Granite genesis related to geodynamics from Hf—Y in zircon

2000 ◽  
Vol 91 (1-2) ◽  
pp. 245-256 ◽  
Author(s):  
Jean-Pierre Pupin
Keyword(s):  
Phase 1 ◽  
Morphological Variability ◽  
Space Distribution ◽  
Accessory Mineral ◽  
Magmatic Zircon ◽  
Phase 2 ◽  
Genetic Groups ◽  
Magmatic Rocks ◽  
Chemical Variability ◽  
Definition Of

Zircon is a very interesting accessory mineral, a kind of ‘crustal diamond’, easily recycled and recording through large morphological variability the main rock-forming events. Since 1985, a systematic study of chemical variability of zircon in magmatic rocks has led to the definition of three main generations in zircon populations: inherited phase 1, magmatic phase 2 and late magmatic phase 3. Hafnium and yttrium appear to be the most useful for source characterisation, especially if using phase 2 data. As a consequence, a new diagram of HfO2versus Y2O3is proposed, divided into domains la to 6b to describe the distribution of the genetic groups and the specific domains for anorogenic and orogenic rocks. Zircon in anorogenic granitoids: tholeiitic plagiogranites (high Y, low Hf), hypersolvus (medium to low Y, low Hf) and subsolvus (medium to high Y and Hf) alkaline granites/rhyolites, has separate mean distributions. Genetic relations existing between rocks with obvious textural differences (granites, microgranites, rhyolites) are also recognised. Zircon in orogenic granitoids is Y-poor and shows a very limited distribution, but the minimal average values in magmatic zircon vary from 11 000 wt ppm HfO2in the calc-alkaline suite, to 12 000 ppm in the peraluminous porphyritic granites and to 13 500 ppm in entirely crustal anatectic granites and migmatites. Mixing-mingling processes are proposed to explain the intermediate characteristics of zircons and rocks in the peraluminous porphyritic and K-subalkaline granites. This is consistent with the time emplacement and space distribution of these two orogenic members, but leads to a new proposal of emplacement of some alkaline subsolvus magmas during orogenic cycles.

An Analysis of Privacy Language in the Scholarly Literature on Mental Health Apps

2021 ◽  
pp. 212-239
Author(s):  
Maureen Ebben ◽  
Julien S. Murphy
Keyword(s):  
Mental Health ◽  
Phase 1 ◽  
Critical Discourse ◽  
Phase 2 ◽  
Phase 3 ◽  
Scholarly Literature ◽  
Health Apps ◽  
Technological Possibility ◽  
Thematic Approach ◽  
Definition Of

This chapter charts the language of privacy in published scholarship on mental health apps. What definition of privacy is assumed? What meanings of privacy are deployed in the research about mental health apps? Using a qualitative thematic approach, this analysis shows that privacy language can be understood as occurring in three phases: Phase 1: Discourse of Technological Possibility; Phase 2: Discourse of Privacy Challenges and Threats; and Phase 3: Discourse of Advocacy. The authors discuss each of these phases and propose a more critical discourse of privacy by identifying the issues inherent in understanding privacy as security.

A phase I/II study of lenvatinib (LEN) plus everolimus (EVE) in recurrent and refractory pediatric solid tumors, including CNS tumors.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 10527-10527
Author(s):  
Filemon S. Dela Cruz ◽  
Elizabeth Fox ◽  
Jodi Ann Muscal ◽  
Ivan Kirov ◽  
James I. Geller ◽  
...  
Keyword(s):  
Dose Escalation ◽  
Phase 1 ◽  
Single Agent ◽  
High Grade Glioma ◽  
Cns Tumors ◽  
Phase 2 ◽  
Pediatric Solid Tumors ◽  
Group Methods ◽  
Grade 3 ◽  
Definition Of

10527 Background: Proangiogenic signaling pathways cooperate with mTOR-mediated regulation of cell growth and maintenance to drive development of many pediatric cancers. We report results of the phase 1 dose escalation for LEN + EVE in pediatric patients (pts) with recurrent solid and CNS tumors conducted by Children’s Oncology Group. Methods: Dose escalation was conducted using a rolling-6 design. Pts received LEN + EVE orally once daily in continuous 28-day cycles. Dose determination was based on toxicity (CTCAE v4.03) during cycle 1. Pharmacokinetics (PK) of plasma LEN and EVE were monitored. Results: 17 pts were enrolled (9 male; 8 female). Median (range) age was 10 (3–21) years; 8 pts had CNS tumors. 17 were evaluable for dose-limiting toxicity (DLT). Enrollment started at dose level 1 (DL 1; LEN 11 mg/m2 + EVE 3 mg/m2) and, after treatment of 3 pts, was initially de-escalated to DL –1 (LEN 8 mg/m2 + EVE 3 mg/m2) due to DLT of proteinuria in 1 pt and self-resolving headache in another who, on review, did not meet the definition of DLT. No pts enrolled at DL –1 (n = 5) experienced DLT. Overall, DLTs were observed in 2 of the first 6 patients enrolled at DL 1: the initial pt with proteinuria and 1 more pt with hypertriglyceridemia and hypercholesteremia. Because 2 pts had reversible DLT of different categories not related to Cmax or AUC, the DL 1 cohort was expanded to enroll an additional 6 pts, none of whom had DLT. Thus, 2/12 pts experienced DLT at DL 1. Overall, most common treatment-emergent adverse events (TEAEs; ≥ 50% of pts) were diarrhea, hypertension, hypertriglyceridemia, vomiting, abdominal pain, headache, and hypothyroidism. 47% of pts had ≥ 1 treatment-related TEAE grade ≥ 3; the most frequent was proteinuria (n = 2). On cycle 1 day 15, mean (SD) Cmax (ng/mL) for LEN at DL –1 and DL 1, respectively, was 314 (150) and 359 (270), and mean (SD) AUC0-8h (hr•ng/mL) for LEN was 1570 (935) and 1780 (1100). Taking all toxicities and PK into account, no further dose escalation was recommended. Best overall response in pts with measurable disease was 2/11 stable disease, 7/11 progressive disease, and 2/11 not evaluable. Conclusions: The recommended phase 2 dose of LEN + EVE in children with solid and CNS tumors was LEN 11 mg/m2 + EVE 3 mg/m2, with maximum daily doses capped at 18 mg and 5 mg, respectively. The toxicity profile was no more than additive to single-agent therapy. PK exposure was comparable with children on single-agent LEN and to adults receiving LEN + EVE. Enrollment to the phase 2 portion (Ewing sarcoma, high-grade glioma, and rhabdomyosarcoma strata) is ongoing. Clinical trial information: NCT03245151.

scholarly journals Analysis and reporting of stratified cluster randomized trials—a systematic survey

Trials ◽  
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Sayem Borhan ◽  
Alexandra Papaioannou ◽  
Jinhui Ma ◽  
Jonathan Adachi ◽  
Lehana Thabane
Keyword(s):  
Randomized Trials ◽  
Phase 1 ◽  
Data Abstraction ◽  
Phase 2 ◽  
Intervention Effect ◽  
Stratification Variable ◽  
Baseline Characteristics ◽  
Cluster Randomized ◽  
Definition Of ◽  
Methodological Aspects

Abstract Background In order to correctly assess the effect of intervention from stratified cluster randomized trials (CRTs), it is necessary to adjust for both clustering and stratification, as failure to do so leads to misleading conclusions about the intervention effect. We have conducted a systematic survey to examine the current practices about analysis and reporting of stratified CRTs. Method We used the search terms to identify the stratified CRTs from MEDLINE since the inception to July 2019. In phase 1, we screened the title and abstract for English-only studies and selected, including the main results paper of the identified protocols, for the next phase. In phase 2, we screened the full text and selected studies for data abstraction. The data abstraction form was piloted and developed using the REDCap. We abstracted data on multiple design and methodological aspects of the study including whether the primary method adjusted for both clustering and stratification, reporting of sample size, randomization, and results. Results We screened 2686 studies in the phase 1 and selected 286 studies for phase 2—among them 185 studies were selected for data abstraction. Most of the selected studies were two-arm 140/185 (76%) and parallel-group 165/185 (89%) trials. Among these 185 studies, 27 (15%) of them did not provide any sample size or power calculation, while 105 (57%) studies did not mention any method used for randomization within each stratum. Further, 43 (23%) and 150 (81%) of 185 studies did not provide the definition of all the strata, while more than 60% of the studies did not include all the stratification variable(s) in the flow chart or baseline characteristics table. More than half 114/185 (62%) of the studies did not adjust the primary method for both clustering and stratification. Conclusion Stratification helps to achieve the balance among intervention groups. However, to correctly assess the intervention effect from stratified CRTs, it is important to adjust the primary analysis for both stratification and clustering. There are significant deficiencies in the reporting of methodological aspects of stratified CRTs, which require substantial improvements in several areas including definition of strata, inclusion of stratification variable(s) in the flow chart or baseline characteristics table, and reporting the stratum-specific number of clusters and individuals in the intervention groups.

An Analysis of Privacy Language in the Scholarly Literature on Mental Health Apps

2021 ◽  
pp. 264-285
Author(s):  
Maureen Ebben ◽  
Julien S. Murphy
Keyword(s):  
Mental Health ◽  
Phase 1 ◽  
Critical Discourse ◽  
Phase 2 ◽  
Phase 3 ◽  
Scholarly Literature ◽  
Health Apps ◽  
Technological Possibility ◽  
Thematic Approach ◽  
Definition Of

This chapter charts the language of privacy in published scholarship on mental health apps. What definition of privacy is assumed? What meanings of privacy are deployed in the research about mental health apps? Using a qualitative thematic approach, this analysis shows that privacy language can be understood as occurring in three phases: Phase 1: Discourse of Technological Possibility; Phase 2: Discourse of Privacy Challenges and Threats; and Phase 3: Discourse of Advocacy. The authors discuss each of these phases and propose a more critical discourse of privacy by identifying the issues inherent in understanding privacy as security.

scholarly journals Morphological Analysis of the Bone Serrated Points from Early Neolithic Complexes of Shamanka 2 Burial Ground

2021 ◽  
Vol 35 ◽  
pp. 17-51
Author(s):  
V. I. Bazaliiskii ◽  
◽  
A. A. Tyutrin ◽  
A. W. Weber ◽  
◽  
...  
Keyword(s):  
Morphological Analysis ◽  
Phase 1 ◽  
Type I ◽  
Burial Ground ◽  
Phase 2 ◽  
Structural Elements ◽  
Group I ◽  
Curved Blade ◽  
Definition Of ◽  
Base Structure

An analysis of the bone serrated points from the burial complexes of Shamanka 2 burial ground is presented. The origin of the collection makes it “ritual”, which may explain the large number of undamaged items. Several spikes have been broken intentionally at the time of their interment. Supposedly, several points have been specifically made for interment. In accordance with the morphological analysis, we have identified two groups of serrated spikes: (I) detachable tools and (II) non-detachable tools. Differences in structural elements of the stopper-line determine 7 types of harpoons (95 items), and variations in base structure define 2 types of points of leisters, javelins, spears etc. (6 items), while 15 fragments of blade were excluded from the analysis. Harpoons of the Type I-1 and Type I-2 are divided into 9 varieties, in accordance with structural elements of the blade. Harpoons of the Type I-3 are divided into 2 subtypes due to differences in structural elements of the shaft. Harpoons of the I-4 – I-7 types are represented by only 1 item for each type and are considered to be individual tools. Group I (harpoons) consist mostly of tools with an orifice for line lashing (89 items). Harpoons that feature stopper-line structural elements without through hole are represented here by only 6 items. II-2 type points with a unilaterally beveled base represent most non-detachable barbed tools – 5 items. II-1 type points with a wedgelike base (in a profile) consist of only 1 item. The designated types and varieties of Shamanka II cemetery barbed spikes correlate with items from different synchronous and asynchronous sites of both bordering and substantially remote regions. Serrated points are found mainly in male burials but absent in children's burials. Chronologically, 111 barbed spikes relate to the Phase 1 of the Shamanka 2 cemetery functioning. Five more spikes were recorded in 3 burials of the Phase 2. Barbed spikes of the chronological Phase 2 are represented with 4 items of the I-1.4 variety from burials No. 108-1 and 64-2, as well as 1 item of the I-2-1 variety from a grave No. 49. The last artifact probably represents an ideal model of two-row harpoons with symmetrically situated barbs and a sword-like spike. Harpoons with a curved blade (Type I-1.4) were registered only in burials of the chronological Phase 2. The barbed spikes of the I-1 and I-2 types, which feature a stopper-line with through holes and lateral projections, correlate with a definition of harpoons of the Kitoi type.

scholarly journals EduIMPACT: A scale for measuring the impact of literacy programmes for youth and adults

2021 ◽  
Author(s):  
Oscar Iván Gutiérrez-Carvajal ◽  
Mónica Perdomo ◽  
Jenny Lorena Agredo ◽  
Geisler Dayani Rojas
Keyword(s):  
Phase 1 ◽  
Education Programme ◽  
Measurement Scale ◽  
Phase 2 ◽  
Group Discussions ◽  
Life Project ◽  
Individual Interviews ◽  
Definition Of ◽  
The University ◽  
The Impact

AbstractThis article presents an instrument for measuring the effectiveness of literacy programmes for youth and adults. To assess the impact of participation on individual learners’ lives and their environment, the authors developed a structure comprising five main dimensions: (1) “personal sphere” (six sub-dimensions); (2) “social skills” (six sub-dimensions); (3) “life project” (four sub-dimensions); (4) “knowledge” (five sub-dimensions); and (5) “economic situation” ´(five sub-dimensions). Phase 1 of developing this instrument included the definition of dimensional and sub-dimensional features; Phase 2 comprised drafting the design of the measurement scale. During Phase 1, the authors conducted focus group discussions and individual interviews with 15 students, 14 teachers, 10 graduates and 2 former managers of a Colombian second-chance adult education programme called Avancemos [Let’s go forward]. The programme was launched in 1993 and has since been further developed by the University of Ibagué. During Phase 2, six specialists in education and psychology validated the survey items in an expert trial. In the third phase of development, the authors finalised a survey questionnaire to test their scale and distributed it among 132 Avancemos graduates, of whom 124 (63 women and 61 men) returned completed forms. In their analysis of the results, the authors found that their instrument, which they named EduIMPACT, had proved useful for evaluating and acting upon the programme’s perception among its target group.

Rationalization and internalization

2001 ◽  
Vol 60 (4) ◽  
pp. 215-230 ◽  
Author(s):  
Jean-Léon Beauvois
Keyword(s):  
Phase 1 ◽  
Facilitatory Effect ◽  
Phase 2 ◽  
Causal Explanations ◽  
Reduction Effect ◽  
Dissonance Reduction

After having been told they were free to accept or refuse, pupils aged 6–7 and 10–11 (tested individually) were led to agree to taste a soup that looked disgusting (phase 1: initial counter-motivational obligation). Before tasting the soup, they had to state what they thought about it. A week later, they were asked whether they wanted to try out some new needles that had supposedly been invented to make vaccinations less painful. Agreement or refusal to try was noted, along with the size of the needle chosen in case of agreement (phase 2: act generalization). The main findings included (1) a strong dissonance reduction effect in phase 1, especially for the younger children (rationalization), (2) a generalization effect in phase 2 (foot-in-the-door effect), and (3) a facilitatory effect on generalization of internal causal explanations about the initial agreement. The results are discussed in relation to the distinction between rationalization and internalization.

PENERAPAN MODEL QUANTUM LEARNING UNTUK MENINGKATKAN HASIL BELAJAR AUTOCAD SISWA KELAS X TEKNIK PEMESINAN SMK NEGERI 1 STABAT

2013 ◽  
Vol 5 (1) ◽  
Author(s):  
Abdul Hasan Saragih
Keyword(s):  
Positive Response ◽  
Phase 1 ◽  
First Grade ◽  
Learning Model ◽  
Second Phase ◽  
Phase 2 ◽  
Phase 3 ◽  
The Third ◽  
Third Phase ◽  
Quantum Learning

This classroom research was conducted on the autocad instructions to the first grade of mechinary class of SMK Negeri 1 Stabat aiming at : (1) improving the student’ archievementon autocad instructional to the student of mechinary architecture class of SMK Negeri 1 Stabat, (2) applying Quantum Learning Model to the students of mechinary class of SMK Negeri 1 Stabat, arising the positive response to autocad subject by applying Quantum Learning Model of the students of mechinary class of SMK Negeri 1 Stabat. The result shows that (1) by applying quantum learning model, the students’ achievement improves significantly. The improvement ofthe achievement of the 34 students is very satisfactory; on the first phase, 27 students passed (70.59%), 10 students failed (29.41%). On the second phase 27 students (79.41%) passed and 7 students (20.59%) failed. On the third phase 30 students (88.24%) passed and 4 students (11.76%) failed. The application of quantum learning model in SMK Negeri 1 Stabat proved satisfying. This was visible from the activeness of the students from phase 1 to 3. The activeness average of the students was 74.31% on phase 1,81.35% on phase 2, and 83.63% on phase 3. (3) The application of the quantum learning model on teaching autocad was very positively welcome by the students of mechinary class of SMK Negeri 1 Stabat. On phase 1 the improvement was 81.53% . It improved to 86.15% on phase 3. Therefore, The improvement ofstudent’ response can be categorized good.

In situ deteriorating patient simulation in general practice

2020 ◽  
Vol 70 (suppl 1) ◽  
pp. bjgp20X711425
Author(s):  
Joanna Lawrence ◽  
Petronelle Eastwick-Field ◽  
Anne Maloney ◽  
Helen Higham
Keyword(s):  
Life Support ◽  
Early Recognition ◽  
Phase 1 ◽  
Patient Simulation ◽  
Medical Emergency ◽  
Phase 2 ◽  
Action Plans ◽  
Integrated Simulation ◽  
Deteriorating Patient

BackgroundGP practices have limited access to medical emergency training and basic life support is often taught out of context as a skills-based event.AimTo develop and evaluate a whole team integrated simulation-based education, to enhance learning, change behaviours and provide safer care.MethodPhase 1: 10 practices piloted a 3-hour programme delivering 40 minutes BLS and AED skills and 2-hour deteriorating patient simulation. Three scenarios where developed: adult chest pain, child anaphylaxis and baby bronchiolitis. An adult simulation patient and relative were used and a child and baby manikin. Two facilitators trained in coaching and debriefing used the 3D debriefing model. Phase 2: 12 new practices undertook identical training derived from Phase 1, with pre- and post-course questionnaires. Teams were scored on: team working, communication, early recognition and systematic approach. The team developed action plans derived from their learning to inform future response. Ten of the 12 practices from Phase 2 received an emergency drill within 6 months of the original session. Three to four members of the whole team integrated training, attended the drill, but were unaware of the nature of the scenario before. Scoring was repeated and action plans were revisited to determine behaviour changes.ResultsEvery emergency drill demonstrated improved scoring in skills and behaviour.ConclusionA combination of: in situ GP simulation, appropriately qualified facilitators in simulation and debriefing, and action plans developed by the whole team suggests safer care for patients experiencing a medical emergency.

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