scholarly journals Loss of antigen-presenting molecules (MHC class I and TAP-1) in lung cancer

1996 ◽  
Vol 73 (2) ◽  
pp. 148-153 ◽  
Author(s):  
P Korkolopoulou ◽  
L Kaklamanis ◽  
F Pezzella ◽  
AL Harris ◽  
KC Gatter
Keyword(s):  
Lung Cancer ◽  
Mhc Class I ◽  
Class I ◽  
Antigen Presenting

MHC class I-presented lung cancer-associated tumor antigens identified by immunoproteomics analysis are targets for cancer-specific T cell response

2011 ◽  
Vol 74 (5) ◽  
pp. 728-743 ◽  
Author(s):  
Vivekananda Shetty ◽  
Gomathinayagam Sinnathamby ◽  
Zacharie Nickens ◽  
Punit Shah ◽  
Julie Hafner ◽  
...  
Keyword(s):  
Lung Cancer ◽  
T Cell ◽  
Mhc Class I ◽  
Cell Response ◽  
Tumor Antigens ◽  
T Cell Response ◽  
Class I

scholarly journals The Major Histocompatibility Complex of Old World Camels—A Synopsis

Cells ◽  
2019 ◽  
Vol 8 (10) ◽  
pp. 1200 ◽  
Author(s):  
Plasil ◽  
Wijkmark ◽  
Elbers ◽  
Oppelt ◽  
Burger ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Mhc Class I ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Class I ◽  
Class Iii ◽  
Old World ◽  
Histocompatibility Complex ◽  
Mhc Class Iii ◽  
Antigen Presenting

This study brings new information on major histocompatibility complex (MHC) class III sub-region genes in Old World camels and integrates current knowledge of the MHC region into a comprehensive overview for Old World camels. Out of the MHC class III genes characterized, TNFA and the LY6 gene family showed high levels of conservation, characteristic for MHC class III loci in general. For comparison, an MHC class II gene TAP1, not coding for antigen presenting molecules but functionally related to MHC antigen presenting functions was studied. TAP1 had many SNPs, even higher than the MHC class I and II genes encoding antigen presenting molecules. Based on this knowledge and using new camel genomic resources, we constructed an improved genomic map of the entire MHC region of Old World camels. The MHC class III sub-region shows a standard organization similar to that of pig or cattle. The overall genomic structure of the camel MHC is more similar to pig MHC than to cattle MHC. This conclusion is supported by differences in the organization of the MHC class II sub-region, absence of functional DY genes, different organization of MIC genes in the MHC class I sub-region, and generally closer evolutionary relationships of camel and porcine MHC gene sequences analyzed so far.

scholarly journals The Structure of the MHC Class I Molecule of Bony Fishes Provides Insights into the Conserved Nature of the Antigen-Presenting System

2017 ◽  
Vol 199 (10) ◽  
pp. 3668-3678 ◽  
Author(s):  
Zhaosan Chen ◽  
Nianzhi Zhang ◽  
Jianxun Qi ◽  
Rong Chen ◽  
Johannes M. Dijkstra ◽  
...  
Keyword(s):  
Mhc Class I ◽  
Class I ◽  
Mhc Class I Molecule ◽  
Bony Fishes ◽  
Antigen Presenting

scholarly journals Chlamydia trachomatisImmune Evasion via Downregulation of MHC Class I Surface Expression Involves Direct and Indirect Mechanisms

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Joyce A. Ibana ◽  
Danny J. Schust ◽  
Jun Sugimoto ◽  
Takeshi Nagamatsu ◽  
Sheila J. Greene ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Mhc Class I ◽  
Mhc Class Ii ◽  
Surface Expression ◽  
Class I ◽  
Cell Surface Expression ◽  
Class I Mhc ◽  
Pathogen Entry ◽  
Antigen Presenting ◽  
Immune Detection

GenitalC. trachomatisinfections typically last for many months in women. This has been attributed to several strategies by whichC. trachomatisevades immune detection, including well-described methods by whichC. trachomatisdecreases the cell surface expression of the antigen presenting molecules major histocompatibility complex (MHC) class I, MHC class II, and CD1d in infected genital epithelial cells. We have harnessed new methods that allow for separate evaluation of infected and uninfected cells within a mixed population of chlamydia-infected endocervical epithelial cells to demonstrate that MHC class I downregulation in the presence ofC. trachomatisis mediated by direct and indirect (soluble) factors. Such indirect mechanisms may aid in priming surrounding cells for more rapid immune evasion upon pathogen entry and help promote unfettered spread ofC. trachomatisgenital infections.

scholarly journals Assembly and Antigen-Presenting Function of MHC Class I Molecules in Cells Lacking the ER Chaperone Calreticulin

Immunity ◽  
2002 ◽  
Vol 16 (1) ◽  
pp. 99-109 ◽  
Author(s):  
Bin Gao ◽  
Raju Adhikari ◽  
Mark Howarth ◽  
Kimitoshi Nakamura ◽  
Marielle C Gold ◽  
...  
Keyword(s):  
Mhc Class I ◽  
Class I ◽  
Er Chaperone ◽  
Antigen Presenting ◽  
Mhc Class I Molecules ◽  
In Cells

scholarly journals Differential binding affinity of mutated peptides for MHC class I is a predictor of survival in advanced lung cancer and melanoma

2018 ◽  
Vol 29 (1) ◽  
pp. 271-279 ◽  
Author(s):  
E. Ghorani ◽  
R. Rosenthal ◽  
N. McGranahan ◽  
J.L. Reading ◽  
M. Lynch ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Binding Affinity ◽  
Mhc Class I ◽  
Class I ◽  
Advanced Lung Cancer ◽  
Differential Binding

Nitrosylation of Platelet MHC Class I Molecules Directs Their Movement into the Immunosuppressive MHC Class I Processing Pathway within Antigen Presenting Cells.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 837-837
Author(s):  
John W. Semple ◽  
Edwin R. Speck ◽  
John Freedman
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Mhc Class I ◽  
Cd8 T Cells ◽  
Brefeldin A ◽  
Antigen Presenting Cells ◽  
Class I ◽  
Antigen Presenting ◽  
Platelet Transfusions

Abstract Previous studies have demonstrated that recipient mice require the production of nitric oxide (NO) within their antigen presenting cells (APC) in order to generate IgG anti-donor immunity against allogeneic platelet transfusions. NO has a complex biochemistry and several of its conjurors could be involved in this response; the most obvious is peroxynitrite (ONOO-) generated by the spontaneous combination of NO and superoxide (O2•−). ONOO- is a potent oxidant that can spontaneously nitrosylate lysine and tyrosine residues in proteins within the phagolysosome. To address the role of ONOO- in platelet immunity, we transfused GP91 PHOX knockout mice that lack the ability to produce O2•− and thus ONOO-. Results show that when wild type C57BL/6 mice were transfused with allogeneic BALB/c platelets, they developed a weak IgG anti-donor antibody response by the fifth transfusion. In contrast, PHOX KO mice generated IgG anti-donor antibodies by the 2nd transfusion and their IgG anti-donor antibody titres were significantly higher than the WT recipients. This suggested that ONOO- and protein nitrosylation may be linked with an immunosuppressive event within the recipient. This was confirmed by demonstrating that in vitro nitrosylation of platelet antigens with the ONOO- donor SIN-1 inhibited the ability of the platelets to mount an IgG immune response when transfused into allogeneic recipients. Nitrosylated platelet antigen trafficking within recipient APC was assessed by using adherent macrophages and various inhibitors of processing. When adherent APC were pulsed with nitrosylated platelet antigens in the presence of either Brefeldin A or proteosome inhibitors, IgG anti-platelet immunity against the platelets was restored. Furthermore, the IgG immunity could also be rescued against the nitrsosylated platelets if the recipients were first depleted of CD8+ T cells by injection of a monoclonal antibody. These results suggest that if platelet antigens are nitrosylated within antigen presenting cells, they are preferentially shunted to the MHC class I processing pathway and presented to CD8+ T cells that suppress the IgG immune response. Thus, it appears that reactive oxygen species act as intracellular regulators that determine whether a productive IgG immune response against platelet transfusions will occur.

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