Cannabis and Its Different Strains

2021 ◽  
pp. 1-10
Author(s):  
Anna Muro ◽  
Ramon Cladellas ◽  
Judit Castellà
Keyword(s):  
Control Group ◽  
Temporal Perception ◽  
Self Medication ◽  
Therapeutic Uses ◽  
Before And After ◽  
Cannabis Consumption ◽  
Short And Long Term ◽  
Different Strains ◽  
Main Effects

Abstract. Previous studies show how time perception can be altered by cannabis consumption, but it is not clear yet whether cannabis produces temporal underproductions or overproductions after acute cannabis intoxication. The present study aimed to analyze a sample of 50 regular cannabis users controlling for cannabis strain (sativa, indica, and hybrid) and to compare their scores in a temporal production task before and after consuming cannabis with a control group of 49 nonusers. Results showed that cannabis intake leads to overproductions, suggesting that regular users’ internal tempo slows down after acute intoxication. However, the analyses of main effects showed that indica users, both at baseline levels and after consuming, reported significant underproductions compared to controls, sativa, and hybrid users, and the cannabis-induced effects had a higher magnitude after smoking in the indica-strain group. Results highlight the relevance of including the type of strain consumed in cannabis studies, and they are discussed in terms of short- and long-term alterations in temporal perception under the light of the self-medication theory and the therapeutic uses of cannabis.

scholarly journals Cannabis and its different strains: do they have differential effects on time perception?

2021 ◽  
Author(s):  
Anna Muro ◽  
Ramon Cladellas ◽  
Judit Castellà
Keyword(s):  
Time Perception ◽  
Control Group ◽  
Self Medication ◽  
Therapeutic Uses ◽  
Before And After ◽  
Cannabis Consumption ◽  
Short And Long Term ◽  
Different Strains ◽  
Main Effects

Previous studies show how time perception can be altered by cannabis consumption, but it is not clear yet whether cannabis produces temporal underproductions or overproductions after acute cannabis intoxication. The present study aimed to analyze a sample of 50 regular cannabis users controlling for cannabis strain (sativa, indica, and hybrid) and to compare their scores in a temporal production task before and after consuming cannabis with a control group of 49 non-users. Results showed that cannabis intake leads to overproductions, suggesting that regular users’ internal tempo slows down after acute intoxication. However, the analyses of main effects showed that indica users, both at baseline levels and after consuming, reported significant underproductions compared to controls, sativa, and hybrid users, and the cannabis-induced effects had a higher magnitude after smoking in the indica-strain group. Results highlight the relevance of including the type of strain consumed in cannabis studies and they are discussed in terms of short- and long-term alterations in temporal perception under the light of the self-medication theory and the therapeutic uses of cannabis.

Time-Dependent Changes in Excitability After One-Trial Conditioning of Hermissenda

1997 ◽  
Vol 78 (6) ◽  
pp. 3460-3464 ◽  
Author(s):  
Terry Crow ◽  
Vilma Siddiqi
Keyword(s):  
Time Dependent ◽  
Control Group ◽  
Type B ◽  
Control Groups ◽  
Phototactic Behavior ◽  
Parallel Processes ◽  
Short And Long Term ◽  
A Site ◽  
Different Levels

Crow, Terry and Vilma Siddiqi. Time-dependent changes in excitability after one-trial conditioning of Hermissenda. J. Neurophysiol. 78: 3460–3464, 1997. The visual system of Hermissenda has been studied extensively as a site of cellular plasticity produced by classical conditioning. A one-trial conditioning procedure consisting of light paired with the application of serotonin (5-HT) to the exposed, but otherwise intact, nervous system produces suppression of phototactic behavior tested 24 h after conditioning. Short- and long-term enhancement (STE and LTE) of excitability in identified type B photoreceptors is a cellular correlate of one-trial conditioning. LTE can be expressed in the absence of STE suggesting that STE and LTE may be parallel processes. To examine the development of enhancement, we studied its time-dependent alterations after one-trial conditioning. Intracellular recordings from identified type B photoreceptors of independent groups collected at different times after conditioning revealed that enhanced excitability follows a biphasic pattern in its development. The analysis of spikes elicited by 2 and 30 s extrinsic current pulses at different levels of depolarization showed that enhancement reached a peak 3 h after conditioning. From its peak, excitability decreased toward baseline control levels 5–6 h after conditioning followed by an increase to a stable plateau at 16 to 24 h postconditioning. Excitability changes measured in cells from unpaired control groups showed maximal changes 1 h posttreatment that rapidly decremented within 2 h. The conditioned stimulus (CS) elicited significantly more spikes 24 h postconditioning for the conditioned group as compared with the unpaired control group. The analysis of the time-dependent development of enhancement may reveal the processes underlying different stages of memory for this associative experience.

Reduced volume and increased training intensity elevate muscle Na+-K+pump α2-subunit expression as well as short- and long-term work capacity in humans

2009 ◽  
Vol 107 (6) ◽  
pp. 1771-1780 ◽  
Author(s):  
Jens Bangsbo ◽  
Thomas P. Gunnarsson ◽  
Jesper Wendell ◽  
Lars Nybo ◽  
Martin Thomassen
Keyword(s):  
Endurance Training ◽  
Muscle Protein ◽  
Work Capacity ◽  
Control Group ◽  
Muscle Adaptations ◽  
Subunit Expression ◽  
Short And Long Term ◽  
And Performance ◽  
Trained Runners

The present study examined muscle adaptations and alterations in work capacity in endurance-trained runners as a result of a reduced amount of training combined with speed endurance training. For a 6- to 9-wk period, 17 runners were assigned to either a speed endurance group with a 25% reduction in the amount of training but including speed endurance training consisting of six to twelve 30-s sprint runs 3–4 times/wk (SET group n = 12) or a control group ( n = 5), which continued the endurance training (∼55 km/wk). For the SET group, the expression of the muscle Na+-K+pump α2-subunit was 68% higher ( P < 0.05) and the plasma K+level was reduced ( P < 0.05) during repeated intense running after 9 wk. Performance in a 30-s sprint test and the first of the supramaximal exhaustive runs was improved ( P < 0.05) by 7% and 36%, respectively, after the speed endurance training period. In the SET group, maximal O2uptake was unaltered, but the 3-km (3,000-m) time was reduced ( P < 0.05) from 10.4 ± 0.1 to 10.1 ± 0.1 min and the 10-km (10,000-m) time was improved from 37.3 ± 0.4 to 36.3 ± 0.4 min (means ± SE). Muscle protein expression and performance remained unaltered in the control group. The present data suggest that both short- and long-term exercise performances can be improved with a reduction in training volume if speed endurance training is performed and that the Na+-K+pump plays a role in the control of K+homeostasis and in the development of fatigue during repeated high-intensity exercise.

scholarly journals Predicting the cumulative medical load of COVID-19 outbreaks after the peak in daily fatalities

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0247272
Author(s):  
Claudius Gros ◽  
Roser Valenti ◽  
Lukas Schneider ◽  
Benedikt Gutsche ◽  
Dimitrije Marković
Keyword(s):  
Phase Space ◽  
Sir Model ◽  
Reaction Model ◽  
Space Representation ◽  
Cumulative Number ◽  
Short Term ◽  
Before And After ◽  
The Status ◽  
Short And Long Term

The distinct ways the COVID-19 pandemic has been unfolding in different countries and regions suggest that local societal and governmental structures play an important role not only for the baseline infection rate, but also for short and long-term reactions to the outbreak. We propose to investigate the question of how societies as a whole, and governments in particular, modulate the dynamics of a novel epidemic using a generalization of the SIR model, the reactive SIR (short-term and long-term reaction) model. We posit that containment measures are equivalent to a feedback between the status of the outbreak and the reproduction factor. Short-term reaction to an outbreak corresponds in this framework to the reaction of governments and individuals to daily cases and fatalities. The reaction to the cumulative number of cases or deaths, and not to daily numbers, is captured in contrast by long-term reaction. We present the exact phase space solution of the controlled SIR model and use it to quantify containment policies for a large number of countries in terms of short and long-term control parameters. We find increased contributions of long-term control for countries and regions in which the outbreak was suppressed substantially together with a strong correlation between the strength of societal and governmental policies and the time needed to contain COVID-19 outbreaks. Furthermore, for numerous countries and regions we identified a predictive relation between the number of fatalities within a fixed period before and after the peak of daily fatality counts, which allows to gauge the cumulative medical load of COVID-19 outbreaks that should be expected after the peak. These results suggest that the proposed model is applicable not only for understanding the outbreak dynamics, but also for predicting future cases and fatalities once the effectiveness of outbreak suppression policies is established with sufficient certainty. Finally, we provide a web app (https://itp.uni-frankfurt.de/covid-19/) with tools for visualising the phase space representation of real-world COVID-19 data and for exporting the preprocessed data for further analysis.

scholarly journals EFFECT OF COMBINATION OF HYPNOBREASTFEEDING AND ACUPRESSURE ON ANXIETY AND WOUND PAIN IN POST-CAESAREAN MOTHERS

2017 ◽  
Vol 3 (5) ◽  
pp. 525-532
Author(s):  
Diah Evawanna Anuhgera ◽  
Tjahjono Kuncoro ◽  
Sri Sumarni ◽  
Mardiyono Mardiyono ◽  
Ari Suwondo
Keyword(s):  
Public Hospital ◽  
Alternative Therapy ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Group Data ◽  
Before And After ◽  
Wound Pain ◽  
And Control

Background: Post-cesarean mothers often experience anxiety and discomfort due to long-term pain. The combination of hypnobreastfeeding and acupressure is considered to be effective in reducing anxiety and pain levels. Objective: This study aims to examine the effect of combination of hypnobreastfeeding and acupressure on anxiety and pain levels in post-caesarean mothers.Methods: This study was a true experiment with pretest-posttest control group design, conducted in the Ambarawa Public Hospital on 5 November to 9 December 2016. There were 36 participants selected using stratified random sampling, with 18 assigned in the experiment and control group. Data were analyzed using paired t-test and wilcoxon test.Results: There were statistically significant differences of anxiety and pain levels before and after intervention in the experiment and control group with p-value 0.001 (<0.05).Conclusion: The combination of hypnobreastfeeding and acupressure has a significant effect in reducing anxiety and pain levels in post-cesarean mothers. This intervention could be applied as an alternative therapy in treating post-caesarean mothers.

The Banco de Avío

2021 ◽  
pp. 442-464
Author(s):  
Eric Van Young
Keyword(s):  
Development Strategy ◽  
Textile Industry ◽  
The State ◽  
Development Bank ◽  
Long Term Effects ◽  
Before And After ◽  
Silver Mining ◽  
Short And Long Term ◽  
Textile Sector

At Alamán’s initiative a law of 1830 established the Banco de Avío, a government-funded development bank for the spurring of industrialization, especially in the textile sector, with which his name has forever been associated. His views of industrialization as a development strategy as opposed to a renewed reliance upon silver mining are discussed, as well as the short- and long-term effects of loans made to textile entrepreneurs and the cronyism employed by Alamán both in organizing the Banco itself and in allotting its capital as loans to industrialists. The state of the textile industry in Mexico before and after the Banco is described.

scholarly journals Ellenőrző lista hatása a légútbiztosítás korai szövődményeire felnőttekben

2019 ◽  
Vol 160 (26) ◽  
pp. 1025-1035 ◽  
Author(s):  
Zoltán Pál Szűcs ◽  
János Farkas ◽  
Péter Schimert ◽  
Zsolt Baranyai ◽  
Elek Dinya
Keyword(s):  
Airway Management ◽  
Primary Endpoint ◽  
Soft Tissues ◽  
Controlled Study ◽  
Data Collection Sheet ◽  
Before And After ◽  
Secondary Endpoints ◽  
Short And Long Term ◽  
Prospective Controlled Study

Abstract: Introduction: Airway management is an integral part of general anaesthesia, which may lead to severe short- and long-term complications. Aim: We assessed whether the application of a checklist for the steps of airway management reduces the number of complications in our institute. Method: In our observational, prospective, controlled study we made a checklist and a data collection sheet. Each airway management was performed for one month without the checklist and then for one month in the possession of the checklist. We evaluated the outcome of airway maneuvers and the occurrence of related early complications before and after the introduction of the checklist. The primary endpoint was the incidence of unexpected difficult airway. The secondary endpoints were difficult intubation, successful first intubation, aspiration, cardiac arrest, post-induction hypotension and desaturation, soft tissues/teeth injuries. Our results were also corrected for factors that affect the risk of complications (urgency of interventions, medical experience). Results: We did not find any difference in the frequency of acute complications before the introduction of the checklist (n = 439) and during the subsequent period (n = 423). At the primary endpoint (7.29% and 6.14%), there was no substantive difference (1.15%, 95% CI: –2.26%–4.56%, p = 0.5). No differences were found regarding the secondary and other endpoints. Following the correction of risk factors, there was no impact of the checklist on the incidence of complications. Conclusion: The introduction of the checklist in itself did not result in a significant change in the risk of short-term complications of airway management in our institution. Orv Hetil. 2019; 160(26): 1025–1035.

Lithium Restores Abnormal Platelet 5-HT Transport in Patients with Affective Disorders

1980 ◽  
Vol 136 (3) ◽  
pp. 235-238 ◽  
Author(s):  
Alec Coppen ◽  
Cynthia Swade ◽  
Keith Wood
Keyword(s):  
Blood Platelets ◽  
Lithium Treatment ◽  
Before And After ◽  
Short And Long Term ◽  
5 Ht Uptake ◽  
Depressive Patients ◽  
Rate Of Accumulation

SummaryKinetic analysis of the transport of 5-HT into the blood platelets of depressed patients and recovered depressive patients has shown that the rate of accumulation of 5-hydroxytryptamine (5-HT) is significantly decreased both before and after recovery from the illness. This abnormality is corrected by both short and long-term lithium treatment. As a corollary to these studies, the effect of lithium in vitro on 5-HT uptake has been studied and the results are opposite to those reported in vivo. These findings suggest that lithium acts indirectly, and possible mechanisms of its action are discussed.

Effects of Learning on Smooth Pursuit During Transient Disappearance of a Visual Target

2003 ◽  
Vol 90 (2) ◽  
pp. 972-982 ◽  
Author(s):  
Laurent Madelain ◽  
Richard J. Krauzlis
Keyword(s):  
Smooth Pursuit ◽  
Visual Target ◽  
Visual Signals ◽  
Control Group ◽  
Long Term Effects ◽  
Velocity Gain ◽  
Visual Inputs ◽  
Before And After ◽  
Pursuit Velocity

Previous research has demonstrated learning in the pursuit system, but it is unclear whether these effects are the result of changes in visual or motor processing. The ability to maintain smooth pursuit during the transient disappearance of a visual target provides a way to assess pursuit properties in the absence of visual inputs. To study the long-term effects of learning on nonvisual signals for pursuit, we used an operant conditioning procedure. By providing a reinforcing auditory stimulus during periods of accurate tracking, we increased the pursuit velocity gain during target blanking from 0.59 in the baseline session to 0.89 after 8 to 10 daily sessions of training. Learning also reduced the occurrence of saccades. The learned effects generalized to untrained target velocities and persisted in the presence of a textured visual background. In a yoked-control group, the reinforcer was independent of the subjects' responses, and the velocity gain remained unchanged (from 0.6 to 0.63, respectively, before and after training). In a control group that received no reinforcer, gain increased slightly after repetition of the task (from 0.63 to 0.71, respectively, before and after training). Using a model of pursuit, we show that these effects of learning can be simulated by modifying the gain of an extra-retinal signal. Our results demonstrate that learned contingencies can increase eye velocity in the absence of visual signals and support the view that pursuit is regulated by extra-retinal signals that can undergo long-term plasticity.

Aerobic Exercise Training and Cardiorespiratory Fitness in Older Adults: A Randomized Control Trial

1999 ◽  
Vol 7 (4) ◽  
pp. 374-383 ◽  
Author(s):  
Richard A. Boileau ◽  
Edward McAuley ◽  
Demetra Demetriou ◽  
Naveen K. Devabhaktuni ◽  
Gregory L. Dykstra ◽  
...  
Keyword(s):  
Heart Rate ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Exercise Program ◽  
The Elderly ◽  
Aerobic Exercise Training ◽  
Moderate Intensity ◽  
Control Group ◽  
Before And After

A trial was conducted to examine the effect of moderate aerobic exercise training (AET) on cardiorespiratory (CR) fitness. Previously sedentary participants, age 60-75 years, were randomly assigned to either AET treatment or a control group for 6 months. The AET consisted of walking for 40 min three times/week at an intensity that elevated heart rate to 65% of maximum heart rate reserve. The control group performed a supervised stretching program for 40 min three times/week. CR fitness was assessed before and after the treatments during a grade-incremented treadmill walking test. Both absolute and relative peak V̇O2 significantly increased (p < .01) in the AET group, whereas they decreased modestly in the control group. Maximum treadmill time increased significantly (p < .01) in the AET group relative to the control group. These results indicate that CR fitness as measured by peak V̇O2 modestly improves in the elderly with a moderate-intensity, relatively long-term aerobic exercise program.

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