scholarly journals Acute Exercise Improves Prefrontal Cortex but not Hippocampal Function in Healthy Adults

2015 ◽  
Vol 21 (10) ◽  
pp. 791-801 ◽  
Author(s):  
Julia C. Basso ◽  
Andrea Shang ◽  
Meredith Elman ◽  
Ryan Karmouta ◽  
Wendy A. Suzuki
Keyword(s):  
Prefrontal Cortex ◽  
Cognitive Function ◽  
Aerobic Exercise ◽  
Cognitive Functions ◽  
Medial Temporal Lobe ◽  
Acute Exercise ◽  
Digit Span ◽  
Verbal Learning ◽  
Control Group ◽  
Randomized Controlled

AbstractThe effects of acute aerobic exercise on cognitive functions in humans have been the subject of much investigation; however, these studies are limited by several factors, including a lack of randomized controlled designs, focus on only a single cognitive function, and testing during or shortly after exercise. Using a randomized controlled design, the present study asked how a single bout of aerobic exercise affects a range of frontal- and medial temporal lobe-dependent cognitive functions and how long these effects last. We randomly assigned 85 subjects to either a vigorous intensity acute aerobic exercise group or a video watching control group. All subjects completed a battery of cognitive tasks both before and 30, 60, 90, or 120 min after the intervention. This battery included the Hopkins Verbal Learning Test-Revised, the Modified Benton Visual Retention Test, the Stroop Color and Word Test, the Symbol Digit Modalities Test, the Digit Span Test, the Trail Making Test, and the Controlled Oral Word Association Test. Based on these measures, composite scores were formed to independently assess prefrontal cortex- and hippocampal-dependent cognition. A three-way mixed Analysis of Variance was used to determine whether differences existed between groups in the change in cognitive function from pre- to post-intervention testing. Acute exercise improved prefrontal cortex- but not hippocampal-dependent functioning, with no differences found between delay groups. Vigorous acute aerobic exercise has beneficial effects on prefrontal cortex-dependent cognition and these effects can last for up to 2 hr after exercise. (JINS, 2015, 21, 791–801)

scholarly journals Short-term interval aerobic exercise training does not improve memory functioning in relapsing-remitting multiple sclerosis—a randomized controlled trial

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e6037 ◽  
Author(s):  
Lisa Baquet ◽  
Helge Hasselmann ◽  
Stefan Patra ◽  
Jan-Patrick Stellmann ◽  
Eik Vettorazzi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Randomized Controlled Trial ◽  
Aerobic Exercise ◽  
Controlled Trial ◽  
Verbal Learning ◽  
Control Group ◽  
Randomized Controlled ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis

Background Only few aerobic exercise intervention trials specifically targeting cognitive functioning have been performed in multiple sclerosis. Objective and Methods This randomized controlled trial with 34 patients in the intervention group (IG) (mean: 38.2 years (±9.6)) and 34 patients in the control group (CG) (mean: 39.6 years (±9.7)) aimed to determine the effects of aerobic exercise on cognition in relapsing-remitting multiple sclerosis (RRMS). The primary outcome was verbal learning assessed by the verbal learning and memory test (VLMT). Patients were randomized to an IG or a waitlist CG. Patients in the IG exercised according to an individually tailored training schedule (with two to three sessions per week for 12 weeks). The primary analysis was carried out using the intention-to-treat (ITT) sample with ANCOVA adjusting for baseline scores. Results A total of 77 patients with RRMS were screened and 68 participants randomized (CG n = 34; IG n = 34). The sample comprised 68% females, had a mean age of 39 years, a mean disease duration of 6.3 years, and a mean expanded disability status scale of 1.8. No significant effects were detected in the ITT analysis for the primary endpoint VLMT or any other cognitive measures. Moreover, no significant treatment effects were observed for quality of life, fatigue, or depressive symptoms. Conclusion This study failed to demonstrate beneficial effects of aerobic exercise on cognition in RRMS. The trial was prospectively registered at clinicaltrials.gov (NCT02005237).

Does cognition-specific computer training have better clinical outcomes than non-specific computer training? A single-blind, randomized controlled trial

2017 ◽  
Vol 32 (2) ◽  
pp. 213-222 ◽  
Author(s):  
Ji-Hyuk Park ◽  
Jin-Hyuck Park
Keyword(s):  
Cognitive Function ◽  
Short Form ◽  
Digit Span ◽  
Verbal Learning ◽  
Bodily Pain ◽  
Computer Training ◽  
Cognitive Domain ◽  
Adult Intelligence Scale ◽  
Randomized Controlled ◽  
Complex Figure

Objective: The purpose of this study was to investigate differences between non-specific computer training (NCT) and cognition-specific computer training (CCT). Design: Randomized controlled experimental study. Setting: Local community welfare center. Subjects: A total of 78 subjects with mild cognitive impairment (MCI) were randomly assigned to the NCT ( n = 39) or CCT group ( n = 39). Intervention: The NCT group underwent NCT using Nintendo Wii for improving functional performance, while the CCT group underwent CCT using CoTras for improving function of the cognitive domain specifically. Subjects in both groups received 30-minute intervention three times a week for 10 weeks. Main measures: To identify effects on cognitive function, the Wechsler Adult Intelligence Scale (WAIS) digit span subtests, Rey Auditory Verbal Learning Test (RAVLT), Trail Making Test–Part B (TMT-B), Rey–Osterrieth Complex Figure Test, and Modified Taylor Complex Figure (MTCF) were used. Health-related quality of life (HRQoL) was assessed using the Short-Form 36-item questionnaire. Results: After 10 weeks, the WAIS subtests (digit span forward: 0.48 ± 0.08 vs. 0.12 ± 0.04; digit span backward: 0.46 ± 0.09 vs. 0.11 ± 0.04) and HRQoL (vitality: 9.05 ± 1.17 vs. 2.69 ± 1.67; role-emotional: 8.31 ± 1.20 vs. 4.15 ± 0.71; mental health: 11.62 ± 1.63 vs. 6.95 ± 1.75; bodily pain: 4.21 ± 2.17 vs. 0.10 ± 0.38) were significantly higher in the NCT group ( P < 0.05). Conclusion: NCT was superior to CCT for improving cognitive function and HRQoL of elderly adults with MCI.

scholarly journals Short-term aerobic training does not improve memory functioning in relapsing remitting multiple sclerosis – a randomized controlled trial

2018 ◽  
Author(s):  
L Baquet ◽  
H Hasselmann ◽  
S Patra ◽  
JP Stellmann ◽  
E Vettorazzi ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Aerobic Exercise ◽  
Verbal Memory ◽  
Exercise Intervention ◽  
Controlled Trial ◽  
Verbal Learning ◽  
Intervention Group ◽  
Control Group ◽  
Randomized Controlled ◽  
Relapsing Remitting

AbstractBackgroundOnly few aerobic exercise intervention trials specifically targeting cognitive functioning have been performed in MS.Objective and methodsThis randomized controlled trial aimed to determine the effects of aerobic exercise on cognition in relapsing-remitting MS. The primary outcome was verbal memory (Verbal learning and memory test, VLMT). Patients were randomized to an intervention group (IG) program or a waitlist control group (CG). Patients in the IG exercised according to an individually tailored training schedule (with 2-3 sessions per week for 12 weeks). The primary analysis was carried out using the intention-to-treat (ITT) sample with ANCOVA adjusting for baseline scores.Results77 RRMS patients were screened and 68 participants randomized (CG n=34; IG n=34). The sample comprised 68% females, had a mean age of 39 years, a mean disease duration of 6.3 years, and a mean EDSS of 1.8. No significant effects were detected in the ITT analysis for the primary endpoint VLMT or any other cognitive measures. Moreover, no significant treatment effects were observed for quality of life, fatigue, or depressive symptoms.ConclusionThis study failed to demonstrate beneficial effects of aerobic exercise on cognition in RRMS.The trial was prospectively registered at clinicaltrials.gov (NCT02005237).

Moderate to heavy infections ofTrichuris trichiuraaffect cognitive function in Jamaican school children

Parasitology ◽  
1992 ◽  
Vol 104 (3) ◽  
pp. 539-547 ◽  
Author(s):  
C. Nokes ◽  
S. M. Grantham-McGregor ◽  
A. W. Sawyer ◽  
E. S. Cooper ◽  
B. A. Robinson ◽  
...  
Keyword(s):  
Cognitive Function ◽  
School Children ◽  
Cognitive Functions ◽  
Short Term Memory ◽  
Control Group ◽  
Long Term Memory ◽  
Double Blind ◽  
Term Memory ◽  
Confounding Variables ◽  
Placebo Trial

A double-blind placebo trial was conducted to determine the effect of moderate to high loads ofTrichuris trichiura(whipworm) infection on the cognitive functions of 159 school children (age 9–12 years) in Jamaica. Infected children were randomly assigned to Treatment or Placebo groups. A third group of randomly selected uninfected children were assigned to a Control for comparative purposes. The improvement in cognitive function was evaluated using a stepwise multiple linear regression, designed to control for any confounding variables. The expulsion of worms led to a significant improvement in tests of auditory short-term memory (P< 0.02;P< 0.01), and a highly significant improvement in the scanning and retrieval of long-term memory (P< 0.001). After 9 weeks, treated children were no longer significantly different from an uninfected Control group in these three tests of cognitive function. The removal ofT. trichiurawas more important thanAscaris lumbricoidesin determining this improvement. The results suggest that whipworm infection has an adverse effect on certain cognitive functions which is reversible by therapy.

scholarly journals Effects of Diet, Aerobic Exercise, or Both on Non-HDL-C in Adults: A Meta-Analysis of Randomized Controlled Trials

Cholesterol ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
George A. Kelley ◽  
Kristi S. Kelley
Keyword(s):  
Aerobic Exercise ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Statistical Significance ◽  
Density Lipoprotein ◽  
Control Group ◽  
Controlled Trials ◽  
Mixed Effect ◽  
Randomized Controlled ◽  
Effect Model

Purpose. To use the meta-analytic approach to examine the effects of diet (D), aerobic exercise (E), or both (DE) on non-high-density lipoprotein cholesterol (non-HDL-C) in adults. Methods. Randomized controlled trials in adults ≥18 years of age were included. A mixed-effect model was used to combine effect size (ES) results within each subgroup and to compare subgroups (Qb). Heterogeneity was examined using the Q and I2 statistics, and 95% confidence intervals (CI) were also calculated. Statistical significance was set at P≤0.05, while a trend for statistical significance was set between P>0.05, and ≤0.10. Results. A statistically significant exercise minus control group decrease in non-HDL-C was found for DE (7 ESs, 389 participants, x¯=-11.1 mg/dL, 95%  CI=−21.7 to −0.6, P=0.04, Q=2.4, P=0.88, I2=0%), a trend for the D group (7 ESs, 402 participants, x¯=−8.5 mg/dL, 95%  CI=−18.6 to 1.6, P=0.10, Q=0.76, P=0.99, I2=0%), and no change for the E group (7 ESs, 387 participants, x¯=3.0 mg/dL, 95%   CI=−7.1 to 13.1, P=0.56, Q=0.78, P=0.99, I2=0%). Overall, no statistically significant between-group differences were found (Qb=4.1, P=0.12). Conclusions. Diet combined with aerobic exercise may reduce non-HDL-C among adults in some settings.

Continuous versus intermittent aerobic exercise in the improvement of quality of life for women with polycystic ovary syndrome: A randomized controlled trial

2019 ◽  
pp. 135910531986980 ◽  
Author(s):  
Victor Barbosa Ribeiro ◽  
Iris Palma Lopes ◽  
Rosana Maria dos Reis ◽  
Rafael Costa Silva ◽  
Maria Célia Mendes ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Polycystic Ovary Syndrome ◽  
Aerobic Exercise ◽  
Aerobic Training ◽  
Polycystic Ovary ◽  
Control Group ◽  
Ovary Syndrome ◽  
Testosterone Levels ◽  
Randomized Controlled

Polycystic ovary syndrome predisposes alterations which contribute to the reduction of quality of life. This randomized controlled clinical trial study was to evaluate the effect of two protocols of aerobic exercise on quality of life in women with polycystic ovary syndrome. Women were allocated to three groups: continuous aerobic training ( n = 28), intermittent aerobic training ( n = 29), and control group (no training; n = 30). Testosterone levels, body composition indices, and quality of life were assessed at baseline and after 16 weeks of intervention. Both protocols were effective to improve testosterone levels, anthropometric indices, and quality of life in polycystic ovary syndrome women. Thus, these protocols should be included in the clinical environment to improve clinical parameters psychological, biological and social health to this population.

Agomelatine vs fluoxetine: Efficacy and improvement of cognitive functions in patients with MDD

2016 ◽  
Vol 33 (S1) ◽  
pp. S405-S405
Author(s):  
E. Aydın ◽  
M. Güleç ◽  
E. Oral ◽  
A.G. Daloğlu
Keyword(s):  
Cognitive Functions ◽  
Rating Scale ◽  
Word Association ◽  
Digit Span ◽  
Verbal Learning ◽  
Wisconsin Card Sorting Test ◽  
Card Sorting ◽  
Neurocognitive Functions ◽  
Significant Difference ◽  
Competing Interest

IntroductionIn major depressive disorder (MDD) neurocognitive functions are impaired. In addition to melatonergic properties of agomelatine, via 5-HT2C antagonism it increases extracellular noradrenaline and dopamine in frontal cortex and may improve the neurocognitive functions of patients with MDD.Aims and objectivesTo investigate the extent of neurocognitive improvement and efficacy of agomelatine and fluoxetine in patients with MDD.Material and methodAgomelatine 25 mg/day (n: 24) and fluoxetine 20 mg/day (n: 24) were administered to drug-naive unipolar, non-psychotic, non-suicidal MDD patients according to DSM-IV. Evaluations were performed just before the treatment and at the sixth week of treatment via administering Hamilton Depression Rating Scale, Rey Auditory Verbal Learning Test, Controlled Oral Word Association Test (COWAT), Digit Span Test (DST), Trail Making Test (TMT-A/B), Stroop Test and Wisconsin Card Sorting Test.ResultsBoth agomelatine and fluoxetine was found to be efficacious for the treatment of MDD (P < 0.05 for both). Further there was no difference between the antidepressant efficacy of two drugs. Both of the drugs improved measured neurocognitive functions (P < 0.05), except scores of DST (P > 0.05) and only fluoxetine improved significantly scores of COWAT (P < 0.05). Only in terms of TMT-B there was significant difference between groups and agomelatine was superior to fluoxetine (P < 0.05).ConclusionAgomelatine and fluoxetine were efficacious in treatment of MDD. Furthermore both of the drugs improved cognitive functions in patients with MDD. Superiority of agomelatine in improvement of executive functioning (TMT-B) is important and therefore it could be an appropriate choice for MDD patients who have pronounced executive disturbances.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Cognitive Disorders in Hospitalized Adolescent Anorectic and Bulimic Patients

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1 ◽  
Author(s):  
I. Namyslowska ◽  
B. Remberk ◽  
A. Krempa-Kowalewska
Keyword(s):  
Eating Disorders ◽  
Adolescent Girls ◽  
Cognitive Functions ◽  
Digit Span ◽  
Young Patients ◽  
Cognitive Disorders ◽  
Control Group ◽  
Research Results ◽  
Digit Span Test ◽  
Span Test

Objective:The problem of cognitive dysfunction in eating disorders remains controversial and the research results are not univocal. Because of that, research was undertaken on a homogenous group of young patients suffering from eating disorders, hospitalized in the adolescent unit.Method:The cognitive functions were assessed by Wisconsin Card Sorting Test (WCST) and Digit Span Test in the group of 60 adolescent girls (30 anorectic, 30 bulimic) of the same age and compared with the control group of 39 healthy adolescent girls. Also the relation of cognitive disorders with some clinical features of the illness such as the degree of weight loss, BMI at the admission and discharge and the results of EDI test were assessed.Results:Research results did not show statistically significant differences in the performance in the WCST between anorectic and bulimic patients and the control group. However, the group of anorectic patients show the tendency to perform worse in some parameters of WCST (TA, TE, PE, %PE, %CLR) than the control group, althought the results do not reach statistical significance. The results of the bulimic patients were better (p=0.04) than the control group in the Digit Span Test.No correlation was found between clinical data and results in WCST in eating disorder groups of patients while the correlation was found between results of Digit Span Test and BMI at admission in both clinical groups.Conclusions:The research does not fully confirms that patients suffering from eating disorders show deficits in cognitive functions.

Temporal Effects of Acute Walking Exercise on Learning and Memory Function

2017 ◽  
Vol 32 (7) ◽  
pp. 1518-1525 ◽  
Author(s):  
Eveleen Sng ◽  
Emily Frith ◽  
Paul D. Loprinzi
Keyword(s):  
Episodic Memory ◽  
Learning And Memory ◽  
Acute Exercise ◽  
Verbal Learning ◽  
Moderate Intensity ◽  
Control Group ◽  
Memory Encoding ◽  
Temporal Effects ◽  
Better Than

Purpose: To evaluate the temporal effects of acute exercise on episodic memory. Design: A quasi-experimental study. Sample: Eighty-eight college students (N = 22 per group). Measures: Four experimental groups were evaluated, including a control group, exercising prior to memory encoding, exercising during encoding, and exercising during memory consolidation. The exercise stimulus consisted of a 15-minute moderate-intensity walk on a treadmill. Participants completed the Rey Auditory Verbal Learning Test (RAVLT) to assess learning and memory. Prospective memory was assessed via a Red Pen Task. Long-term memory (recognition and attribution) of the RAVLT was assessed 20 minutes and 24 hours after exercise. Analysis: Repeated-measures analysis of variance (ANOVA) assessed the performance of RAVLT scores of trials 1 to 5 across groups. One-way ANOVA assessed the performance of individual trials across groups, whereas χ2 assessed the performance of the Red Pen Task across groups. Results: Regarding learning, the interaction of groups × trial was marginally statistically significant ( F12,332 = 1.773, P = .05), indicating that the group which exercised before encoding did better than the group that exercised during encoding and consolidation. For both 24-hour recognition and attribution performance, the group that exercised before memory encoding performed significantly better than the group that exercised during consolidation ( P = .05 recognition, P = .006 attribution). Discussion: Engaging in a 15-minute bout of moderate-intensity walking before a learning task was effective in influencing long-term episodic memory.

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