scholarly journals 141 Moderating Perspectives of Long Acting Injectable Use of Antipsychotics: A Literature Review

CNS Spectrums ◽  
2020 ◽  
Vol 25 (2) ◽  
pp. 289-290 ◽  
Author(s):  
Kathy Riedford
Keyword(s):  
Medication Compliance ◽  
First Episode ◽  
Current Trends ◽  
Number Of Factors ◽  
Episode Psychosis ◽  
Potential Improvement ◽  
Long Acting ◽  
The Cost ◽  
A Current

Abstract:Long acting injectable (LAI) antipsychotics are indicated for individuals suffering from schizophrenia, delusional disorder, schizoaffective disorder and bipolar disorder. Even though LAIs have traditionally been used for a subgroup of patients who were not compliant with oral treatments or who were a high risk to others, current trends are changing with increased options and availability of these treatments. A number of factors are implicated in the reversal of this trend including perspectives of patients and perspectives of providers. There is not abundant literature available regarding robust studies to examine these perspectives, but this presentation provides a current summary of available literature.Some factors that influence perspectives of both patients and providers include knowledge about LAIs, cost of LAIs and the traditional views of these agents as being used under coercive circumstances. Altering perspectives has been a primary barrier to increase the use of these agents. Evidence clearly supports the use of early intervention for individuals with first episode psychosis, and poor medication compliance results in poorer treatment outcomes. With the potential improvement in quality of life and potentially decreasing the cost burden of this illness in society, this avenue for treatment must be a strong consideration for all involved in the treatment of the aforementioned disorders.

QUALITY OF INDIVIDUAL AND GROUP LEVEL INTERVENTIONS FOR FIRST EPISODE PSYCHOSIS AT THE TERTIARY PSYCHIATRIC HOSPITAL IN UGANDA.

2020 ◽  
Author(s):  
Emmanuel Kiiza Mwesiga ◽  
Noeline Nakasujja ◽  
Lawrence Nankaba ◽  
Juliet Nakku ◽  
Seggane Musisi
Keyword(s):  
Psychiatric Hospital ◽  
Psychotic Disorders ◽  
First Episode Psychosis ◽  
First Episode ◽  
Group Level ◽  
Group Interventions ◽  
Episode Psychosis ◽  
Essential Components ◽  
The Individual

Introduction: Individual and group level interventions have the largest effect on outcomes in patients with the first episode of psychosis. The quality of these individual and group level interventions provided to first-episode psychosis patients in Uganda is unclear.Methods: The study was performed at Butabika National Psychiatric Teaching and referral hospital in Uganda. A retrospective chart review of recently discharged adult in-patients with the first episode of psychosis was first performed to determine the proportion of participants who received the different essential components for individual and group level interventions. From the different proportions, the quality of the services across the individual and group interventions was determined using the first-Episode Psychosis Services Fidelity Scale (FEPS-FS). The FEPS-FS assigns a grade of 1-5 on a Likert scale depending on the proportion of patients received the different components of the intervention. Results: The final sample included 156 first-episode psychosis patients. The median age was 27 years [IOR (24-36)] with 55% of participants of the female gender. 13 essential components across the individual and group interventions were assessed and their quality quantified. All 13 essential components had poor quality with the range of scores on the FEPS-FS of 1-3. Only one essential component assessed (use of single antipsychotics) had moderate quality.Discussion: Among current services at the National psychiatric hospital of Uganda, the essential for individual and group level interventions for psychotic disorders are of low quality. Further studies are required on how the quality of these interventions can be improved.

#3117 Fregoli syndrome in primary and secondary psychosis: a case level meta-analysis

2021 ◽  
Vol 92 (8) ◽  
pp. A18-A18
Author(s):  
Maria Teixeira-Dias ◽  
Amber Kaur Dadwal ◽  
Graham Blackman
Keyword(s):  
Right Hemisphere ◽  
English Literature ◽  
Meta Analysis ◽  
First Episode ◽  
Bias Assessment ◽  
Random Effects Models ◽  
Episode Psychosis ◽  
Treatment Responses ◽  
The Right

Objectives/AimsFregoli syndrome is a rare delusion characterised by the misidentification of an individual, typically of someone who the patient has an emotional link towards. The pathoaetiology of Fregoli syndrome remains largely a mystery, however, it has been described in patients experiencing either a primary or secondary (organic) psychosis. We sought to compare the neuropsychiatric features of Fregoli syndrome in primary and secondary psychosis.MethodsA patient-level meta-analysis was conducted. Five databases were searched for any descriptions of Fregoli syndrome. The patients and the psychotic episodes details alongside the co-occurring neuropsychiatric features and treatment responses were extracted. A risk of bias assessment was carried by scoring the methodological quality of all case studies. Random-effects models were used to pool the data and odds ratios and 95% confidence intervals were estimated for each of the neuropsychiatric features extracted between primary and secondary psychoses groups.ResultsA total of 119 patients (62 with primary psychosis, 50 with secondary psychosis and 7 with mixed or unknown aetiology) with Fregoli syndrome were identified in the English literature. Persecutory features were more likely to occur in patients with primary Fregoli syndrome (OR = 0.26, 95% CI[0.10;0.67], p < 0.01). In addition, Fregoli syndrome in the context of a first-episode psychosis (OR = 11.00, 95% CI [2.45;49.39], p < 0.01) and in the presence of neuroimaging abnormalities (OR = 20.19, 95% CI [4.36; 93.47], p < 0.01) was significantly associated with secondary aetiology. Patients in the secondary psychosis group (n=14) showed more right hemisphere lesions than patients in the primary psychosis group (n=1), however this trend was not significant (p = 0.10). Furthermore, no statistical differences between psychoses groups were found for the demographic, clinical and neurophysiological features analysed.ConclusionsThis is the first meta-analysis investigating the features of Fregoli syndrome in primary and secondary psychosis.Findings suggest that secondary causes of Fregoli syndrome are associated with a first-episode of psychosis and that neuroimaging abnormalities, particularly in the right hemisphere, are associated with a secondary organic cause.

scholarly journals КОМПЛЕКСНАЯ ОЦЕНКА КОНКУРЕНТОСПОСОБНОСТИ ПЕРЕРАБОТАННОЙ ПЛОДООВОЩНОЙ ПРОДУКЦИИ

2019 ◽  
pp. 6-12
Author(s):  
Н. Р. Асадуллина
Keyword(s):  
Practical Significance ◽  
Vegetable Production ◽  
Fruit And Vegetable ◽  
Transport Costs ◽  
Expert Opinions ◽  
Number Of Factors ◽  
Vegetable Products ◽  
Quality Of Products ◽  
The Cost

Formulation of the problem. The article reflects the assessment of the competitiveness of processed fruit and vegetable products, the qualitative characteristics of fruit and vegetable products are substantiated, as well as the parameters of the degree of consistency of expert opinions based on the calculation of the concordance coefficient. The purpose of the research is to reflect and characterize existing methods of integrated assessment of the competitiveness of processed fruit and vegetable products. The object of research – the process of determining the quality of products produced, as well as the competitiveness of processed fruit and vegetable products. The methods used in the research – logical, comparative, analytical, scientific and methodological. The hypothesis of the research is to assume the dependence of the competitiveness of processed fruit and vegetable products and its sales volumes. The statement of basic materials. The buyer prefers products depending on the purpose and use of this product. In the course of further processing, the buyer pays attention to the volume of packaging, the suitability of the packaging for the content of the product in it, the maximum time for the storage of products. The article suggests such indicators of quality of processed fruit and vegetable production: biochemical composition of products; packaging of products; design and design of products; appearance and consistency; terms of product suitability; cost of production per kilogram of production. The originality and practical significance of the research is that the author substantiates the degree of influence of the proposed indicators on competitiveness on the basis of expert assessments. The number of points is determined depending on the number of factors considered. The degree of consensus of expert opinions is established on the basis of calculating the coefficient of concordation. Conclusions of the research. In the process of packaging the product and its production must take into account the directions of its use. For further industrial consumption, processed fruit and vegetable products can be made with a higher content of dry soluble substances, vitamins, sugars, and acidity. This will save on the cost of packaging, transport costs, and handling operations.

scholarly journals S110. LONG-ACTING ARIPIPRAZOLE IN FIRST-EPISODE PSYCHOSIS: DOES ONE SIZE FIT ALL?

2019 ◽  
Vol 45 (Supplement_2) ◽  
pp. S349-S349
Author(s):  
Marie-Michelle Tremblay ◽  
Sarah-Maude Rioux ◽  
Charlie Fraser ◽  
Anne-Pierre Bouffard ◽  
Sophie L’Heureux ◽  
...  
Keyword(s):  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis ◽  
Long Acting

Paliperidone palmitate log-acting injection in patients with psychotic active clinic: start, change or increase of dose

2016 ◽  
Vol 33 (S1) ◽  
pp. s249-s250
Author(s):  
A.L. Gonzalez Galdamez ◽  
M.D. Piqueras Acevedo ◽  
M.R. Raposo Hernández ◽  
I. Martínez Pérez ◽  
P. Manzur Rojas ◽  
...  
Keyword(s):  
Acute Exacerbation ◽  
Descriptive Study ◽  
First Episode Psychosis ◽  
Paliperidone Palmitate ◽  
First Episode ◽  
Antipsychotic Treatment ◽  
Early Stages ◽  
Episode Psychosis ◽  
Competing Interest ◽  
Long Acting

The aim is to describe the experience of treatment with Paliperidone Palmitate long acting injection (PP) in patients with psychotic active clinic, whether diagnoses with schizophrenia or in patients with the first episode psychosis, as well as to reflect the improvement in the control of the symptoms that the patients can improve increasing the dose.MethodsWe have done a descriptive study of 34 patients hospitalized in psychiatry between January and July 2015 for psychotic active clinic who started treatment with PP or the previous dose was increased.Results91.2% of patients admitted for acute exacerbation of their usual pathology and 8.8% for a first episode psychosis. In the CGI scale, all the patients admitted scored as severe or markedly ill; going mostly mildly ill at discharge. For 55.9% of patients, the treatment was changed to PP, 29.4% of the dose was increased PP and 14.7% antipsychotic treatment was started with PP. Among patients change treatment, the main reason was non-adherence (47.4%). 70.6% of our patients were discharged with PP as only antipsychotic and 29.4% which was discharged with another antipsychotic, the most frequent association was of PP with Quetiapine (80%).ConclusionsPP is a highly effective medicament in the treatment of the schizophrenia that improves the adherence to the treatment, so in our experience and we consider it a medicament to be considered in the early stages of the disease. According to our experience and there are patients who can benefit from better control of symptoms adjusting the dose individually.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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