The association between caffeine and cognitive decline: examining alternative causal hypotheses

2014 ◽  
Vol 26 (4) ◽  
pp. 581-590 ◽  
Author(s):  
K. Ritchie ◽  
M.L. Ancelin ◽  
H. Amieva ◽  
O. Rouaud ◽  
I. Carrière
Keyword(s):  
Cognitive Decline ◽  
Depressive Symptomatology ◽  
Coffee Consumption ◽  
Diabetes Type 2 ◽  
Total Sample ◽  
Elderly Persons ◽  
Caffeine Consumption ◽  
Alternative Pathways ◽  
Increased Risk

ABSTRACTBackground:Numerous studies suggest that higher coffee consumption may reduce the rate of aging-related cognitive decline in women. It is thus potentially a cheap and widely available candidate for prevention programs provided its mechanism may be adequately understood. The assumed effect is that of reduced amyloid deposition, however, alternative pathways notably by reducing depression and diabetes type 2 risk have not been considered.Methods:A population study of 1,193 elderly persons examining depressive symptomatology, caffeine consumption, fasting glucose levels, type 2 diabetes onset, serum amyloid, and factors known to affect cognitive performance was used to explore alternative causal models.Results:Higher caffeine consumption was found to be associated with decreased risk of incident diabetes in men (HR = 0.64; 95% CI 0.42–0.97) and increased risk in women (HR = 1.51; 95% CI 1.08–2.11). No association was found with incident depression. While in the total sample lower ratio Aβ42/Aβ40 levels (OR = 1.36, 95% CI 1.05–1.77, p = 0.02) were found in high caffeine consumers, this failed to reach significance when the analyses were stratified by gender.Conclusions:We found no evidence that reduced risk of cognitive decline in women with high caffeine consumption is moderated or confounded by diabetes or depression. The evidence of an association with plasma beta amyloid could not be clearly demonstrated. Insufficient proof of causal mechanisms currently precludes the recommendation of coffee consumption as a public health measure. Further research should focus on the high estrogen content of coffee as a plausible alternative explanation.

scholarly journals Obstructive Sleep Apnoea and Type 2 Diabetes

2014 ◽  
Vol 10 (01) ◽  
pp. 35 ◽  
Author(s):  
Abd A Tahrani ◽  
Asad Ali ◽  
◽  
Keyword(s):  
Type 2 Diabetes ◽  
Risk Factor ◽  
Medical Condition ◽  
Diabetes Type 2 ◽  
Sleep Apnoea ◽  
Obstructive Sleep ◽  
Increased Risk ◽  
Osa Treatment ◽  
The Impact

With the growing prevalence of obesity, the burden of type 2 diabetes is increasing. Obstructive sleep apnea (OSA) is a very common medical condition that is associated with increased risk for cardiovascular disease and mortality. Obesity is a common risk factor for OSA and type 2 diabetes and hence it is not surprising that OSA and type 2 diabetes are interlinked. OSA has been shown to be an independent risk factor for the development of incident pre-diabetes/type 2 diabetes. OSA is also associated with worse glycemic control and vascular disease in patients with type 2 diabetes. However, evidence for the benefits of OSA treatment in patients with type 2 diabetes is still lacking. The aim of this article is to provide an overview of OSA, the relationships between OSA and dysglycemia and the impact of OSA in patients with type 2 diabetes, highlighting recent advances in the field.

scholarly journals Diabetes type 2 diabetes in the elderly – solved and unsolved questions

2016 ◽  
Vol 19 (4) ◽  
pp. 322-330
Author(s):  
Tat'jana Vladimirovna Saprina ◽  
Nailja Maratovna Fajzulina
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus Type 2 ◽  
Diabetes Type 2 ◽  
The Elderly ◽  
Diabetes Type ◽  
Elderly Persons ◽  
Basic Information

The number of elderly persons with diabetes mellitus type 2 is expected to progressively increase. Management of this category of patients should be individualised and include the adequate correction of hyperglycaemia, prevention of long-term complications, prevention of hypoglycaemia, reduction of cardiovascular mortality and preservation of quality of life. This article summarises basic information on the pathophysiology of carbohydrate metabolism, peculiarities of the course of diabetes and use of antidiabetic drugs in the elderly. Special attention is paid to reviewing the goals of glycaemic control and proposed clinical guidelines.

scholarly journals Obstructive Sleep Apnoea and Type 2 Diabetes

2010 ◽  
Vol 10 (1) ◽  
pp. 43 ◽  
Author(s):  
Abd A Tahrani ◽  
Asad Ali ◽  
◽  
Keyword(s):  
Type 2 Diabetes ◽  
Risk Factor ◽  
Obstructive Sleep Apnoea ◽  
Medical Condition ◽  
Diabetes Type 2 ◽  
Sleep Apnoea ◽  
Obstructive Sleep ◽  
Increased Risk ◽  
The Impact

With the growing prevalence of obesity, the burden of type 2 diabetes is increasing. Obstructive sleep apnoea (OSA) is a very common medical condition that is associated with increased risk of cardiovascular disease and mortality. Obesity is a common risk factor for OSA and type 2 diabetes and hence it is not surprising that OSA and type 2 diabetes are interlinked. OSA has been shown to be an independent risk factor for the development of incident pre-diabetes/type 2 diabetes. OSA is also associated with worse glycaemic control and vascular disease in patients with type 2 diabetes. However, evidence for the benefits of OSA treatment in patients with type 2 diabetes is still lacking. The aim of this article is to provide an overview of OSA, the relationships between OSA and dysglycaemia and the impact of OSA in patients with type 2 diabetes, highlighting recent advances in the field.

Long-term light and moderate exercise intervention similarly prevent both hippocampal and glycemic dysfunction in pre-symptomatic type 2 diabetic rats

2021 ◽  
Author(s):  
Subrina Jesmin ◽  
Takeru Shima ◽  
Mariko Soya ◽  
Kanako Takahashi ◽  
Koki Omura ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Exercise Intervention ◽  
Treadmill Running ◽  
Monocarboxylate Transporter ◽  
Moderate Intensity ◽  
Moderate Exercise ◽  
Memory Dysfunction ◽  
Oletf Rats ◽  
Increased Risk

A pre-diabetic population has an increased risk of cognitive decline as well as type 2 diabetes mellitus (T2DM). The present study investigated whether the progression of memory dysfunction and dysregulated brain glycogen metabolism is prevented with four months of exercise intervention from the pre-symptomatic stage in T2DM rat model. Memory function and biochemical and molecular profiles were assessed in the pre-symptomatic stage of OLETF rats, a T2DM model, with LETO rats as genetic control. These rats were subjected to light- or moderate-intensity treadmill running for four months with repetition of the same experiments. Significant hippocampal-dependent memory dysfunction was observed in the pre-symptomatic stage of OLETF rats, accompanied by downregulated levels of hippocampal monocarboxylate transporter 2 (MCT2), a neuronal lactate-transporter, without alteration in hippocampal glycogen levels. Four months of light or moderate exercise from the pre-symptomatic stage of T2DM normalized glycemic parameters and also hippocampal molecular normalization through MCT2, glycogen, and brain-derived neurotrophic factor (BDNF) levels with the improvement of memory dysfunction in OLETF rats. A four-month exercise regimen from the pre-symptomatic stage of T2DM at light and moderate intensities contributed to the prevention of the development of T2DM and the progression of cognitive decline with hippocampal lactate-transport and BDNF improvement.

scholarly journals FINDRISK and occupation: need of prevention of diabetes type 2 at the workplace

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
K Lyubomirova ◽  
M Tabanska ◽  
L Hristova ◽  
M Samuneva ◽  
M Yancheva ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cardiovascular Risk ◽  
Older Workers ◽  
Significant Proportion ◽  
Diabetes Type 2 ◽  
Diabetes Type ◽  
Increased Risk

Abstract Background Diabetes mellitus is a risk factor for atherosclerosis, cardiovascular morbidity and increased mortality. Identifying people at a high risk of developing diabetes determine the prognosis and quality of life of the patients and prevent the development of macrovascular complications of diabetes. Within the framework of an international project, the ten-year risk of developing type 2 diabetes mellitus in two age groups workers (up to 25 and over 55) of four economic sectors (construction, clothing, hairdressing and cosmetics, and healthcare) has been estimated. Methods The survey included 150 workers from four economic activities. The FINDRISK questionnaire was distributed among them. Plasma glucose and serum lipids (HDL, LDL, triglycerides) were analyzed. The statistical analysis of the results was done using SPSS 16. Results The mean FINDRISK score for the age group up to 25 years is 3.6 ± 3.8, and for respondents above 55 years - 10.1 ± 5.0. The analysis highlights the higher risk of developing diabetes among healthcare workers, where the score of older workers is 11.63 ± 6.61, as well as in the textile and clothing industry (11.17 ± 4.3). These results call attention to a potential link between the occupation and the risk of developing type 2 diabetes in these sectors of the economy and the need for additional measures to search for causes and prevention. Conclusions A significant proportion of the participants over 55 years old in the healthcare and textile and clothing sectors are at an increased risk of developing type 2 diabetes, which requires a change in lifestyle, as well as the identification of workplace hazards that lead to these results. The FINDRISK questionnaire can serve as an indirect assessment of the cardiovascular risk of older workers. Additional preventive measures are needed to limit the risk of developing type 2 diabetes mellitus as well as cardiovascular risk in the identified risky occupations. Key messages Occupation could contribute to the life style risk factors for developing diabetes type 2. Occupational risk reduction measures and health promotion are needed to protects workers.

scholarly journals The Choice of Method of Surgical Correction of Complicated Forms of Diabetes Type-2

2019 ◽  
Vol 4 (4) ◽  
Keyword(s):  
Myocardial Infarction ◽  
Type 2 Diabetes ◽  
Coronary Heart Disease ◽  
Renal Failure ◽  
Diabetic Retinopathy ◽  
Diabetes Type 2 ◽  
Diabetes Type ◽  
Increased Risk ◽  
Patients With Diabetes

Type 2 diabetes is a chronic disease. In terms of growth rates, such as disease, AIDS, tuberculosis, and malaria. Frightening diabetes in the young. According to some data, it’s estimated that there has been a 20% reduction in the rate of 20%. It is known that the most frequent complications of type 2 diabetes are: 2-4 times increased risk strokes, Coronary heart disease - 80% of patients with diabetes have suffered myocardial infarction, Diabetic nephropathy - the main cause of chronic renal failure diabetic retinopathy main cause of blindness, diabetic angioneuropathy - the main cause of amputation.

Possible relationships of selected food items to osteoporosis among a group of Iraqi women

2022 ◽  
Vol 63 (4) ◽  
pp. 171-175
Author(s):  
May fawzi Saleh ◽  
Jawad Aldiwan ◽  
Ammar H. Ahmed
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Coffee Consumption ◽  
Total Sample ◽  
Cross Sectional Study ◽  
Mineral Density ◽  
Daily Consumption ◽  
Cross Sectional ◽  
Increased Risk ◽  
Iraqi Women

Background: Osteoporosis is a global health problem which is estimated to affect more than 200 million people worldwide, especially postmenopausal women. It is characterized by decreased bone mineral density leading to fragility and increased risk of fractures.  Objective: This study was conducted to explore the consumption of inappropriate foods related to osteoporosis among a group of Iraqi women. JFac Med Baghdad 2021; Vol.63, No. 4 Received: Sep., 2021 Accepted: Nov., 2021 Published: Jan., 2021   Patients and methods: A cross sectional study of 140 females aged ≥ 40 years attending polyclinics in Al-Dora sector in Baghdad city from 18th January to 24th April 2021. The bone mineral density was measured by portable quantitative calcaneal ultrasound machine (osteosystem) and the bone was assessed for osteoporosis by T-score. Food frequency questionnaire was used for collecting data related to food consumption. Results: Out of the total sample, 74 (52.9%) were found to be osteoporotic. There was a significant association with high salt and coffee consumption with the occurrence of osteoporosis (77.3% and 83.3%, respectively, p = 0.001), compared to those who did not consume caffeinated drinks. Participants with daily consumption of caffeinated drinks had a highly significant association with osteoporosis (21.8% vs 100%, p = 0.001). Conclusion: Excessive consumption of salty foods and caffeinated beverages appears to exert a negative effect on bone mineral density and the occurrence of osteoporosis among the studied group of Iraqi women.

Green coffee as a novel agent for Alzheimer’s disease prevention by attenuating diabetes

2014 ◽  
Vol 5 (2) ◽  
Author(s):  
Merina Varghese ◽  
Lap Ho ◽  
Jun Wang ◽  
Wei Zhao ◽  
Samara Levine ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Type 2 Diabetes ◽  
Alzheimer's Disease ◽  
Coffee Consumption ◽  
Diabetes Type 2 ◽  
Health Concern ◽  
Protective Effects ◽  
Green Coffee ◽  
Active Components

AbstractDiabetes type 2, caused mainly by insulin resistance, is growing in incidence worldwide. In addition to being a major public health concern, type 2 diabetes is also a risk factor for dementia, including Alzheimer’s disease type dementia. Coffee consumption is reported to have protective effects in both diabetes and Alzheimer’s disease. We review here the reported beneficial effects of coffee in both disease conditions and the previously identified active ingredients of coffee. Furthermore, we revisit our recent findings of improved glucose utilization in the periphery and in the brain in a mouse model of high-fat diet induced type 2 diabetes after treatment with a decaffeinated green coffee preparation. Overall, consumption of coffee appears to improve diabetes and reduce the risk of dementia, although future studies are required to further identify the active components and the type of coffee that is most effective in addressing these conditions.

Trigger Factors for Spontaneous Intracerebral Hemorrhage: A Case-Crossover Study

Stroke ◽  
2021 ◽  
Author(s):  
Ellis S. van Etten ◽  
Kanishk Kaushik ◽  
Wilmar M.T. Jolink ◽  
Emma A. Koemans ◽  
Merel S. Ekker ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Coffee Consumption ◽  
Spontaneous Intracerebral Hemorrhage ◽  
Caffeine Consumption ◽  
Vigorous Exercise ◽  
Trigger Factors ◽  
Case Crossover ◽  
Increased Risk ◽  
Potential Trigger ◽  
Vessel Rupture

Background and Purpose: Whether certain activities can trigger spontaneous intracerebral hemorrhage (ICH) remains unknown. Insights into factors that trigger vessel rupture resulting in ICH improves knowledge on the pathophysiology of ICH. We assessed potential trigger factors and their risk for ICH onset. Methods: We included consecutive patients diagnosed with ICH between July 1, 2013, and December 31, 2019. We interviewed patients on their exposure to 12 potential trigger factors (eg, Valsalva maneuvers) in the (hazard) period soon before onset of ICH and their normal exposure to these trigger factors in the year before the ICH. We used the case-crossover design to calculate relative risks (RR) for potential trigger factors. Results: We interviewed 149 patients (mean age 64, 66% male) with ICH. Sixty-seven (45%) had a lobar hemorrhage, 60 (40%) had a deep hemorrhage, 19 (13%) had a cerebellar hemorrhage, and 3 (2%) had an intraventricular hemorrhage. For ICH in general, there was an increased risk within an hour after caffeine consumption (RR=2.5 [95% CI=1.8–3.6]), within an hour after coffee consumption alone (RR=4.8 [95% CI=3.3–6.9]), within an hour after lifting >25 kg (RR=6.6 [95% CI=2.2–19.9]), within an hour after minor head trauma (RR=10.1 [95% CI=1.7–60.2]), within an hour after sexual activity (RR=30.4 [95% CI=16.8–55.0]), within an hour after straining for defecation (RR=37.6 [95% CI=22.4–63.4]), and within an hour after vigorous exercise (RR=21.8 [95% CI=12.6–37.8]). Within 24 hours after flu-like disease or fever, the risk for ICH was also increased (RR=50.7 [95% CI=27.1–95.1]). Within an hour after Valsalva maneuvers, the RR for deep ICH was 3.5 (95% CI=1.7–6.9) and for lobar ICH the RR was 2.0 (95% CI=0.9–4.2). Conclusions: We identified one infection and several blood pressure related trigger factors for ICH onset, providing new insights into the pathophysiology of vessel rupture resulting in ICH.

scholarly journals Oral Disease in Relation to Future Risk of Dementia and Cognitive Decline: Prospective Cohort Study Based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (Advance) Trial

2011 ◽  
Vol 28 (1) ◽  
pp. 49-52 ◽  
Author(s):  
G.-D. Batty ◽  
Q. Li ◽  
R. Huxley ◽  
S. Zoungas ◽  
B.-A. Taylor ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cognitive Decline ◽  
Tooth Loss ◽  
Oral Disease ◽  
Modified Release ◽  
Increased Risk ◽  
Natural Teeth ◽  
Controlled Evaluation

AbstractObjectiveExamine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes.MethodsA total of 11,140 men and women aged 55–88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up.ResultsRelative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95% confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes.ConclusionsTooth loss was associated with an increased risk of both dementia and cognitive decline.

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