Práškové částice pro plicní podání

The deposition of a drug to its required destination is crucial for effective lung treatment. It is important to design a suitable formulation that delivers the active ingredient to the desired site and resists the natural cleansing mechanisms of the airways. Large porous particles used as active substance carriers appear to be the most effective option for lung drug delivery. The present article provides a basic overview of the mechanisms of deposition of dry inhalable powders and methods of their preparation and evaluation. Spray drying together with micronization and crystallization techniques are among the most used methods of preparation of the discussed particles. Besides, these techniques can be combined with other production processes (encapsulation, emulsification, etc.). The evaluation of the properties of particles suitable for pulmonary application is based on specific requirements for their density, porosity, shape, aerodynamic parameters, and deposition in the lungs, which can now be simulated on an accurate model of artificial lungs.

Experimental and Numerical Analysis of the Impeller Backside Cavity in a Centrifugal Compressor for CAES

Relying on a closed test rig of a high-power intercooling centrifugal compressor for compressed air energy storage (CAES), this study measured the static pressure and static temperature at different radii on the static wall of the impeller backside cavity (IBC) under variable rotating speeds. Simultaneously, the coupled computations of all mainstream domains with IBC or not were used for comparative analysis of the aerodynamic performances of the compressor and the internal flow field in IBC. The results show that IBC has a significant impact on coupling characteristics including pressure ratio, efficiency, torque, shaft power, and axial thrust of the centrifugal compressor. The gradients of radial static pressure and static temperature in IBC both increase with the decrease of mainstream flow or the increase of rotating speed, whose distributions are different under variable rotating speeds due to the change of the aerodynamic parameters of mainstream.

Aircraft Control Parameter Estimation Using Self-Adaptive Teaching-Learning-Based Optimization with an Acceptance Probability

This work presents a metaheuristic (MH) termed, self-adaptive teaching-learning-based optimization, with an acceptance probability for aircraft parameter estimation. An inverse optimization problem is presented for aircraft longitudinal parameter estimation. The problem is posed to find longitudinal aerodynamic parameters by minimising errors between real flight data and those calculated from the dynamic equations. The HANSA-3 aircraft is used for numerical validation. Several established MHs along with the proposed algorithm are used to solve the proposed optimization problem, while their search performance is investigated compared to a conventional output error method (OEM). The results show that the proposed algorithm is the best performer in terms of search convergence and consistency. This work is said to be the baseline for purely applying MHs for aircraft parameter estimation.

AERODYNAMIC OPTIMISATION OF DEVELOPED LAND SUSTAINABLE TOWER ISLAND

Economic and usable benefits from the proper land development may be programmed as early as at the stage of designing by forming structures that are both economic and comfortable, which is in accordance with assumptions of architechnology. This work presents the method of calculating particular aerodynamic parameters of the urban complex Sustainable Tower Island in KobylnicaLigowiec. The article analyses the wind speed and its pressure on walls of buildings depending on the height above ground level. Knowing these parameters allows optimisation of the location of devices collecting energy from renewable energy sources.

Airfoil Analysis and Effect of Wing Shape Optimization on Aerodynamic Parameters in a Steady Flight

The work in this paper deals with reconstructing and optimizing the wing geometry of an Unmanned Combat Aerial Vehicle for improved performance and reviewing the impact of the modification on flight parameters in a steady flight. The behavior of airfoils at planned flight conditions under I.S.A. is checked in XFLR5 software. Following up by 2-D CFD and boundary layer analysis of former and new airfoil, dimensions of the wing are re-developed, keeping the fuselage and tail structure same. The existing wing and the optimized wing design is analyzed by Vortex Lattice Method and Triangular Panel Method, with an objective to make the shape of the wing aerodynamically suitable for an increased Lift to Drag ratio and thereby minimizing drag coefficients.

ASSESSMENT AND ANALYSIS OF AERODYNAMIC PARAMETERS OF AIR FLOWS FOR EFFECTIVE SELECTION OF AIR SUPPLY SCHEMES IN COAL MINES

The article examines a complex technical system on the example of air supply of coal mines, characterized by: multicomponent, a large number of quantitative and qualitative parameters, nonlinearity of interdependencies between them; incompleteness of information, the complexity of experimental research, the risks of dangerous situations and the catastrophic nature of their consequences; the uniqueness of the modes and conditions of the systems functioning. The aim of the work is to develop a methodology for assessing and analyzing the aerodynamic parameters of air flows for the effective selection of air supply schemes in coal mines using the decomposition method. Research methodology: the solution of the set tasks is based on modern methods of mathematical statistics; graph theory; decision theory; apparatus of mathematical logic; factor analysis; mathematical modeling; set theory; reliability theory and systems analysis. Research results. A method for the analysis and analytical modeling of complex technical systems of variable structure (CTS VS) is developed, focused on the features of these systems and their processes in conditions of incomplete information, different quality data on their state and functioning, which differs from the known ones by a combination of the capabilities of analytical and statistical approaches to the construction of CTS VS models, which allows to adapt to changes in systemic and external factors, improve the accuracy of modeling, and also typify the presentation of fuzzy situational features for effective management of the CTS VS. Conclusion. A method has been developed for assessing the reliability of the parameters of the CTS VS based on the algorithms for analyzing and assessing the reliability of the CTS VS, the algorithm for the formation of the most complete subsets listing in the graph all possible compatible subsets of a given set of vertices differing in that they are based on the analysis of enlarged states and decomposition of the structural diagram, which allows analytical and statistical studies to significantly increase the accuracy of assessing the reliability of CTS VS and reduce the amount of calculations. Result: the proposed methods were used to solve the problems of air distribution control in coal mines.

Acoustic, Myoelectric, and Aerodynamic Parameters of Euphonic and Dysphonic Voices: A Systematic Review of Clinical Studies

Background: At present, there is no clinical consensus on the concept of normal and dysphonic voices. For many years, the establishment of a consensus on the terminology related to normal and pathological voices has been studied, in order to facilitate the communication between professionals in the field of the voice. Aim: systematically review the literature to compare and learn more precisely the measurable and objective characteristics of the acoustic, aerodynamic and surface electromyographic parameters of the normal and dysphonic voices. Methods: The PRISMA 2020 methodology was used as a review protocol together with the PICO procedure to answer the research question through six databases. Results: In total, 467 articles were found. After duplicate records were removed from the selection, the inclusion and exclusion criteria were applied and 19 articles were eligible. A qualitative synthesis of the included studies is presented in terms of their methodology and results. Conclusions: Studying the acoustic, aerodynamic, and electromyographic parameters with more precision, in both normal and dysphonic voices, will allow health professionals working in the field of voice (speech therapy, otorhinolaryngology, phoniatrics, etc.) to establish a diagnostic and detailed consensus of the vocal pathology, enhancing the communication and generalization of results worldwide.

Development of cost-effective shock tube based on experimental and numerical analysis

Purpose The purpose of the study is to design economical shock tube. It is an instrument used for experimental investigations not only related to shock phenomena but also for the behavior of the material when it is subjected to high-speed flow. The material used here in this shock tube is stainless steel ss304 and aluminum. A shock tube consists of two sections, namely, the driver and the driven. The gas in the driven and driver is filled with atmospheric air and nitrogen, respectively, under the predominant condition. Design/methodology/approach The focus of the study is on the design and fabrication of shock tubes. a shock tube is a research tool to make an aerodynamic test in the presence of high pressure and temperature by generating moving normal shock waves under controlled conditions. Findings The main necessity for instrumentation in the shock tube experiment is to know the velocity of the moving shock wave from which the other parameters can be calculated. the pressure transducers are located in the shock tube in various locations to measure aerodynamic parameters in terms of pressure. Originality/value The main objective of this project work is to make an experimental setup to produce supersonic velocity with the readily available material in the market in a highly safe manner.