Fatal outbreaks of jaundice in pregnancy and the epidemic history of hepatitis E

2012 ◽  
Vol 140 (5) ◽  
pp. 767-787 ◽  
Author(s):  
C.-G. TEO

SUMMARYSpace–time clustering of people who fall acutely ill with jaundice, then slip into coma and death, is an alarming phenomenon, more markedly so when the victims are mostly or exclusively pregnant. Documentation of the peculiar, fatal predisposition of pregnant women during outbreaks of jaundice identifies hepatitis E and enables construction of its epidemic history. Between the last decade of the 18th century and the early decades of the 20th century, hepatitis E-like outbreaks were reported mainly from Western Europe and several of its colonies. During the latter half of the 20th century, reports of these epidemics, including those that became serologically confirmed as hepatitis E, emanated from, first, the eastern and southern Mediterranean littoral and, thereafter, Southern and Central Asia, Eastern Europe, and the rest of Africa. The dispersal has been accompanied by a trend towards more frequent and larger-scale occurrences. Epidemic and endemic hepatitis E still beset people inhabiting Asia and Africa, especially pregnant women and their fetuses and infants. Their relief necessitates not only accelerated access to potable water and sanitation but also vaccination against hepatitis E.

Linguistics ◽  
2019 ◽  
Author(s):  
Alexander Beider

According to its main system-level characteristics, Yiddish belongs to the High German branch of West Germanic languages. During its development, it underwent an important influence of Hebrew. In modern times, we can distinguish three main varieties of Yiddish: (1) Western Yiddish in western German-speaking territories; (2) Yiddish spoken until the 20th century in Central Europe (Czech and East German lands), and (3) Eastern Yiddish in eastern Europe. From the point of view of Germanistics, it is appropriate to consider that the inception of Yiddish varieties corresponds to the Early New High German period (1350–1650). It was during that period that the Jewish vernacular idiom started to have system-level differences in comparison to the dialects spoken by German Christians, namely, in phonology and grammar. Before that period, differences surely existed in such domains, surface level for any language, as orthography and lexicon. The German dialects from southern Germany represent the linguistic basis for Western Yiddish. The medieval Bohemian dialect of German represents the linguistic basis for Yiddish spoken in Central Europe and eastern Europe. Due to permanent contacts with the Slavic Christian population, Eastern Yiddish underwent numerous changes in all of its systems due to the strong influence of Polish, Ukrainian, and Belarusian. It eventually branched into three subdialects: Lithuanian Yiddish, Polish Yiddish, and Ukrainian Yiddish. In modern times, in numerous countries the decline of the use of Yiddish as a living language was related to the assimilation of local Jews to the culture of the Gentile majority. At the end of the 18th century and during the 19th century it was the case in various German-speaking provinces of Central Europe and western Europe where local Jews abandoned Yiddish in favor to German. Similar shifts to the dominant non-Jewish languages took place during the 20th century in various western European countries. In the USSR, during the 1920s and the 1930s the shift to Russian was already well advanced. For those who survived the Holocaust, the assimilation accelerated during the following decades. In Poland, Lithuania, Hungary, and Romania, Yiddish-speaking communities were decimated by the Holocaust. In North America, most immigrant families shifted to English within a generation or two. Yet, because of a permanent influx of masses of native speakers between the 1880s and the 1920s, Yiddish was actively used until the mid-20th century even in certain secular Jewish groups. However, during the second half of the 20th century its decline was accelerated outside of certain Haredi groups.


Author(s):  
Vera V. Serdechnaia ◽  

The article is devoted to the analysis of the concept of literary romanticism. The research aims at a refinement of the “romanticism” concept in relation to the history of the literary process. The main research methods include conceptual analysis, textual analysis, comparative historical research. The author analyzes the semantic genesis of the term “romanticism”, various interpretations of the concept, compares the definitions of different periods and cultures. The main results of the study are as follows. The history of the term “romanticism” shows a change in a number of definitions for the same concept in relation to the same literary phenomena. By the end of the 20th century, realizing the existence of significant contradictions in the content of the term “romanticism”, researchers often come to abandon it. At the same time, the steady use of the term “romanticism” testifies to the subject-conceptual component that exists in it, which does not lose its relevance, but just needs a theoretical refinement. Conclusion: one have to revise an approach to romanticism as a theoretical concept, based on the change in the concept of an individual in Europe at the end of the 18th century. It is the newly discovered freedom of an individual predetermines the rethinking for the image of the author as a creator and determines the artistic features of literary romanticism.


Diacronia ◽  
2018 ◽  
Author(s):  
Gheorghe Chivu

The history of the verbal forms sum and sunt, introduced into the literary writing by the Transylvanian Latinist School, reveals a winding process in the elaboration of certain cultured norms proper to the modern literary Romanian. Not at all linear, this process was concurrently influenced by two, often divergent, tendencies that were active from the end of the 18th century up to the beginning of the 20th century: the use of some cultured forms, borrowed from Latin or created according to Latin patterns; and the revitalization of certain linguistic forms with regional diffusion. Initially proposed as literary pronunciations, the two verbal forms were soon adopted and used as etymological graphic forms that corresponded to sîm and suntu from certain conservative patois. During the second half of the 19th century (sum), and during the first decades of the 20th century (sunt), the two graphic forms became orthoepic norms as well, due to the phonological tradition of the Romanian writing.


2020 ◽  
Vol 11 (2) ◽  
pp. 86
Author(s):  
Evi Diliana Rospia ◽  
Andari Wuri Astuti ◽  
Retno Mawarti

Preeclampsia and eclampsia are the second direct cause of maternal death worldwide, estimated to complicate 2-8% of all pregnancies, the global prevalence of preeclampsia is around 4.6%. The purpose of this scoping review is to provide an overview of studies related to antenatal support, access and services to mothers with a history of preeclampsia in pregnancy. The authors identify studies that explain preeclampsia in pregnancy from several databases namely PubMed, ProQuest, EBSCO and Springer Link. Searches are limited to studies published in English and present data for the 2009-2019 period. The identified study was reviewed using PRISMA Flowchart. Studies with qualitative and quantitative designs that explore the experiences of pregnant women regarding antenatal support, access and services were selected for review, while studies that were not experience related to antenatal support, access and services to mothers with a history of preeclampsia in pregnancy were excluded. A total of twelve articles were reviewed which obtained three sub-themes of support, namely the support of husband, family and health workers, from the theme of access obtained three sub-themes namely information search, modification programs and the availability of health workers. From the theme of antenatal care, four sub-themes are found, namely unsustainable care, lack of information, screening and feeling empowered. Pregnant women with preeclampsia need support from a partner or family and health workers. Information and screening need to be improved in antenatal care.


Geografie ◽  
2016 ◽  
Vol 121 (1) ◽  
pp. 187-207
Author(s):  
Zdeněk R. Nešpor

The article introduces the field of necrogeography to Czech social geography and provides information on existing (nationwide) data sources. The author takes the issue of Protestant confessional cemeteries as an example, briefly outlines the history of these special types of burial fields (established principally from the end of the 18th century until approximately the mid-20th century), and provides a historical geographical analysis of their regional distribution in the Czech Lands. The article proves the impact of religious and geographical factors on the emergence (and eventual demise) of non-Catholic Christian confessional cemeteries and, at the same time, the research unveiled a number of important research questions to be addressed by Czech necrogeography in the future.


2021 ◽  
Vol 27 ◽  
Author(s):  
Anastasios Liberis ◽  
Stamatis Petousis ◽  
Panagiotis Tsikouras

: Dyslipidemia represents a major risk factor for cardiovascular disease. In addition, severe hypertriglyceridemia is an important cause of acute pancreatitis. Accordingly, the increase in serum lipid levels that are observed during pregnancy have potentially important implications. The management of dyslipidemia in pregnancy is further complicated by the lack of safety data during this period for most of the lipid-lowering agents. In the present review, we discuss the most important lipid disorders in pregnant women and their management. Pregnancy is characterized by increases in both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, which might result in severe complications both for the mother and the fetus. Accordingly, LDL-C and triglyceride levels should be monitored during pregnancy, particularly in women with a history of dyslipidemia. Diet is the mainstay of management of dyslipidemia in pregnant women and apheresis can also be considered in patients with homozygous familial hypercholesterolemia or severe hypertriglyceridemia. However, there is a pressing need for studies that with evaluate the safety of lipid-lowering agents during pregnancy.


Author(s):  
Antony Polonsky

This chapter highlights how the collapse of communism in eastern Europe and the Soviet Union initiated a new period in the history of the Jews in the area. Poland was now a fully sovereign country, and Ukraine, Belarus, Lithuania, and Moldova also became independent states. Post-imperial Russia faced the task of creating a new form of national identity. This was to prove more difficult than in other post-imperial states since, unlike Britain and France, the tsarist empire and its successor, the Soviet Union, had not so much been the ruler of a colonial empire as an empire itself. All of these countries now embarked, with differing degrees of enthusiasm, on the difficult task of creating liberal democratic states with market economies. For the Jews of the area, the new political situation allowed both the creation and development of Jewish institutions and the fostering of Jewish cultural life in much freer conditions, but also facilitated emigration to Israel, North America, and western Europe on a much larger scale.


Author(s):  
Ranjana Mishra ◽  
Arun H. Nayak ◽  
Madhuri Mehendale

Background: Hepatitis E in pregnancy has been a subject of interest in the recent years as the available research work is very limited and conflicting especially in pregnant women as compared to infection in men and non- pregnant women in which the disease is usually self- limiting. The mechanism of liver injury in hepatitis E is not clear and no conclusive theories about the exact pathogenesis are available. This study was done to gain insight into the effects of hepatitis E virus on pregnancy in terms of maternal and fetal outcome.Methods: Total of 40 pregnant women with Hepatitis E Virus IgM antibodies was included in the study. Hepatitis cases due to other viral and non-infective causes were excluded. Maternal outcomes in terms of mode of delivery, complications like PPH, hepatic encephalopathy, fulminant hepatic failure, coagulopathy and maternal mortality was studied. Fetal outcomes in terms of intrauterine fetal deaths, stillbirth, live births, and neonatal deaths were studied.Results: This study showed high mortality rates (42.5%) in pregnant women with hepatitis E. The most common obstetric complication was IUFD (45%) followed by preterm labor (32.5%) and postpartum hemorrhage (22.5%). Hepatic encephalopathy (62.5%) was the commonest medical complication followed by coagulopathy (25%). A statistically significant association was found between the presence of medical complications and poor maternal outcome.Conclusions: Hepatitis E virus infection in pregnancy often has a fulminant course with poor maternal and fetal outcome. Its management therefore requires an early diagnosis, and a multidisciplinary approach.


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