Role of the Autoimmune Regulator (AIRE ) gene in alopecia areata: Strong association of a potentially functional AIRE polymorphism with alopecia universalis

2002 ◽  
Vol 60 (6) ◽  
pp. 489-495 ◽  
Author(s):  
R. Tazi-Ahnini ◽  
M.J. Cork ◽  
D.J. Gawkrodger ◽  
M.P. Birch ◽  
D. Wengraf ◽  
...  
Keyword(s):  
Alopecia Areata ◽  
Strong Association ◽  
Alopecia Universalis ◽  
Autoimmune Regulator ◽  
Aire Gene

Investigation of the p.Ser278Arg polymorphism of the autoimmune regulator (AIRE) gene in alopecia areata

2006 ◽  
Vol 68 (1) ◽  
pp. 58-61 ◽  
Author(s):  
J. Pforr ◽  
B. Blaumeiser ◽  
T. Becker ◽  
Y. Freudenberg-Hua ◽  
S. Hanneken ◽  
...  
Keyword(s):  
Alopecia Areata ◽  
Autoimmune Regulator ◽  
Aire Gene

Wenn die Haare einen verlassen und nie mehr wiederkehren

Praxis ◽  
2003 ◽  
Vol 92 (19) ◽  
pp. 912-914
Author(s):  
von Mühlenen ◽  
Schaub
Keyword(s):  
Alopecia Areata ◽  
Alopecia Universalis

Ein 23-järiger Mann leidet seit Kindheit an Haarverlust mit einem fast kompletten Fehlen der Kopfhaare seit seinem sechsten Altersjahr. In den letzten Monaten war es zu einem Fortschreiten der Erkrankung mit Entwicklung einer Alopecia universalis gekommen. Wir diskutieren die Pathogenese, Differentialdiagnose und Therapie der Alopecia areata.

scholarly journals Uric Acid and Hypertension: Prognostic Role and Guide for Treatment

2021 ◽  
Vol 10 (3) ◽  
pp. 448
Author(s):  
Federica Piani ◽  
Arrigo F. G. Cicero ◽  
Claudio Borghi
Keyword(s):  
Clinical Trials ◽  
Uric Acid ◽  
Mendelian Randomization ◽  
Strong Association ◽  
Epidemiological Studies ◽  
Hypertensive Disease ◽  
Genetic Studies ◽  
Lowering Therapy ◽  
The Relationship

The relationship between serum uric acid (SUA) and hypertension has been a subject of increasing interest since the 1870 discovery by Frederick Akbar Mahomed. Several epidemiological studies have shown a strong association between high SUA levels and the presence or the development of hypertension. Genetic analyses have found that xanthine oxidoreductase (XOR) genetic polymorphisms are associated with hypertension. However, genetic studies on urate transporters and Mendelian randomization studies failed to demonstrate a causal relationship between SUA and hypertension. Results from clinical trials on the role of urate-lowering therapy in the management of patients with hypertension are not uniform. Our study sought to analyze the prognostic and therapeutic role of SUA in the hypertensive disease, from uric acid (UA) biology to clinical trials on urate-lowering therapies.

scholarly journals “Snow Scenes”: Exploring the Role of Memory and Place in Commemorating Extreme Winters

2016 ◽  
Vol 8 (1) ◽  
pp. 5-19 ◽  
Author(s):  
Alexander Hall ◽  
Georgina Endfield
Keyword(s):  
Rural Communities ◽  
Local Level ◽  
Strong Association ◽  
Potential Effect ◽  
Cultural Dimensions ◽  
Extreme Weather Events ◽  
National Narratives ◽  
Local Climate ◽  
Weather Events

Abstract Scholars are increasingly focusing on the cultural dimensions of climate, addressing how individuals construct their understanding of climate through local weather. Research often focuses on the importance of widespread conceptualizations of mundane everyday weather, although attention has also been paid to extreme weather events and their potential effect on popular understandings of local climate. This paper introduces the “Snow Scenes” project, which aimed to engage rural communities in Cumbria, England, with their memories of extreme and severe past winter conditions in the region. Collating memories across a wide demographic, using a variety of methods, individual memories were analyzed alongside meteorological and historical records. By exploring these memories and their associated artifacts, this paper aims to better understand the role of memory and place in commemorating extreme winters. First, it is demonstrated how national narratives of exceptional winters are used by individuals as benchmarks against which to gauge conditions. Second, this paper identifies how specific locations and landmarks help to place memories and are shown to be important anchors for individuals’ understanding of their climate. Third, the paper considers how memories of severe winters are often nostalgic in their outlook, with a strong association between snowy winters, childhood, and childhood places. Fourth, it is illustrated how such events are regularly connected to important personal or familial milestones. Finally, the paper reflects on how these local-level experiences of historical extreme events may be central to the shaping of popular understandings of climate and also, by extension, climate change.

THE ROLE OF AGONISTS AND ANTAGONISTS OF THE WNT SIGNALING PATHWAY IN PATIENTS WITH ANDROGENIC ALOPECIA AND ALOPECIA AREATA

2021 ◽  
pp. 87-95
Author(s):  
Samoylova A.V. ◽  
Snimshchikova I.A. ◽  
Plotnikova M.O. ◽  
Yakushkina N.Y.
Keyword(s):  
Wnt Signaling ◽  
Hair Follicle ◽  
Signaling Pathway ◽  
Alopecia Areata ◽  
Intracellular Signaling ◽  
Wnt Signaling Pathway ◽  
Follicle Cells ◽  
Androgenic Alopecia ◽  
Active Population

Alopecia is a common pathology among the active population, which leads not only to cosmetic defects, but also to the development of somatic diseases against the background of traumatic effects and chronic stress. The pathogenetic mechanisms of hair follicle formation are complex and diverse, since numerous factors, including the components of the Wnt signaling pathway, have an effect on its morphogenesis, the study of which is the subject of this study. The search for possible early markers of the development of alopecia led to interest in the study of the main morphogenic proteins of WNT - the signaling pathway (one of the intracellular signaling pathways, which control the development of blood vessels, as well as the growth and division of hair follicle cells) sclerostin and β-catenin among patients with androgenic and alopecia areata. The article presents data on the quantitative content of β-catenin and sclerostin in the blood serum in patients with androgenic and alopecia areata. Their possible pathways of complex interaction and influence on the morphogenesis of the hair follicle and the activity of the Wnt-signaling pathway have been analyzed, and the relationship between changes in the level of morphogenic proteins of the WNT-signaling pathway with sex and the course of the disease has been described. Establishment of the prognostic role of morphogenic proteins of the WNT signaling pathway in androgenic and alopecia areata will allow not only identify the personal risk of disease progression and to determine approaches to targeted therapy, but to develop and introduce updated diagnostic screening into dermatological practice.

Looking into a New Challenge, DKA and Covid-19 A Review on Pediatric DKA Cases during New Coronavirus Pandemic Who is to Blame, the Virus or Health System?

2021 ◽  
Vol 5 (7) ◽  
pp. 01-04
Author(s):  
Vida Tajiknia ◽  
Maryam Ghandali ◽  
Ardavan Ahmadvand ◽  
Ali Afrasiabi ◽  
Reza Pirdehghan ◽  
...  
Keyword(s):  
Immune System ◽  
Virus Infection ◽  
Pediatric Patients ◽  
Strong Association ◽  
Diabetes Type ◽  
Diabetes Type 1 ◽  
The World ◽  
Existing Data

Since the first month of this new pandemic situation, all around the world healthcare system has been facing different challenges and difficulties; patients with chronic diseases such as cancer or diabetes with impaired immune system were at greater risk of infections and complications. It goes without saying that this issue was extremely important among pediatric clinicians dealing with diabetic pediatrics. Diabetes is the number one chronic illness among pediatric patients and the most dangerous and frightened complication of it is Diabetic Ketoacidosis (DKA). Studies have shown a strong association between pandemic and increase in new diabetes type 1 cases and its lethal complication called DKA. Here we are going to take a look at existing data and report about cases with this condition trying to find the missing piece of a big puzzle; what is the role of Covid-19 in causing Diabetes in previously healthy kids and what is the real association between SARS-COV2 virus infection and DKA? We are going to review different studies, possible mechanism, new t1dm cases and old cases, with or without covid infection, DKA cases and its severity.

scholarly journals Mouthrinses containing alcohol and oral cancer: revision of epidemiological studies

2007 ◽  
Vol 21 (spe) ◽  
pp. 16-22 ◽  
Author(s):  
Silvia Adriana López de Blanc ◽  
Ana María Baruzzi
Keyword(s):  
Oral Cancer ◽  
Strong Association ◽  
Epidemiological Studies ◽  
Clear Relationship

The strong association between alcohol usage and the development of oral cancer (OC) has been reported in numerous papers. As some mouthrinses contain significant amounts of ethanol, a possible relationship to this pathology has been considered. The purpose of the present paper is to analyze several epidemiological studies which evaluated the association between commercial mouthrinses and the etiology of OC. Although some authors report an association, most of the studies are unclear and sometimes contradictory. The controversial aspects regarding the role of alcohol in OC may also make difficult to find a clear relationship between the use of mouthrinses containing alcohol and OC.

scholarly journals Association between spectator and other roles in school bullying

2016 ◽  
Vol 26 (3) ◽  
pp. 352
Author(s):  
Marcela Almeida Zequinão ◽  
Pâmella De Medeiros ◽  
Beatriz Pereira ◽  
Fernando Luiz Cardoso
Keyword(s):  
Public Schools ◽  
Negative Reinforcement ◽  
Strong Association ◽  
School Bullying ◽  
The Other ◽  
Seventh Grade ◽  
Santa Catarina ◽  
The Third ◽  
Aggressive Behaviours

Introduction: The school bullying is characterized by repetitiveness of aggression and the intentionality to injure or cause suffering to others. The bystanders to this phenomenon tend to be mainly responsible for the course that bullying will take and its results. Objective: To analyse the association between the role of bystander with the other possible roles played in bullying. Method: A total of 409 children from the third to seventh grade participated in this study, with an average age of 11 years (SD = 1.61), enrolled in two municipal public schools in Florianópolis, Santa Catarina, Brazil. The instruments used were: one of the scales of the Questionnaire for the Study of Violence Among Peers, to identify bystanders, and the Olweus Questionnaire, to describe the possible roles played in school bullying. Results: It was found that most of the participants assumed the role of bystander in school bullying. However, an association was found with regard to gender and being a bystander. Also, strong association was found between being a bystander and the other roles played in bullying, primarily in relation to the bullies. Conclusion: These results reinforce the importance of bystanders in these aggressions, not only because they represent most of the participants, but mainly because of the positive or negative reinforcement they can offer in these aggressive behaviours. Therefore, the incentive and the encouragement of these students to denounce the aggressors, as well as defending the victims is essential to reduce school bullying.

scholarly journals Use of Artificial Intelligence as a Predictor of the Response to Treatment in Alopecia Areata

Iproceedings ◽  
10.2196/35433 ◽  
2021 ◽  
Vol 6 (1) ◽  
pp. e35433
Author(s):  
Fernando Alarcón-Soldevilla ◽  
Francisco José Hernández-Gómez ◽  
Juan Antonio García-Carmona ◽  
Celia Campoy Carreño ◽  
Ramon Grimalt ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Alopecia Areata ◽  
Predictive Value ◽  
Data Augmentation ◽  
Conflicts Of Interest ◽  
The United States ◽  
Response To Treatment ◽  
Disease Evolution ◽  
Dermatological Disease

Background Artificial intelligence (AI) has emerged in dermatology with some studies focusing on skin disorders such as skin cancer, atopic dermatitis, psoriasis, and onychomycosis. Alopecia areata (AA) is a dermatological disease whose prevalence is 0.7%-3% in the United States, and is characterized by oval areas of nonscarring hair loss of the scalp or body without evident clinical variables to predict its response to the treatment. Nonetheless, some studies suggest a predictive value of trichoscopic features in the evaluation of treatment responses. Assuming that black dots, broken hairs, exclamation marks, and tapered hairs are markers of negative predictive value of the treatment response, while yellow dots are markers of no response to treatment according to recent studies, the absence of these trichoscopic features could indicate favorable disease evolution without treatment or even predict its response. Nonetheless, no studies have reportedly evaluated the role of AI in AA on the basis of trichoscopic features. Objective This study aimed to develop an AI algorithm to predict, using trichoscopic images, those patients diagnosed with AA with a better disease evolution. Methods In total, 80 trichoscopic images were included and classified in those with or without features of negative prognosis. Using a data augmentation technique, they were multiplied to 179 images to train an AI algorithm, as previously carried out with dermoscopic images of skin tumors with a favorable response. Subsequently, 82 new images of AA were presented to the algorithm, and the algorithm classified these patients as responders and non-responders; this process was reviewed by an expert trichologist observer and presented a concordance higher than 90% with the algorithm identifying structures described previously. Evolution of the cases was followed up to truly determine their response to treatment and, therefore, to assess the predictive value of the algorithm. Results In total, 32 of 40 (80%) images of patients predicted as nonresponders scarcely showed response to the treatment, while 34 of 42 (81%) images of those predicted as responders showed a favorable response to the treatment. Conclusions The development of an AI algorithm or tool could be useful to predict AA evolution and its response to treatment. However, further research is needed, including larger sample images or trained algorithms, by using images previously classified in accordance with the disease evolution and not with trichoscopic features. Conflicts of Interest None declared.

Sign in / Sign up

Export Citation Format

Share Document