Nanoparticle-Based Wound Dressing: Recent Progress in the Detection and Therapy of Bacterial Infections

Porous polysaccharides have recently attracted attention due to their porosity, abundance, and excellent properties such as sustainability and biocompatibility, thereby resulting in their numerous applications. Recent years have seen a rise in the number of studies on the utilization of polysaccharides such as cellulose, chitosan, chitin, and starch as aerogels due to their unique performance for the fabrication of porous structures. The present review explores recent progress in porous polysaccharides, particularly cellulose and chitosan, including their synthesis, application, and future outlook. Since the synthetic process is an important aspect of aerogel formation, particularly during the drying step, the process is reviewed in some detail, and a comparison is drawn between the supercritical CO2 and freeze drying processes in order to understand the aerogel formation of porous polysaccharides. Finally, the current applications of polysaccharide aerogels in drug delivery, wastewater, wound dressing, and air filtration are explored, and the limitations and outlook of the porous aerogels are discussed with respect to their future commercialization.

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Atypical Bacterial Infections Explained by a Concomitant Virus Infection

PEDIATRICS ◽

10.1542/peds.76.3.411 ◽

1985 ◽

Vol 76 (3) ◽

pp. 411-414

Author(s):

Ron Dagan ◽

Caroline B. Hall ◽

Marilyn A. Menegus

Keyword(s):

Early Childhood ◽

Virus Infection ◽

Bacterial Infection ◽

Clinical Manifestation ◽

Bacterial Infections ◽

Recent Progress ◽

Clinical Presentation ◽

Virus Detection ◽

Dual Infection ◽

Dual Infections

Because both viral and bacterial infections are common during early childhood, dual infections are not unexpected. However, the clinical manifestation of such combined infections may be, difficult to interpret, and they are often misdiagnosed as "atypical bacterial infection." Five patients with concomitant viral-bacterial infections are described. In all five cases, virus detection enabled the physicians to better understand an otherwise puzzling clinical presentation. In view of the recent progress in rapid viral diagnoses and the potential of antiviral drugs, the possibility of dual infection should be investigated more often.

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Preparation of Nanofibers with Renewable Polymers and Their Application in Wound Dressing

International Journal of Polymer Science ◽

10.1155/2016/4672839 ◽

2016 ◽

Vol 2016 ◽

pp. 1-17 ◽

Cited By ~ 17

Author(s):

Ying Zhao ◽

Yihui Qiu ◽

Huanhuan Wang ◽

Yu Chen ◽

Shaohua Jin ◽

...

Keyword(s):

Extracellular Matrix ◽

Wound Healing ◽

Cell Adhesion ◽

Specific Surface ◽

Wound Dressing ◽

Recent Progress ◽

High Specific Surface Area ◽

High Porosity ◽

Renewable Polymers ◽

Good Biocompatibility

Renewable polymers have attracted considerable attentions in the last two decades, predominantly due to their environmentally friendly properties, renewability, good biocompatibility, biodegradability, bioactivity, and modifiability. The nanofibers prepared from the renewable polymers can combine the excellent properties of the renewable polymer and nanofiber, such as high specific surface area, high porosity, excellent performances in cell adhesion, migration, proliferation, differentiation, and the analogous physical properties of extracellular matrix. They have been widely used in the fields of wound dressing to promote the wound healing, hemostasis, skin regeneration, and treatment of diabetic ulcers. In the present review, the different methods to prepare the nanofibers from the renewable polymers were introduced. Then the recent progress on preparation and properties of the nanofibers from different renewable polymers or their composites were reviewed; the application of them in the fields of wound dressing was emphasized.

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Synthesis of Yeast-Immobilized and Copper Nanoparticle-Dispersed Carbon Nanofiber-Based Diabetic Wound Dressing Material: Simultaneous Control of Glucose and Bacterial Infections

ACS Applied Bio Materials ◽

10.1021/acsabm.8b00018 ◽

2018 ◽

Vol 1 (2) ◽

pp. 246-258 ◽

Cited By ~ 12

Author(s):

Pratibha Bhadauriya ◽

Himanshu Mamtani ◽

Mohammad Ashfaq ◽

Alok Raghav ◽

Arun K. Teotia ◽

...

Keyword(s):

Wound Dressing ◽

Bacterial Infections ◽

Carbon Nanofiber ◽

Copper Nanoparticle ◽

Diabetic Wound ◽

Simultaneous Control

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Magnesium oxide incorporated electrospun membranes inhibit bacterial infections and promote healing process of infected wounds

Journal of Materials Chemistry B ◽

10.1039/d1tb00217a ◽

2021 ◽

Author(s):

Mingyue Liu ◽

Xiaoyu Wang ◽

Haiyan Li ◽

Changlei Xia ◽

Zhengni Liu ◽

...

Keyword(s):

Wound Healing ◽

Magnesium Oxide ◽

Wound Dressing ◽

Bacterial Infections ◽

Healing Process ◽

Infected Wounds ◽

Electrospun Membranes ◽

Nanofibrous Membranes ◽

Mgo Nanoparticle ◽

Healing Processes

Bacterial infections cause serious secondary damages to wounds and hinder wound healing processes. We prepared magnesium oxide (MgO) nanoparticle-incorporated nanofibrous membranes by electrospinning and investigated their potential for wound dressing...

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Antimicrobial Films based on Chitosan, Collagen, and ZnO for Skin Tissue Regeneration

Biointerface Research in Applied Chemistry ◽

10.33263/briac114.1198511995 ◽

2020 ◽

Vol 11 (4) ◽

pp. 11985-11995

Keyword(s):

Zinc Oxide ◽

Tissue Regeneration ◽

Wound Dressing ◽

Bacterial Infections ◽

Cell Activity ◽

The Past ◽

Major Interest ◽

Ft Ir ◽

Ft Ir Spectroscopy

Bacterial infections represent a health issue worldwide. Over the past years, major interest has been given to developing new antibacterial and regenerative materials due to the increasing number of infections with pathogenic strains and the alarming antibiotic resistance. Polymer films and membranes with protective or even anti-infectious activity were developed. Some of them were based on nanoparticles with the main advantage that the resistance's development only seldom appears. Considering the Collagenic nature of the skin and the beneficial properties of Chitosan, the two polymers were proposed to be used in developing nanostructured wound dressing loaded with ZnO nanoparticles. These nanostructured materials confer promising characteristics to be used as anti-infectious wound dressing being biocompatible, antimicrobial against C. albicans and S. aureus, and highly hydrophilic able to absorb over 2300% water, which confer the premises of maintaining proper humidity and exudate absorption during wound healing. Fibrillar structures with Chitosan, Collagen, and Zinc Oxide can be an alternative for tissue regeneration. Electrospinning was used to fabricate fibrillar structures consisting of doing Chitosan, Collagen, and Zinc Oxide. The Zinc Oxide was used to defend the wound against infections and the beneficial role of Zn2+ in enhancing cell activity. The morphology of the fibrillar structures was studied by scanning electron microscopy while Collagen integrity by FT-IR spectroscopy.

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Electrospun Antibacterial Nanomaterials for Wound Dressings Applications

Membranes ◽

10.3390/membranes11120908 ◽

2021 ◽

Vol 11 (12) ◽

pp. 908

Author(s):

Aysegul Gul ◽

Izabela Gallus ◽

Akshat Tegginamath ◽

Jiri Maryska ◽

Fatma Yalcinkaya

Keyword(s):

Wound Healing ◽

Wound Dressing ◽

Bacterial Infections ◽

Antimicrobial Agents ◽

Chronic Wounds ◽

Antibacterial Properties ◽

Electrospun Nanofibers ◽

Electrospinning Process ◽

Wound Dressings ◽

Promising Solution

Chronic wounds are caused by bacterial infections and create major healthcare discomforts; to overcome this issue, wound dressings with antibacterial properties are to be utilized. The requirements of antibacterial wound dressings cannot be fulfilled by traditional wound dressing materials. Hence, to improve and accelerate the process of wound healing, an antibacterial wound dressing is to be designed. Electrospun nanofibers offer a promising solution to the management of wound healing, and numerous options are available to load antibacterial compounds onto the nanofiber webs. This review gives us an overview of some recent advances of electrospun antibacterial nanomaterials used in wound dressings. First, we provide a brief overview of the electrospinning process of nanofibers in wound healing and later discuss electrospun fibers that have incorporated various antimicrobial agents to be used in wound dressings. In addition, we highlight the latest research and patents related to electrospun nanofibers in wound dressing. This review also aims to concentrate on the importance of nanofibers for wound dressing applications and discuss functionalized antibacterial nanofibers in wound dressing.

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Development of Tannin-bridged Cerium Oxide Microcubes-chitosan Cryogel as a Multifunctional Wound Dressing

10.21203/rs.3.rs-1043996/v1 ◽

2021 ◽

Author(s):

Muzhou Teng ◽

Zhijia Li ◽

Zhihui Lu ◽

Keke Wu ◽

Jinshan Guo

Keyword(s):

Wound Healing ◽

Wound Dressing ◽

Bacterial Infections ◽

Inflammatory Cytokine ◽

Interleukin 10 ◽

Sprague Dawley ◽

Necrosis Factor Alpha ◽

Anti Inflammatory

Abstract Background: Efficient resolution of oxidative stress, inflammation and bacterial infections are crucial for wound healing. To surmount these problems, tannic acid (TA)-bridged CeO2 microcubes and chitosan (CS) (CS-TA@CeO2) cryogel was fabricated through hydrogen bonding interactions as a multifunctional wound dressing. Results: The physicochemical characterizations confirmed the successful introduction and uniform incorporation of TA@CeO2 microcubes into CS network. Thus-obtained CS-TA@CeO2 cryogels displayed suitable porous structure and swelling ratio. The CS-TA@CeO2 cryogels exhibited favorable antioxidant ability evidenced by scavenging more than 82.9% ROS in vitro and significantly increasing the antioxidant enzyme levels in vivo. The anti-inflammatory ability of the cryogels was confirmed by the downregulated expression of the inflammatory cytokine, tumor necrosis factor-alpha (TNF-α) and the upregulated expression of the anti-inflammatory cytokine, interleukin-10 (IL-10). The multifunctional cryogels also showed excellent antibacterial activities against Gram-positive (S.aureus) and Gram-negative (E.coli) bacteria. Furthermore, the cryogels can promote the adhesion and proliferation of mouse fibroblasts (L929) cells. Moreover, CS-TA@CeO2 cryogels presented excellent hemostatic performance in rat tail amputation model. In vivo Sprague-Dawley (SD) rats full-thickness experiments illustrated that the cryogels can significantly accelerate wound healing through providing considerable antioxidant activity, promoting angiogenesis, and increasing collagen deposition. Conclusions: Overall, the multifunctional CS-TA@CeO2 cryogels showed great potential for wound healing.

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An outbreak of acute skin and soft tissue infections including necrotizing fasciitis in Kalwala village, India, 2018: Public health implications for the lymphatic filariasis elimination program

Transactions of the Royal Society of Tropical Medicine and Hygiene ◽

10.1093/trstmh/traa046 ◽

2020 ◽

Vol 114 (10) ◽

pp. 742-750

Author(s):

Kiran Kumar Maramraj ◽

Kavitha Latha ML ◽

Tanzin Dikid ◽

Sushma Choudhary ◽

Sukrutha Reddy ◽

...

Keyword(s):

Soft Tissue ◽

Necrotizing Fasciitis ◽

Lymphatic Filariasis ◽

Wound Dressing ◽

Bacterial Infections ◽

Lower Limbs ◽

Soft Tissue Infections ◽

Health Seeking ◽

Health Seeking Behavior ◽

Seeking Behavior

Abstract Background A cluster of 15 acute skin and soft tissue infections (SSTIs), including two cases of necrotizing fasciitis, reported in July 2018 from Kalwala village, led us to investigate and describe their epidemiology and to provide recommendations. Methods Cases, defined as localized painful swelling and redness in Kalwala residents from 1 December 2017 to 20 August 2018, were identified from hospital records and house-to-house surveys. We conducted an unmatched case-control study to identify risk factors for severity. We cultured wound samples and environmental samples from wound-dressing stations. Results We identified 36 cases (median age: 55 [range 17–80] y; 78% male), village attack rate 1% (36/4337) and no deaths. In 34 cases (94%), lower limbs were involved. Lymphatic filariasis (LF) was a common predisposing condition (67%). Comorbidities (diabetes or hypertension) (OR=9; 95% CI 2.0 to 41.1), poor limb hygiene (OR=16; 95% CI 2.8 to 95.3) and poor health-seeking behavior (OR=5; 95% CI 1.6 to 30.8) were associated with severity. All seven wound samples and 8/11 samples from wound-dressing stations showed atypical polymicrobial growth (Pseudomonas, Proteus, Klebsiella, Escherichia coli and Clostridium). Conclusion The outbreak of SSTIs among older males with LF was due to secondary bacterial infections and severity was associated with comorbidities, poor hygiene and health-seeking behavior, and likely contamination during wound-dressing. The LF elimination program managers was alerted, programmatic interventions were scaled up, home/facility-based morbidity and comorbidity management was facilitated and the outbreak was rapidly contained.

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