Perfluorinated Alkyl Acids in Blood Serum from Primiparous Women in Sweden: Serial Sampling during Pregnancy and Nursing, And Temporal Trends 1996–2010

Objective The objective of the study was to examine specific patterns of Twitter usage using common reference to tinnitus. Method The study used cross-sectional analysis of data generated from Twitter data. Twitter content, language, reach, users, accounts, temporal trends, and social networks were examined. Results Around 70,000 tweets were identified and analyzed from May to October 2018. Of the 100 most active Twitter accounts, organizations owned 52%, individuals owned 44%, and 4% of the accounts were unknown. Commercial/for-profit and nonprofit organizations were the most common organization account owners (i.e., 26% and 16%, respectively). Seven unique tweets were identified with a reach of over 400 Twitter users. The greatest reach exceeded 2,000 users. Temporal analysis identified retweet outliers (> 200 retweets per hour) that corresponded to a widely publicized event involving the response of a Twitter user to another user's joke. Content analysis indicated that Twitter is a platform that primarily functions to advocate, share personal experiences, or share information about management of tinnitus rather than to provide social support and build relationships. Conclusions Twitter accounts owned by organizations outnumbered individual accounts, and commercial/for-profit user accounts were the most frequently active organization account type. Analyses of social media use can be helpful in discovering issues of interest to the tinnitus community as well as determining which users and organizations are dominating social network conversations.

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Studies on a Blood Serum Proteolytic Enzyme with Particular Reference to Gastric Secretory Function

Gastroenterology ◽

10.1016/s0016-5085(19)36280-8 ◽

1953 ◽

Vol 25 (1) ◽

pp. 14-23 ◽

Cited By ~ 18

Author(s):

Austin B. Chinn

Keyword(s):

Blood Serum ◽

Proteolytic Enzyme ◽

Secretory Function

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Clinical Studies of Blood Lipid Metabolism: II. Blood Serum Variations of Cholesterol, Phospholipids, Neutral Fats, Total Lipids, and Blood Lipid Fraction Percentages in Peptic Ulcer Patients

Gastroenterology ◽

10.1016/s0016-5085(52)80214-8 ◽

1952 ◽

Vol 20 (1) ◽

pp. 79-89 ◽

Cited By ~ 4

Author(s):

A. Allen Goldbloom

Keyword(s):

Peptic Ulcer ◽

Lipid Metabolism ◽

Blood Serum ◽

Clinical Studies ◽

Lipid Fraction ◽

Blood Lipid ◽

Total Lipids

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Concentration of selected micro-nutrients in saliva among women in menopausal period treated with hormone replacement therapy

Osteologie/Osteology ◽

10.1055/s-0038-1630097 ◽

2013 ◽

Vol 22 (01) ◽

pp. 46-51

Author(s):

M. Rahnama ◽

I. Jastrzêbska-Jamrogiewicz ◽

R. Jamrogiewicz

Keyword(s):

Bone Mineral Density ◽

Hormone Replacement Therapy ◽

Blood Serum ◽

Replacement Therapy ◽

Hormone Replacement ◽

Surgical Removal ◽

Femoral Bone ◽

Mineral Density ◽

Natural Menopause ◽

Copper Zinc

Summary Objective: The aim of this study was to observe the variability of the level of copper, zinc and manganese in saliva amongst women with hypoestrogenia, treated and untreated with hormone replacement therapy (HRT). Methods: The study was conducted on a group of 60 women treated and untreated with HRT. Half of the patients were after natural menopause and other half was after surgical removal of ovaries. Research on micronutrients in non-stimulated saliva and blood serum was carried out in 2005. Tests on saliva were repeated in 2010. Investigation of bone mineral density (BMD) of femoral bone was performed in year 2010. Results: Statistical analysis of concentration of copper and zinc revealed a linear correlation between the levels of these microelements in blood serum and saliva. The study revealed that HRT has a beneficial effect on BMD and the concentration of copper and manganese in saliva and blood serum of patients after the menopause. Patients treated with HRT showed higher BMD values than groups not treated with hormones. Conclusions: Saliva appears to be a promising diagnostic material which can be used to analyze the content of trace elements, but further research should be carried out on a broader research group.

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Modelling In-Patient Bed Usage Behaviour in a Department of Geriatric Medicine

Methods of Information in Medicine ◽

10.1055/s-0038-1634894 ◽

1993 ◽

Vol 32 (01) ◽

pp. 79-81 ◽

Cited By ~ 14

Author(s):

P. Millard ◽

S. McClean

Keyword(s):

Census Data ◽

Geriatric Medicine ◽

Temporal Trends ◽

Exponential Model ◽

Bed Occupancy ◽

Lengths Of Stay ◽

Geriatric Hospital ◽

Using Data ◽

Acute Patients

Abstract:The flow of patients through geriatric hospitals has been previously described in terms of acute and long-stay states where the bed occupancy at a census point is modelled by a mixed exponential model. Using data for sixteen years the model was fitted to successive annual census points, in order to provide a description of temporal trends. While the number of acute patients has remained fairly stable during the period, the model shows that there has been a decrease in the number of long-stay patients. Mean lengths of stay in our geriatric hospital before death or discharge have decreased during the study period for both acute and long-stay patients.Using these fits of the mixed exponential model to census data, a method is provided for predicting future turnover of patients. These predictions are reasonably good, except when the turnover patterns go through a period of flux in which assumption of stability no longer holds. Overall, a methodology is presented which relates census analysis to the behaviour of admission cohorts, thus producing a means of predicting future behaviour of patients and identifying where there is a change in patterns.

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Do Extra-Platelet Sources Contribute to the Plasma Level of Thrombospondin?

Thrombosis and Haemostasis ◽

10.1055/s-0038-1642769 ◽

1988 ◽

Vol 59 (02) ◽

pp. 273-276 ◽

Cited By ~ 8

Author(s):

J Dawes ◽

D A Pratt ◽

M S Dewar ◽

F E Preston

Keyword(s):

Platelet Count ◽

Background Concentration ◽

Serum Concentrations ◽

Bone Marrow Depression ◽

Serial Sampling ◽

Control Serum ◽

Platelet Release ◽

Highly Correlated ◽

The Relationship

SummaryThrombospondin, a trimeric glycoprotein contained in the platelet α-granules, has been proposed as a marker of in vivo platelet activation. However, it is also synthesised by a range of other cells. The extraplatelet contribution to plasma levels of thrombospondin was therefore estimated by investigating the relationship between plasma thrombospondin levels and platelet count in samples from profoundly thrombocytopenic patients with marrow hypoplasia, using the platelet-specific α-granule protein β-thromboglobulin as control. Serum concentrations of both proteins were highly correlated with platelet count, but while plasma β-thromboglobulin levels and platelet count also correlated, there was no relationship between the number of platelets and thrombospondin concentrations in plasma. Serial sampling of patients recovering from bone marrow depression indicated that the plasma thrombospondin contributed by platelets is superimposed on a background concentration of at least 50 ng/ml probably derived from a non-platelet source, and plasma thrombospondin levels do not simply reflect platelet release.

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A Prospective Study of Haemostatic Tests at 28 Weeks Gestation as Predictors of Pre-Eclampsia and Growth Retardation

Thrombosis and Haemostasis ◽

10.1055/s-0038-1646567 ◽

1989 ◽

Vol 61 (02) ◽

pp. 243-245 ◽

Cited By ~ 4

Author(s):

J G Thornton ◽

B J Molloy ◽

P S Vinall ◽

P R Philips ◽

R Hughes ◽

...

Keyword(s):

Discriminant Analysis ◽

Prospective Study ◽

Fetal Growth ◽

Growth Retardation ◽

Degradation Products ◽

Fetal Growth Retardation ◽

Fibrin Degradation Products ◽

A Prospective Study ◽

Primiparous Women ◽

Significant Model

SummaryA panel of haemostatic tests was perfomed on 400 primiparous women at 28 weeks to test whether one or more could predict the development of pregnancy complications. Fifteen women subsequently developed pre-eclampsia with significant proteinuria and 13 delivered growth retarded infants. There were no significant differences between mothers in the pre-eclampsia group and 22 randomly selected controls. A stepwise logistic discriminant analysis of the data did not produce a significant model. In the growth retarded group only beta thromboglobulin levels were significantly lower than in the controls (p <0.05), although in the logistic discriminant analysis the inclusion of both beta thromboglobulin and fibrin degradation products led to a borderline significant improvement in fit of the model. We conclude that the haemostatic variables studied are not significantly changed at 28 weeks nor clinically useful predictors of either pre-eclampsia or fetal growth retardation.

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Antiheparin Activity of Human Serum and Platelet Factor 4

Thrombosis and Haemostasis ◽

10.1055/s-0038-1649105 ◽

1973 ◽

Vol 30 (01) ◽

pp. 093-105 ◽

Cited By ~ 1

Author(s):

C.H.J Sear ◽

L Poller ◽

F.R.C Path

Keyword(s):

Molecular Weight ◽

Ionic Strength ◽

Blood Serum ◽

Whole Blood ◽

Platelet Rich Plasma ◽

Gel Filtration ◽

Normal Serum ◽

Platelet Factor ◽

Mean Values ◽

Antiheparin Activity

SummaryThe antiheparin activity of normal serum has been studied by comparing the antiheparin activities of sera obtained from normal whole blood, platelet-rich plasma and platelet-’free’ plasma with a purified platelet extract during differential isoelectric precipitation and by gel filtration chromatography.The mean values for the activity of PRP-serum and PFP-serum were 106% (S.D. 11) and 10% (S.D. 3) of untreated whole blood respectively. The activity of whole blood serum, PRP serum and whole blood serum plus platelet extract precipitated under identical physical conditions, i.e. pH 7.0, I =0.008, indicating that the activities of the three samples are probably associated with PF4. PF4 precipitated from human platelet extract at pH 4.0, but this is probably due to the difference in the two biochemical environments investigated, i.e. serum and platelet extract.The gel filtration experiments revealed striking similarities between the major antiheparin activities of serum and platelet extract. At physiological pH and ionic strength both activities were associated with high molecular weight material, but at physiological pH and elevated ionic strength both activities behaved as much smaller entities of molecular weight between 25,000 and 30,000 daltons and it seems very likely that both activities are associated with the same molecule, i.e. PF4.

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