A Brief History of the Collaboration between Dr Nathan Gillespie and Professor Nick Martin Including Personal Reflections

2020 ◽  
Vol 23 (2) ◽  
pp. 94-95
Author(s):  
Nathan A. Gillespie
Keyword(s):  
Psychoactive Substance ◽  
Twin Data ◽  
Cross Sectional ◽  
Training And Supervision ◽  
History Of ◽  
Psychoactive Substance Use ◽  
Longitudinal Twin Data ◽  
Longitudinal Twin Study ◽  
Personal Reflections ◽  
Meta Analyses

AbstractThis article describes Dr Nathan Gillespie’s PhD training and supervision under Professor Nick Martin and their ongoing collaborations. Drs Gillespie and Martin have collaborated on numerous biometrical genetic analyses applied to cross-sectional and longitudinal twin data, combined molecular and phenotypic modeling, as well as genomewide meta-analyses of psychoactive substance use and misuse. Dr Gillespie remains an active collaborator with Professor Martin, including ongoing data collection, analysis and publications related to the Brisbane Longitudinal Twin Study.

scholarly journals Associations between psychoactive substance use and sensation seeking behavior among drivers in Norway

2019 ◽  
Author(s):  
Ragnhild Elén Gjulem Jamt ◽  
Hallvard Gjerde ◽  
Håvard Furuhaugen ◽  
Giovanni Romeo ◽  
Vigdis Vindenes ◽  
...  
Keyword(s):  
Substance Use ◽  
Sensation Seeking ◽  
Psychoactive Substance ◽  
Cross Sectional ◽  
Polydrug Use ◽  
The North ◽  
Seeking Behavior ◽  
Psychoactive Substance Use ◽  
Cross Sectional Design ◽  
Sensation Seeking Scale

Abstract BackgroundDrug use and risky driving is associated with sensation seeking. The aim of this study was to investigate the association between use of psychoactive substances and levels of the sensation seeking personality trait as measured with the Brief Sensation Seeking Scale 4 among drivers in Norway. MethodA cross-sectional design was applied to estimate the association between psychoactive substance use and sensation seeking behavior. Drivers in normal traffic were included in two roadside surveys: one in the north (September 2014 – October 2015) and the other in the south-east of Norway (April 2016 – April 2017). Oral fluid was analyzed for alcohol and psychoactive drugs, and data on sex, age and time of participation were recorded. Participants filled in the Brief Sensation Seeking Scale 4 questionnaire. ResultsA total of 8053 drivers were included, of which 32% were women and 62% were under 40 years. The prevalence of alcohol was 0.3%, stimulants 0.6%, tetrahydrocannabinol 1.4% and benzodiazepines and/or z-hypnotics 2.0% and polydrug use 0.6% Associations between the use of tetrahydrocannabinol or benzodiazepines and/or z-hypnotics and a low score on the “thrill and adventure seeking” domain of the Brief Sensation Seeking Scale 4 (OR = 1.723, 95% C.I. = 1.001- 2.966, p = 0.05) were found. Associations were also found between the use of stimulants and the highest scores on the “experience seeking” (OR = 2.085, 95% C.I. = 1.084-4.009, p = 0.028) and “disinhibition” (OR = 4.791, 95% C.I. =1.748-13.135, p = 0.002) domains of the Brief Sensation Seeking Scale 4. No associations were found between sensation seeking behavior and alcohol or polydrug use. ConclusionA high degree of sensation seeking was found among drivers who had used stimulants, in contrast to drives who had used tetrahydrocannabinol and benzodiazepines and/or z-hypnotics who showed a low degree of sensation seeking. The combination of sensation seeking behavior and the use of stimulants might lead to increased risky behavior and thus traffic crashes.

scholarly journals Prevalence and associations of psychoactive substance use among male supportive staff members in a tertiary care hospital of Sri Lanka

BJPsych Open ◽  
2021 ◽  
Vol 7 (S1) ◽  
pp. S293-S293
Author(s):  
Chathurie Suraweera ◽  
Iresha Perera ◽  
Priyanka Rupasinghe ◽  
Janith Galhenage
Keyword(s):  
Substance Use ◽  
Sri Lanka ◽  
Alcohol Use ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Psychoactive Substance ◽  
Staff Members ◽  
History Of ◽  
Psychoactive Substance Use

AimsThe study describes the prevalence and associated socio-demographic variables of psychoactive substance use among male supportive staff members at a tertiary care hospital in Sri Lanka.MethodA cross-sectional descriptive study was carried out among male supportive staff members of a tertiary care hospital in Colombo District, Sri Lanka by using a self-administered anonymous questionnaire. Participants were recruited using stratified cluster sampling in thirteen overseer divisions of the hospital. Anonymous questionnaires were collected into a sealed box and analysed using Statistical Package for Social Sciences 20.ResultThe mean age of the 404 male staff members who participated in the study was 38.78(SD = 10.90) years and 71.5% were married. Among them 202 (49.1%) were educated up to grade 6-11 and 30 of them has had encounters with law in the past. Thirty of participants had history of psychoactive substance use in the family. Alcohol was used more than once a month by 127(30.9%) and more than once a week by 19(4.6%) individuals. Among other substances, tobacco, beetle and beedi were used by 104(25.3%), 78(19.0%) and 18(4.4%) respectively at least once a month. Further, 22(5.3%), 20(4.8%), 7(1.7%) and 7(1.7%) participants used Mava, Cannabis, Methamphetamine and Thool respectively at least less than once a month. Heroin, Tramadol and Morphine were used by two individuals at least less than once a month. Among substance using participants, 132 wished to cut down their habit. Most commonly identified (14.1%) adverse consequence was financial issues secondary to psychoactive substance use. Eleven (4.5%) staff members used the substance at hospital. Alcohol use was associated with age more than 35 years (p = 0.039) and history of forensic involvement (p = 0.038). Tobacco(p = 0.000), beetle (p = 0.056), Cannabis (p = 0.000) and mava (p = 0.015) use were significantly associated with positive forensic history. Supportive staff members’ alcohol and cannabis use was associated with tobacco (p = 0.000, p = 0.000) and beetle use (p = 0.001, p = 0.049). Mava use was associated with alcohol (p = 0.060) use in addition to tobacco (p = 0.020) and beetle use (p = 0.008).Binomial logistic regression revealed alcohol use and beetle use were associated with the number of children in family and above associations.ConclusionCommonest psychoactive substance consumed by supportive staff members were alcohol, tobacco, beetle, Cannabis and Mava in descending order of frequency. Forensic history was significantly associated with substance use. True prevalence of substance use can be higher than these values.

Gamma-Butyrolactone Overdose Potentially Complicated by Co-Ingestion of Industrial Solvent N-Methyl-2-Pyrrolidone

2020 ◽  
Author(s):  
Jonathan Melamed ◽  
Roy Gerona ◽  
Paul D Blanc ◽  
Paul Takamoto ◽  
Stephanie Conner ◽  
...  
Keyword(s):  
Substance Use ◽  
Psychoactive Substance ◽  
New Psychoactive Substance ◽  
Use Patterns ◽  
Endogenous Metabolism ◽  
Gamma Hydroxybutyrate ◽  
Other Substances ◽  
History Of ◽  
Psychoactive Substance Use ◽  
Gamma Butyrolactone

Abstract Gamma-hydroxybutyrate (GHB) is misused as an intoxicant, either alone or concurrently with other substances. Because GHB is illegal, the precursor chemicals 1,4-butanediol and gamma-butyrolactone are also misused for the same effect, either through pre-ingestion alteration or endogenous metabolism to GHB. We describe a case of a 50-year-old man with a history of polysubstance misuse who experienced an overdose of GHB from gamma-butyrolactone ingestion. The patient also co-ingested a common industrial solvent, N-methyl-2-pyrrolidone (NMP). This co-ingested substance raised theoretical concern of metabolism to a GHB congener, underscoring that the emergence of new psychoactive substance use patterns requires ongoing vigilance and toxicologic confirmation.

scholarly journals Prevalence and reasons of use of different psychoactive substances among prisoners at Malir Prison, Karachi.

2020 ◽  
Vol 27 (07) ◽  
pp. 1488-1492
Author(s):  
Muhammad Ilyas Jat ◽  
Muhammad Tarique Arain ◽  
Saima Qureshi ◽  
Kheenpal Das ◽  
Anum Haider
Keyword(s):  
Substance Use ◽  
Peer Pressure ◽  
Cross Sectional Study ◽  
Psychoactive Substance ◽  
Psychoactive Substances ◽  
Ethical Considerations ◽  
Cross Sectional ◽  
History Of ◽  
Male Prisoners ◽  
Study Setting

The use psychoactive substances are on the rise in general population and even seen more among those who are involved in criminal activities. There are many reasons for such irrational use of psychoactive substances. Objectives: To determine the prevalence and reasons of use of different psychoactive substances among prisoners at Malir prison, Karachi. Study Design: Descriptive Cross-Sectional study. Setting: Malir prison, Karachi. Period: 22nd April 2019 to 26th May 2019. Material & Methods: This study was conducted at district Malir prison, Karachi. All the cases who were imprisoned due to any reason and had history of psychoactive substance use were enrolled. Thorough history and examination was carried out. Ethical considerations were taken as per international guidelines. Results: Among all 490 male prisoners who used to take different type of psychoactive substance, majority were of age ranges of 21 to 35 years and 55% were married while 44% were single and 1% were divorced or separated. Out of 490 cases 453 (92%) were using different substances thorough routes other than injections while 37 (8%) were injection users. Majority of prisoners 252 (52%) were using Heroin while 86 (17%) were using Crystals, 74 (15%) Cannabis, 37 (8%) Synthetic substances, 24 (5%) Ice, 6 (1%) Opioid and 11 (2%) were using some other type of substance. The most common reason of substance use was peer pressure followed by fun and frustration. Conclusion: Substance use prevalence is high in prison. Existing services for the management of drug dependence are not meeting the global standard of evidence based comprehensive drug treatment and rehabilitation.

Salud mental y consumo de sustancias psicoactivas en adolescentes colombianos

2018 ◽  
Vol 18 (1) ◽  
pp. 97-106
Author(s):  
Viviana Cruz Ramírez ◽  
Carlos Gómez Restrepo ◽  
Carlos J Rincón
Keyword(s):  
Substance Use ◽  
Anxiety Disorders ◽  
Cross Sectional Study ◽  
Psychoactive Substance ◽  
Psychoactive Substances ◽  
Cross Sectional ◽  
Salud Mental ◽  
Psychoactive Substance Use ◽  
National Mental Health ◽  
Consumo De Sustancias

Introducción: Se ha propuesto una estrecha asociación entre trastornos del afecto y ansiedad en adolescentes con consumo de sustancias. Objetivo: Determinar la prevalencia del consumo de sustancias psicoactivas y los trastornos mentales más frecuentes asociados éste consumo, en adolescentes colombianos. Metodología: Estudio transversal, con datos de la Encuesta Nacional de Salud Mental 2015. Con adolescentes entre 12 y 17 años, en quienes se les aplicó CIDI-CAPI (versión 21.1.3) asistida por computador y Assist modificado. Resultados: Se describió información de 408 adolescentes entre 12 y 17 años que reportan consumo de sustancias psicoactivas por lo menos una vez en la vida, siendo una muestra representativa a nivel nacional. Se encontró que la sustancia de mayor consumo fue el alcohol con una prevalencia de 16,6% (IC95% 14,2-19,2), Bogotá constituye la región con mayor consumo de sustancias con una prevalencia de 33,8% (IC95% 24,7-44,2). Ser hombre entre los 16 y 17 años representa un factor de riesgo para consumo de sustancias, así mismo, presentar trastornos del afecto aumenta 2,28 veces el riesgo de consumo de sustancias psicoactivas. Conclusiones: La población adolescente con trastornos del afecto o ansiedad se encuentra en mayor riesgo de consumir sustancias psicoactivas. Introduction: An association between affective and anxiety disorders has been proposed in adolescents with substance use. Objective: To determine the prevalence of psychoactive substance use and the most frequent mental disorders associated with this consumption, in Colombian adolescents. Methods: This is a cross-sectional study that uses data from the National Mental Health Survey 2015. With adolescents between 12 and 17 years old, in whom CIDI-CAPI (version 21.1.3) was applied by computer and modified ASSIST. Results: A total of 408 adolescents between 12 and 17 years old who reported psychoactive substance use at least once in their lives were described , this group was  a representative sample of national population. The most frequent consumed substance was alcohol with a prevalence of 16.6% (95% CI, 14.2-19.2), Bogotá is the region with the highest consumption of substances with a prevalence of 33.8% (IC95 % 24.7-44.2). Otherwise, being a man between 16 and 17 years old represents a risk factor for substance use. Likewise, presenting affective disorders increases by 2.28 times the risk of psychoactive substance use. Conclusions: adolescents with affective or anxiety disorders are at higher risk of psychoactive substances use, making difficult the treatment and desmonstrating the vulnerability of this population. 

scholarly journals Nigerian Medical Students’ Opinions about Individuals who use and Abuse Psychoactive Substances

2013 ◽  
Vol 7 ◽  
pp. SART.S12129
Author(s):  
Bawo O. James ◽  
Joyce O. Omoaregba
Keyword(s):  
Substance Use ◽  
Medical Students ◽  
Attitude Scale ◽  
Health Providers ◽  
Psychoactive Substance ◽  
Psychoactive Substances ◽  
Positive Attitudes ◽  
History Of ◽  
Psychoactive Substance Use ◽  
Use Factors

Substance use disorders are prevalent in Nigeria. The number of available specialist health providers is inadequate to fill the treatment gap. Interventions can be provided by nonspecialist health providers and have been found to be beneficial. However, attitudes toward substance misuse and misusers can impede the provision of this service. We aimed to determine attitudes of medical trainees toward substance use by utilizing a modified form of the Substance Abuse Attitude Scale (SAAS). Medical students (n = 200) had positive attitudes toward individuals who misuse psychoactive substances. The medial students, however, preferred treatment to be offered by trained specialists and held restrictive views regarding cannabis and alcohol use. More positive attitudes were expressed by participants who were male or had a lifetime history of psychoactive substance use. The role of personal and family-related psychoactive substance use factors are probably associated with attitudinal responses and would require further exploration.

scholarly journals Do sexual expectancies and inhibitions predict high-risk sexual behaviours? Evidence from a cross-sectional survey among young psychoactive substance users in the informal settlements of Kampala, Uganda

2020 ◽  
Author(s):  
Tonny Ssekamatte ◽  
Simon P.S. Kibira ◽  
Moses Tetui ◽  
John Bosco Isunju ◽  
Richard K. Mugambe ◽  
...  
Keyword(s):  
Substance Use ◽  
High Risk ◽  
Sexual Partner ◽  
Informal Settlements ◽  
Psychoactive Substance ◽  
Psychoactive Substances ◽  
Sexual Performance ◽  
Cross Sectional ◽  
Sexual Behaviours ◽  
Psychoactive Substance Use

Abstract Background The use of psychoactive substances is a public health challenge among young people in informal settlements. Though rarely examined, the use of psychoactive substances is linked to sexual expectancies and inhibitions, and consequently high-risk sexual behaviours. This study examined the association between sexual expectancies and inhibitions on high-risk sexual behaviours among young psychoactive substance users (PSU) in the informal settlements of Kampala, Uganda.MethodsThis cross-sectional study recruited 744 young PSU in the informal settlements of Kampala. Data were analysed using Stata 14 software. A ‘modified’ Poisson regression model was used for inferential statistics. Results Of the 744 study participants, 45.6% believed that psychoactive substance use improves sexual performance; 43.3% believed that psychoactive substances make sex more pleasurable; while more than half (53.3%) believed that psychoactive substances give courage or confidence to approach a partner for sex. The belief that psychoactive substance use improves sexual performance (PR 1.14, 95% CI: 1.01-1.30), increases the likelihood of engaging in sex (PR 1.20, 95% CI: 1.04-1.40) or gives courage or confidence to approach a sexual partner (PR 1.21, 95% CI: 1.05-1.39) were positively associated with ever having sex while under the influence of psychoactive substances. The belief that a psychoactive substance user, under the influence of psychoactive substances is more likely to engage in sex (PR 1.48, 95% CI: 1.15-1.90), and likely to find it difficult to refuse sex (PR 1.28, 95% CI: 1.06-1.55) were positively associated with engaging in multiple sexual partnerships. The belief that one easily forgets to use a condom when under the influence of psychoactive substances, was positively associated with inconsistent condom use (PR 1.26, 95% CI: 1.09-1.45).Conclusion Psychoactive substance use expectancies such as the belief that psychoactive substances improve sexual performance, and give courage or confidence to approach a sexual partner, and inhibitions such as an increased likelihood of engaging in sexual intercourse, finding difficulties in refusing to engage in sexual intercourse, and forgetting to use condoms while intoxicated predicted high-risk sexual behaviours among young PSU. Therefore, is essential to implement sexual and reproductive health and risk reduction interventions targeting young PSU in informal settlements.

scholarly journals Associations Between Psychoactive Substance Use And Sensation Seeking Behavior Among Drivers In Norway

2019 ◽  
Author(s):  
Ragnhild Elén Gjulem Jamt ◽  
Hallvard Gjerde ◽  
Håvard Furuhaugen ◽  
Giovanni Romeo ◽  
Vigdis Vindenes ◽  
...  
Keyword(s):  
Substance Use ◽  
Sensation Seeking ◽  
Psychoactive Substance ◽  
Cross Sectional ◽  
Polydrug Use ◽  
The North ◽  
Seeking Behavior ◽  
Psychoactive Substance Use ◽  
Cross Sectional Design ◽  
Sensation Seeking Scale

Abstract Background/aim Drug use and risky driving is associated with sensation seeking. The aim of this study was to investigate the association between use of psychoactive substances and levels of the sensation seeking personality trait as measured with the Brief Sensation Seeking Scale 4 among drivers in Norway. Method A cross-sectional design was applied to estimate the association between psychoactive substance use and sensation seeking behavior. Drivers in normal traffic were included in two roadside surveys: one in the north (September 2014 – October 2015) and the other in the south-east of Norway (April 2016 – April 2017). Oral fluid was analyzed for alcohol and psychoactive drugs, and data on sex, age and time of participation were recorded. Participants filled in the Brief Sensation Seeking Scale 4 questionnaire. Results A total of 8053 drivers were included, of which 32% were women and 62% were under 40 years. The prevalence of alcohol was 0.3%, stimulants 0.6%, tetrahydrocannabinol 1.4%, benzodiazepines and/or z-hypnotics 2.0% and polydrug use 0.6%. Associations between the use of tetrahydrocannabinol or benzodiazepines and/or z-hypnotics and a low score on the “thrill and adventure seeking” domain of the Brief Sensation Seeking Scale 4 (OR = 1.723, 95% C.I. = 1.001- 2.966). Associations were also found between the use of stimulants and the highest scores on the “experience seeking” (OR = 2.085, 95% C.I. = 1.084-4.009) and “disinhibition” (OR = 4.791, 95% C.I. =1.748-13.135) domains of the Brief Sensation Seeking Scale 4. No associations were found between sensation seeking behavior and alcohol or polydrug use. Conclusion A high degree of sensation seeking was found among drivers who had used stimulating drugs, in contrast to drives who had used tetrahydrocannabinol and benzodiazepines and/or z-hypnotics who showed a low degree of sensation seeking. The combination of sensation seeking behavior and the use of stimulants might lead to increased risky behavior and thus traffic crashes.

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