Anaerobic Biotransformation of Organoarsenical Pesticides Monomethylarsonic Acid and Dimethylarsinic Acid

2006 ◽  
Vol 54 (11) ◽  
pp. 3959-3966 ◽  
Author(s):  
Reyes Sierra-Alvarez ◽  
Umur Yenal ◽  
Jim A. Field ◽  
Mike Kopplin ◽  
A. Jay Gandolfi ◽  
...  
Keyword(s):  
Dimethylarsinic Acid ◽  
Monomethylarsonic Acid ◽  
Anaerobic Biotransformation

scholarly journals Pharmacokinetic Properties of Arsenic Species after Intravenous and Intragastrical Administration of Arsenic Trioxide Solution in Cynomolgus Macaques Using HPLC-ICP-MS

Molecules ◽  
2019 ◽  
Vol 24 (2) ◽  
pp. 241 ◽  
Author(s):  
Qiaoli Shi ◽  
Mingyan Ju ◽  
Xiaoxia Zhu ◽  
Hui Gan ◽  
Ruolan Gu ◽  
...  
Keyword(s):  
Arsenic Trioxide ◽  
Inductively Coupled Plasma ◽  
High Performance ◽  
Cynomolgus Macaque ◽  
Arsenic Species ◽  
Dimethylarsinic Acid ◽  
Inductively Coupled ◽  
Monomethylarsonic Acid ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

A rapid and sensitive method was established for arsenic (As) speciation based on high performance liquid chromatography coupled to inductively coupled plasma mass spectrometry (HPLC-ICP-MS). This method was validated for the quantification of four arsenic species, including arsenite (AsIII), arsenate (AsV), monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV) in cynomolgus macaque plasma. Separation was achieved in just 3.7 min with an alkyl reverse phase column and highly aqueous mobile phase containing 20 mM citric acid and 5 mM sodium hexanesulfonate (pH = 4.3). The calibration curves were linear over the range of 5–500 ng·mL−1 (measured as As), with r > 0.99. The above method was validated for selectivity, precision, accuracy, matrix effect, recovery, carryover effect and stability, and applied in a comparative pharmacokinetic study of arsenic species in cynomolgus macaque samples following intravenous and intragastrical administration of arsenic trioxide solution (0.80 mg·kg−1; 0.61 mg·kg−1 of arsenic); in addition, the absolute oral bioavailability of the active ingredient AsIII of arsenic trioxide in cynomolgus macaque samples was derived as 60.9 ± 16.1%.

scholarly journals Arsenic speciation in beverages by direct injection-ion chromatography hydride generation atomic fluorescence spectrometry

2000 ◽  
Vol 22 (2) ◽  
pp. 33-39 ◽  
Author(s):  
E. Moreno ◽  
C Cámara ◽  
W. T. Corns ◽  
D. W. Bryce ◽  
P. B. Stockwell
Keyword(s):  
Certified Reference Materials ◽  
Arsenic Speciation ◽  
Direct Injection ◽  
Hydride Generation ◽  
Standard Addition ◽  
Atomic Fluorescence Spectrometry ◽  
Dimethylarsinic Acid ◽  
Atomic Fluorescence ◽  
Matrix Interferences ◽  
Monomethylarsonic Acid

The procedure developed allows the direct speciation of arsenic in these samples with good sensitivity, selectivity, precision and accuracy. Detection limits determined using the optimized conditions were found to be between 0.16 and 2.9 ng ml−1for arsenite, dimethylarsinic acid, monomethylarsonic acid and arsenate, while standard addition studies showed that the procedure is free from matrix interferences. As no certified reference materials are available for these analytes or matrices, validation was carried out by studying spike recoveries and by comparison of results with an alternative technique.

scholarly journals Multi-elemental risk assessment of various baby rice cereals: some cause for concern?

2021 ◽  
Author(s):  
Nausheen W Sadiq ◽  
Diane Beauchemin
Keyword(s):  
Risk Assessment ◽  
Gastric Juice ◽  
Chromatographic Analysis ◽  
Speciation Analysis ◽  
Young Age ◽  
Dimethylarsinic Acid ◽  
Balanced Diet ◽  
Monomethylarsonic Acid ◽  
Online Methods

This study used batch and online methods to accurately determine how much As, Cr, Se, Cd, Pb, Cu, Fe, and Zn can be leached from baby rice cereals into a baby’s body. Speciation analysis of the saliva and gastric juice leachates was conducted in order to further assess the risk associated with the continued consumption of baby rice cereal for infants. A simple 15-min chromatographic analysis successfully separated 8 species consisting of As(III), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), As(V), Se(IV), Se(VI), (Cr(III)) and Cr(VI). Given that 95-100% As, 29-100% Cr, 62-100% Pb, 70-100% Se, 63-100% Cd, 36-100% Cu, 67-100% Fe, and 70-100% Zn were bio-accessible and the speciation analysis results showed all bio-accessible As and Se to be in the forms of As(V) and Se(VI) and 70-100% of Cr to be in the Cr(III) form, a variety of foods should be fed to infants rather than just baby rice cereal to ensure a well-balanced diet and less exposure to As at such a young age.

scholarly journals Arsenic accumulation, speciation and bioavailability in rice cultivated in arsanilic acid exposed soil

2021 ◽  
Vol 67 (No. 5) ◽  
pp. 307-316
Author(s):  
Wanling He ◽  
Xiaoli Li ◽  
Shu Guo ◽  
Longbang Yang ◽  
Dong Li
Keyword(s):  
Cell Model ◽  
Dry Weight ◽  
In Vitro Digestion ◽  
Dimethylarsinic Acid ◽  
Arsenic Accumulation ◽  
Arsanilic Acid ◽  
Monomethylarsonic Acid ◽  
As Species ◽  
Uptake And Transport

The present study used various amounts of P-arsanilic acid (AsA) in pot experiments to evaluate the effects of AsA on arsenic (As) accumulation, speciation and meanwhile using the in vitro digestion/Caco-2 cell model to evaluate the bioavailability of As in rice. The results indicated a linear relationship between As in rice and As in soil, and at 75 mg AsA/kg of soil, As content in rice exceeded the statutory permissible limit of 0.2 mg As/kg dry weight in China. Speciation studies indicated that inorganic As (Asi), dimethylarsinic acid (DMA), and monomethylarsonic acid (MMA) were the main As species in rice. Bioavailability of As experiment indicated that As uptake and transport amount by Caco-2 cells increased with increasing As accumulation in rice. In general, the content of AsA in soil reached or exceeded 75 mg/kg, which is not suitable for growing rice.  

scholarly journals Arsenic Uptake and Accumulation Mechanisms in Rice Species

Plants ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 129 ◽  
Author(s):  
Tayebeh Abedi ◽  
Amin Mojiri
Keyword(s):  
Vital Role ◽  
Dimethylarsinic Acid ◽  
Critical Factors ◽  
Arsenic Uptake ◽  
Monomethylarsonic Acid ◽  
Factors Influencing ◽  
As Species ◽  
Rice Consumption ◽  
Agronomic Strategies ◽  
Iron And Manganese

Rice consumption is a source of arsenic (As) exposure, which poses serious health risks. In this study, the accumulation of As in rice was studied. Research shows that As accumulation in rice in Taiwan and Bangladesh is higher than that in other countries. In addition, the critical factors influencing the uptake of As into rice crops are defined. Furthermore, determining the feasibility of using effective ways to reduce the accumulation of As in rice was studied. AsV and AsIII are transported to the root through phosphate transporters and nodulin 26-like intrinsic channels. The silicic acid transporter may have a vital role in the entry of methylated As, dimethylarsinic acid (DMA) and monomethylarsonic acid (MMA), into the root. Amongst As species, DMA(V) is particularly mobile in plants and can easily transfer from root to shoot. The OsPTR7 gene has a key role in moving DMA in the xylem or phloem. Soil properties can affect the uptake of As by plants. An increase in organic matter and in the concentrations of sulphur, iron, and manganese reduces the uptake of As by plants. Amongst the agronomic strategies in diminishing the uptake and accumulation of As in rice, using microalgae and bacteria is the most efficient.

Speciation of dimethylarsinic acid and monomethylarsonic acid by gas chromatography–mass spectrometry

1999 ◽  
Vol 832 (1-2) ◽  
pp. 183-190 ◽  
Author(s):  
Zoltán Mester ◽  
György Vitányi ◽  
Roberto Morabito ◽  
Péter Fodor
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Gas Chromatography Mass Spectrometry ◽  
Dimethylarsinic Acid ◽  
Monomethylarsonic Acid ◽  
Chromatography Mass Spectrometry
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