Increased risk of Toxoplasma gondii infection in cancer patients: A meta-analysis of current evidence based on case-control study

Background: The prevalence of Cervical Cancer (CC) is disproportionately higher in developing countries. It is the second most frequent cancer type among Bangladeshi women and the primary cause of morbidity and mortality. However, no previous data reported the association of miR-218-2 gene polymorphisms in Bangladeshi cervical cancer patients. Aim: This case-control study was designed to find the link between the rs11134527 polymorphism in miR-218-2 and CC. Methods: A total of 488 subjects were recruited, comprising 256 cervical cancer patients and 232 healthy females. Genotyping was conducted with the tetra-primer ARMS-PCR technique to detect the association. Results: The results of genotype data showed that rs11134527 obeyed the Hardy-Weinberg equilibrium in both CC cases and controls (P >0.05). Overall, the polymorphism was found to be significantly associated with an increased risk of cervical cancer with AG genotype (AG vs. GG: OR = 2.26, 95% Cl = 1.40-3.66, P = 0.0008), AA genotype (AA vs. GG: OR = 3.64, 95% Cl = 2.17-6.10, P <0.0001), dominant model (AG+AA vs. GG: OR = 2.75, 95% Cl = 1.75-4.31, P <0.0001), recessive model (AA vs. GG+AG: OR = 2.08, 95% Cl = 1.41-3.08, P = 0.0002), and A allele (A vs. G: OR = 1.94, 95% Cl = 1.51-2.51, P <0.0001). All of these correlations remained statistically significant after performing Bonferroni correction (P <0.008). Conclusion: Our study suggests that the rs11134527 polymorphism in the miR-218-2 gene contributes to the susceptibility of CC in Bangladeshi women.

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The association of POLR2E rs3787016 polymorphism and cancer risk: a Chinese case–control study and meta-analysis

Bioscience Reports ◽

10.1042/bsr20180853 ◽

2018 ◽

Vol 38 (6) ◽

Cited By ~ 4

Author(s):

Bifeng Chen ◽

Shang Wang ◽

Guangxin Ma ◽

Jin Han ◽

Jingli Zhang ◽

...

Keyword(s):

Prostate Cancer ◽

Lung Cancer ◽

Liver Cancer ◽

Cancer Risk ◽

Cancer Patients ◽

Case Control Study ◽

Meta Analysis ◽

Case Control ◽

A Genome ◽

Control Study

How single nucleotide polymorphisms in long non-coding RNAs are involved in cancer susceptibility remains poorly understood. We hypothesized that polymerase II polypeptide E (POLR2E) rs3787016 polymorphism, identified in a genome-wide association study of prostate cancer, might be a common genetic risk factor for cancer risk. To address this issue, we here conducted a case–control study to investigate the association of POLR2E rs3787016 polymorphism with risk of liver and lung cancer (including 800 normal controls, 480 liver cancer patients, and 550 lung cancer patients), followed by a meta-analysis. The genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism and confirmed by sequencing. Although no significant association was found for rs3787016 with risk of liver or lung cancer, the further stratified analysis identified that rs3787016 contributed to liver cancer risk particularly for over than 60 years individuals who drink. Moreover, the meta-analysis demonstrated that rs3787016 was associated with overall cancer risk and prostate cancer risk. Collectively, the POLR2E rs3787016 polymorphism may be a valuable biomarker for cancer predisposition.

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Risk Factors for Toxoplasma gondii Infection in Pregnancy: Results of a Prospective Case-Control Study in Norway

American Journal of Epidemiology ◽

10.1093/oxfordjournals.aje.a008942 ◽

1996 ◽

Vol 144 (4) ◽

pp. 405-412 ◽

Cited By ~ 193

Author(s):

G. Kapperud ◽

P. A. Jenum ◽

B. Stray-Pedersen ◽

K. K. Melby ◽

A. Eskild ◽

...

Keyword(s):

Risk Factors ◽

Toxoplasma Gondii ◽

Case Control Study ◽

Case Control ◽

Toxoplasma Gondii Infection ◽

Control Study ◽

Prospective Case Control Study ◽

In Pregnancy

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Seroprevalence of Toxoplasma gondii infection in children with central nervous system disorders in Mansoura, Egypt: a case–control study

Transactions of the Royal Society of Tropical Medicine and Hygiene ◽

10.1093/trstmh/try100 ◽

2018 ◽

Author(s):

Samar N El-Beshbishi ◽

Nora L El-Tantawy ◽

Sara M Elzeky ◽

Khalid F Abdalaziz ◽

Raefa A Atia

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Toxoplasma Gondii ◽

Case Control Study ◽

Case Control ◽

Central Nervous System Disorders ◽

Toxoplasma Gondii Infection ◽

Control Study

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Toxoplasma gondii infection and liver disease: a case-control study in a Northern Mexican population

Parasites & Vectors ◽

10.1186/1756-3305-4-75 ◽

2011 ◽

Vol 4 (1) ◽

Cited By ~ 34

Author(s):

Cosme Alvarado-Esquivel ◽

José Luis Torres-Berumen ◽

Sergio Estrada-Martínez ◽

Oliver Liesenfeld ◽

Miguel Francisco Mercado-Suarez

Keyword(s):

Liver Disease ◽

Toxoplasma Gondii ◽

Case Control Study ◽

Case Control ◽

Mexican Population ◽

Toxoplasma Gondii Infection ◽

Control Study

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Association of the type 2 deiodinase Thr92Ala polymorphism with type 2 diabetes: case–control study and meta-analysis

Acta Endocrinologica ◽

10.1530/eje-10-0419 ◽

2010 ◽

Vol 163 (3) ◽

pp. 427-434 ◽

Cited By ~ 73

Author(s):

José Miguel Dora ◽

Walter Escouto Machado ◽

Jakeline Rheinheimer ◽

Daisy Crispim ◽

Ana Luiza Maia

Keyword(s):

Type 2 Diabetes ◽

Case Control Study ◽

Association Studies ◽

Meta Analysis ◽

Genetic Association Studies ◽

Case Control ◽

Increased Risk ◽

Key Enzyme ◽

Control Study

ObjectiveThe type 2 deiodinase (D2) is a key enzyme for intracellular triiodothyronine (T3) generation. A single-nucleotide polymorphism in D2 (Thr92Ala) has been associated with increased insulin resistance in nondiabetic and type 2 diabetes (DM2) subjects. Our aim was to evaluate whether the D2 Thr92Ala polymorphism is associated with increased risk for DM2.Design and methodsA case–control study with 1057 DM2 and 516 nondiabetic subjects was performed. All participants underwent genotyping of the D2 Thr92Ala polymorphism. Additionally, systematic review and meta-analysis of the literature for genetic association studies of D2 Thr92Ala polymorphism and DM2 were performed in Medline, Embase, LiLacs, and SciELO, and major meeting databases using the terms ‘rs225014’ odds ratio (OR) ‘thr92ala’ OR ‘T92A’ OR ‘dio2 a/g’.ResultsIn the case–control study, the frequencies of D2 Ala92Ala homozygous were 16.4% (n=173) versus 12.0% (n=62) in DM2 versus controls respectively resulting in an adjusted OR of 1.41 (95% confidence intervals (CI) 1.03–1.94, P=0.03). The literature search identified three studies that analyzed the association of the D2 Thr92Ala polymorphism with DM2, with the following effect estimates: Mentuccia (OR 1.40 (95% CI 0.78–2.51)), Grarup (OR 1.09 (95% CI 0.92–1.29)), and Maia (OR 1.22 (95% CI 0.78–1.92)). The pooled effect of the four studies resulted in an OR 1.18 (95% CI 1.03–1.36, P=0.02).ConclusionsOur results indicate that in a case–control study, the homozygosity for D2 Thr92Ala polymorphism is associated with increased risk for DM2. These results were confirmed by a meta-analysis including 11 033 individuals, and support a role for intracellular T3 concentration in skeletal muscle on DM2 pathogenesis.

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