Self-Assembly of Temperature Sensitive Additives in Polypropylene Melt and Its Influence on Viscoelasticity

2022 ◽  
Author(s):  
Mina Farahani ◽  
Yousef Jahani ◽  
Ali Kakanejadifard ◽  
Masahiro Ohshima
Keyword(s):  
Self Assembly ◽  
Temperature Sensitive ◽  
Polypropylene Melt

Supramolecular helical nanostructures from self-assembly of coil–rod–coil amphiphilic molecules incorporating the dianthranide unit

Soft Matter ◽  
2018 ◽  
Vol 14 (33) ◽  
pp. 6822-6827 ◽  
Author(s):  
Shengsheng Yu ◽  
Rui Sun ◽  
Tie Chen ◽  
Long Yi Jin
Keyword(s):  
Aqueous Solution ◽  
Self Assembly ◽  
Temperature Sensitive ◽  
Amphiphilic Molecules

Coil–rod–coil amphiphilic molecules self-assemble in aqueous solution to form temperature-sensitive clew-like and temperature-insensitive nanodisk-like aggregates comprising helical nanofibers.

scholarly journals Self-Assembly of Temperature Sensitive Unilamellar Vesicles by a Blend of Block Copolymers in Aqueous Solution

Polymers ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 63 ◽  
Author(s):  
Jong Dae Jang ◽  
Changwoo Do ◽  
Joona Bang ◽  
Young Soo Han ◽  
Tae-Hwan Kim
Keyword(s):  
Block Copolymers ◽  
Hydrophobic Interaction ◽  
Self Assembly ◽  
Small Angle Neutron Scattering ◽  
Mass Fraction ◽  
Temperature Sensitive ◽  
Vesicular Structure ◽  
Wide Range ◽  
Scattering Measurements ◽  
Potential Applications

A self-assembled unilamellar vesicle, which can be used as a drug delivery system, was easily and simply fabricated using a blended system of Pluronic block copolymers. Controlling the hydrophilic mass fraction of block copolymers (by blending the block copolymer with a different hydrophilic mass fraction) and temperature (i.e., the hydrophobic interaction is controlled), a vesicular structure was formed. Small angle neutron scattering measurements showed that the vesicular structure had diameters of empty cores from 13.6 nm to 79.6 nm, and thicknesses of the bilayers from 2.2 nm to 8.7 nm when the hydrophobic interaction was changed. Therefore, considering that the temperature of the vesicle formation is controllable by the concentration of the blended block copolymers, it is possible for them to be applied in a wide range of potential applications, for example, as nanoreactors and nanovehicles.

scholarly journals Effect of Phenolic Acids on Temperature-sensitive Property of Self-assembly of Ionic Pair of Poly(ethylene imine)/(phenylthio)Acetic Acid

2021 ◽  
Author(s):  
Fanyu Zhao ◽  
Jin-Chul Kim
Keyword(s):  
Acetic Acid ◽  
Phenolic Acids ◽  
Self Assembly ◽  
Room Temperature ◽  
Time Lapse ◽  
Solution Temperature ◽  
Temperature Sensitive ◽  
Ionic Pair ◽  
Ethylene Imine ◽  
Interfacial Activity

Abstract The ionic pair self-assembly (IPSAM) composed of poly(ethyleneimine) (PEI) and (phenylthio)acetic acid (PTA) was prepared and the effect of phenolic acids (PAs) (e.g. cinnamic acid (CA), hydroxycinnamic acid (HCA), and dihydroxycinnamic acid (DHCA)) on the upper critical solution temperature (UCST) and the temperature-responsive releasing property of IPSAM were investigated. PEI/PTA ionic pair showed a UCST behavior and the PAs decreased the UCST effective in the order of DHCA > HCA > CA. The PAs were thought to attach to the PEI chain of PEI/PTA ionic pair as pendants. According to the interfacial tensiometry, PEI/PTA(3/7) ionic pair was found to be air/water interface-active due to their amphiphilic property. CA had little effect on the interfacial activity of the ionic pair. HCA and HDCA significantly decreased the interfacial activity possibly because they are more polar than CA thus the hydrophilic and lipophilic balance of PEI/PTA ionic pair could be broken by their attachment to PEI chains. IPSAM was found as nanoparticles whose diameter was tens of nanometer and PAs had little effect on the shape and the size of IPSAM, once the UCST of PEI/PTA/PA ionic pair was above room temperature where the TEM micrographs were taken. If the UCST of PEI/PTA/PA ionic pair was below room temperature, no particulate matters were found on the TEM micrographs. The release degree of cargo loaded in IPSAM increased slowly with time lapse below UCST. Whereas, the release degree increased rapidly with time lapse above UCST, possibly because of the thermally-induced disintegration of IPSAM.

scholarly journals Biomimic Enamel Remineralization by Hybridization Calcium- and Phosphate-Loaded Liposomes with Amelogenin-Inspired Peptide

2012 ◽  
Vol 512-515 ◽  
pp. 1727-1730 ◽  
Author(s):  
Jing Jing Luo ◽  
Tian Yun Ning ◽  
Ying Cao ◽  
Xiao Peng Zhu ◽  
Xiao Hua Xu ◽  
...  
Keyword(s):  
Self Assembly ◽  
Room Temperature ◽  
Solid Phase ◽  
Enamel Surface ◽  
Temperature Sensitive ◽  
Fusion Method ◽  
Mass Ratio ◽  
Biomimetic Mineralization ◽  
Phosphate Ions ◽  
Thermally Triggered

We here report a novel biomimetic mineralization strategy for enamel remineralization by intergration of calcium phosphate loaded and thermally triggered liposomes and a self-assembly amelogenin-inspired peptide. Firstly, calcium and phosphate loaded temperature sensitive liposomes were synthesized by Interdigitation-fusion method with 1,2-bis(palmitoyl)-sn-glycero-3-phosphor- choline (DPPC) and 1,2-bis(myristoyl)-sn-glycero- 3-phosphocholine (DMPC) at mass ratio of 9:1 . The liposomes were stable at room temperature, but slowly released calcium and phosphate ions if heated to 37 °C. Secondly, a novel polyanion amelogenin-inspired oligropeptide (Gln-Pro-Ala)4-Thr-Lys-Arg-Glu-Glu-Val-Asp ) was synthesized by standard solid-phase. Lastly, the mixture of peptide and liposomes solution was exposed to enamel surface at 37 °C. The results showed oriented enamel-like hydroxylapatite evenly deposited on enamel surface.

Adjustable dual temperature-sensitive hydrogel based on self-assembly cross-linking strategy with high stretchable and healable properties

2021 ◽  
Author(s):  
Sijia Ge ◽  
Jiajia Li ◽  
Jian Geng ◽  
Shinian Liu ◽  
Hua Xu ◽  
...  
Keyword(s):  
Human Skin ◽  
Self Assembly ◽  
Cross Linking ◽  
Temperature Sensitive ◽  
Temperature Perception ◽  
Response Range ◽  
Temperature Sensitive Hydrogel ◽  
Perception Function

Developing smart temperature-sensitive hydrogels with wide response range, high stretchable and self-healable properties for simulation of the temperature perception function of the human skin remains a great challenge. Here, a...

scholarly journals Tuneable Peptide Cross-Linked Nanogels for Enzyme Triggered Protein Delivery

2020 ◽  
Author(s):  
Lucia Massi ◽  
Adrian Najer ◽  
Robert Chapman ◽  
Christopher Spicer ◽  
Valeria Nele ◽  
...  
Keyword(s):  
Self Assembly ◽  
Protein Delivery ◽  
Elevated Temperatures ◽  
Inflammatory Diseases ◽  
Polymeric Nanoparticles ◽  
Drug Carrier ◽  
Specific Protein ◽  
Correlation Spectroscopy ◽  
Solution Temperature ◽  
Temperature Sensitive

<p>Many diseases are associated with the dysregulated activity of enzymes, such as matrix metalloproteinases (MMPs). This dysregulation can be leveraged in drug delivery to achieve disease- or site-specific cargo release. Self-assembled polymeric nanoparticles are versatile drug carrier materials due to the accessible diversity of polymer chemistry. However, efficient loading of sensitive cargo, such as proteins, and introducing functional enzyme-responsive behaviour remain challenging. Herein, peptide-crosslinked, temperature-sensitive nanogels for protein delivery were designed to respond to MMP-7, which is overexpressed in many pathologies including cancer and inflammatory diseases. The incorporation of <i>N-</i>cyclopropylacrylamide (NCPAM) into <i>N</i>-isopropylacrylamide (NIPAM)-based copolymers enabled us to tune the polymer lower critical solution temperature from 33 to 44 °C, allowing the encapsulation of protein cargo and nanogel-crosslinking at slightly elevated temperatures. This approach resulted in nanogels that were held together by MMP-sensitive peptides for enzyme-specific protein delivery. We employed a combination of cryogenic transmission electron microscopy (cryo-TEM), dynamic light scattering (DLS), small angle neutron scattering (SANS), and fluorescence correlation spectroscopy (FCS) to precisely decipher the morphology, self-assembly mechanism, enzyme-responsiveness, and model protein loading/release properties of our nanogel platform. Simple variation of the peptide linker sequence and combining multiple different crosslinkers will enable us to adjust our platform to target specific diseases in the future.</p>

Synthesis and Self-Assembly of Block Copolymers Containing Temperature Sensitive and Degradable Chain Segments

2018 ◽  
Vol 18 (5) ◽  
pp. 3266-3273
Author(s):  
Hong-Liang Gong ◽  
Lei Lei ◽  
Shu-Xian Shi ◽  
Yu-Zheng Xia ◽  
Xiao-Nong Chen
Keyword(s):  
Block Copolymers ◽  
Self Assembly ◽  
Temperature Sensitive

scholarly journals Fabrication of Nanoscale Oxide Textured Surfaces on Polymers

Polymers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 2209
Author(s):  
Barun K. Barick ◽  
Neta Shomrat ◽  
Uri Green ◽  
Zohar Katzman ◽  
Tamar Segal-Peretz
Keyword(s):  
Flexible Electronics ◽  
Self Assembly ◽  
Temperature Sensitive ◽  
Textured Surfaces ◽  
Oxide Interface ◽  
Solvent Annealing ◽  
Polymer Substrates ◽  
Uv Crosslinking ◽  
Oxide Nanostructures ◽  
Antibacterial Surfaces

Nanoscale textured surfaces play an important role in creating antibacterial surfaces, broadband anti-reflective properties, and super-hydrophobicity in many technological systems. Creating nanoscale oxide textures on polymer substrates for applications such as ophthalmic lenses and flexible electronics imposes additional challenges over conventional nanofabrication processes since polymer substrates are typically temperature-sensitive and chemically reactive. In this study, we investigated and developed nanofabrication methodologies to create highly ordered oxide nanostructures on top of polymer substrates without any lithography process. We developed suitable block copolymer self-assembly, sequential infiltration synthesis (SIS), and reactive ion etching (RIE) for processes on polymer substrates. Importantly, to prevent damage to the temperature-sensitive polymer and polymer/oxide interface, we developed the process to be entirely performed at low temperatures, that is, below 80 °C, using a combination of UV crosslinking, solvent annealing, and modified SIS and RIE processes. In addition, we developed a substrate passivation process to overcome reactivity between the polymer substrate and the SIS precursors as well as a high precision RIE process to enable deep etching into the thermally insulated substrate. These methodologies widen the possibilities of nanofabrication on polymers.

scholarly journals Tuneable Peptide Cross-Linked Nanogels for Enzyme Triggered Protein Delivery

2020 ◽  
Author(s):  
Lucia Massi ◽  
Adrian Najer ◽  
Robert Chapman ◽  
Christopher Spicer ◽  
Valeria Nele ◽  
...  
Keyword(s):  
Self Assembly ◽  
Protein Delivery ◽  
Elevated Temperatures ◽  
Inflammatory Diseases ◽  
Polymeric Nanoparticles ◽  
Drug Carrier ◽  
Specific Protein ◽  
Correlation Spectroscopy ◽  
Solution Temperature ◽  
Temperature Sensitive

<p>Many diseases are associated with the dysregulated activity of enzymes, such as matrix metalloproteinases (MMPs). This dysregulation can be leveraged in drug delivery to achieve disease- or site-specific cargo release. Self-assembled polymeric nanoparticles are versatile drug carrier materials due to the accessible diversity of polymer chemistry. However, efficient loading of sensitive cargo, such as proteins, and introducing functional enzyme-responsive behaviour remain challenging. Herein, peptide-crosslinked, temperature-sensitive nanogels for protein delivery were designed to respond to MMP-7, which is overexpressed in many pathologies including cancer and inflammatory diseases. The incorporation of <i>N-</i>cyclopropylacrylamide (NCPAM) into <i>N</i>-isopropylacrylamide (NIPAM)-based copolymers enabled us to tune the polymer lower critical solution temperature from 33 to 44 °C, allowing the encapsulation of protein cargo and nanogel-crosslinking at slightly elevated temperatures. This approach resulted in nanogels that were held together by MMP-sensitive peptides for enzyme-specific protein delivery. We employed a combination of cryogenic transmission electron microscopy (cryo-TEM), dynamic light scattering (DLS), small angle neutron scattering (SANS), and fluorescence correlation spectroscopy (FCS) to precisely decipher the morphology, self-assembly mechanism, enzyme-responsiveness, and model protein loading/release properties of our nanogel platform. Simple variation of the peptide linker sequence and combining multiple different crosslinkers will enable us to adjust our platform to target specific diseases in the future.</p>

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