % CI 4·3, 6·5) % for having moderate-to-severe depression, 2·3  (95 % CI 1·7, 3·1) % for having major depression and 3·8  (95 % CI 3·0, 4·6) % for having minor depression. Although the age-adjusted prevalence and the unadjusted OR of having moderate-to-severe depression or major depression decreased linearly with increasing quartiles of 25(OH)D (P < 0·05 for trends), no significant associations remained after adjusting for multiple potential confounders such as demographic variables, lifestyle factors and coexistence of a number of chronic conditions. Neither the age-adjusted prevalence nor the OR (unadjusted or adjusted) of having depression differed significantly by the quartiles of PTH. Thus, in contrast to some of the previous findings, the present results did not show significant associations between serum concentrations of 25(OH)D and PTH and the presence of moderate-to-severe depression, major depression or minor depression among US adults. However, these findings need to be further confirmed in future studies.

scholarly journals Improved Cognitive Function in the Tromsø Study in Norway From 2001 to 2016

2021 ◽  
pp. 10.1212/CPJ.0000000000001115
Author(s):  
Bente Johnsen ◽  
Bjørn Heine Strand ◽  
Ieva Martinaityte ◽  
Ellisiv B. Mathiesen ◽  
Henrik Schirmer
Keyword(s):  
Physical Activity ◽  
Birth Cohort ◽  
Age Groups ◽  
Cohort Effect ◽  
Cognitive Test ◽  
Birth Cohorts ◽  
Cohort Differences ◽  
Level Increase ◽  
Drinking Frequency ◽  
Birth Cohort Effect

AbstractObjective:Physical capacity and cardiovascular risk profiles seem to be improving in the population. Cognition have been improving due to a birth cohort effect, but evidence is conflicting on whether this improvement remains in the latest decades, and what is causing the changes in our population over 60 years old. We aimed to investigate birth cohort differences in cognition.Method:The study comprised 9514 participants from the Tromsø study, an ongoing longitudinal cohort study. Participants were in the ages 60–87 years, born between 1914 and 1956. They did four cognitive tests in three waves during 2001-2016. Linear regression was applied, and adjusted for age, education, blood pressure, smoking, hypercholesterolemia, stroke, heart attack, depression, diabetes, physical activity, alcohol use, BMI and height.Results:Cognitive test scores were better in later-born birth cohorts for all age groups, and in both sexes, compared with earlier born cohorts. Increased education, physical activity, alcohol intake, decreasing smoking prevalence and increasing height was associated with one third of this improvement across birth cohorts in women and one half of the improvement in men.Conclusion:Cognitive results were better in more recent born birth cohorts compared with earlier born, assessed at the same age. The improvement was present in all cognitive domains, suggesting an overall improvement in cognitive performance. The 80-year-olds assessed in 2015-16 performed like 60-year-olds assessed in 2001. The improved scores were associated with increased education level, increase in modest drinking frequency, increased physical activity and for men, smoking cessation and increased height.

Birth cohort differences in fluid cognition in old age: Comparisons of trends in levels and change trajectories over 30 years in three population-based samples.

2015 ◽  
Vol 30 (1) ◽  
pp. 83-94 ◽  
Author(s):  
Peter Karlsson ◽  
Valgeir Thorvaldsson ◽  
Ingmar Skoog ◽  
Pia Gudmundsson ◽  
Boo Johansson
Keyword(s):  
Birth Cohort ◽  
Old Age ◽  
Population Based ◽  
Change Trajectories ◽  
Cohort Differences

Prevalence of Depression After Stroke: The Perth Community Stroke Study

1995 ◽  
Vol 166 (3) ◽  
pp. 320-327 ◽  
Author(s):  
P. W. Burvill ◽  
G. A. Johnson ◽  
K. D. Jamrozik ◽  
C. S. Anderson ◽  
E. G. Stewart-Wynne ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Major Depression ◽  
Acute Stroke ◽  
Population Based ◽  
Depressive Illness ◽  
Minor Depression ◽  
Population Based Study ◽  
Stroke Study ◽  
Prevalence Of Depression ◽  
Recurrent Strokes

BackgroundThe Perth Community Stroke Study (PCSS) was a population-based study of the incidence, cause, and outcome of acute stroke.MethodSubjects from the study were assessed initially, by examination and interview, and at four- and 12-month follow-ups to determine differences in prevalence of depression between the sexes and between patients with first-ever and recurrent strokes.ResultsThe prevalence of depressive illness four months after stroke in 294 patients from the PCSS was 23% (18–28%), 15% (11–19%) major depression and 8% (5–11 %) minor depression. There were no significant differences between the sexes or between patients with first-ever and recurrent strokes. With a non-hierarchic approach to diagnosis of those with depression, 26% of men and 39% of women had an associated anxiety disorder, mainly agoraphobia. Nine per cent of male and 13% of female patients interviewed had evidence of depression at the time of the stroke. Twelve months after stroke 56% of the men were still depressed (40% major and 16% minor), as were 30% of the women (12% major and 18% minor).ConclusionThe prevalence of depression after stroke was comparable with that reported from other studies, and considerably less than that reported from in-patient and rehabilitation units.

scholarly journals Birth cohort differences in the use of medications in a Brazilian population of older elderly: the Bambuí cohort study of aging (1997 and 2008)

2011 ◽  
Vol 27 (suppl 3) ◽  
pp. s435-s443 ◽  
Author(s):  
Antônio Ignácio de Loyola Filho ◽  
Josélia O. A. Firmo ◽  
Elizabeth Uchôa ◽  
Maria Fernanda Lima-Costa
Keyword(s):  
Cohort Study ◽  
Chronic Conditions ◽  
Population Based ◽  
Baseline Survey ◽  
Birth Cohorts ◽  
Antithrombotic Agents ◽  
Medical Visits ◽  
Cohort Differences ◽  
Minas Gerais State ◽  
Recent Cohort

This study examined differences in the use of medications in two birth cohorts (born from 1916 to 1926 and from 1927 to 1937) among older elderly in the population-based cohort study in Bambuí, Minas Gerais State, Brazil. The study used data on participants who were 71-81 years of age in the baseline survey in 1997 (n = 492) and in the 11th wave, in 2008 (n = 620). The number of medications currently consumed (mean = 4.6 and 3.4, respectively) and prevalence of polypharmacy (46.6% and 29.1%, respectively) were higher in the more recent cohort as compared to the earlier one. These differences were independent of gender, age, schooling, number of medical visits in the previous 12 months, and number of chronic conditions. The more recent cohort showed significant differences in the use of psychoactive drugs, lipid modifying agents, drugs for diabetes, and antithrombotic agents, as well as changes in drugs used for arterial hypertension. In general, these changes are consistent with those observed in elderly populations in high-income countries.

scholarly journals Decline in the negative association between low birth weight and cognitive ability

2016 ◽  
Vol 114 (1) ◽  
pp. 84-88 ◽  
Author(s):  
Alice Goisis ◽  
Berkay Özcan ◽  
Mikko Myrskylä
Keyword(s):  
Cohort Study ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Cognitive Ability ◽  
Birth Cohort ◽  
Very Low Birth Weight ◽  
Family Characteristics ◽  
Negative Consequences ◽  
Birth Cohorts ◽  
Cohort Differences

Low birth weight predicts compromised cognitive ability. We used data from the 1958 National Child Development Study (NCDS), the 1970 British Cohort Study (BCS), and the 2000–2002 Millennium Cohort Study (MCS) to analyze how this association has changed over time. Birth weight was divided into two categories, <2,500 g (low) and 2,500–4,500 g (normal) and verbal cognitive ability was measured at the age of 10 or 11 y. A range of maternal and family characteristics collected at or soon after the time of birth were considered. Linear regression was used to analyze the association between birth weight and cognitive ability in a baseline model and in a model that adjusted for family characteristics. The standardized difference (SD) in cognitive scores between low-birth-weight and normal-birth-weight children was large in the NCDS [−0.37 SD, 95% confidence interval (CI): −0.46, −0.27] and in the BCS (−0.34, 95% CI: −0.43, −0.25) cohorts, and it was more than halved for children born in the MCS cohort (−0.14, 95% CI: −0.22, −0.06). The adjustment for family characteristics did not explain the cross-cohort differences. The results show that the association between low birth weight and decreased cognitive ability has declined between the 1950s and 1970s birth cohorts and the 2000--2002 birth cohort, despite a higher proportion of the low-birth-weight babies having a very low birth weight (<1,500 g) in the more recent birth cohort. Advancements in obstetric and neonatal care may have attenuated the negative consequences associated with being born small.

Cognitive functions in depressive disorders: evidence from a population-based study

2004 ◽  
Vol 34 (1) ◽  
pp. 83-91 ◽  
Author(s):  
E. AIRAKSINEN ◽  
M. LARSSON ◽  
I. LUNDBERG ◽  
Y. FORSELL
Keyword(s):  
Major Depression ◽  
Depressive Disorder ◽  
Episodic Memory ◽  
Cognitive Performance ◽  
Verbal Fluency ◽  
Depressive Disorders ◽  
Population Based ◽  
Minor Depression ◽  
Motor Speed ◽  
Mental Flexibility

Background. Most of the available evidence on the effects of depression is based on in- and out-patient samples focusing on individuals suffering from major depression. The aims of this study were to examine cognitive functioning in population-based samples and to determine whether cognitive performance varies as a function of depression subgroup.Method. Population-based samples (aged 20–64 years) with major depression (N=68), dysthymia (N=28), mixed anxiety-depressive disorder (N=25) and minor depression (N=66) were examined on a variety of cognitive tasks (i.e. episodic memory, verbal fluency, perceptual-motor speed and mental flexibility). One hundred and seventy-five non-depressed individuals served as controls.Results. The total group of depressed individuals showed impairments in tasks tapping episodic memory and mental flexibility. Of more interest, however, was the observation that the pattern of impairments varied as a function of depression subgroup: the major depression and mixed anxiety-depressive disorder groups exhibited significant memory dysfunction, whereas individuals with dysthymia showed pronounced difficulties in mental flexibility. Minor depression did not affect cognitive performance. Verbal fluency and perceptual-motor speed were not affected by depression.Conclusions. These results indicate that persons with depressive disorders in the population exhibit cognitive impairments in tasks tapping episodic memory and mental flexibility and that cognitive impairment varies as a function of depressive disorder.

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