Racial Effects on Psychiatric Diagnostic Changes From Admission to Discharge

This study provides the first empiric evidence for the existence of a new epidemic of retinopathy of prematurity-induced blindness. Data from a population-based register of handicapping conditions in the Canadian province of British Columbia, and a birth weight-specific census of live-born infants in British Columbia, were used to determine annual, population-level incidences of retinopathy of prematurity-induced blindness during 1952 to 1983. Changes in incidence since the end of the original epidemic (1954) were determined by subdividing the 29-year period (1955 to 1983) into two intervals (1955 to 1964 and 1965 to 1983). Standardized incidence ratio analyses revealed a marginally significant increase in the overall incidence of retinopathy of prematurity-induced blindness in the later as compared with the earlier period. Infants weighing 750 to 999 g at birth had a significantly increased standardized incidence ratio of 3.07 (95% confidence interval 1.26, 11.06). No increases in risk were observed in heavier or lighter weight infants. Because ascertainment and diagnostic changes do not explain the weight-specific increases in incidence, these results provide the first population-level evidence for a new epidemic.

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Diagnostic accuracy of imaging brain vesicular monoamine transporter type 2 (VMAT2) in clinically uncertain parkinsonian syndrome (CUPS): a 3-year follow-up study in community patients

BMJ Open ◽

10.1136/bmjopen-2018-025533 ◽

2018 ◽

Vol 8 (11) ◽

pp. e025533 ◽

Cited By ~ 3

Author(s):

San San Xu ◽

Paschal K Alexander ◽

Yenni Lie ◽

Vincent Dore ◽

Svetlana Bozinovski ◽

...

Keyword(s):

Diagnostic Accuracy ◽

Clinical Diagnosis ◽

Pet Scan ◽

Vesicular Monoamine Transporter ◽

Monoamine Transporter ◽

Rubral Tremor ◽

Diagnostic Changes ◽

Community Patients

ObjectivesTo further validate the diagnostic utility of 18F-AV-133 vesicular monoamine transporter type 2 (VMAT2) positron emission tomography (PET) in patients with clinically uncertain parkinsonian syndromes (CUPS) by comparison to clinical diagnosis at 3 years follow-up.Design, setting and participantsIn a previous study, we reported that 18F-AV-133 PET in community patients with CUPS changed diagnosis and management and increased diagnostic confidence. The current diagnosis of this cohort was obtained from the patient and treating specialist and compared with the diagnosis suggested 3 years earlier by the 18F-AV-133 PET. A second 18F-AV-133 PET was available in those with a discordant or inconclusive final diagnosis.Study outcome measuresThe primary end point was the proportion of patients who had a follow-up clinical diagnosis, which was concordant with their initial 18F-AV-133 PET scan. Secondary end points were the proportion of patients who had the same diagnosis at follow-up as that reached after the initial scan and the stability of diagnostic changes made after the first scan.Results81 of the 85 patients previously recruited to the CUPS study had follow-up of which 79 had a clinical diagnosis and 2 remained CUPS. The diagnosis was in agreement with the initial 18F-AV-133 PET scan result in 74 cases. Five patients had a discordant diagnosis; one patient with rubral tremor had a severely abnormal scan that had worsened when rescanned; four cases with normal initial and repeat scans had a clinical diagnosis of Parkinson’s disease. Two patients with suspected genetic disorders remained classified as CUPS and both had normal scans. In the 24 CUPS cohort patients where 18F-AV-133 PET initially changed diagnosis, this change was supported by follow-up diagnosis in all but the one rubral tremor case.Conclusion18F-AV-133 PET is a useful tool in improving diagnostic accuracy in CUPS providing results and diagnostic changes that remain robust after 3 years follow-up.

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Racial and Ethnic Effects on Psychotic Psychiatric Diagnostic Changes From Admission to Discharge

The Journal of Clinical Psychiatry ◽

10.4088/jcp.v69n0318 ◽

2008 ◽

Vol 69 (3) ◽

pp. 464-469 ◽

Cited By ~ 5

Author(s):

Deidre M. Anglin ◽

Dolores Malaspina

Keyword(s):

Diagnostic Changes

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Sinus maxillaris mycetoma of odontogenic origin: case report

Brazilian Dental Journal ◽

10.1590/s0103-64402004000300016 ◽

2004 ◽

Vol 15 (3) ◽

pp. 248-250 ◽

Cited By ~ 12

Author(s):

Matjaz Rode ◽

Jernej Podboj ◽

Mirela Kogoj-Rode

Keyword(s):

Case Report ◽

Fungal Infection ◽

Facial Pain ◽

Fungal Infections ◽

Endodontic Treatment ◽

Diagnostic Methods ◽

Odontogenic Origin ◽

Upper Jaw ◽

Root Apices ◽

Diagnostic Changes

Fungal infections are on the increase and those of the jaw cavities with Aspergillus species may be connected with the root apices of teeth in the upper jaw. Diagnostic changes in the sinus maxillaris and certain types of facial pain may be indicative of fungal infection. The authors report a case of aspergillosis sinusitis and describe the diagnostic methods and treatment of this infection that may be associated with endodontic treatment.

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A Fluorescent Kinase Inhibitor that Exhibits Diagnostic Changes in Emission upon Binding

Angewandte Chemie International Edition ◽

10.1002/anie.201909536 ◽

2019 ◽

Vol 58 (42) ◽

pp. 15000-15004

Author(s):

Cassandra L. Fleming ◽

Patrick A. Sandoz ◽

Tord Inghardt ◽

Björn Önfelt ◽

Morten Grøtli ◽

...

Keyword(s):

Kinase Inhibitor ◽

Diagnostic Changes

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Ward rounds: missed learning opportunities in diagnostic changes?

The Clinical Teacher ◽

10.1111/j.1743-498x.2010.00408.x ◽

2011 ◽

Vol 8 (1) ◽

pp. 17-21 ◽

Cited By ~ 4

Author(s):

Aneel Bhangu ◽

Gemma Hartshorne

Keyword(s):

Learning Opportunities ◽

Ward Rounds ◽

Diagnostic Changes

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Stability of early-phase primary psychotic disorders with concurrent substance use and substance-induced psychosis

The British Journal of Psychiatry ◽

10.1192/bjp.bp.105.015784 ◽

2007 ◽

Vol 190 (2) ◽

pp. 105-111 ◽

Cited By ~ 61

Author(s):

Carol L. M. Caton ◽

Deborah S. Hasin ◽

Patrick E. Shrout ◽

Robert E. Drake ◽

Boanerges Domínguez ◽

...

Keyword(s):

Mental Illness ◽

Substance Use ◽

Early Phase ◽

Psychotic Disorders ◽

History Of ◽

Dsm Iv ◽

The Stability ◽

Primary Substance ◽

Diagnostic Changes

BackgroundThe stability of the diagnostic distinction between a substance-induced psychosis and a primary psychotic disorder co-occurring with substance use is not established.AimsTo describe DSM – IV diagnostic changes over 1 year and determine the predictive validity of baseline indicators of the substance-induced psychosis v. primary psychosis distinction.MethodWe conducted a 1-year follow-up study of 319 psychiatric emergency department admissions with diagnoses of early-phase psychosis and substance use comorbidity.ResultsOf those with a baseline DSM—IV diagnosis of substance-induced psychosis, 25% had a diagnosis of primary psychosis at follow-up. These patients had poorer premorbid functioning, less insight into psychosis and greater family mental illness than patients with a stable diagnosis of substance-induced psychosis. Reclassifying change cases to primary psychoses on follow-up, key baseline predictors of the primary/substance-induced distinction at 1 year also included greater family history of mental illness in the primary psychosis group.ConclusionsFurther study of substance-induced psychoses should employ neuroscientific and behavioural approaches. Study findings can guide more accurate diagnoses at first treatment.

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Temporal trends in incidence of childhood cancer in Switzerland, 1985-2014

10.1101/670224 ◽

2019 ◽

Author(s):

Grit Sommer ◽

Matthias Schindler ◽

Shelagh Redmond ◽

Verena Pfeiffer ◽

Garyfallos Konstantinoudis ◽

...

Keyword(s):

Childhood Cancer ◽

Temporal Trends ◽

List Type ◽

Standard Population ◽

European Standard Population ◽

Increasing Trend ◽

Cns Tumours ◽

Rising Incidence ◽

Changes In Risk ◽

Diagnostic Changes

STRUCTURED ABSTRACTBackgroundIncidence of childhood cancer increased in most countries worldwide, but the reasons are unclear. This study investigates trends in childhood cancer incidence in Switzerland from 1985 to 2014.MethodsWe extracted data on all childhood cancer cases diagnosed at ages 0-14 years in Switzerland from the Swiss Childhood Cancer Registry. We included ICCC-3 main groups I-XII and calculated age-standardised, cumulative, and age-specific incidence for different diagnostic groups. We analysed trends in annual age-standardised incidence using JoinPoint regression models.ResultsOver the study period from 1985-2014, 5104 of 5486 cancer diagnoses (93%) were microscopically verified. The proportion of children treated in paediatric cancer centres increased from 84% during 1985-1994 to 93% in 1995-2004 and 98% in 2005-2014 (p<0.001). Using the 2010 European standard population, age-standardised incidence was 143 in 1985-1994, 154 in 1995-2004, and 162 per million in 2005-2014. Over the period 1985-2014, incidence for all cancers increased by 0.7% (95% confidence interval [CI] 0.5-1.0) per year, 0.8% (95% CI 0.2%-1.4%) for leukaemias, 3.8% (95% CI 1.7%-6.0%) for epithelial neoplasms and melanomas, and 3.0% (95% CI 1.3%-4.6%) for CNS tumours for the period 1985-2002.ConclusionTrends in incidence were driven mostly by increases among leukaemias and CNS tumours. For CNS tumours, observed trends may be explained at least partially by diagnostic changes and improved registration. For leukaemias, rising incidence may be real and at least partly due to changes in risk factors.HighlightsIn Switzerland, incidence of childhood cancer increased by 18% from 1985-2014.Increase in incidence was mainly caused by brain tumours and leukaemias.Improved registration and diagnostics may have increased brain tumour incidence.Increasing trend for leukaemias may be real, but reasons remain elusive.

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