Perception of Firefighters on Risk of Exposure to Respiratory Health Hazard: A Qualitative Analysis in Malaysia

Firefighters are exposed to multiple occupational hazards, where one of the hazards is chemical hazard that can affect the respiratory system. However, little is known regarding the perception of firefighters on the source of exposure to respiratory hazards, particularly in Malaysia. This work aims to explore the firefighter’s perspective on respiratory hazard exposure and to examine the compliance of the use of personal protective equipment (PPE). In-depth interviews were employed among 12 firefighters at Fire and Rescue Department of Malaysia in September 2020. The interview recordings were transcribed verbatim and of thematic analysis done via the NVIVO 12 programme. All participants were Malay, male, and married. The respiratory hazard exposure perceived can be divided into occupational source (e.g. exposure to smoke from firefighting, fire training, firefight demonstration, commuting, firefight vehicles: chemicals and dust) and non-occupational source (e.g. smoking). Firefighter recognised both the importance of wearing PPE and the fact they are still not compliant in wearing it. They also perceived wearing PPE as burden and having only a limited stock of PPE. Education and training need to be reinforced to strengthen firefighters’ risk perception, hazard identification, and risk assessment of hazards exposure. Strict standard operating procedure (SOP) and supervision during firefighters’ task is crucial to reduce hazard exposure and increase PPE compliance. Systematic and thorough inventory management is needed to ensure adequate PPE supply. Post qualitative analysis, the firefighters’ perception on respiratory hazard exposure was obtained, demonstrating that the analysis is ready for further study.

Integration of Epigenetic Mechanisms into Non-Genotoxic Carcinogenicity Hazard Assessment: Focus on DNA Methylation and Histone Modifications

Epigenetics involves a series of mechanisms that entail histone and DNA covalent modifications and non-coding RNAs, and that collectively contribute to programing cell functions and differentiation. Epigenetic anomalies and DNA mutations are co-drivers of cellular dysfunctions, including carcinogenesis. Alterations of the epigenetic system occur in cancers whether the initial carcinogenic events are from genotoxic (GTxC) or non-genotoxic (NGTxC) carcinogens. NGTxC are not inherently DNA reactive, they do not have a unifying mode of action and as yet there are no regulatory test guidelines addressing mechanisms of NGTxC. To fil this gap, the Test Guideline Programme of the Organisation for Economic Cooperation and Development is developing a framework for an integrated approach for the testing and assessment (IATA) of NGTxC and is considering assays that address key events of cancer hallmarks. Here, with the intent of better understanding the applicability of epigenetic assays in chemical carcinogenicity assessment, we focus on DNA methylation and histone modifications and review: (1) epigenetic mechanisms contributing to carcinogenesis, (2) epigenetic mechanisms altered following exposure to arsenic, nickel, or phenobarbital in order to identify common carcinogen-specific mechanisms, (3) characteristics of a series of epigenetic assay types, and (4) epigenetic assay validation needs in the context of chemical hazard assessment. As a key component of numerous NGTxC mechanisms of action, epigenetic assays included in IATA assay combinations can contribute to improved chemical carcinogen identification for the better protection of public health.

Principles of dose-setting in toxicology studies: the importance of kinetics for ensuring human safety

Regulatory toxicology seeks to ensure that exposures to chemicals encountered in the environment, in the workplace, or in products pose no significant hazards and produce no harm to humans or other organisms, i.e., that chemicals are used safely. The most practical and direct means of ensuring that hazards and harms are avoided is to identify the doses and conditions under which chemical toxicity does not occur so that chemical concentrations and exposures can be appropriately limited. Modern advancements in pharmacology and toxicology have revealed that the rates and mechanisms by which organisms absorb, distribute, metabolize and eliminate chemicals—i.e., the field of kinetics—often determine the doses and conditions under which hazard, and harm, are absent, i.e., the safe dose range. Since kinetics, like chemical hazard and toxicity, are extensive properties that depend on the amount of the chemical encountered, it is possible to identify the maximum dose under which organisms can efficiently metabolize and eliminate the chemicals to which they are exposed, a dose that has been referred to as the kinetic maximum dose, or KMD. This review explains the rationale that compels regulatory toxicology to embrace the advancements made possible by kinetics, why understanding the kinetic relationship between the blood level produced and the administered dose of a chemical is essential for identifying the safe dose range, and why dose-setting in regulatory toxicology studies should be informed by estimates of the KMD rather than rely on the flawed concept of maximum-tolerated toxic dose, or MTD.

Review and Improvement of Chemical Hazard Risk Management of Korean Occupational Safety and Health Agency

In 2012, the Korean Occupational Safety and Health Agency developed Chemical Hazard Risk Management (CHARM) as a risk assessment tool. This study aims to reorganize the CHARM technique by complementing its logical loopholes, while evaluating the risk to enterprises and verifying this technique by applying it to some enterprises in Korea. The optimized technique changed the method of quantitative assessment and evaluation criteria, matched the risk level with the required control level, and specified the use of control practice. For the target enterprises, for several assessment methods, risk levels, hazard bands, exposure bands, and the risk assessment results were derived, and the same types of options were compared. Fewer informational methods resulted in more conservative results of risk levels and hazard bands. Since the control status of the enterprises could not be confirmed and the substances handled at the target enterprises were limited in this study, a follow-up study should be performed with more target materials and additional information on the current control status of the enterprises.

Sugars Replacement as a Strategy to Control the Formation of α-Dicarbonyl and Furanic Compounds during Cookie Processing

In the last decade, several preventive strategies were considered to mitigate the chemical hazard accumulation in food products. This work aimed to study the effect of different sugars on the development of the main chemical hazard in cookies. For this purpose, model biscuits prepared using sucrose, fructose, and glucose were baked at different temperatures (150, 170, and 190 °C) and for different times (from 5 to 45 min), and the levels of α-dicarbonyl compounds, such as 3-deoxyglucosone (3-DG), glyoxal (GO) and methylglyoxal (MGO), 5-hydroxymethylfurfural (HMF), and furanic aromatic compounds were monitored. The replacement of sucrose in the cookie recipes with monosaccharides had as a consequence the highest accumulation of 3-DG (200–600 times higher), MGO, HMF, and furanic volatile compounds, while the use of sucrose allowed for maintaining the 3-DG, MGO, and HMF levels at less than 10 mg/kg dry matter in cookies for the estimated optimal baking time. Moreover, cookies with sucrose were characterised in terms of volatile compounds, mainly in terms of lipid oxidation products, while cookies with fructose or glucose baked at the highest temperature were characterised almost exclusively by Maillard reaction products, confirming a faster development of this reaction during baking at the studied temperatures.

Setting priorities: Testing a tool to assess and prioritize workplace chemical hazards

BACKGROUND: Workplace Hazardous Materials Information System (WHMIS) training is obligatory for Ontario workplaces. The purpose of this training is to help workers understand the health and safety issues associated with using chemicals, including how to understand the information contained in the Safety Data Sheets (SDSs) that come with all chemicals. However, many workers still do not know how hazardous workplace chemicals can be and they find it difficult to objectively determine the level of hazard posed by the chemicals they use. OBJECTIVE: A team of researchers, unions, and health and safety associations created a tool for Joint Health and Safety Committees (JHSC) of small and medium-sized businesses to help them identify, assess and prioritize the health hazards posed by workplace chemicals using SDSs as the primary source of information. METHODS: The team recruited the JHSCs of six workplaces to pilot the usefulness of the Chemical Hazard Assessment and Prioritization (CHAP) tool. The CHAP tool helps workplaces rank their chemicals within one of five hazard levels using information contained in SDSs. RESULTS: Despite a difficult recruitment process, the participating JHSCs thought the CHAP process of assessing and prioritizing their workplace chemicals was useful. It raised their awareness of chemical hazards, increased their understanding of SDSs, and helped them prioritize their chemicals for improved control measures. CONCLUSIONS: Small and medium-sized businesses found the tool to be useful, but suggested that an electronic version would be easier to use.

Critical assessment of occupational health hazard in hospitality industry in Kano state, Nigeria

<p class="abstract"><strong>Background:</strong> It is a known fact that different occupations are occupied with different forms of hazard. Regardless to the nature, size and the enterprise scope of operation, the occupations available in the enterprise are no doubt associated with one form of hazard or the other. The purpose of this study was to critically assess the occupational hazard in hospitality industry in Kano state.</p><p class="abstract"><strong>Methods:</strong> A total of 384 people from the selected hotels were recruited to form the sample of the study using simple random sampling technique. The instrument used for data collection in the study was self-administered semi-structured questionnaire. Data collected were analysed using statistical package for the social sciences (SPSS) version 20. </p><p class="abstract"><strong>Results:</strong> In this study 50.0% of the respondents were ≤25 years and 54.9% of the respondents were male. More than three-fifths (64.0%) were civil servants, and most of the respondents (63.0%) were single. About 53.4% of them had tertiary level of education and above. Slightly below four-fifths (79.9%) of the respondents knew about physical work hazard and 75.0% of them were aware that physical work hazard can cause ailment and subsequently ill-health to employees and customers. Close to seven-tenths (69.8%) of the respondents understood what is meant by biological factors when issue relating to work hazard is being addressed. Little above half (53.4%) of the respondents knew what chemical hazard is all about and 75.8% of the respondents mentioned that if workable measures are implemented, this will reduce the occurrence of work related hazards.</p><strong>Conclusions:</strong> There is lack of proper knowledge regarding the physical, chemical and biological hazards among the study participants. Government must provide suitable and enforcement laws that will enforce laws towards sustainable organizational safety.