The Carnegie Uaxactun Project and the Development of Maya Archaeology

AbstractThe Carnegie Institution of Washington's 1924–1937. Uaxactun Project, one of the first large-scale excavations in the Maya area, established the role of dirt archaeology in Maya studies. The archaeologists who worked on this pioneering project developed many field methods and approaches that remain in use today. A review of the project and of the careers of its participants shows the critical role the Carnegie Uaxactun Project has played in the history of Maya archaeology.

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Friends of Rose Canyon

California History ◽

10.1525/ch.2018.95.3.2 ◽

2018 ◽

Vol 95 (3) ◽

pp. 2-20 ◽

Cited By ~ 1

Author(s):

Andrew Wiese

Keyword(s):

Open Space ◽

Critical Role ◽

First Century ◽

Grassroots Politics ◽

History Of ◽

University City ◽

Participant Observer ◽

The Rose

Place-based activism has played a critical role in the history of urban and environmental politics in California. This article explores the continuing significance of environmental place making to grassroots politics through a case study of Friends of Rose Canyon, an environmental group in San Diego. Based in the fast-growing University City neighborhood, Friends of Rose Canyon waged a long, successful campaign between 2002 and 2018 to prevent construction of a bridge in the Rose Canyon Open Space Park in their community. Using historical and participant observer methodologies, this study reveals how twenty-first-century California urbanites claimed and created meaningful local places and mobilized effective politics around them. It illuminates the critical role of individual activists; suggests practical, replicable strategies for community mobilization; and demonstrates the significant impact of local activism at the urban and metropolitan scales.

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CHEK2∗1100delC Mutation and Risk of Prostate Cancer

Prostate Cancer ◽

10.1155/2014/294575 ◽

2014 ◽

Vol 2014 ◽

pp. 1-9 ◽

Cited By ~ 24

Author(s):

Victoria Hale ◽

Maren Weischer ◽

Jong Y. Park

Keyword(s):

Prostate Cancer ◽

Current Knowledge ◽

Prostate Cancer Screening ◽

Critical Role ◽

Prostate Cancer Risk ◽

Conclusive Evidence ◽

Increased Risk ◽

History Of ◽

Cancer Studies

Although the causes of prostate cancer are largely unknown, previous studies support the role of genetic factors in the development of prostate cancer.CHEK2plays a critical role in DNA replication by responding to double-stranded breaks. In this review, we provide an overview of the current knowledge of the role of a genetic variant, 1100delC, ofCHEK2on prostate cancer risk and discuss the implication for potential translation of this knowledge into clinical practice. Currently, twelve articles that discussedCHEK2∗1100delC and its association with prostate cancer were identified. Of the twelve prostate cancer studies, five studies had independent data to draw conclusive evidence from. The pooled results of OR and 95% CI were 1.98 (1.23–3.18) for unselected cases and 3.39 (1.78–6.47) for familial cases, indicating thatCHEK2∗1100delC mutation is associated with increased risk of prostate cancer. Screening for CHEK2∗1100delC should be considered in men with a familial history of prostate cancer.

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Trust in scientists in times of pandemic: Panel evidence from 12 countries

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.2108576118 ◽

2021 ◽

Vol 118 (40) ◽

pp. e2108576118

Author(s):

Yann Algan ◽

Daniel Cohen ◽

Eva Davoine ◽

Martial Foucault ◽

Stefanie Stantcheva

Keyword(s):

Large Scale ◽

Social Trust ◽

Critical Role ◽

Individual Level ◽

Individual Support ◽

Compliant Behavior ◽

Paradoxical Effects ◽

The Government ◽

Nonpharmaceutical Interventions

This article analyzes the specific and critical role of trust in scientists on both the support for and compliance with nonpharmaceutical interventions (NPIs) during the COVID-19 pandemic. We exploit large-scale, longitudinal, and representative surveys for 12 countries over the period from March to December 2020, and we complement the analysis with experimental data. We find that trust in scientists is the key driving force behind individual support for and compliance with NPIs and for favorable attitudes toward vaccination. The effect of trust in government is more ambiguous and tends to diminish support for and compliance with NPIs in countries where the recommendations from scientists and the government were not aligned. Trust in others also has seemingly paradoxical effects: in countries where social trust is high, the support for NPIs is low due to higher expectations that others will voluntary social distance. Our individual-level longitudinal data also allows us to evaluate the effects of within-person changes in trust over the pandemic: we show that trust levels and, in particular, trust in scientists have changed dramatically for individuals and within countries, with important subsequent effects on compliant behavior and support for NPIs. Such findings point out the challenging but critical need to maintain trust in scientists during a lasting pandemic that strains citizens and governments.

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Conclusion

The Unreliable Nation ◽

10.7551/mitpress/9780262036511.003.0009 ◽

2017 ◽

Keyword(s):

National Identity ◽

Geographical Distribution ◽

Crucial Role ◽

Large Scale ◽

Small Scale ◽

Modern History ◽

Late Modernity ◽

History Of ◽

Definition Of

This chapter extends the book’s insights about nature, technology, and nation to the larger history of the modern period. While the modern nation loses its grip as a locus of identity and analysis, attempts to understand the operation, disruption, and collapse of continental and global infrastructures continue to mix the natural and the machinic in ways that define them both. Those vulnerabilities emphasize large-scale catastrophe; historiographically, they mask the crucial role of small-scale failures in the experience and culture of late modernity, including its definition of nature. Historical actors turned the uneven geographical distribution of small-scale failures into a marker of distinctive local natures and an element of regional and national identity. Attending to those failures helps not only situate cold-war technologies in the larger modern history of natural and machinic orders; it helps provincialize the superpowers by casting problematic “other” natures as central and primary.

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It’s All in the Reading

Arts ◽

10.3390/arts9010019 ◽

2020 ◽

Vol 9 (1) ◽

pp. 19

Author(s):

Déirdre Kelly

Keyword(s):

Contemporary Art ◽

Mass Production ◽

Large Scale ◽

Book Production ◽

Art Practice ◽

The Arts ◽

History Of ◽

First Time ◽

The City

It seems inherent in the nature of contemporary artist’s book production to continue to question the context for the genre in contemporary art practice, notwithstanding the medium’s potential for dissemination via mass production and an unquestionable advantage of portability for distribution. Artists, curators and editors operating in this sector look to create contexts for books in a variety of imaginative ways, through exhibition, commission, installations, performance and, of course as documentation. Broadening the discussion of the idea of the book within contemporary art practice, this paper examines the presence and role of book works within the context of the art biennale, in particular the Venice Art Biennale of which the 58th iteration (2019) is entitled ‘May You Live In Interesting Times’ and curated by Ralph Rugoff, with an overview of the independent International cultural offerings and the function of the ‘Book Pavilion’. Venetian museums and institutions continue to present vibrant diverse works within the arena of large-scale exhibitions, recognising the position that the book occupies in the history of the city. This year, the appearance for the first time, of ‘Book Biennale’, opens up a new and interesting dialogue, taking the measure of how the book is being promoted and its particular function for visual communication within the arts in Venice and beyond.

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The critical role of magnetic helicity in astrophysical large-scale dynamos

Plasma Physics and Controlled Fusion ◽

10.1088/0741-3335/51/12/124043 ◽

2009 ◽

Vol 51 (12) ◽

pp. 124043 ◽

Cited By ~ 19

Author(s):

Axel Brandenburg

Keyword(s):

Large Scale ◽

Critical Role ◽

Magnetic Helicity

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Reputation, Status Networks, and the Art Market

Arts ◽

10.3390/arts8030081 ◽

2019 ◽

Vol 8 (3) ◽

pp. 81 ◽

Cited By ~ 1

Author(s):

L.E.A. Braden ◽

Thomas Teekens

Keyword(s):

Network Analysis ◽

Market Research ◽

Large Scale ◽

Art Market ◽

High Status ◽

Exhibition History ◽

Bibliographic Data ◽

History Of ◽

Influence Process

The effect of an artist’s prestige on the price of artwork is a well-known, central tenant in art market research. In considering how an artist’s prestige proliferates, much research examines networks, where certain artistic groupings and associations promote individual member’s artistic standing (i.e., “associative status networks”). When considering the role of associative status networks, there are two models by which status may increase. First, the confirmation model suggests that actors of similar status are associated with each other. Second, the increase model suggests that a halo effect occurs, whereby an individual’s status increases by association with higher-status artists. In this research, we examine the association of artists through museum exhibition to test confirmation versus increase models, ascertaining whether prestige acquisition is a selection or influence process. This research capitalizes on the retrospective digitization of exhibition catalogues, allowing for large-scale longitudinal analysis heretofore unviable for researchers. We use the exhibition history of 1148 artists from the digitized archives of three major Dutch museums (Stedelijk, Boijmans-Van Beuningen, Van Abbe) from 1930 to 1989, as well as data on artists’ market performance from artprice.com and bibliographic data from the WorldCat database. We then employ network analysis to examine the 60-year interplay of associative status networks and determine how different networks predict subsequent auction performance. We find that status connections may have a point of diminishing returns by which comparison to high prestige peers increases one’s own prestige to a point, after which a high-status comparison network becomes a liability.

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The role of haploinsufficiency of RPS14 and p53 activation in the molecular pathogenesis of the 5q- syndrome

Pediatric Reports ◽

10.4081/pr.2011.s2.e10 ◽

2011 ◽

Vol 3 (2s) ◽

pp. 10 ◽

Cited By ~ 6

Author(s):

Jacqueline Boultwood

Keyword(s):

Mouse Model ◽

Large Scale ◽

Critical Role ◽

Ribosomal Gene ◽

Molecular Pathogenesis ◽

Erythroid Progenitor ◽

Great Insight ◽

P53 Activation ◽

Distinct Subtype

In recent years we have gained great insight into the molecular pathogenesis of the 5q- syndrome, a distinct subtype of myelodysplasia. The demonstration of haploinsufficiency of the ribosomal gene RPS14 (mapping to the commonly deleted region) and the finding that this is the cause of the erythroid defect in the 5qsyndrome represent major advances. A mouse model of the human 5q- syndrome generated by large-scale deletion of the Cd74-Nid67 interval (containing RPS14) further supports a critical role for RPS14 haploinsufficiency. It is widely accepted that ribosomal deficiency results in p53 activation and defective erythropoiesis and the crossing of the ‘5q- mice’ with p53 deficient mice ameliorated the erythroid progenitor defect. Emerging data suggests that the p53 activation observed in the mouse model may also apply to the human 5q- syndrome.

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GPIHBP1 C89F Neomutation and Hydrophobic C-Terminal Domain G175R Mutation in Two Pedigrees with Severe Hyperchylomicronemia

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2011-1444 ◽

2011 ◽

Vol 96 (10) ◽

pp. E1675-E1679 ◽

Cited By ~ 49

Author(s):

Sybil Charrière ◽

Noël Peretti ◽

Sophie Bernard ◽

Mathilde Di Filippo ◽

Agnès Sassolas ◽

...

Keyword(s):

Critical Role ◽

Phenotypic Expression ◽

Missense Mutations ◽

Terminal Domain ◽

Apoa5 Gene ◽

Key Enzyme ◽

History Of ◽

Functional Consequences ◽

Signal Peptide Polymorphism

Abstract Context: GPIHBP1 is a new endothelial binding site for lipoprotein lipase (LPL), the key enzyme for intravascular lipolysis of triglyceride-rich lipoproteins (TGRL). We have identified two new missense mutations of the GPIHBP1 gene, C89F and G175R, by systematic sequencing in a cohort of 376 hyperchylomicronemic patients without mutations on the LPL, APOC2, or APOA5 gene. Objective: Phenotypic expression and functional consequences of these two mutations were studied. Design: We performed clinical and genotypic studies of probands and their families. GPIHBP1 functional alterations were studied in CHO pgsA-745 transfected cells. Results: Probands are an adult with a homozygous G175R mutation and a child with a hemizygous C89F neomutation and a deletion of the second allele. C89F mutation was associated with a C14F signal peptide polymorphism on the same haplotype. Both patients had resistant hyperchylomicronemia, low LPL activity, and history of acute pancreatitis. In CHO pgsA-745 cells, both G175R and C14F variants reduce the expression of GPIHBP1 at the cell surface. C89F mutation is responsible for a drastic LPL-binding defect to GPIHBP1. C14F may further potentiate C89F effect. Conclusions: The emergence of hyperchylomicronemia in the generation after a neomutation further establishes a critical role for GPIHBP1 in TGRL physiopathology in humans. Our results highlight the crucial role of C65-C89 disulfide bond in LPL binding by GPIHBP1 Ly6 domain. Furthermore, we first report a mutation of the hydrophobic C-terminal domain that impairs GPIHBP1 membrane targeting.

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