Electron Microscopy of Carcinomas of the Lung

1974 ◽  
Vol 32 ◽  
pp. 16-17
Author(s):  
B. Mackay ◽  
M. Mandavia ◽  
J. M. Lukeman ◽  
C. F. Mountain
Keyword(s):  
Electron Microscopy ◽  
Poor Prognosis ◽  
Light And Electron Microscopy ◽  
Malignant Neoplasm ◽  
Therapeutic Modalities ◽  
The Poor ◽  
Diagnosis And Classification ◽  
Methods Of Treatment ◽  
Insight Into

Carcinoma of the lung is the most common malignant neoplasm in males and the incidence continues to rise. The inadequacy of current methods of treatment is reflected in the poor prognosis: only 5% of patients survive for more than five years following diagnosis.In order to assess the effectiveness of new therapeutic modalities, accurate pathologic diagnosis is essential, and it is recognized that a proportion of these tumors can not be accurately classified by light microscopy alone. We have now studied over one hundred lung carcinomas with correlated light and electron microscopy, and our findings indicate that electron microscopy can be an invaluable aid in the diagnosis and classification of the tumors. Study of the fine structure of the tumor cells can provide the basis for a more precise classification than is currently used in clinical studies, and additionally give insight into problems of histogenesis.

Characterization of Electrophoretic Lipoprotein Fractions: Immunochemical and Electron Microscopic Studies

1972 ◽  
Vol 18 (6) ◽  
pp. 534-538
Author(s):  
Mario Werner ◽  
Albert L Jones
Keyword(s):  
Electron Microscopy ◽  
Particle Size ◽  
Electrophoretic Pattern ◽  
Electron Microscopic ◽  
Lipoprotein Subfractions ◽  
New Techniques ◽  
Microscopic Studies ◽  
Insight Into

Abstract To improve the characterization of electrophoretic lipoprotein subfractions, we developed two new techniques for analyzing lipoproteins after electrophoresis on thin agarose layers. Overlay with antisera exactly localizes specific apoproteins without any distortion caused by antigen diffusion; electron microscopy of eluted fractions determines the varying particle-size distribution. Applied together, these methods can detect individual differences between hyperlipemic samples that are not immediately apparent in the electrophoretic pattern, and should provide valuable new insight into the classification of hyperlipoproteinemias.

Electron microscopy study of 496 cases of lupus nephritis: A single-center experience

Lupus ◽  
2021 ◽  
pp. 096120332098453
Author(s):  
Bahar Bagheri ◽  
Seyed Mohammad Owji ◽  
Simin Torabinezhad ◽  
Hadi Raeisi Shahraki ◽  
Amirhossein Kamalinia ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Lupus Nephritis ◽  
Light Microscopy ◽  
Lupus Erythematosus ◽  
Interstitial Fibrosis ◽  
Renal Involvement ◽  
Correct Classification ◽  
Tubular Atrophy ◽  
Diagnosis And Classification

Introduction Renal involvement is seen in about 40-82% of systemic lupus erythematosus (SLE) Asian patients. The exact diagnosis and classification of lupus nephritis are important for treatment and prognosis. This study aimed to investigate the value of electron microscopy (EM) in the diagnosis and classification of lupus nephritis compared with light microscopy. Method In this cross-sectional referral-center 16-year study of lupus nephritis, the final diagnosis was based on the EM study. Primary light microscopy findings were compared with EM diagnosis. Moreover, Immunofluorescence patterns distribution was assessed. Results From 496 patients diagnosed with lupus nephritis based on EM, 225(45.4%) of patients were categorized in class IV, followed by 98(19.7%), 93(18.8%), 46(9.3%), and 14(2.8%) who were categorized into classes of II, III, V, and VI respectively. Only 1(0.2%) patient belonged to class I, and 19(3.8%) cases were diagnosed with mixed two classes. Using EM was essential for diagnosing 25.6% of cases taking the correct classification by light microscopy into account; however, disregarding correct classification, this could change to a 7.4% contribution rate of EM. The most common cause of misdiagnosis, disregarding incorrect classification, was inadequate or wrong tissue. Positive associations were detected between tubular atrophy and interstitial fibrosis of both electron and light microscopy with different classes (P < 0.001). Conclusion While light microscopy is highly accurate for diagnosing lupus nephritis regardless of correct classification, EM contributes substantially to the correct classification of lupus nephritis types.

PROGNOSIS OF THE OUTCOME OF PREGNANCIES IN DIABETICS

1965 ◽  
Vol 50 (1) ◽  
pp. 70-78 ◽  
Author(s):  
Jørgen Pedersen ◽  
Lars Mølsted Pedersen
Keyword(s):  
Perinatal Mortality ◽  
Poor Prognosis ◽  
Point Of View ◽  
Premature Delivery ◽  
Consecutive Series ◽  
Length Of Treatment ◽  
The Poor ◽  
Pregnancy In Diabetics ◽  
Weight Groups

ABSTRACT In order to improve the possibilities of predicting the outcome of pregnancy in diabetics, we analysed a consecutive series of 304 pregnancies in 263 diabetic women in the Royal Maternity Department B, Rigshospitalet, Copenhagen, during the 5-year period 1959-1963. The period of supervision and treatment during pregnancy varied greatly. The perinatal mortality in the 306 infants was 17.9%. According to the results of this analysis, patients with a poor prognosis were divided into the following four groups: Pregnant women who developed (1) hyperpyretic pyelitis, (2) pre-coma or severe acidosis, (3) toxaemia, or patients who could be so described, (4) »neglectors« These four groups, and the classification, are designated PBSP (Prognostically Bad Signs during Pregnancy). The mothers of 130 infants belonged to one or more of the four groups of PBSP, and among the infants of these mothers the perinatal mortality was 31.5% as compared with 7.9% in the group of 176 infants without PBSP during pregnancy. The poor prognosis for the pregnancies with PBSP applies to all foetal weight groups. In addition, these pregnancies terminate in premature delivery twice as often as the others. It is demonstrated that from the prognostic point of view, nothing is gained by including hydramnios in PBSP. The risk involved by a PBSP complication to the foetus depends on the White (1949) class in which it occurs. A combination of White's classification of pregnant diabetics with regard to foetal prognosis used together with the present classification improves the possibility of predicting the foetal prognosis in a series of pregnant diabetics which is mixed as regards the length of treatment during pregnancy.

scholarly journals Multi-Omics Analysis in Initiation and Progression of Meningiomas: From Pathogenesis to Diagnosis

2020 ◽  
Vol 10 ◽  
Author(s):  
Jiachen Liu ◽  
Congcong Xia ◽  
Gaiqing Wang
Keyword(s):  
Early Diagnosis ◽  
Poor Prognosis ◽  
Scientific Basis ◽  
High Grade ◽  
Intracranial Tumors ◽  
Pathological Mechanism ◽  
Growing Body ◽  
Diagnosis And Classification ◽  
Subsequent Intervention

Meningiomas are common intracranial tumors that can be cured by surgical resection in most cases. However, the most disconcerting is high-grade meningiomas, which frequently recur despite initial successful treatment, eventually conferring poor prognosis. Therefore, the early diagnosis and classification of meningioma is necessary for the subsequent intervention and an improved prognosis. A growing body of evidence demonstrates the potential of multi-omics study (including genomics, transcriptomics, epigenomics, proteomics) for meningioma diagnosis and mechanistic links to potential pathological mechanism. This thesis addresses a neglected aspect of recent advances in the field of meningiomas at multiple omics levels, highlighting that the integration of multi-omics can reveal the mechanism of meningiomas, which provides a timely and necessary scientific basis for the treatment of meningiomas.

scholarly journals Oral Malignant Melanoma: A Case Report

2021 ◽  
Vol 122 (3) ◽  
pp. 222-227
Author(s):  
Suman Sen ◽  
Sheuli Sen ◽  
M. Geetha Kumari ◽  
Sufia Khan ◽  
Subhasini Singh
Keyword(s):  
Malignant Melanoma ◽  
Poor Prognosis ◽  
Hard Palate ◽  
Middle Age ◽  
Early Recognition ◽  
Malignant Neoplasm ◽  
Pigmented Lesions ◽  
The Poor ◽  
Pigmented Lesion ◽  
Oral Malignant Melanoma

Melanoma is a malignant neoplasm of the epidermal melanocytes. Awareness and early recognition of pigmented lesion inside oral cavity helps in initial diagnosis and further investigation and treatment. Oral malignant melanoma is a rare aggressive neoplasm commonly seen among middle age. The diagnosis of melanoma initiates from the pre-existing pigmented lesions. The poor prognosis of oral melanomas requires that pigmented lesions of undetermined origin be routinely biopsied. A case of malignant melanoma of hard palate with its clinical, radiological and histopathological presentation along with brief review is presented. Prognosis of these lesion is poor with survival rate of 5 years.

A Follow-up Study of Female Narcotic Addicts: Variables Related to Outcome

1974 ◽  
Vol 125 (584) ◽  
pp. 28-33 ◽  
Author(s):  
P. T. d'Orbán
Keyword(s):  
Poor Prognosis ◽  
Psychological Characteristics ◽  
Prognostic Indicators ◽  
Follow Up Study ◽  
The Poor ◽  
Follow Up Studies ◽  
The Individual ◽  
The Relationship ◽  
Methods Of Treatment

The poor prognosis of narcotic dependence is generally recognized, but this is a field in which it is specially difficult to make predictions about the outcome of treatment in the individual patient. Vaillant (1966a) noted that abstinence appears to depend more on the addict's ability to discover satisfying alternatives to his addiction than on methods of treatment. In an attempt to identify prognostic indicators in narcotic dependence a number of follow-up studies have examined the relationship between outcome and various social and psychological characteristics of the patients studied. While most follow-up studies are of male addicts or of samples containing only a small proportion of women, the present study is concerned with the outcome in a sample of 66 female narcotic addicts.

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