scholarly journals Engagement and Retention of Suicide Attempters in Clinical Research

Crisis ◽  
2010 ◽  
Vol 31 (2) ◽  
pp. 62-68 ◽  
Author(s):  
Carly J. Gibbons ◽  
Shannon Wiltsey Stirman ◽  
Gregory K. Brown ◽  
Aaron T. Beck
Keyword(s):  
Randomized Controlled Trial ◽  
Statistical Power ◽  
Suicide Attempts ◽  
Longitudinal Research ◽  
Controlled Trial ◽  
Treatment Protocol ◽  
Drop Out ◽  
Retention Rates ◽  
Suicide Attempters ◽  
Randomized Controlled

Background: High attrition rates in longitudinal research can limit study generalizability, threaten internal validity, and decrease statistical power. Research has demonstrated that there can be significant differences between participants who complete a research study and those who drop out prematurely, and that treatment outcomes may be dependent on retention in a treatment protocol. Aims: The current paper describes the challenges encountered when implementing a randomized controlled trial of cognitive therapy for the prevention of suicide attempts and the solutions developed to overcome these problems. Methods: Problems unique to suicide attempters are discussed, and strategies successfully implemented to boost retention rates are provided. Results: The methods implemented appeared to increase retention rates in the randomized controlled trial. Conclusions: Many steps can be taken to work with this difficult population, and researchers are encouraged to be as involved and flexible with participants as possible.

Treatment Fidelity Procedures for an Aphasia Intervention Within a Randomized Controlled Trial: Design, Feasibility, and Results

2020 ◽  
Vol 29 (1S) ◽  
pp. 412-424
Author(s):  
Elissa L. Conlon ◽  
Emily J. Braun ◽  
Edna M. Babbitt ◽  
Leora R. Cherney
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Treatment Protocol ◽  
Treatment Fidelity ◽  
Protocol Adherence ◽  
Study Condition ◽  
Randomized Controlled ◽  
Aphasia Therapy ◽  
Percent Accuracy ◽  
Over Time

Purpose This study reports on the treatment fidelity procedures implemented during a 5-year randomized controlled trial comparing intensive and distributed comprehensive aphasia therapy. Specifically, the results of 1 treatment, verb network strengthening treatment (VNeST), are examined. Method Eight participants were recruited for each of 7 consecutive cohorts for a total of 56 participants. Participants completed 60 hr of aphasia therapy, including 15 hr of VNeST. Two experienced speech-language pathologists delivered the treatment. To promote treatment fidelity, the study team developed a detailed manual of procedures and fidelity checklists, completed role plays to standardize treatment administration, and video-recorded all treatment sessions for review. To assess protocol adherence during treatment delivery, trained research assistants not involved in the treatment reviewed video recordings of a subset of randomly selected VNeST treatment sessions and completed the fidelity checklists. This process was completed for 32 participants representing 2 early cohorts and 2 later cohorts, which allowed for measurement of protocol adherence over time. Percent accuracy of protocol adherence was calculated across clinicians, cohorts, and study condition (intensive vs. distributed therapy). Results The fidelity procedures were sufficient to promote and verify a high level of adherence to the treatment protocol across clinicians, cohorts, and study condition. Conclusion Treatment fidelity strategies and monitoring are feasible when incorporated into the study design. Treatment fidelity monitoring should be completed at regular intervals during the course of a study to ensure that high levels of protocol adherence are maintained over time and across conditions.

scholarly journals Protocol of a Multi-centric Randomized Controlled Trial to Evaluate Efficacy of Telephone-Based Psychosocial Interventions on Future Suicide Risk in Suicide Attempters

2020 ◽  
Vol 42 (6_suppl) ◽  
pp. S39-S45
Author(s):  
Ram Pratap Beniwal ◽  
Priya Sreedaran ◽  
Uttara Chari ◽  
Ashok MV ◽  
Triptish Bhatia
Keyword(s):  
Mental Health ◽  
Randomized Controlled Trial ◽  
Mental Health Treatment ◽  
Suicide Attempts ◽  
Controlled Trial ◽  
Psychosocial Interventions ◽  
Health Treatment ◽  
Risk Of Death ◽  
Randomized Controlled ◽  
Telephone Reminders

Background: Persons with previous history of a suicide attempt are at increased future risk of death by suicide. These vulnerable individuals, however, do not seek receive or seek help from mental health services. Telephone-based psychosocial interventions are potential strategies in augmenting mental health care in such persons. Methods: We aim to compare the efficacy of telephone-based psychosocial interventions (TBPI) with routine telephone reminders in persons with recent suicide attempts using a multi-site, parallel group, rater-blind, two-arm randomized controlled trial design in 362 participants. In the first group, participants will receive three sessions of TBPI comprising of brief supportive interventions, problem-solving strategies, and reminders for adherence to prescribed mental health treatment at weekly intervals. In the second group, participants will receive three telephone reminders for adherence to prescribed mental health treatment at weekly intervals. We will follow up participants for 6 months. Primary outcomes are suicidal ideation scores on Beck’s Scale for Suicide Ideation and number of repeat suicide attempts. Secondary outcomes are scores on Beck’s Hopelessness Scale, Beck’s Depression Inventory, Connor–Davidson Resilience Scale and Visual Analogue Rating Scales for acceptability of interventions. Outcomes will be assessed at 1, 3, and 6 months after receiving telephone interventions or reminders. Results: The trial is currently underway after prospective registration under Clinical Trials Registry of India and has recruited 260 participants till August 15, 2020. Conclusion: This study has potential to generate evidence on additional strategies for use along with standard mental health treatments in management of high-risk suicide behaviors.

scholarly journals Family nurture intervention (FNI): methods and treatment protocol of a randomized controlled trial in the NICU

2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Martha G Welch ◽  
◽  
Myron A Hofer ◽  
Susan A Brunelli ◽  
Raymond I Stark ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Treatment Protocol ◽  
Randomized Controlled

Improving Recruitment, Retention, and Cultural Saliency of Health Promotion Efforts Targeting African American Men: A Scoping Review

2021 ◽  
Author(s):  
Guillermo M Wippold ◽  
Sarah Grace Frary ◽  
Demetrius A Abshire ◽  
Dawn K Wilson
Keyword(s):  
Health Promotion ◽  
Randomized Controlled Trial ◽  
African American ◽  
Scoping Review ◽  
African American Men ◽  
Controlled Trial ◽  
Target Population ◽  
Retention Rates ◽  
Randomized Controlled ◽  
Post Test

Abstract Background When health promotion efforts intend to include African American men, they experience challenges with recruitment and retention, in addition to limited cultural saliency—interventions that do not align the cultural preferences and experiences of the target population produce less effective results. Purpose This scoping review provides an understanding of (a) how health promotion efforts among African American men are developed and implemented, in addition to the (b) main outcomes, (c) retention rates, and (d) methodological rigor of those efforts. Methods The following databases were used: PubMed, EMBASE (Ovid), PsycINFO (EBSCO), CINAHL (EBSCO), Web of Science (Clarivate), and ProQuest. Included studies were restricted to those: (a) conducted among African American men and (b) reported the effects of a health promotion intervention. Interventions using single-group pre–post study, post-test-only study, non-randomized controlled trial, and randomized controlled trial (RCT) study designs were included. Results The results indicate that varying degrees of customization in the design and implementation of health promotion efforts targeting African American can improve recruitment, retention, and health-related outcomes. Results draw attention to the need for community input when designing and implementing efforts targeting these men. Conclusions These results indicate that opportunities exist to innovate health promotion efforts among African American men, such as the intentional incorporation of the community’s values, perspectives, and preferences in the effort (i.e., cultural saliency) and explicitly indicating how the efforts were culturally tailored to improve saliency. Opportunities also exist to innovate health promotion efforts among African American men based on literature-derived best practices.

scholarly journals Exercise before, during, and after Hospitalization for Allogeneic Hematological Stem Cell Transplant: A Feasibility Randomized Controlled Trial

2020 ◽  
Vol 9 (6) ◽  
pp. 1854
Author(s):  
Daniel Santa Mina ◽  
Lianne B. Dolan ◽  
Jeffrey H. Lipton ◽  
Darren Au ◽  
Encarna Camacho Pérez ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Stem Cell ◽  
Stem Cell Transplant ◽  
Controlled Trial ◽  
Retention Rates ◽  
Cell Transplant ◽  
Walk Test ◽  
Randomized Controlled ◽  
Six Minute Walk Test ◽  
Minute Walk

People with cancer who undergo allogeneic hematological stem cell transplant (allo-HSCT) experience significant deconditioning that can compromise quality of life. Exercise has shown to be beneficial before or after allo-HSCT; however, little is known about exercise therapy delivered across the continuum of care. We conducted a feasibility randomized controlled trial of exercise delivered prior to admission, during the inpatient stay, and after discharge versus control in people with planned allo-HSCT. Feasibility was assessed via recruitment and retention rates, the incidence of adverse events, and adherence to the exercise prescription. Estimates of efficacy were measured at baseline, one week prior to hospital admission, and 100 days and one year after transplant. The recruitment and retention rates were 20% and 33%, respectively. One serious adverse event occurred during the baseline six-minute walk test that precluded participation in the study and no adverse events were associated with the intervention. From baseline to pre-transplant, the intervention group improved six-minute walk test distances by 45 m (95% CI: −18.0 to 108.7)—a finding that warrants further investigation with an adequately powered trial. Our study contributes important feasibility considerations and pilot data for future exercise intervention research in allo-HSCT recipients.

scholarly journals Pengaruh vitamin C terhadap peroksidasi lipid, gejala klinik dan kualitas hidup penderita tonsilitis kronik

2018 ◽  
Vol 5 (2) ◽  
Author(s):  
Nancy Liwikasari ◽  
Farokah . ◽  
Suprihati .
Keyword(s):  
Randomized Controlled Trial ◽  
Vitamin C ◽  
Random Sampling ◽  
Controlled Trial ◽  
Simple Random Sampling ◽  
Drop Out ◽  
Randomized Controlled

Latar belakang: Masalah tonsilitis kronik sering pada anak. Gejala klinik yang muncul berdampak negatif sehingga menurunkan kualitas hidup. Radikal bebas berperan dalam tonsilitis kronik. Potensi kerusakan radikal bebas dibatasi antioksidan. Tujuan: Membuktikan vitamin C menurunkan kadar peroksidasi lipid, memperbaiki gejala klinik dan kualitas hidup penderita tonsilitis kronik. Material dan metode: Penelitian Randomized Controlled Trial dengan simple random sampling. Penilaian kadar peroksidasi lipid, gejala klinik dan kualitas hidup dilakukan sebelum dan sesudah pemberian vitamin C. Hasil: Total 51 penderita, 10 drop out dan 41 dianalisis. Kadar peroksidasi lipid sesudah perlakuan kelompok vitamin C (3,41 (0,53-4,65)) tidak berbeda bermakna dibandingkan sebelum perlakuan (3,43 (0,39-4,16)) (p=0,237). Skor total gejala klinik sesudah perlakuan kelompok vitamin C (14,76±4,34) lebih rendah dibandingkan sebelum perlakuan (20,38±5,25) (p=0,000). Skor total kualitas hidup sesudah perlakuan kelompok vitamin C (65 (52 – 79)) lebih rendah dibandingkan sebelum perlakuan (78 (57 – 88)) (p=0,000). Kesimpulan: Kadar peroksidasi lipid yang diberikan vitamin C tidak berbeda bermakna dibandingkan tanpa diberikan vitamin C (p=0,237). Gejala klinik dan kualitas hidup yang diberikan vitamin C lebih baik dibandingkan tanpa diberikan vitamin C. Kata kunci: tonsilitis kronis, kadar peroksidasi lipid, gejala klinik, kualitas hidup

scholarly journals The Online Life Story Book: A randomized controlled trial on the effects of a digital reminiscence intervention for people with (very) mild dementia and their informal caregivers

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0256251
Author(s):  
Teuntje R. Elfrink ◽  
Christina Ullrich ◽  
Miriam Kunz ◽  
Sytse U. Zuidema ◽  
Gerben J. Westerhof
Keyword(s):  
Randomized Controlled Trial ◽  
Life Story ◽  
Controlled Trial ◽  
Neuropsychiatric Symptoms ◽  
Informal Caregivers ◽  
Drop Out ◽  
Future Research ◽  
Caregiver Distress ◽  
Mild Dementia ◽  
Randomized Controlled

This paper describes a randomized controlled trial on the Online Life Story Book (OLSB), a digital reminiscence intervention for people with (very) mild dementia living at home. The aim of the study was to investigate the effectiveness of the OLSB on (i) neuropsychiatric symptoms (NPS) in persons with dementia and (ii) the distress and quality of life (QOL) of primary informal caregivers. A randomized controlled trial with individual randomization to one of two conditions was conducted: 1) intervention “Online Life Story Book”; 2) wait list control condition. In the intervention OLSB, a trained volunteer guided the participants through the process of creating an OLSB in approximately 5 meetings within a period of 8–10 weeks. Participants in the control condition received care as usual while they waited for 6 months before starting. Outcomes on NPS and distress and QOL of the informal caregiver were assessed at baseline (baseline, T0), 3 months (T1) and 6 months (T2) post baseline. Of the 42 persons with dementia, 23 were female and 19 were male. They had a mean age of 80 years, ranging from 49 to 95. The total drop-out rate was 14.3 percent. Small but insignificant effects on NPS, caregiver distress and QOL of caregivers were found with the exception of self-rated caregiver distress that reduced significantly during the intervention. One reason to explain the results might be that the included participants were in relatively good health. Practical challenges during the intervention could have affected the results as well. It might also be that the intervention caused effects on other outcomes than NPS and caregiver distress. In future research, it is important to study the effects in persons with more complaints and higher distress and to be careful in the selection of outcome variables in relation to the reminiscence functions served by the intervention.

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