Apolipoprotein E (APOE) ϵ4 Allele Is Associated with Increased Symptom Reporting Following Sports Concussion

2015 ◽  
Vol 22 (1) ◽  
pp. 89-94 ◽  
Author(s):  
Victoria C. Merritt ◽  
Peter A. Arnett
Keyword(s):  
Apolipoprotein E ◽  
Symptom Score ◽  
Neuropsychological Testing ◽  
Apoe Genotype ◽  
Collegiate Athletes ◽  
Symptom Clusters ◽  
Total Symptom Score ◽  
Symptom Scale ◽  
Sports Concussion ◽  
The Relationship

AbstractExploring the relationship between genetic factors and outcome following brain injury has received increased attention in recent years. However, few studies have evaluated the influence of genes on specific sequelae of concussion. The purpose of this study was to determine how the ϵ4 allele of the apolipoprotein E (APOE) gene influences symptom expression following sports-related concussion. Participants included 42 collegiate athletes who underwent neuropsychological testing, including completion of the Post-Concussion Symptom Scale (PCSS), within 3 months after sustaining a concussion (73.8% were evaluated within 1 week). Athletes provided buccal samples that were analyzed to determine the make-up of their APOE genotype. Dependent variables included a total symptom score and four symptom clusters derived from the PCSS. Mann-Whitney U tests showed higher scores reported by athletes with the ϵ4 allele compared to those without it on the total symptom score and the physical and cognitive symptom clusters. Furthermore, logistic regression showed that the ϵ4 allele independently predicted those athletes who reported physical and cognitive symptoms following concussion. These findings illustrate that ϵ4+ athletes report greater symptomatology post-concussion than ϵ4- athletes, suggesting that the ϵ4 genotype may confer risk for poorer post-concussion outcome. (JINS, 2016, 22, 89–94)

scholarly journals The Relationship Between the Post-Concussion Symptom Scale and State-Trait Anxiety Inventory in Concussed Athletes

2019 ◽  
Vol 34 (5) ◽  
pp. 755-755
Author(s):  
K Stephenson-Brown ◽  
A Otwell ◽  
P Schatz ◽  
M Womble ◽  
R J Elbin
Keyword(s):  
Trait Anxiety ◽  
State Anxiety ◽  
Rank Order ◽  
Statistical Significance ◽  
Symptom Clusters ◽  
State Trait Anxiety Inventory ◽  
Adolescent Athletes ◽  
Symptom Scale ◽  
Clinical Visit ◽  
The Relationship

Abstract Purpose To document the relationship between concussion symptoms and state anxiety in concussed adolescent athletes. Methods One hundred fifty-three concussed athletes (mean age=16.06, SD=1.62 yrs.) completed the Post-Concussion Symptom Scale (PCSS) and the State-Trait Anxiety Inventory (STAI) at their initial clinical visit within 30 days of injury (M=8.29, SD=6.46 days). Due to violations of normality (Shapiro-Wilk=.95), Spearman’s Rank Order correlations were conducted between STAI state scores and PCSS affective, somatic, cognitive-migraine-fatigue, and sleep clusters and total symptoms. Correlations were also conducted within sub-samples of patients seen within one week (M=3.80, SD=1.72days) and 8 – 30 days post-injury (M=13.91, SD=5.76 days). Statistical significance was set at (p<.05). Results In the total sample (n=153), STAI state scores were significantly associated with total symptoms (r=.54), and the affective (r=.53), sleep (r=.44), cognitive-migraine-fatigue (r=.47), and somatic (r=.33) symptom clusters. All significant relationships among STAI state scores and PCSS total symptoms and symptom clusters were retained for patients seen within 1 week as well as patients completing their first clinical visit 8-30 days post-concussion (p<.05). Conclusion Post-concussion endorsement of concussion symptoms increases as a function of state anxiety. Although the PCSS affective symptom cluster is not a validated measure to diagnose anxiety; these findings support the utility of the PCSS to evaluate for potentially elevated anxiety in concussed adolescent athletes.

scholarly journals Apolipoprotein E Genotype and the Relationship Between Chitinase 3–Like Protein 1 and Postoperative Delirium

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 249-249
Author(s):  
Sarinnapha Vasunilashorn ◽  
Long Ngo ◽  
Sharon Inouye ◽  
Tamara Fong ◽  
Richard Jones ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Postoperative Delirium ◽  
Linear Models ◽  
Inflammatory Marker ◽  
Apoe Genotype ◽  
Confusion Assessment Method ◽  
Assessment Method ◽  
Reactive Protein ◽  
Increased Risk ◽  
The Relationship

Abstract Apolipoprotein E (APOE) ɛ4 does not confer increased risk of delirium in older surgical patients; however, ɛ4 status modifies the relationship of C-reactive protein (CRP) with delirium: increased risk for delirium in ɛ4 carriers with high CRP. We examine whether APOE genotype modifies the established association between inflammatory marker chitinase-3-like protein-1 (CHI3LI/YKL-40) and delirium in patients without dementia age≥70 undergoing major non-cardiac surgery. We performed APOE genotyping using PCR, considering APOE ɛ4 vs. non-ɛ4 carriers. Plasma YKL-40, measured on postoperative day 2 by ELISA, was examined using sample-based quartiles (Q1-Q4). Delirium status was determined with daily interviews rating the Confusion Assessment Method, augmented by a validated chart review. We used generalized linear models adjusted for age, sex, surgery type, and stratified by APOE ɛ4 status. Among the 557 patients, 19% were APOE ɛ4 carriers, and 24% developed postoperative delirium. The YKL-40-delirium relationship differed by APOE status. Among APOE non-ɛ4 carriers, we found a significant relationship between YKL-40 and delirium (relative risk [RR](95% confidence interval [CI] for YKL-40 Q4 vs. Q1: 2.6(1.4-4.9) and Q3 vs. Q1: 2.3(1.2-4.5); p-trend&lt;.01). Among APOE ɛ4 carriers, YKL-40 was not significantly associated with delirium (RR(95% CI) for YKL-40 Q4 vs. Q1: 2.0(0.6-6.6) and Q3 vs. Q1:1.1(0.3-3.5); p-trend=0.37). APOE non-ɛ4 carriers may have increased risk of delirium conferred by post-surgical inflammation specific to the type 2 immune response (high YKL-40). These results differ from prior results with CRP, and raise the possibility that APOE genotype may interact at different points in the inflammatory pathway leading to delirium.

Sleep Deprived or Concussed? The Acute Impact of Self-Reported Insufficient Sleep in College Athletes

2020 ◽  
pp. 1-12 ◽  
Author(s):  
Kaitlin E. Riegler ◽  
Erin T. Guty ◽  
Garrett A. Thomas ◽  
Peter A. Arnett
Keyword(s):  
Neuropsychological Test ◽  
Collegiate Athletes ◽  
Symptom Scale ◽  
Insufficient Sleep ◽  
Sample Mean ◽  
Objective Performance ◽  
Valid Comparison ◽  
The Relationship ◽  
Negative Health Outcomes ◽  
Sleep Difficulties

Abstract Objective: Sleep deprivation is common among both college students and athletes and has been correlated with negative health outcomes, including worse cognition. As such, the current study sought to examine the relationship between sleep difficulties and self-reported symptoms and objective neuropsychological performance at baseline and post-concussion in collegiate athletes. Method: Seven hundred seventy-two collegiate athletes completed a comprehensive neuropsychological test battery at baseline and/or post-concussion. Athletes were separated into two groups based on the amount of sleep the night prior to testing. The sleep duration cutoffs for these group were empirically determined by sample mean and standard deviation (M = 7.07, SD = 1.29). Results: Compared with athletes getting sufficient sleep, those getting insufficient sleep the night prior to baseline reported significantly more overall symptoms and more symptoms from each of the five symptom clusters of the Post-Concussion Symptom Scale. However, there were no significant differences on objective performance indices. Secondly, there were no significant differences on any of the outcome measures, except for sleep symptoms and headache, between athletes getting insufficient sleep at baseline and those getting sufficient sleep post-concussion. Conclusion: Overall, the effect of insufficient sleep at baseline can make an athlete appear similar to a concussed athlete with sufficient sleep. As such, athletes completing a baseline assessment following insufficient sleep could be underperforming cognitively and reporting elevated symptoms that would skew post-concussion comparisons. Therefore, there may need to be consideration of prior night’s sleep when determining whether a baseline can be used as a valid comparison.

Physical Exercise Moderates the Relationship of Apolipoprotein E (APOE) Genotype and Dementia Risk: A Population-Based Study

2017 ◽  
Vol 56 (1) ◽  
pp. 297-303 ◽  
Author(s):  
Barbara Fenesi ◽  
Hanna Fang ◽  
Ana Kovacevic ◽  
Mark Oremus ◽  
Parminder Raina ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Apolipoprotein E ◽  
Apoe Genotype ◽  
Population Based ◽  
Population Based Study ◽  
Dementia Risk ◽  
Relationship Of ◽  
The Relationship

Cognitive asymmetries associated with apolipoprotein E genotype in patients with Alzheimer's disease

2003 ◽  
Vol 9 (5) ◽  
pp. 751-759 ◽  
Author(s):  
MICHAEL J. FINTON ◽  
JOHN A. LUCAS ◽  
JULIE D. RIPPETH ◽  
DARYL L. BOHAC ◽  
GLENN E. SMITH ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Apolipoprotein E ◽  
Cognitive Performance ◽  
Cognitive Abilities ◽  
Apoe Genotype ◽  
Unique Contribution ◽  
Apoe Ε4 ◽  
Ε4 Allele ◽  
The Relationship

The relationship between apolipoprotein E (apoE) genotype and cognitive performance was examined in 200 patients with probable Alzheimer's disease (AD). Differences between composite measures of verbal and nonverbal functioning were used to define asymmetric patterns of cognition. Patients who were homozygous for apoE ε4 demonstrated relatively worse nonverbal as compared to verbal cognitive ability. In contrast, participants who were heterozygous for apoE ε4 or who possessed no ε4 allele demonstrated relatively equivalent verbal and nonverbal cognitive abilities. Although age and dementia severity also contributed to these patterns, apoE genotype appears to have a significant unique contribution to cognitive performance in these individuals. The ε4 allele may thus be associated with a specific neurocognitive phenotype among patients with AD, with the overall pattern of cognitive asymmetry dependent upon ε4 dose. (JINS, 2003, 9, 751–759.)

Apolipoprotein E genotype and lifetime cognitive decline

2008 ◽  
Vol 20 (1) ◽  
pp. 109-123 ◽  
Author(s):  
Nicholas A. Kozauer ◽  
Michelle M. Mielke ◽  
Gary Kwun Chuen Chan ◽  
George W. Rebok ◽  
Constantine G. Lyketsos
Keyword(s):  
Cognitive Decline ◽  
Apolipoprotein E ◽  
Verbal Learning ◽  
Apoe Genotype ◽  
Recall Task ◽  
Cognitive Testing ◽  
Older Individuals ◽  
Delayed Recall ◽  
Epidemiologic Catchment Area Study ◽  
The Relationship

ABSTRACTObjective: The relationship of apolipoprotein E (APOE) genotype to lifetime cognitive decline was examined over 22 years in a large community-based population study.Method: The sample for the present study was derived from follow-up of a probability sample of the adult household residents of East Baltimore. From the Baltimore cohort of the Epidemiologic Catchment Area Study, genotype data were collected on 818 participants at the study's fourth wave between 2003 and 2004. Participants were administered the Mini-mental State Examination (MMSE) at all four study waves. Three tests of verbal learning – immediate recall, delayed recall, and word recognition – were completed at waves 3 and 4. The 659 participants for whom genetic data were available had also completed cognitive testing at all time points. Test scores and changes in these scores were examined by APOE genotype group (x/x or 4/x) in younger and older subcohorts defined by age at wave 4 (< or ≥ age 65).Results: Cross-sectional wave 4 scores on all four cognitive tasks were lower in APOEε4 carriers when compared to non-carriers. In longitudinal univariate models ε4 carriers in the younger cohort demonstrated a greater annual rate of decline on a delayed recall task and MMSE. After adjusting for covariates only the decline in the delayed recall task was significant.Conclusion: We report an association between APOE genotype and decline in delayed recall and possibly MMSE over this extended time period limited to younger individuals. The lack of an association between APOE and decline in older individuals is likely to be the result of survival bias. Although a clear association exists between APOE genotype and cognitive decline or dementia in late life, these findings suggest that over the lifespan the relationship between APOE and cognitive decline is more complicated.

scholarly journals Apolipoprotein E Polymorphisms and Parkinson Disease With or Without Dementia: A Meta-Analysis Including 6453 Participants

2018 ◽  
Vol 32 (1) ◽  
pp. 3-15 ◽  
Author(s):  
Ruoyi Sun ◽  
Simin Yang ◽  
Bing Zheng ◽  
Jianping Liu ◽  
Xiaowei Ma
Keyword(s):  
Parkinson Disease ◽  
Apolipoprotein E ◽  
Protective Factor ◽  
Meta Analysis ◽  
Apoe Genotype ◽  
Case Control ◽  
Case Group ◽  
Case Control Studies ◽  
Ε4 Allele ◽  
The Relationship

A large number of case–control studies have investigated the association of apolipoprotein E ( APOE) polymorphisms with Parkinson disease (PD) and Parkinson disease dementia (PDD), with inconsistent results. This meta-analysis aimed to evaluate the relationship between APOE polymorphisms and PD/PDD risk. We searched for published studies in PubMed, Web of Science, WanFang Data (in Chinese), and CNKI (in Chinese) from inception to June 2017. Case–control studies reporting part or complete APOE genotype and allele frequency data were included. Pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated using RevMan 5.3 software. A total of 39 studies involving 6453 cases with PD, with 461 cases with PDD, and 6855 controls were included in this meta-analysis. The results showed that the APOE ε3 allele was a protective factor for PD (OR = 0.90, 95% CI: 0.81-0.99; P = .04), whereas no significant differences in PD risk among all cases compared to controls were found for APOE ε2 and ε4. In Asian subgroups, the APOE ε4 allele was shown to be a risk factor for PD (OR = 1.22, 95% CI: 1.01-1.46; P = .04). Additionally, APOE polymorphisms were significantly associated with PDD risk in the entire case group (ε3: OR = 0.72, 95% CI: 0.58-0.89, P = .003; ε4: OR = 1.46, 95% CI: 1.12-1.88, P = .004) and in Asian subgroups.

NEUROPSYCHOLOGICAL CHANGES IN PATIENTS WITH A CONSEQUENCE OF TRAUMATIC BRAIN INJURY

2020 ◽  
Vol 3 (1) ◽  
pp. 44-46
Author(s):  
Istatillo Shodjalilov ◽  
◽  
Saoda Igamova ◽  
Aziza Djurabekova
Keyword(s):  
Traumatic Brain Injury ◽  
Cognitive Impairment ◽  
Brain Injury ◽  
Neuropsychological Testing ◽  
Anxiety And Depression ◽  
Psychopathological Symptoms ◽  
Neuropsychological Changes ◽  
The Relationship

The incidence of cognitive impairment in TBI is high, depending on the severity. At the same time, psychopathological symptoms in the form of asthenia, increased anxiety and depression are encountered among patients with TBI. The work studied the relationship between cognitive and psychopathological symptoms in patients with TBI using neuropsychological testing on scales.

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