Dendrimer-Based Nanogels for Cancer Nanomedicine Applications

2021 ◽  
Author(s):  
Shewaye Lakew Mekuria ◽  
Zhijun Ouyang ◽  
Cong Song ◽  
João Rodrigues ◽  
Mingwu Shen ◽  
...  
Keyword(s):  
Cancer Nanomedicine

scholarly journals Lipid-Based Nanoparticles in the Clinic and Clinical Trials: From Cancer Nanomedicine to COVID-19 Vaccines

Vaccines ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 359
Author(s):  
Thai Thanh Hoang Thi ◽  
Estelle J. A. Suys ◽  
Jung Seok Lee ◽  
Dai Hai Nguyen ◽  
Ki Dong Park ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Clinical Trials ◽  
Physicochemical Properties ◽  
Solid Lipid Nanoparticles ◽  
Drug Delivery Systems ◽  
Lipid Nanoparticles ◽  
Therapeutic Vaccines ◽  
Cancer Nanomedicine ◽  
Fundamental Research ◽  
Further Development

COVID-19 vaccines have been developed with unprecedented speed which would not have been possible without decades of fundamental research on delivery nanotechnology. Lipid-based nanoparticles have played a pivotal role in the successes of COVID-19 vaccines and many other nanomedicines, such as Doxil® and Onpattro®, and have therefore been considered as the frontrunner in nanoscale drug delivery systems. In this review, we aim to highlight the progress in the development of these lipid nanoparticles for various applications, ranging from cancer nanomedicines to COVID-19 vaccines. The lipid-based nanoparticles discussed in this review are liposomes, niosomes, transfersomes, solid lipid nanoparticles, and nanostructured lipid carriers. We particularly focus on the innovations that have obtained regulatory approval or that are in clinical trials. We also discuss the physicochemical properties required for specific applications, highlight the differences in requirements for the delivery of different cargos, and introduce current challenges that need further development. This review serves as a useful guideline for designing new lipid nanoparticles for both preventative and therapeutic vaccines including immunotherapies.

scholarly journals Cancer nanomedicine: is targeting our target?

2016 ◽  
Vol 1 (9) ◽  
Author(s):  
Twan Lammers ◽  
Fabian Kiessling ◽  
Marianne Ashford ◽  
Wim Hennink ◽  
Daan Crommelin ◽  
...  
Keyword(s):  
Cancer Nanomedicine

scholarly journals From Nanoparticles to Cancer Nanomedicine: Old Problems with New Solutions

Nanomaterials ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1727
Author(s):  
Chi-Ling Chiang ◽  
Ming-Huei Cheng ◽  
Chih-Hsin Lin
Keyword(s):  
Surface Modification ◽  
Immune Responses ◽  
Cancer Patients ◽  
Tumor Tissue ◽  
Developmental Process ◽  
Engineered Nanomaterials ◽  
Technological Advances ◽  
Cancer Nanomedicine ◽  
Made In ◽  
Target Cancer

Anticancer nanomedicines have been studied over 30 years, but fewer than 10 formulations have been approved for clinical therapy today. Despite abundant options of anticancer drugs, it remains challenging to have agents specifically target cancer cells while reducing collateral toxicity to healthy tissue. Nanocompartments that can be selective toward points deeply within malignant tissues are a promising concept, but the heterogeneity of tumor tissue, inefficiency of cargo loading and releasing, and low uniformity of manufacture required from preclinical to commercialization are major obstacles. Technological advances have been made in this field, creating engineered nanomaterials with improved uniformity, flexibility of cargo loading, diversity of surface modification, and less inducible immune responses. This review highlights the developmental process of approved nanomedicines and the opportunities for novel materials that combine insights of tumors and nanotechnology to develop a more effective nanomedicine for cancer patients.

Lung cancer nanomedicine: potentials and pitfalls

Nanomedicine ◽  
2015 ◽  
Vol 10 (21) ◽  
pp. 3203-3212 ◽  
Author(s):  
Deniz Ali Bölükbas ◽  
Silke Meiners
Keyword(s):  
Lung Cancer ◽  
Cancer Nanomedicine

scholarly journals Carbon Dots for Cancer Nanomedicine: A Bright Future

2021 ◽  
Author(s):  
Samer Bayda ◽  
Emanuele Amadio ◽  
Simone Cailotto ◽  
Yahima Frión-Herrera ◽  
Alvise Perosa ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Carbon Dots ◽  
Causes Of Death ◽  
Cancer Therapies ◽  
Therapeutic Approaches ◽  
Bright Future ◽  
Cancer Nanomedicine ◽  
The World

Cancer remains one of the main causes of death in the world. Early diagnosis and effective cancer therapies are required to treat this pathology. Traditional therapeutic approaches are limited by...

scholarly journals Design Principles for Clinical Efficacy of Cancer Nanomedicine: A Look into the Basics

ACS Nano ◽  
2013 ◽  
Vol 7 (4) ◽  
pp. 2878-2882 ◽  
Author(s):  
Shiladitya Sengupta ◽  
Ashish Kulkarni
Keyword(s):  
Clinical Efficacy ◽  
Design Principles ◽  
Cancer Nanomedicine

scholarly journals Current and Future Advancements of Raman Spectroscopy Techniques in Cancer Nanomedicine

2021 ◽  
Vol 22 (23) ◽  
pp. 13141
Author(s):  
Elisabetta Canetta
Keyword(s):  
Raman Spectroscopy ◽  
Imaging Techniques ◽  
Rapid Development ◽  
Surface Enhanced Raman Spectroscopy ◽  
Cancer Diagnostics ◽  
Raman Signal ◽  
Therapeutic Effects ◽  
Cancer Nanomedicine

Raman scattering is one of the most used spectroscopy and imaging techniques in cancer nanomedicine due to its high spatial resolution, high chemical specificity, and multiplexity modalities. The flexibility of Raman techniques has led, in the past few years, to the rapid development of Raman spectroscopy and imaging for nanodiagnostics, nanotherapy, and nanotheranostics. This review focuses on the applications of spontaneous Raman spectroscopy and bioimaging to cancer nanotheranostics and their coupling to a variety of diagnostic/therapy methods to create nanoparticle-free theranostic systems for cancer diagnostics and therapy. Recent implementations of confocal Raman spectroscopy that led to the development of platforms for monitoring the therapeutic effects of anticancer drugs in vitro and in vivo are also reviewed. Another Raman technique that is largely employed in cancer nanomedicine, due to its ability to enhance the Raman signal, is surface-enhanced Raman spectroscopy (SERS). This review also explores the applications of the different types of SERS, such as SERRS and SORS, to cancer diagnosis through SERS nanoprobes and the detection of small-size biomarkers, such as exosomes. SERS cancer immunotherapy and immuno-SERS (iSERS) microscopy are reviewed.

Just so stories: The random acts of anti-cancer nanomedicine performance

2014 ◽  
Vol 10 (8) ◽  
pp. 1661-1666 ◽  
Author(s):  
Seyed Moein Moghimi ◽  
Zahra Shadi Farhangrazi
Keyword(s):  
Anti Cancer ◽  
Cancer Nanomedicine
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