PP18 An Access Evidence IT Solution Within A Pharmaceutical Company

Introduction:During 2014, Roche tested whether the EUnetHTA HTA Core Model© was a useful, exhaustive and relevant value framework to promote efficiencies in scoping, storing and sharing health technology assessment (HTA) evidence within a pharmaceutical company. The conclusion was positive and Roche decided to build a cloud based information technology (IT) platform to store all relevant HTA evidence to support global and regional market access activities, tagged with metadata according to the HTA Core Model©., The platform should be user-friendly and promote efficiencies and knowledge sharing across the organization. Eventually this platform may also be used by external stakeholders to access relevant HTA evidence.Methods:In order to better equip global functions, regions and affiliates in a major pharmaceutical company with user-friendly and fast access to product-relevant HTA and payer evidence as well as access evidence plans, an easy-to-use IT-based platform was needed. The platform, internally called #TAg, is a central repository of information to support market access activities and promote collaboration between Affiliate, Region and Global teams. The platform uses metadata to label all types of evidence and uses the HTA Core Model© domains to categorize the evidence.Results:The platform #TAg was developed throughout 2016/2017 and officially launched on 1 October 2017. Within the first 30 days, the platform has been readily accepted by affiliates, regions and global functions through significant use uptake as measured by user registration and download activities. In addition, #TAg was used successfully in a pilot project for a submission to an external HTA body.Conclusions:A complete knowledge management system for HTA evidence is important for driving efficiency in scoping, storing and disseminating access evidence information within a pharmaceutical company. #TAg has so far proved a good start on such a system with further development expected in the coming years.

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Timely, consistent, transparent assessment of market access evidence: implementing tools based on the HTA Core Model® in a pharmaceutical company

International Journal of Technology Assessment in Health Care ◽

10.1017/s0266462318003653 ◽

2019 ◽

Vol 35 (1) ◽

pp. 10-16 ◽

Cited By ~ 1

Author(s):

Pierre Ducournau ◽

Cornelia Irl ◽

Iain Tatt ◽

Mary McCarvil ◽

Marlene Gyldmark

Keyword(s):

Pharmaceutical Company ◽

Market Access ◽

Health Technology ◽

Mitigation Strategies ◽

Core Model ◽

Development Teams ◽

Fit For Purpose ◽

Assessment Of Evidence ◽

The Impact ◽

Evidence Generation

AbstractObjectivesEvidence requirements and assessment methods access differ between health technology assessment (HTA) agencies. The HTA Core Model® provides a standardized approach to HTA, targeting evidence sharing and collaboration between participating HTA bodies. It is fit for purpose from an industry perspective and was used by pharmaceutical company Roche to develop a framework for internal assessment of evidence required for market access and coverage/reimbursement (“access evidence”).MethodsTools were developed to systematically scope, assess, plan, and summarize access evidence generation. The tools were based mainly on the first four HTA Core Model® domains and rolled-out in selected development teams in 2017. Five months after full implementation, the impact of tools was assessed in an internal survey.ResultsSystematic access evidence generation started with the Access Evidence Questionnaire, to scope evidence requirements and identify evidence gaps. Findings were summarized in the Access Evidence Metric, which assessed the alignment of available/planned evidence against HTA bodies’ requirements and developed scope mitigation strategies. The Access Evidence Plan was then used to plan and document (additional) evidence generation. Once generated, evidence was summarized in the Access Evidence Dossier. A survey of twenty-seven Roche employees involved in evidence generation showed that the tools made discussions around access strategies and evidence more efficient and transparent.ConclusionsThe HTA Core Model® provided a useful framework around which to optimize internal evidence generation and assessment. The benefits of using a standardized HTA approach in industry mirror those expected from implementing the HTA Core Model® in HTA agencies.

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The Red Legs RATED tool to improve diagnosis of lower limb cellulitis in the emergency department

British Journal of Nursing ◽

10.12968/bjon.2021.30.12.s22 ◽

2021 ◽

Vol 30 (12) ◽

pp. S22-S29

Author(s):

Gillian O'Brien ◽

Patricia White

Keyword(s):

Emergency Department ◽

Lower Limb ◽

Treatment Guidelines ◽

Positive Impact ◽

Data Gathering ◽

Pilot Project ◽

Accurate Diagnosis ◽

Evidence Based ◽

Significant Burden ◽

User Friendly

Background: Lower limb cellulitis poses a significant burden for the Irish healthcare system. Accurate diagnosis is difficult, with a lack of validated evidence-based tools and treatment guidelines, and difficulties distinguishing cellulitis from its imitators. It has been suggested that around 30% of suspected lower limb cellulitis is misdiagnosed. An audit of 132 patients between May 2017 and May 2018 identified a pattern of misdiagnosis in approximately 34% of this cohort. Objective: The aim of this pilot project was to develop a streamlined service for those presenting to the emergency department with red legs/suspected cellulitis, through introduction of the ‘Red Leg RATED’ tool for clinicians. Method: The tool was developed and introduced to emergency department clinicians. Individuals (n=24) presenting with suspected cellulitis over 4 weeks in 2018 were invited to participate in data gathering. Finally, clinician questionnaire feedback regarding the tool was evaluated. Results: Fourteen participants consented, 6 female and 8 male with mean age of 65 years. The tool identified 50% (n=7) as having cellulitis, of those 57% (n=4) required admission, 43% (n=3) were discharged. The remainder who did not have cellulitis (n=7) were discharged. Before introduction of the tool, all would typically have been admitted to hospital for further assessment and management of suspected lower limb cellulitis. Overall, 72% (n=10) of patients who initially presented with suspected cellulitis were discharged, suggesting positive impact of the tool. Clinician feedback suggested all were satisfied with the tool and contents. Conclusion: The Red Leg RATED tool is user friendly and impacts positively on diagnosis treatment and discharge. Further evaluation is warranted.

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IS THE EUNETHTA HTA CORE MODEL® FIT FOR PURPOSE? EVALUATION FROM AN INDUSTRY PERSPECTIVE

International Journal of Technology Assessment in Health Care ◽

10.1017/s0266462318000594 ◽

2018 ◽

Vol 34 (5) ◽

pp. 458-463 ◽

Cited By ~ 6

Author(s):

Marlene Gyldmark ◽

Kristian Lampe ◽

Jörg Ruof ◽

Johannes Pöhlmann ◽

Ansgar Hebborn ◽

...

Keyword(s):

Technology Use ◽

Market Access ◽

Economic Value ◽

Clinical Effectiveness ◽

Health Technology ◽

Core Model ◽

European Network ◽

Survey Results ◽

Fit For Purpose ◽

Evidence Generation

Objectives:The HTA Core Model® was developed to improve the transferability of health technology assessment (HTA) between settings. The model has been used by HTA agencies but is also of interest to manufacturers, for improving internal evidence generation and communicating with other HTA stakeholders. To establish if the model is fit for purpose from an industry perspective, the pharmaceutical company Roche, collaborating with the European Network for HTA (EUnetHTA), conducted an assessment of the model.Methods:A questionnaire was developed to evaluate all assessment elements in the HTA Core Model v2.0 for their usefulness in meeting payers’ evidence needs and demonstrating value. The questionnaire was completed by country affiliate teams working in evidence generation and reimbursement submissions for pharmaceuticals. Survey results were discussed in workshops to ensure consistency and alignment between teams.Results:The questionnaire was completed by six teams. An additional team from global pricing and market access participated in workshops. Model domains pertaining to the health problem and current technology use, technology description, clinical effectiveness, and economic value were considered most important because they meet payers’ evidence needs. Overall, the model was considered useful to improve the efficiency of HTA evidence generation, share evidence internally, and communicate value to payers and HTA agencies.Conclusions:From an industry perspective, the HTA Core Model provides a useful framework and common terminology for efficient generation of transferable HTA evidence. The timeliness, efficiency, and transparency of HTA processes could be improved by a more standardized approach to HTA across settings.

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A Post-Pandemic Strategy to Support Lifelong and Work-Integrated Learning

10.4018/978-1-7998-8213-8.ch013 ◽

2022 ◽

pp. 203-219

Author(s):

Peter Mozelius

Keyword(s):

Communities Of Practice ◽

Lifelong Learning ◽

Real World ◽

Knowledge Society ◽

Pilot Project ◽

Insurance Companies ◽

Integrated Learning ◽

Pedagogical Aspect ◽

Work Integrated Learning ◽

User Friendly

Lifelong work-integrated learning is a key challenge in the growing knowledge society, with the Corona pandemic as a catalyst for technology enhancement. This chapter argues for the need of a post-pandemic strategy that rethinks not only the pedagogical aspect but also the technology enhanced and collaborative aspects of lifelong and work-integrated learning. The strategy that is presented in this chapter is based on the author's experience from the BUFFL initiative, a pilot project for industry development at banks and insurance companies through technology-enhanced lifelong learning. The recommendation is a strategy tailored for the target group that supports the work-integrated learning aim of academia providing useful theories for real-world tasks in the industry. Some important components in the strategy are 1) to extend pedagogy with andragogy and heutagogy, 2) the design of user-friendly hybrid environments, and 3) blended communities of practice.

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Reconfiguring Performance Information Linking with Accountability

Active Citizen Participation in E-Government ◽

10.4018/978-1-4666-0116-1.ch001 ◽

2012 ◽

pp. 1-19

Author(s):

Étienne Charbonneau ◽

Younhee Kim

Keyword(s):

Performance Measurement ◽

Government Accountability ◽

Performance Information ◽

Measurement Systems ◽

Performance Reporting ◽

Reporting Systems ◽

External Stakeholders ◽

Performance Measurement Systems ◽

And Performance ◽

User Friendly

Over the past decade, performance information has been widely available to citizens along with the expansion of e-government, which has magnified communications between citizens and government as well as citizen direct participation in government business. If citizens are informed more about government performance, citizen trust in government should improve. However, there is, in effect, little use of performance information by citizens, since availability to citizens is not very visible. To disseminate the results of performance measurement effectively, government should pay attention to the improvement of performance measurement systems and performance reporting systems with citizen-centered approaches. User-friendly reporting should not just simplify the multi-layers of performance measurement for improving performance itself. Rather, this chapter suggests applying different approaches to present complicated performance information to citizens. Performance reporting should be constructed in modernized, innovative, and user-focused ways to stimulate the use of performance information by external stakeholders, which can promote government accountability.

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Recent advances in user-friendly computational tools to engineer protein function

Briefings in Bioinformatics ◽

10.1093/bib/bbaa150 ◽

2020 ◽

Author(s):

Carlos Eduardo Sequeiros-Borja ◽

Bartłomiej Surpeta ◽

Jan Brezovsky

Keyword(s):

Protein Engineering ◽

Protein Design ◽

Protein Function ◽

Transport Processes ◽

Allosteric Communication ◽

Protein Nucleic Acid ◽

Nucleic Acid Interactions ◽

User Friendly ◽

Ligand Transport ◽

Further Development

Abstract Progress in technology and algorithms throughout the past decade has transformed the field of protein design and engineering. Computational approaches have become well-engrained in the processes of tailoring proteins for various biotechnological applications. Many tools and methods are developed and upgraded each year to satisfy the increasing demands and challenges of protein engineering. To help protein engineers and bioinformaticians navigate this emerging wave of dedicated software, we have critically evaluated recent additions to the toolbox regarding their application for semi-rational and rational protein engineering. These newly developed tools identify and prioritize hotspots and analyze the effects of mutations for a variety of properties, comprising ligand binding, protein–protein and protein–nucleic acid interactions, and electrostatic potential. We also discuss notable progress to target elusive protein dynamics and associated properties like ligand-transport processes and allosteric communication. Finally, we discuss several challenges these tools face and provide our perspectives on the further development of readily applicable methods to guide protein engineering efforts.

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The Use of Photographs as a Means of Obtaining Views of Occupational Therapy Held by Children with Learning Disabilities: A Pilot Study

British Journal of Occupational Therapy ◽

10.1177/030802269806100307 ◽

1998 ◽

Vol 61 (3) ◽

pp. 116-120 ◽

Cited By ~ 2

Author(s):

Debbie Joy ◽

Anita Young ◽

Val Harvais ◽

Rosemary Chesson

Keyword(s):

Learning Disabilities ◽

Occupational Therapy ◽

Goal Attainment ◽

Reliability And Validity ◽

Pilot Project ◽

Special School ◽

Behavioural Difficulties ◽

Children’S Views ◽

Further Development ◽

Emotional And Behavioural Difficulties

As an adjunct to a pilot project on the use of Goal Attainment Scaling in occupational therapy for children with learning disabilities, children's views of therapeutic intervention were explored. These were investigated by means of interviews held at the residential special school that the children attended and were carried out by a therapist who was unknown to them. During the interview, six photographs (three therapy and three non-therapy related) were presented. Each child's response was recorded by the interviewer. Despite the seven children having emotional and behavioural difficulties, all cooperated during the interviews, looking at the photographs and not displaying any challenging behaviour. When the children's responses were categorised in terms of their unique styles of communication, more positive reactions to the photographs relating to occupational therapy than to the others were noted. It is acknowledged, however, that further development work is required in order to establish the reliability and validity of the method.

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Determinants of and barriers to adoption of digital therapeutics for mental health at scale in the NHS

BMJ Innovations ◽

10.1136/bmjinnov-2019-000384 ◽

2020 ◽

Vol 6 (3) ◽

pp. 92-98

Author(s):

Matt G Williams ◽

Richard Stott ◽

Nicki Bromwich ◽

Susie K Oblak ◽

Colin A Espie ◽

...

Keyword(s):

Mental Health ◽

Digital Literacy ◽

Market Access ◽

Qualitative Content Analysis ◽

Digital Health ◽

Decision Makers ◽

Structured Interviews ◽

Barriers To Adoption ◽

Information Governance ◽

Further Development

ObjectivesAlthough it is widely acknowledged that digital therapeutics will play a significant role in the future delivery of healthcare, the method by which these innovations may be commissioned by the National Health Service, at scale, remains unclear. This study explores English health commissioners’ experiences of, and attitudes towards, adopting digital healthcare innovations.Methods37 commissioners and decision-makers from a range of sectors within the health profession were invited to participate in structured interviews to gather relevant examples of experience and opinions. 14 commissioners participated and the notes from the resulting interviews were interpreted using qualitative content analysis. Controlled interpretation was applied to the categorised responses, paraphrasing and classifying into themes.ResultsCommon determinants and barriers to adoption of digital mental health expressed during the interview process included commissioners’ lack of familiarity with technology, information governance, digital literacy of users and decision-makers.ConclusionsRecognition of identified barriers may be helpful for innovators when developing engagement and market access strategies and suggest areas for focus and further development within the commissioning process to accommodate digital health solutions.

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Organizational and economic-and-legal problems of the transition from the equity residential construction to project financing

MATEC Web of Conferences ◽

10.1051/matecconf/201926507035 ◽

2019 ◽

Vol 265 ◽

pp. 07035

Author(s):

Arkady Larionov ◽

Magomed Omarov ◽

Ilya Kostusenko

Keyword(s):

National Economy ◽

Housing Construction ◽

Residential Construction ◽

Project Financing ◽

Economic Interests ◽

Regional Market ◽

Legal Problems ◽

Economic Methods ◽

Further Development ◽

Governmental Control

The paper focuses on the features and specificity of the regional market of residential construction in the Moscow region. The authors claim and prove that the solution of complex modern problems of residential construction and the creation of conditions for its further development is directly related to the reasonable application of the existing repertoire of organizational and economic methods of governmental control over this national economy sector. The article represents the authors’ opinion on implementing the new laws on equity housing construction that have come into force and their consequences in terms of the well-balanced protection of the rights of citizens participating in equity construction and the economic interests of developers. A possible scenario of premature abandonment of equity construction and the transition to project financing is described.

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EUHFORIA in the ESA Virtual Space Weather Modelling Centre

10.5194/egusphere-egu2020-5259 ◽

2020 ◽

Author(s):

Stefaan Poedts

Keyword(s):

Space Weather ◽

Radiation Belt ◽

Flux Rope ◽

Virtual Space ◽

Prototype System ◽

System A ◽

First Results ◽

Efficient Integration ◽

User Friendly ◽

Further Development

The goal of the ESA project "Virtual Space Weather Modelling Centre - Part 3" (2019-2021) is to further develop the Virtual Space Weather Modelling Centre (VSWMC), building on the Part 2 prototype system and focusing on the interaction with the ESA SSA SWE system. A first, limited version went operational in May 2019 under the H-ESC umbrella on the ESA SSA SWE Portal. The objective and scopes of this new project include: the efficient integration of new models and new model couplings, including daily automated end-to-end (Sun to Earth) simulations, the further development and wider use of the coupling toolkit&#160; and front-end GUI, making the operational system more robust and user-friendly. The VSWMC-Part 3 project started on 1 October 2019.EUHFORIA (&#8216;European heliospheric forecasting information asset&#8217;) is integrated in the VSWMC and will be upgraded with alternative coronal models (Multi-VP and Wind-Predict) and flux-rope CME models, and new couplings will be made available, e.g. to more advanced magnetospheric models and radiation belt models, geo-effects models, and even SEP models. The first results will be discussed and put into perspective.

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