scholarly journals Seroprevalence and risk factors of Toxoplasma gondii infection in oral cancer patients in China: a case–control prospective study

2018 ◽  
Vol 146 (15) ◽  
pp. 1891-1895 ◽  
Author(s):  
N. Zhou ◽  
X. Y. Zhang ◽  
Y. X. Li ◽  
L. Wang ◽  
L. L. Wang ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Oral Cancer ◽  
Cancer Patients ◽  
Eastern China ◽  
Case Control ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Subjects ◽  
Logistic Analysis ◽  
Oral Cancer Patients ◽  
Toxoplasma Gondii Infection

AbstractOver the recent years, potential associations between Toxoplasma gondii (T. gondii) infection and cancer risk have attracted a lot of attention. Nevertheless, the association between T. gondii infection and oral cancer remains relatively unexplored. We performed a case–control study of 861 oral cancer patients and 861 control subjects from eastern China with the aim to detect antibodies to T. gondii by enzyme-linked immunosorbent assay (ELISA) in these patients. The results showed that oral cancer patients (21.72%, 187/861) had a significantly higher seroprevalence than control subjects (8.25%, 71/861) (P < 0.001). Among them, 144 (16.72%) oral cancer patients and 71 (8.25%) control subjects were positive for IgG antibodies to T. gondii, while 54 (6.27%) oral cancer patients and 9 (1.05%) controls were positive for IgM antibodies to T. gondii. In addition, multiple logistic analysis showed that T. gondii infection in oral cancer patients was associated with blood transfusion history, keeping cats at home, and oyster consumption. To our knowledge, this is the first study that provided a serological evidence of an association between T. gondii infection and oral cancer patients. However, further studies are necessary to elucidate the role of T. gondii in oral cancer patients.

scholarly journals Toxoplasma gondii Infection in Dustmen in Northeastern China: A Case-Control Seroprevalence Study

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Ruo-Lan Jiang ◽  
Quan Zhao ◽  
Jing Jiang ◽  
Xue-Long Chen ◽  
Xiao-Xuan Zhang ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
First Record ◽  
Case Control ◽  
Northeastern China ◽  
Enzyme Linked Immunosorbent Assay ◽  
Serum Samples ◽  
Igm Antibodies ◽  
Control Subjects ◽  
The Government ◽  
At Home

Background. Toxoplasmosis is caused by an intracellular parasite Toxoplasma gondii, which can infect many hosts including humans. Methods. In order to estimate whether dustmen are more susceptible to T. gondii, a case-control study was conducted containing 332 dustmen from Jilin and Heilongjiang in Northeastern China, as well as 332 general populations from the same regions as control subjects. Serum samples were tested IgG and IgM antibodies to T. gondii using the enzyme-linked immunosorbent assay (ELISA). Results. The overall anti-T. gondii IgG was 15.06% (50/332) in dustmen compared with 9.64% (32/332) in the controls (P = 0.0337). Also, 5 (1.51%) dustmen had anti-T. gondii IgM antibodies compared with 2 (0.60%) control individuals (P = 0.2543). A significant association was only found between dustmen and level of T. gondii IgG in comparison with the control subjects. Seroprevalence of T. gondii IgG antibodies in male dustmen was significant higher than male control subjects (P = 0.0399). Dustmen from Jilin had the significant higher T. gondii IgG rate (P = 0.0143), in comparison with the control subjects from Jilin. Moreover, dustmen raising cat at home had the significant higher T. gondii IgG rate (P = 0.0097), in comparison with the control subjects. Risk factor analysis suggested that raising cat at home and not having habits of washing hand before eating were mainly related to the T. gondii infection in dustmen. Conclusions. This is the first record of seroprevalence of T. gondii infection in dustmen in Jilin and Heilongjiang provinces in Northeastern China. These findings also suggest that the government departments should pay close attention to the toxoplasmosis in dustmen in Northeastern China.

scholarly journals Evaluation of serum immunoglobulin (IgG, IgM, IgA) in oral cancer patients – A case control study

2021 ◽  
Vol 33 (2) ◽  
pp. 189
Author(s):  
VivekM Tarsariya ◽  
Nilesh Raval ◽  
DhavalN Mehta ◽  
MukeshK Asrani ◽  
VijayK Asrani ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Patients ◽  
Case Control Study ◽  
Case Control ◽  
Serum Immunoglobulin ◽  
Oral Cancer Patients ◽  
Control Study

scholarly journals Seroepidemiology of Toxoplasma gondii infection in patients with liver disease in eastern China

2017 ◽  
Vol 145 (11) ◽  
pp. 2296-2302 ◽  
Author(s):  
A. L. TIAN ◽  
G. X. LI ◽  
H. M. ELSHEIKHA ◽  
D. S. GARDNER ◽  
X. Y. ZHANG ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Disease ◽  
Toxoplasma Gondii ◽  
Eastern China ◽  
Multivariate Logistic Regression Analysis ◽  
Protozoan Parasite ◽  
Enzyme Linked Immunosorbent Assay ◽  
Serum Samples ◽  
Igm Antibodies ◽  
Toxoplasma Gondii Infection

SUMMARYThe role of the protozoan parasite Toxoplasma gondii in the pathogenesis of liver disease has recently gained much interest. The aim of this study was to determine the prevalence and risk factors associated with T. gondii infection in patients with liver disease from three cities in Shandong and Henan provinces, China. A case–control study was conducted from December 2014 to November 2015 and included 1142 patients with liver disease and 1142 healthy controls. Serum samples were collected from all individuals and were examined with enzyme-linked immunosorbent assay for the presence of anti-T. gondii IgG and IgM antibodies. Information on the demographics, clinical, and lifestyle characteristics of the participants was collected from the medical records and by the use of a questionnaire. The prevalence of anti-T. gondii IgG was 19·7% in patients with liver disease compared with 12·17% in the controls. Only 13 patients had anti-T. gondii IgM antibodies compared with 12 control individuals (1·14% vs. 1·05%, respectively). The highest seroprevalence was detected in patients with liver cancer (22·13%), followed by hepatitis patients (20·86%), liver cirrhosis patients (20·42%), and steatosis patients (20%). Multivariate logistic regression analysis indicated that consumption of raw meat (odds ratio (OR) = 1·32; 95% confidence interval (CI) 1·01–1·71; P = 0·03) and source of drinking water from wells (OR = 1·56; 95% CI 1·08–2·27; P = 0·01) were independent risk factors for T. gondii infection in liver disease patients. These findings indicate that T. gondii infection is more likely to be present in patients with liver disease. Therefore, efforts should be directed toward health education of populations at high risk of T. gondii infection and measures should be taken to protect vulnerable patients with liver disease.

scholarly journals Association Between Rare Earth Element Cerium and the Risk of Oral Cancer: A Case-Control Study in Southeast China

2021 ◽  
Vol 9 ◽  
Author(s):  
Baochang He ◽  
Jing Wang ◽  
Jing Lin ◽  
Jinfa Chen ◽  
Zhaocheng Zhuang ◽  
...  
Keyword(s):  
Rare Earth ◽  
Oral Cancer ◽  
Cancer Patients ◽  
Case Control Study ◽  
Case Control ◽  
Leafy Vegetables ◽  
Inverse Association ◽  
Oral Cancer Patients ◽  
High Level ◽  
Control Study

Cerium (Ce), the most abundant of rare earth elements in the earth's crust, has received much health concerns due to its wide application in industry, agriculture, and medicine. The current study aims to evaluate whether there is an association between Ce exposures and the risk of developing oral cancer. Serum Ce level of 324 oral cancer patients and 650 matched healthy controls were measured by inductively coupled plasma mass spectrometry. Association between Ce level and the risk of oral cancer was estimated with an unconditional logistic regression model. Serum Ce concentrations in the oral cancer patients and controls were 0.57 (0.21–3.02) μg/L and 2.27 (0.72–4.26) μg/L, respectively. High level of Ce was associated with a decreased risk of oral cancer (OR: 0.60, 95% CI: 0.43–0.84). Stronger inverse associations between high level of Ce and oral cancer risk were observed among those with smoking (OR: 0.46, 95% CI: 0.27–0.79), drinking (OR: 0.50, 95% CI: 0.26–0.96), limited intake of leafy vegetables (OR: 0.40, 95% CI: 0.22–0.71) and fish (OR: 0.52, 95% CI: 0.33–0.83). There were significant multiplicative interactions between Ce level and alcohol drinking or intake of leafy vegetables and fish (all Pinteraction &lt;0.05). This preliminary case-control study suggests an inverse association between high serum Ce level and the risk of oral cancer. Further prospective studies with a larger sample size are needed to confirm the findings.

scholarly journals Tobacco Use Among Oral Cancer Patients in Two Selected Hospitals of Dhaka City - A Case Control Study

2014 ◽  
Vol 4 (1) ◽  
pp. 4-7
Author(s):  
SA Urmi ◽  
I Zerin ◽  
MSA Farzan ◽  
MA Kabir
Keyword(s):  
Oral Cancer ◽  
Cancer Patients ◽  
Tobacco Use ◽  
Case Control Study ◽  
Case Control ◽  
Dhaka City ◽  
Dental Research ◽  
Oral Cancer Patients ◽  
Control Study

DOI: http://dx.doi.org/10.3329/bjdre.v4i1.18008 Bangladesh Journal of Dental Research & Education Vol.4(1) 2014: 4-7

scholarly journals Toxoplasma gondii Infection in Diabetes Mellitus Patients in China: Seroprevalence, Risk Factors, and Case-Control Studies

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Yong-Xin Li ◽  
Hai Xin ◽  
Xiang-Yan Zhang ◽  
Cui-Ying Wei ◽  
Yu-He Duan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Toxoplasma Gondii ◽  
Case Control ◽  
Future Research ◽  
Case Control Studies ◽  
Serum Samples ◽  
Control Subjects ◽  
Toxoplasma Gondii Infection ◽  
And Control

The association between Toxoplasma gondii (T. gondii) infection and diabetes mellitus remains controversial. With the improvement of living standards, the prevalence rate of diabetes is steadily increasing in China. Thus, it is necessary to explore the possible association between toxoplasmosis and diabetes mellitus in China. Hence, case-control studies were conducted to explore the T. gondii seroprevalence and identify the risk factors and possible transmission routes of T. gondii infection in different types of diabetes, including type 1 diabetes (T1DM), type 2 diabetes (T2DM), and gestational diabetes (GDM) patients in China. Four hundred serum samples for each type of diabetes mellitus, matched with 400 control subjects for each group, were collected and examined for anti-T. gondii IgG and IgM antibodies using commercially available enzyme immunoassay kits. The total T. gondii seroprevalence in T1DM, T2DM, and GDM patients was 16.50%, 23.50%, and 21.25%, respectively. Each type of diabetes mellitus patients had a significantly higher T. gondii seroprevalence than the control subjects. Multivariate regression identified three variables as risk factors for T. gondii infection in diabetes patients, including keeping cats at home and consumption of raw oysters for T1DM patients and consumption of raw/undercooked meat and raw oysters for T2DM patients, which may help to guide future research and control policies in diabetes mellitus patients.

The impact of comorbidities on survival in oral cancer patients: a population-based, case-control study

2020 ◽  
pp. 1-7
Author(s):  
Mustafa Ghanizada ◽  
Kathrine Kronberg Jakobsen ◽  
Jakob Schmidt Jensen ◽  
Irene Wessel ◽  
Jesper Filtenborg Tvedskov ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Patients ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Oral Cancer Patients ◽  
The Impact ◽  
Control Study

scholarly journals Testican 1 (SPOCK1) and protein tyrosine phosphatase, receptor type S (PTPRS) show significant increase in saliva of tobacco users with oral cancer

2018 ◽  
Vol 3 ◽  
pp. 2057178X1880053
Author(s):  
Vishalakshi Nanjappa ◽  
Remya Raja ◽  
Aneesha Radhakrishnan ◽  
Ankit P Jain ◽  
Keshava K Datta ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Patients ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Conditioned Media ◽  
Receptor Type ◽  
Enzyme Linked Immunosorbent Assay ◽  
Potential Candidate ◽  
Protein Tyrosine ◽  
Oral Cancer Patients

Objectives: To identify potential candidate proteins which are secretory in nature and present at a higher abundance in oral cancer patients with tobacco habits. Methods: Conditioned media of tobacco-treated and -untreated non-neoplastic oral keratinocytes were analyzed using iTRAQ-based mass spectrometry. Hypersecreted proteins; SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 (SPOCK1); prosaposin (PSAP); and protein tyrosine phosphatase, receptor type S (PTPRS) were validated by enzyme-linked immunosorbent assay (ELISA) using saliva samples from oral cancer patients who are tobacco users. Results: Proteomic analysis of tobacco-treated and -untreated cells led to the identification of 2873 proteins. Among these, 378 proteins showed high abundance and 253 proteins showed low abundance (2-fold cutoff) in conditioned-media of tobacco-treated cells. ELISA-based validation showed significantly higher levels of SPOCK1, PSAP, and PTPRS in oral cancer patients with tobacco chewing habits compared to healthy controls. However, PSAP showed low specificity compared to SPOCK1 and PTPRS. Conclusions: This study indicates significantly increased levels of SPOCK1, PSAP, and PTPRS in saliva of oral cancer patients with tobacco habits. These protein biomarkers might be useful to identify tobacco users with high risk of developing oral cancers.

scholarly journals Seroprevalence and risk factors of Toxoplasma gondii infection in children with leukemia in Shandong Province, Eastern China: a case—control prospective study

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e6604 ◽  
Author(s):  
Na Zhou ◽  
Haiyang Fu ◽  
Zhongjun Wang ◽  
Hailei Shi ◽  
Yang Yu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Toxoplasma Gondii ◽  
Blood Transfusion ◽  
Eastern China ◽  
Case Control ◽  
Lymphocytic Leukemia ◽  
Healthy Children ◽  
Igm Antibodies ◽  
Control Subjects ◽  
History Of

Limited information is available concerning the epidemiology of Toxoplasma gondii infection in children with leukemia in Eastern China. Therefore, a case-control study was conducted to estimate the seroprevalence of toxoplasmosis in this patient group and to identify risk factors and possible routes of infection. Serum samples were collected from 339 children with leukemia and 339 age matched health control subjects in Qingdao from September 2014 to March 2018. Enzyme linked immunoassays were used to screen anti- T. gondii IgG and anti- T. gondii IgM antibodies. Forty-eight (14.2%) children with leukemia and 31 (9.1%) control subjects were positive for anti-T. gondii IgG antibodies (P < 0.05), while 13 (3.8%) patients and 14 (4.1%) controls were positive for anti-T. gondii IgM antibodies (P = 0.84). Multivariate analysis showed exposure to soil and a history of blood transfusion were risk factors for T. gondii infection. Compared with IgG, patients with a history of blood transfusion were more likely to present anti- T. gondii IgM (P = 0.003). Moreover, patients with chronic lymphocytic leukemia and acute lymphocytic leukemia had higher T. gondii seroprevalence in comparison to control subjects (P = 0.002 and P = 0.016, respectively). The results indicated that the seroprevalence of T. gondii infection in children with leukemia is higher than that of healthy children in Eastern China. This information may be used to guide future research and clinical management, and further studies are necessary to elucidate the role of T. gondii in children with leukemia.

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