Modified Rice Bran Beneficial for Weight Loss of Mice as a Major and Acute Adverse Effect of Cisplatin

BACKGROUND With the explosion of web 2.0 technology, patients have taken to the internet to share experiences about their health conditions and treatments. Online drug review portals currently allow patients to their experiences with drugs they used in managing their conditions. These data sources could be harnessed for patient-reported real-world evidence to understand the impact of drugs on the users. OBJECTIVE To understand patients’ opinions about long-term AOMs (phentermine-topiramate, orlistat, naltrexone-bupropion, lorcaserin, and liraglutide) through online patient-posted user reviews. To determine the frequency of occurrence of key obesity treatment outcomes and build a multi-label classification model for detecting key obesity outcome topics. METHODS We crawled drug.com, askaapatient.com, webmd.com, druglib.com, and extracted reviews posted by the users of long-term AOMs about their experience with the drugs. Next, we carried out a generic lexicon-based document-level sentiment analysis by matching the words in the reviews of each AOM with their polarity classes in the sentiment dictionary. We then calculated the scaled sentiment score to measure how averagely positive the patient’s opinion is towards the drugs. The frequencies of occurrence of weight, adverse effect, glycemic, blood pressure, lipidemic outcome topics in the posted reviews were analyzed. A Multi-label classification model for classifying obesity outcome related topics was built and tested. RESULTS Patients expressed the most positive opinion for lorcaserin with a scaled sentiment score of 0.139, followed by phentermine-topiramate with scaled sentiment score of 0.04. Orlistat and naltrexone-bupropion had scaled-sentiment scores of -0.008 and -0.02 respectively. Having a scaled sentiment score -0.036, liraglutide was the most negatively appraised long-term AOM by patients’ reviews. Comparing the frequency of occurrence of weight and cardiometabolic topic in the reviews, weight loss outcome was the dominant topic, occurring in 1585 reviews, adverse effect topic occurred in 1273 reviews, glycemic outcome topic occurred in 92 reviews, blood pressure outcome topic occurred in 72 reviews, lipidemic outcome topic occurred in 48 reviews and topic on pulse outcome occurred in 31 reviews. The Multi-label classification model trained with the patient-posted AOM reviews has F1 score of 0.98, 0.55, 0.67, 0.80, and 0.67 in predicting AOM-related weight loss, adverse effect, , glycemic, blood pressure, lipidemic and pulse topics respectively in free text form. CONCLUSIONS Sentiment analysis of patient-posted long-term AOM reviews could be useful in understanding patient‘s experience with long-term AOMs. Despite having being withdrawn for the market, lorcaserin was the most positively appraised long-term AOM followed by phentermine-topiramate, orlistat, naltrexone-bupropion, and liraglutide. The users of AOMs commented most on the weight and safety (adverse effects) outcomes of AOMs than cardio-metabolic outcomes of their treatments. Classification model trained with patient posted AOM reviews had a good performance in detecting efficacy and safety signals occurring in text documents. sentiments/opinions formed by obese and overweight patients from their experience with long-term AOMs could be used in demonstrating the values of the medications, as part of patient-reported real-world evidence.

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Anticonvulsant and acute adverse effect profiles of picolinic acid 2-fluoro-benzylamide in various experimental seizure models and chimney test in mice

Fundamental and Clinical Pharmacology ◽

10.1111/j.1472-8206.2007.00547.x ◽

2008 ◽

Vol 22 (1) ◽

pp. 69-74 ◽

Cited By ~ 14

Author(s):

Jarogniew J. Luszczki ◽

Mariusz J. Swiader ◽

Katarzyna Swiader ◽

Ryszard Paruszewski ◽

Waldemar A. Turski ◽

...

Keyword(s):

Adverse Effect ◽

Picolinic Acid ◽

Seizure Models ◽

Acute Adverse Effect ◽

Chimney Test

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Sertraline induced acute mandibular dystonia

Journal of Neurosciences in Rural Practice ◽

10.4103/0976-3147.169804 ◽

2015 ◽

Vol 06 (04) ◽

pp. 586-587 ◽

Cited By ~ 6

Author(s):

Dhanya Raveendranathan ◽

Swaminath Rao

Keyword(s):

Adverse Effect ◽

Personality Disorder ◽

Serotonin Reuptake ◽

Dopaminergic System ◽

Serotonin Reuptake Inhibitors ◽

Drug Induced ◽

Acute Adverse Effect ◽

Emotionally Unstable Personality Disorder

ABSTRACTSpecific serotonin reuptake inhibitors have been linked with the occurrence of drug-induced parkinsonism, dystonia, dyskinesia, and akathisia. Here, we describe a patient with a diagnosis of emotionally unstable personality disorder and depression who developed severe mandibular dystonia with sertraline in the absence of concurrent prescription of medications, which have potential action on the dopaminergic system. This case highlights the need for clinicians to be aware of this alarming acute adverse effect with sertraline, which is conventionally considered to be well-tolerated and safe.

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Produksi Telur Ayam Ras Petelur dengan Pemberian Pakan Fermentasi Berbasis Azolla sebagai Substitusi Sebagian Ransum Komersil

Jurnal Ilmiah Mahasiswa Pertanian ◽

10.17969/jimfp.v2i4.5333 ◽

2017 ◽

Vol 2 (4) ◽

Author(s):

Lilyanda Fadilla ◽

Zulfan Zulfan ◽

Muhammad Aman Yaman

Keyword(s):

Adverse Effect ◽

Rice Bran ◽

Soybean Meal ◽

Egg Production ◽

Partial Substitution ◽

Experimental Unit ◽

Commercial Diet ◽

Randomized Design ◽

Completely Randomized Design ◽

Determine Effect

Abstrak. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian pakan fermentasi yang tersusun dari azolla, dedak padi, dedak jagung, dan bungkil kedelai sebagai substitusi sebagian ransum komersil terhadap produksi telur ayam ras petelur. Penelitian ini dilakukan di Laboratorium Lapangan Peternakan (LLP), Univeritas Syiah Kuala, tanggal 13 Februari‒12 April 2017. Penelitian ini menggunakan 48 ekor ayam ras petelur. Rancangan yang digunakan adalah Rancangan Acak Lengkap terdiri dari 4 perlakuan dan 4 ulangan. Ransum perlakuan adalah ransum komersil yang disubstitusi dengan bahan pakan fermentasi berbahan 15% azolla sebanyak 0, 5, 10, dan 15%. Berdasarkan hasil penelitian dapat disimpulkan bahwa meskipun secara statistik tidak nyata (P0,05). penggunaan bahan pakan fermentasi (yang tersusun dari azolla 15% + dedak padi 30% + dedak jagung 30% + bungkil kedelai 25%) sebanyak-banyaknya 15% sebagai subtsitusi ransum komersil ayam petelur selama bulan pertama periode produksi telur mampu memacu produksi telur ayam ras dengan massa telur yang lebih tinggi. Kata kunci : azolla, fermentasi, ayam, produksi telur (Egg Production of Laying Hens Fed Fermentation Feed Based on Azolla sp as Partial Substitution of Commercial Diet)Abstract. The objective of this study was to determine effect of inclusion of fermentation feed constituted of 15% Azolla sp + 30% rice bran+ 30% corn bran + 25% soybean meal as partial substitution of commercial diet on egg production of laying chickens. As many as 48 pullets were used in this study. The study was performed in to completely randomized design, consisted of 4 treatments and 4 replications. Replication was an experimental unit consisted of 3 birds. The results of study indicated that although statistically no significant effects were detected (P0,05) the inclusion of 15% fermentation feed based on 15% Azolla sp could be used up to 15% to substitute of commercial diet without adverse effect on egg production. It was supposed that fermentation feed based on 15% Azolla sp tend to increase egg production and egg mass.Keywords: Azolla sp, fermentation, chicken, egg production

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Safety and Side-effects of Alprazolam Controlled Study in Agoraphobia with Panic Disorder

The British Journal of Psychiatry ◽

10.1192/bjp.165.1.79 ◽

1994 ◽

Vol 165 (1) ◽

pp. 79-86 ◽

Cited By ~ 28

Author(s):

G. H. O'Sullivan ◽

H. Noshirvani ◽

M. Basoglu ◽

I. M. Marks ◽

R. Swinson ◽

...

Keyword(s):

Adverse Effect ◽

Weight Loss ◽

Side Effects ◽

Panic Disorder ◽

Adverse Reactions ◽

Drug Group ◽

Drop Out ◽

Controlled Study ◽

Impaired Memory ◽

Drop Out Rate

BackgroundThe widespread use of benzodiazepines has led to increasing recognition of their unwanted effects. The efficacy of alprazolam and placebo in panic disorder with agoraphobia, and the side-effect and adverse effect profiles of both drug groups were measured.MethodIn London and Toronto 154 patients who met DSM–III criteria for panic disorder with agoraphobia were randomised to alprazolam or placebo. Subjects in each drug group also received either exposure or relaxation. Treatment was from weeks 0 to 8 and was then tapered from weeks 8 to 16.ResultsMean alprazolam dose was 5 mg daily. Compared with placebo subjects, alprazolam patients developed more adverse reactions (21 % v. 0%) of depression, enuresis, disinhibition and aggression; and more side-effects, particularly sedation, irritability, impaired memory, weight loss and ataxia. Side-effects tended to diminish during treatment but remained significant at week 8. Despite this, the drop-out rate was low.ConclusionsAlprazolam caused side-effects and adverse effects during treatment but many patients were willing to accept these.

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