Evaluation of persistent, bioaccumulative, toxic chemicals under the Frank R. Lautenberg chemical safety for the 21st century act

2020 ◽  
Author(s):  
James Yan
Keyword(s):  
21St Century ◽  
Toxic Chemicals ◽  
Chemical Safety

Principles for construction of bioluminescent enzyme biotests for analysis of complex media

2019 ◽  
Vol 485 (2) ◽  
pp. 229-233
Author(s):  
V. P. Kalyabina ◽  
E. N. Esimbekova ◽  
I. G. Torgashina ◽  
K. V. Kopylova ◽  
V. A. Kratasyuk
Keyword(s):  
Fruits And Vegetables ◽  
Rapid Assessment ◽  
Test System ◽  
Maximum Sensitivity ◽  
Toxic Chemicals ◽  
Complex Media ◽  
Luminescent Bacterium ◽  
Chemical Safety ◽  
Minimal Impact

We formulated the principles of designing bioluminescent enzyme tests for assessing the quality of complex media which consist in providing the maximum sensitivity to potentially toxic chemicals at a minimal impact of uncontaminated complex media. The developed principles served as a basis for designing a new bioluminescent method for an integrated rapid assessment of chemical safety of fruits and vegetables which is based on using the luminescent bacterium enzymes (NAD(P)H:FMN oxidoreductase and luciferase) as a test system.

scholarly journals Risk science in the 21st century: a data-driven framework for incorporating new technologies into chemical safety assessment

2017 ◽  
Vol 20 (1/2/3) ◽  
pp. 88 ◽  
Author(s):  
Russell S. Thomas ◽  
Ricky Cheung ◽  
Margit Westphal ◽  
Daniel Krewski ◽  
Melvin E. Andersen
Keyword(s):  
21St Century ◽  
Safety Assessment ◽  
New Technologies ◽  
Data Driven ◽  
Chemical Safety

scholarly journals PCBs in Older Buildings: Measuring PCB Levels in Caulk and Window Glazing Materials in Older Buildings

Environments ◽  
2019 ◽  
Vol 6 (2) ◽  
pp. 15 ◽  
Author(s):  
Lantis Osemwengie ◽  
Jade Morgan
Keyword(s):  
United States ◽  
Quality Control ◽  
Polychlorinated Biphenyls ◽  
21St Century ◽  
The United States ◽  
Control Analysis ◽  
Chemical Safety ◽  
Quality Control Analysis ◽  
The U.S

A method for the determination of polychlorinated biphenyls (PCBs) in caulk and glazing materials was developed and evaluated by application to a combination of 36 samples of caulk and glazing materials, from four schools in the northeastern area of the United States. Quality control analysis showed a range of 45 to 170% for spike recovery from the various samples and a range of 10.9 to 20.1% difference in precision among replicates. The result for the samples analyzed showed that three of the four schools sampled contained caulking and glazing materials with levels of PCBs >50 μg/g (range 54.6 μg/g to 445,000 μg/g). Across the four schools, 24% of collected caulk and glazing samples contained elevated PCB levels relative to the U.S. Environmental Protection Agency’s (EPA) bulk product waste criterion of 50 μg/g under “The Frank R. Lautenberg Chemical Safety for the 21st Century Act.” The PCBs determined in the samples, exhibited characteristic chromatographic patterns similar to those of Aroclors 1242, 1248, 1254, 1260, 1262, and a 1016/1254 mix.

scholarly journals The International Register of Potentially Toxic Chemicals (IRPTC) of UNEP

1982 ◽  
Vol 9 (1) ◽  
pp. 59-63
Author(s):  
Alexander I. Kucherenko ◽  
Jan W. Huismans
Keyword(s):  
Data Storage ◽  
Data Bank ◽  
Relevant Information ◽  
Toxic Chemicals ◽  
Global Network ◽  
United Nations Environment Programme ◽  
Chemical Safety ◽  
Storage And Retrieval ◽  
Chemical Hazard ◽  
And Control

Until recently there has been no international register or international network linking national registers for the exchange of information on, and for, chemical hazard assessment and control. The International Register of Potentially Toxic Chemicals (IRPTC) was established by the United Nations Environment Programme (UNEP) in 1976 and is now in full operation.The objectives assigned to the Register concern the establishment of a global network of contributing partners through which it can develop its data-bank containing relevant information for an assessment of environmental hazards caused by chemicals, and disseminate this information to decision-making bodies, national authorities, international organizations and other institutions, and to the scientific community that is concerned with the evaluation and control of chemicals in the environment.The IRPTC operations involve preparation of data profiles for chemicals, the development of a computerized data storage and retrieval system, a query–response service, and the publication of a 4-monthly Register Index, a periodical Bulletin, and other documents. These contain information on chemicals, international and national activities related to issues of chemical safety, and also legislative and regulatory measures for protection of the health of humans and of the environment from the noxious effects of chemicals.

Acetaminophen: Neonatal hepatotoxicity due to late pregnancy exposure

1987 ◽  
Vol 45 ◽  
pp. 718-719
Author(s):  
G.A. Miranda ◽  
M.A. Arroyo ◽  
C.A. Lucio ◽  
M. Mongeotti ◽  
S.S. Poolsawat
Keyword(s):  
Low Dose ◽  
Fetal Liver ◽  
Late Pregnancy ◽  
Toxic Chemicals ◽  
Control Group ◽  
High Dose ◽  
Over The Counter ◽  
Liver And Kidney ◽  
Neonatal Liver ◽  
Childbearing Women

Exposure to drugs and toxic chemicals, during late pregnancy, is a common occurrence in childbearing women. Some studies have reported that more than 90% of pregnant women use at least 1 prescription; of this, 60% used more than one. Another study indicated that 80% of the consumed drugs were not prescribed, and of this figure, 95% were “over-the-counter” drugs. Acetaminophen, the safest of all over-the-counter drugs, has been reported to induce fetal liver necrosis in man and animals and to have abortifacient and embryocidal action in mice. This study examines the degree to which acetaminophen affects the neonatal liver and kidney, when a fatty diet is simultaneously fed to the mother during late pregnancy.Timed Swiss Webster female mice were gavaged during late pregnancy (days 16-19) with fat suspended acetaminophen at a high dose, HD = 84.50 mg/kg, and a low dose, LD = 42.25 mg/kg; a control group received fat alone.

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