The Fine Structure of Primordial Germ Cells of the Rat
Primordial germ cells are readily recognizable in embryos of the rat due to their large size, generally rounded shape and prominent nuclei with uniformly dispersed heterochromatin. They often have blunted pseudopodal processes at one end and small ruffles or trailing processes at the other, characteristics expected from their known ameboid activity- and migratory abilities. Also, the cytoplasm is rich in polyribosomes and contains a modest amount of rough endoplasmic reticulum and the mitochondria are frequently larger and less dense than those of adjacent somatic cells.In addition to these general characteristics, there are features unique to germ cells which allow them to be identified with certainty. These are: 1) small vesicles containing an irregular, dense core and 2) discrete accumulations of fibrous material known as nuage. Both of these features are present in other species and at other times in the life history of germ cells. The dense-cored vesicles have been noted in fetal and early postnatal mouse oogonia and oocytes, and in hamster and rabbit oocytes.