Il Fattore Costituzionale Del Cancro Studiato Sul Ratto Col Metodo Della Parabiosi

1952 ◽  
Vol 1 (2) ◽  
pp. 153-158
Author(s):  
Carlo Foà
Keyword(s):  
Abdominal Cavity ◽  
The Other ◽  
Round Cell ◽  
Cell Sarcoma ◽  
Long Duration ◽  
The Common ◽  
The Individual ◽  
Better Than

SummaryWe describe a fortuitous observation on two rats united in parabiosis since nearly a year.One of the two, belonging to an oncoreceptive race, fell sick of a round cell sarcoma, of extremely malignant nature, which spread itself through various metastases to all the organism, invading especially the lungs and causing tha animal’s death.The other, of oncorefractory race, did not fall sick, although he was united to the first by abundant vascular and lymphatic communications, and that the common abdominal cavity was full of an hemorrhagic exsudation containing numberless cells coming from the tumorous decomposition. As the question is of a parabiosis of long duration and of a natural tumor of great malignity, the observation, better than the preceding ones on grafted tumors, favours the demonstration of the importance of the individual constitution of a subject sick or not of cancer.

scholarly journals Kinetic probes for inter-domain co-operation in human somatic angiotensin-converting enzyme

2005 ◽  
Vol 391 (3) ◽  
pp. 641-647 ◽  
Author(s):  
Olga E. Skirgello ◽  
Peter V. Binevski ◽  
Vladimir F. Pozdnev ◽  
Olga A. Kost
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Enzymatic Activity ◽  
Active Site ◽  
The Other ◽  
Converting Enzyme ◽  
Human Enzyme ◽  
Independent Functions ◽  
The Common ◽  
The Individual ◽  
Hydrolysis Of

s-ACE (the somatic form of angiotensin-converting enzyme) consists of two homologous domains (N- and C-domains), each bearing a catalytic site. Negative co-operativity between the two domains has been demonstrated for cow and pig ACEs. However, for the human enzyme there are conflicting reports in the literature: some suggest possible negative co-operativity between the domains, whereas others indicate independent functions of the domains within s-ACE. We demonstrate here that a 1:1 stoichiometry for the binding of the common ACE inhibitors, captopril and lisinopril, to human s-ACE is enough to abolish enzymatic activity towards FA {N-[3-(2-furyl)acryloyl]}-Phe-GlyGly, Cbz (benzyloxycarbonyl)-Phe-His-Leu or Hip (N-benzoylglycyl)-His-Leu. The kinetic parameters for the hydrolysis of seven tripeptide substrates by human s-ACE appeared to represent average values for parameters obtained for the individual N- and C-domains. Kinetic analysis of the simultaneous hydrolysis of two substrates, Hip-His-Leu (S1) and Cbz-Phe-His-Leu (S2), with a common product (His-Leu) by s-ACE at different values for the ratio of the initial concentrations of these substrates (i.e. σ=[S2]0/[S1]0) demonstrated competition of these substrates for binding to the s-ACE molecule, i.e. binding of a substrate at one active site makes the other site unavailable for either the same or a different substrate. Thus the two domains within human s-ACE exhibit strong negative co-operativity upon binding of common inhibitors and in the hydrolysis reactions of tripeptide substrates.

Epidemics as Leisure Killers: The Transformation of Japan’s Entertainment Industry in the Second Half of the 19th Century

2021 ◽  
Vol 31 (1) ◽  
pp. 195-217
Keyword(s):  
19Th Century ◽  
Social Disorganization ◽  
The Other ◽  
Entertainment Industry ◽  
Economic Changes ◽  
The Past ◽  
The Common ◽  
The Individual ◽  
The 19Th Century

Among the various human attitudes toward a pandemic, along with fear, despair and anger, there is also an urge to praise the catastrophe or imbue it with some sort of hope. In 2020 such hopes were voiced in the stream of all the other COVID-19 reactions and interpretations in the form of predictions of imminent social, political or economic changes that may or must be brought on by the pandemic, or as calls to “rise above” the common human sentiment and see the pandemic as some sort of cruel-but-necessary bitter pill to cure human depravity or social disorganization. Is it really possible for a plague of any kind to be considered a relief? Or perhaps a just punishment? In order to assess the validity of such interpretations, this paper considers the artistic reactions to the pandemics of the past, specifically the images of the plague from Alexander Pushkin’s play Feast During the Plague, Antonin Artaud’s essay “The Theatre and the Plague” and Albert Camus’s novel The Plague. These works in different ways explore an attitude in which a plague can be praised in some respect. The plague can be a means of self-overcoming and purification for both an individual and for society. At the same time, Pushkin and Camus, each in his own way and by different means, show the illusory nature of that attitude. A mass catastrophe can reveal the resources already present in humankind, but it does not help either the individual or the society to progress.

Newman and the Spiritual Crisis of the Occident

1947 ◽  
Vol 9 (2) ◽  
pp. 230-246
Author(s):  
Otto Karrer
Keyword(s):  
The Other ◽  
Anglo Saxon ◽  
Inner Life ◽  
Philosophical Thinking ◽  
Anglican Church ◽  
The Common ◽  
Religious Mind ◽  
Long Life ◽  
The Individual ◽  
Spiritual Conflicts

Newman's is perhaps the most illustrious religious mind in the modern Anglo-Saxon world. Exactly half of his long life (1801–1890) was devoted to the Anglican Church, the other half to the Catholic. However clear and unequivocal his conversion, his intellectual position is nevertheless the same in both periods. The sources of his inner life stem from the revelation of the Eternal, which came to him when he was fifteen years old and never left him his whole life long. His philosophical thinking is influenced by English empiricism that involves an attitude of restraint concerning intellectual speculation. It is in conformity with the English love of the concrete, of the individual-personal element and, with due respect to the spirit of tradition, of Christian freedom. And even though Newman's theology is rooted in ancient Christian tradition, his missionary conscience is directed towards the future, towards the spiritual conflicts of the twentieth century. Their unfolding he sensed with astonishing prevision. Just as his sermons and writings are divided almost equally between the two periods of his life (with the exception of perhaps one decade at the height of his career, in which he saw himself doomed almost to inactivity because of tragic misunderstandings), so his life's work has become the common possession of all Christendom, first, in his native land and, then, increasingly in other countries. For what Newman has to say actually concerns the whole Christian world.

ORGANIZATIONAL STRATEGY, INDIVIDUAL PERSONALITY AND INNOVATION BEHAVIOR

2005 ◽  
Vol 13 (01) ◽  
pp. 7-19 ◽  
Author(s):  
BJØRN WILLY ÅMO ◽  
LARS KOLVEREID
Keyword(s):  
Corporate Entrepreneurship ◽  
The Other ◽  
Business Graduates ◽  
Individual Personality ◽  
Competing Models ◽  
The Individual ◽  
Personality Models ◽  
Innovation And Change ◽  
Better Than ◽  
Innovation Behavior

Two competing models of innovation behavior in organizations are tested. The first model is derived from the corporate entrepreneurship literature, suggesting that the extent to which the organization has a deliberate entrepreneurship strategy determine employees' involvement in innovation and change (Kanter, 1984). The competing model is derived from the intrapreneurship literature, primarily Pinchot (1985) and Pinchot and Pellman (1999), where the emphasis is on the employee's individual personality measured by items derived from Pinchot's (1985) test: "Are you an intrapreneur?" Both models are compared to a base model that contains relevant control variables. Finally, a fourth model, which combines all variables are compared to the other three. The models are tested using a sample of 634 business graduates employed in a diverse set of occupations and organizations. The results indicate that both the strategy and personality models outperform the base model. Moreover, the model that combines the personality of the individual and the strategy of the organization performs even better than the each of the two models separately.

scholarly journals In Architecture Inference The role of inference in the development of creative abilities of architecture student

2017 ◽  
Vol 5 (2) ◽  
pp. 64-79
Author(s):  
Basim Hasan Almajedi ◽  
Aymen Abdul hussein Jawad
Keyword(s):  
Architectural Design ◽  
Common Factors ◽  
New Product ◽  
Research Problem ◽  
The Other ◽  
Product Architecture ◽  
Inference Process ◽  
The Common ◽  
The Individual

Inference process is an important part in the architectural design process as well as to realize the different aspects of the product architecture, and plays an important role in bringing new products of an innovator and contrary to traditional productions, through the investment of available data and linking them with the individual and previous expertise and experience for getting creative output in architecture. The research  Inference in the architecture field in addition to the other importance of cognitive fields, And the in architecture Special through students from them problems in the weak evidentiary have a base, from here the research problem of (Ambiguity of available knowledge about the role of inference Resources in the development of creative ability with the architecture students), to achieve the goal of research in architectural directed toward investment sources inference in generating solutions to creative problems of design to get into creative output in architecture, to highlight the research hypotheses, was where the hypothesis key b (Whenever inventories increased in the architecture students memory, increased his capabilities and creative skills in design), to be then test these hypotheses through questionnaire to a group of students, where it was found that (The multiplicity of views and reasoning process by the architecture students help him to produce and give many and varied images of processors design solutions, which may contain the common factors that contribute to the formation of a new product of an architect and has a unique and iconic properties).

scholarly journals Someone Else’s Child: A Co-Constructed, Performance Autoethnography of Adoption from Three Perspectives

2021 ◽  
Author(s):  
Robin Danzak ◽  
Christina Gunther ◽  
Michelle Cole
Keyword(s):  
Relevant Literature ◽  
Family Members ◽  
Group Processes ◽  
Reflective Writing ◽  
The Other ◽  
Transnational Adoption ◽  
School Year ◽  
The Common ◽  
The Individual ◽  
Document Review

Through a framework of reconciling the other, this collaborative autoethnographic performance co-constructs the adoption experience from three perspectives in three different families: a mother struggling with the ethical and emotional implications of the transnational adoption of her daughter; an adult reflecting on her childhood as an adoptee feeling loved, but different; and a woman who met her biological sister at age 28 after her parents revealed a lifelong secret. To develop individual adoption narratives, we applied autoethnographic tools of interactive interviews with family members, reflective writing, and document review (Ellis, 2004) of photos, letters, emails, and calendars. During one school year, we met monthly to discuss relevant literature, share and critique each other’s methods and writing, and identify the common themes in our three, diverse experiences. The result of the iteration of the individual and group processes is a script that weaves together our adoption stories, the discoveries of ourselves, and how, after negotiating feelings and identities, we reconciled the other through positive, loving relationships.

Imagined Exegesis: Text and Picture in the Exegetical Works of Rupert of Deutz, Honorius Augustodunensis, and Gerhoch of Reichersberg

Traditio ◽  
1988 ◽  
Vol 44 ◽  
pp. 145-169 ◽  
Author(s):  
Michael Curschmann
Keyword(s):  
Fourteenth Century ◽  
Thirteenth Century ◽  
The Other ◽  
Common Denominator ◽  
Collective Knowledge ◽  
The Common ◽  
The Individual ◽  
Mind's Eye ◽  
The Doors

Probably not long before the middle of the thirteenth century, Richard of Fournival, cleric, physician, and author, sent to an unnamed lady the autograph copy of his richly illustrated Bestiaire d'amours. In the prologue, Richard goes to some lengths to explain and justify the inclusion of pictures: hearing (oir) and vision (veir) are the doors through which collective knowledge is transmitted to the individual mind and memory (memoire), and word (parole) and picture (peinture) are the paths to these doors. Either one or the other route could have been chosen — in principle, they represent equivalent alternatives — but Richard is sending both words and pictures, because he wants to make doubly sure that the lady will indeed remember, that is to say, make his love the object of her own memory. The common denominator for word and picture is ‘image,’ and that is the notion on which the illustrator of one of the fourteenth-century copies of the Bestiaire based his introduction to the corresponding modes of reception: on folio 86v he depicted a reader who imagines what he reads (fig. 1); battle-ready warriors of romance stand before this seated figure in the privacy of his own room (indicated by the drapes), before his mind's eye, as it were, conjured up by the words of the text.

Modeling for the Aerodynamics Analysis of the Four Blades Movable Vanes Type Vertical Axis Wind Turbine (VVAWT)

2015 ◽  
Vol 793 ◽  
pp. 338-342
Author(s):  
Kadhim Hussein Suffer ◽  
Ghulam Abdul Quadir ◽  
Khairul Azwan bin Ismail ◽  
Ryspek Uzobomatove
Keyword(s):  
Wind Turbine ◽  
Turbulence Models ◽  
Vertical Axis ◽  
The Other ◽  
Vertical Axis Wind Turbine ◽  
Computational Fluid Dynamics Cfd ◽  
Aerodynamic Parameters ◽  
The Individual ◽  
Better Than ◽  
Good Agreement

The power generated by a Vertical Axis Wind Turbine (VAWT) depends on the drag force generated by the individual blades and interactions between them in a rotating configuration. The present Analysis is on attempt to predict numerically the coefficient of drag and other aerodynamic parameters for a four blade Vane type Vertical Axis Wind Turbine (VVAWT) with different blades and vanes position. For numerical investigation, commercial available computational fluid dynamics CFD software GAMBIT and FLUENT are used. In this numerical analysis the Shear Stress Transport (SST) k-ω turbulence model is used which is better than the other turbulence models available as suggested by some researchers. The computed results show good agreement with published experimental results.

scholarly journals The Sonority Sequencing Principle and the Structure of Slovak Consonant Clusters

2021 ◽  
Vol 56 ◽  
Author(s):  
Renáta Gregová
Keyword(s):  
Functional Approach ◽  
The Other ◽  
Consonant Clusters ◽  
The Common ◽  
The Creation ◽  
The Individual

The Sonority Sequencing Principle and the Structure of Slovak Consonant ClustersIn line with the Sonority Sequencing Principle (SSP), the centre of the syllable is the most sonorous sound and the sonority of the other segments in the syllable drops towards the syllable edges. Nevertheless, in many languages, there are syllable onsets and codas that violate this principle of sonority. Following the functional approach proposed by Jerzy Kuryłowicz, types of word/syllable-initial and word/syllable-final clusters in standard Slovak were delimited. A sonority-based analysis of those clusters revealed that almost 40% of the common initial consonant sequences violate the SSP. The situation with the final clusters is similar. These findings indicate that the creation of consonant clusters in a language does not depend solely on the sonority of the individual segments but also follows other phonological and/or perceptual regularities connected with the process of communication. Zasada sekwencji sonorności a struktura zbitek spółgłoskowych w języku słowackimZgodnie z zasadą sekwencji sonorności (Sonority Sequencing Principle, SSP) jądro sylaby jest dźwiękiem o najwyższej sonorności, a sonorność pozostałych segmentów sylaby maleje wraz z odległością od jądra. Niemniej jednak w wielu językach występują nagłosy i wygłosy, które naruszają tę zasadę. Przyjmując podejście funkcjonalne zaproponowane przez Jerzego Kuryłowicza, wyróżniono typy zbitek w nagłosie i wygłosie w standardowym języku słowackim. Ich analiza pod względem sonorności wykazała, że prawie 40% sekwencji powszechnie występujących w nagłosie narusza zasadę sekwencji sonorności. W przypadku wygłosu wynik był podobny. Ustalenia te wskazują, że tworzenie zbitek spółgłoskowych nie zależy wyłącznie od sonorności poszczególnych segmentów, ale również od innych prawidłowości fonologicznych i/lub percepcyjnych związanych z procesem komunikacji.

scholarly journals Traditional and Modern Concepts of Rhetoric: Six Peculiarities

wisdom ◽  
2020 ◽  
Vol 16 (3) ◽  
pp. 18-27
Author(s):  
Hovhannes HOVHANNISYAN
Keyword(s):  
The Other ◽  
Theoretical Knowledge ◽  
Philosophical Theory ◽  
Human Communication ◽  
Direct Speech ◽  
Modern System ◽  
Logical Content ◽  
The Common ◽  
The One ◽  
The Individual

The article explores the common denominators and differences of traditional and modern understandings of rhetoric. It reveals main tendencies of development of rhetoric as a field of theoretical knowledge and transformations of the problematics. The issue of interrelation between logical-content and extra-logical (psychological, aesthetic, ethical, linguistic, ritual) factors in traditional and modern concepts of rhetoric is discussed. The following thesis is substantiated that in modern concepts of rhetoric both the arsenal of tricks used and the area of operation are expanded to include other forms and manifestations of human communication in line with the individual-to-audience model. It is argued that, unlike traditional rhetoric, which is largely monologue-based, modern concepts mostly implement rhetoric tricks in negotiation, debate, and competition situations. The article analyzes the issue of correlation between oral public and direct speech on the one hand, and, on the other, written speech and mediated means of communication in the traditional and modern concepts of rhetoric. The view is substantiated that in the modern system of rhetoric, much importance is attached to ethical questions, to the issues whether the means used are permissible or inadmissible in terms of effective communication norms. The relations between the philosophical theory of rhetoric (general rhetoric) and its individual spheres are discussed.

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