scholarly journals Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies

2017 ◽  
Vol 117 (2) ◽  
pp. 203-209 ◽  
Author(s):  
Muhammad A Alvi ◽  
Maurice B Loughrey ◽  
Philip Dunne ◽  
Stephen McQuaid ◽  
Richard Turkington ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Immune Checkpoint ◽  
Immune Checkpoint Inhibitor ◽  
Checkpoint Inhibitor ◽  
Molecular Profiling ◽  
Signet Ring Cell ◽  
Signet Ring ◽  
Ring Cell

KMT2C as a positive predictor for treatment of immune checkpoint inhibitor and correlation with immune infiltrates in colorectal cancer (CRC).

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 3538-3538
Author(s):  
Ling Zhang ◽  
Jianping Song ◽  
Yiting Wang ◽  
Yaoxu Chen
Keyword(s):  
Colorectal Cancer ◽  
Survival Data ◽  
Immune Checkpoint ◽  
Immune Checkpoint Inhibitor ◽  
Immune Cell ◽  
Checkpoint Inhibitor ◽  
Colon Adenocarcinoma ◽  
Treg Cells ◽  
Prognostic Effect

3538 Background: Lysine Methyltransferase 2C (KMT2C), a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family, possesses histone methylation activity and is involved in transcriptional co-activation. Present study has shown that KMT2C is positive correlated with better efficacy of Immune checkpoint inhibitor (ICI) in NSCLC. However, the role of KMT2C in treatment of ICI on colorectal cancer (CRC) is still unknown. Methods: NGS (Next Generation Sequencing) was performed on 1628 CRC patients. TMB of these patients were analyzed. A public accessible cohort (Samstein2018) with data from 130 CRC patients were used to investigate the correlation between KMT2C mutation and efficacy of ICI. WES and survival data of TCGA database (1099 CRC) was used to analyze prognostic effect of KMT2C mutation. Furthermore, CIBERSORT was used to analyze the tumor-infiltrating immune cells present in COAD（colon adenocarcinoma, 404 patients）from TCGA database. Results: Among 1628 CRC patient, 230(14.1%) had KMT2C mutation. TMB was positive correlated with KMT2C mutation (Mut vs. WT, 30.75 vs. 7.26 mut/Mb, p < 0.0001). The Samstein2018 cohort showed that KMT2C mutations (15.4%, 20/130) were significantly associated with better OS (Mut vs. WT, 11.5 vs. 7.5 month, HR = 0.29; 95% CI, 0.1-0.81; P = 0.012), and a higher TMB was also observed in KMT2C-Mut group (p = 1.98e-08). In TCGA, no association between KMT2C mutation and OS was observed (P = 0.23), suggesting that was not prognostic factor. Moreover, we analyzed the relationship between KMT2C mutation and immune cell infiltration through CRC TCGA database. The results showed, in COAD, KMT2C mutation was positively correlated with the abundance of CD8+ T cells (P = 0.0014), B cells (P = 0.014), M1 macrophages (P = 0.015), neutrophil (P = 0.0019) and NK cells (P = 0.043), and negatively correlated with Treg cells (p = 0.0063). Conclusions: KMT2C has an impact on the immune microenvironment and may be used as a potential positive predictor for treatment of ICI on CRC patients. The role of KMT2C in immunotherapy warrant further studies.

A STUDY OF HISTOPATHOLOGICAL DISTRIBUTION IN COLORECTAL CANCER

2021 ◽  
pp. 24-25
Author(s):  
Shipra Singh ◽  
Kailash Chand Jat ◽  
Ajit Singh ◽  
Kunal Purohit
Keyword(s):  
Colorectal Cancer ◽  
Surgical Techniques ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Lymph Node Status ◽  
Sex Distribution ◽  
Surgical Specimen ◽  
Signet Ring ◽  
Ring Cell ◽  
Causes Of Deaths

Despite of advances in surgical techniques and adjuvant chemotherapeutic regimens, colorectal cancer remains one of the major leading causes of deaths worldwide. Histopathology is an important factor in the treatment and prognosis of cancer. The purpose of this study was to describe the different histopathological pattern in colorectal cancer. 81 cases of colorectal carcinoma received in pathology department over a period of four years were included in the study. The surgical specimen and colonoscopic biopsies' gross features were noted and samples were stained with Haematoxylin and Eosin. Detailed microscopic examination of tumor with lymph node status was done followed by histological typing. Grading of the tumor, age and sex distribution of cases were also noted. The commonest histopathological nding was adenocarcinoma 75.32% followed by mucinous adenocarcinoma 9.88% and signet ring cell carcinoma 8.64%. Among 61 cases of adenocarcinoma most commonly moderately differentiated adenocarcinoma 60.66% was noted.

scholarly journals Colorectal Signet Ring Cell Carcinoma in a Young Pregnant Woman

2020 ◽  
Vol 13 (1) ◽  
pp. 182-187
Author(s):  
Francisco Ibargüengoitia Ochoa ◽  
Gerardo Miranda Dévora ◽  
Leonardo Silva Lino ◽  
Cintia Sepulveda Rivera ◽  
Diego González Vázquez ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Carcinoma ◽  
Stage Iv ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
High Morbidity ◽  
Cancer Stage ◽  
Signet Ring ◽  
Histologic Differentiation ◽  
Ring Cell

Colorectal cancer during pregnancy is one of the less common neoplasms with an incidence of 0.8 in 100,000 pregnancies. Primary colonic signet ring cell carcinoma is a weird variety, characterized by a poor histologic differentiation, with a high morbidity-mortality rate. The case of a 24-year-old patient with a 22-week-old pregnancy and colorectal cancer stage IV in palliative state is presented, with a devastating result. Early diagnosis represents a challenge because of the presentation form and the histologic aggressiveness of this disease. We suggest that colorectal cancer during pregnancy must be treated by a multidisciplinary team.

scholarly journals Predictors of Lymph Node Metastasis and Prognosis in pT1 Colorectal Cancer Patients with Signet-Ring Cell and Mucinous Adenocarcinomas

2017 ◽  
Vol 41 (5) ◽  
pp. 1753-1765 ◽  
Author(s):  
Bao-Rong Song ◽  
Chang-Chun Xiao ◽  
Zhao-Kun Wu
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Survival Rate ◽  
Local Excision ◽  
Signet Ring Cell ◽  
Rectal Tumors ◽  
Node Metastasis ◽  
Colon Cancers ◽  
Signet Ring ◽  
Ring Cell

Background/Aims: The local excision of early colorectal cancer is limited by the presence of lymph node metastasis (LNM). Signet-ring cell carcinomas (SRC) and mucinous adenocarcinomas (MAC) are two relatively infrequent histological subtypes. However, little is known about the predictors of LNM and prognosis to support the feasibility of local excision in early-stage SRC and MAC. Methods: The Surveillance Epidemiology and End Results Database were used to identify all patients with pT1 adenocarcinomas, including conventional adenocarcinoma (AC), MAC, and SRC. The prevalence of LNM was assessed, and the long-term survival rate in the above three types of colorectal cancer was calculated. Results: SRC accounted for 0.3% and MAC accounted for 4.4% of the entire cohort of colorectal adenocarcinomas. Compared to AC, MRC and SRC were more often located in the proximal colon, and exhibited a higher grade. The incidence of LNM in AC, MAC, and SRC was 10.6%, 17.2%, and 33.3% for colon cancers and 14.8%, 25.9%, and 46.2% for rectal cancers, respectively. In patients with lymph nodes resected no less than 12, incidence of LNM in AC, MRC, and SRC was 12%, 21%, and 44% for colon tumors and 17%, 30%, and 14% for rectal tumors, respectively. Although, colon patients MAC showed an entirely worse survival rate than AC, rectum patients MAC showed a similar prognosis to AC. We found that in patients with rectal tumors, SRC had a worse 3 and 5-year prognosis than AC. However, for colon cancers, the prognosis of SRC was similar to that of AC. Histology was not found to be an independent prognostic factor in multivariate survival analysis. Conclusions: MAC and SRC are two distinct subtypes of colorectal cancer that require special attention despite their relatively rare prevalence. pT1 patients with SRC of the rectum and patients with MAC of the colon have higher incidences of LNM, and with these adverse outcomes, local excision is not recommended. AlthoughMAC of the rectum and SRC of colon have a high rate of LNM, the prognosis of these types are similar to that of AC.

Predictors of lymph node metastasis and prognosis in early colorectal cancer patients with signet-ring cell and mucinous adenocarcinomas.

2016 ◽  
Vol 34 (4_suppl) ◽  
pp. 717-717
Author(s):  
Baorong Song ◽  
Yongming Yu ◽  
Xiao Song ◽  
Xinxiang Li ◽  
Xiaoyu Dai ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Local Excision ◽  
Signet Ring Cell ◽  
Early Colorectal Cancer ◽  
Node Metastasis ◽  
Signet Ring ◽  
Ring Cell ◽  
Colorectal Adenocarcinomas

717 Background: The local excision of early colorectal cancer is limited by the presence of lymph node metastasis. Signet-ring cell carcinomas and mucinous adenocarcinomas are two relatively infrequent histological subtypes. However, little is known about the predictors of lymph node metastases and prognosis to support the feasibility of local excision in early-stage signet-ring cell and mucinous colorectal adenocarcinomas. Methods: The Surveillance Epidemiology and End Results Database (1988 to 2006) from the National Cancer Institute was used to identify all patients with T1 adenocarcinomas, including conventional adenocarcinoma (AC), mucinous adenocarcinomas (MAC), and signet-ring cell carcinoma (SRC). The prevalence of lymph node metastasis was assessed, and the long-term survival rate in the above three types of colorectal cancer was calculated. Results: Final cohorts of 47,260 patients were eligible for analysis. SRC accounted for 0.3% and MAC accounted for 3.7% of the entire cohort of colorectal adenocarcinomas. Compared to AC, SRC and MAC more frequently presented at a younger age, were located in the proximal colon, and exhibited a higher grade. The incidence of lymph node metastasis in AC, MAC, and SRC was 5.8%, 10.8%, and 15.3%, respectively. Patients with SRC were associated with a worse prognosis, regardless of the tumor location. Patients with MAC of the rectum, but not the colon, were associated with a reduced implication of prognosis. After adjusting for other clinicopathological factors, SRC and MAC of the rectum were independently associated with a high risk of death (HR 2.70, CI 1.77-4.12 and HR 1.65, CI 1.38-1.98 for SRC and MAC, respectively). Histology was not found to be an independent prognostic factor in patients with colon cancer. Conclusions: MAC and SRC are two distinct subtypes of colorectal cancer that require special attention despite their relatively rare prevalence. T1 patients with SRC and patients with MAC of the rectum have higher incidences of lymph node metastasis (LNM), and with these adverse outcomes, local excision is not recommended. Although MAC of the colon has a high rate of LNM, the prognosis of this type is similar to that of AC.

Signet ring cell colorectal cancer: Genomic insights into a rare subpopulation of colorectal adenocarcinoma.

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 606-606
Author(s):  
Krittiya Korphaisarn ◽  
Van Karlyle Morris ◽  
Michael J. Overman ◽  
David R. Fogelman ◽  
Imad Shureiqui ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colorectal Adenocarcinoma ◽  
Cpg Island ◽  
Signet Ring Cell ◽  
Molecular Characteristics ◽  
Advanced Tumor Stage ◽  
Molecular Features ◽  
Advanced Tumor ◽  
Signet Ring ◽  
Ring Cell

606 Background: Colorectal signet ring cell carcinoma (SRCC) has been shown to be associated with advanced tumor stage at presentation and worse outcomes. Due to the rarity of this subtype, 1% of all colorectal adenocarcinoma (CRC), little is known about its molecular characteristics. We aimed to characterize the molecular alterations of this subgroup. Methods: Metastatic CRC (mCRC) patients (pts) with signet ring cell (SC) histology who had tumors evaluated with next generation sequencing between February 2009 and November 2015 were reviewed. SC mCRC were classified into 2 groups; SRCC (>50% of signet cells) and adenocarcinoma (AC) with SC component. Genomic alterations, microsatellite instability (MSI) and CpG island methylator phenotype (CIMP) status noted in SC mCRC were compared to non-SC mCRC pts from the Assessment of Targeted Therapies Against Colorectal Cancer program at MD Anderson Cancer Center using Pearson’s χ 2 test. Results: A total of 665 mCRC pts were included in this study. 93 pts (14%) had SC histology of which 30 (32.3%) pts were SRCC. The Table below shows key cancer genes mutation frequencies. Conclusions: Colorectal SRCC has distinct molecular features compared with non-SC and AC with SC component CRC. The frequencies of KRAS, PIK3CA and APC mutations were lower than the frequencies reported in non-SC CRC. SRCC was not associated with MSI-H or CIMP-H tumor in this study. Further studies on identification of activated pathways underlying this worse prognosis and potential therapeutic targets are required. [Table: see text]

scholarly journals Trends in the Incidence and Survival Rates of Colorectal Signet-Ring Cell Carcinoma in the South Korean Population: Analysis of the Korea Central Cancer Registry Database

2021 ◽  
Vol 10 (18) ◽  
pp. 4258
Author(s):  
Ji-Hoon Kim ◽  
Hyunil Kim ◽  
Jin Woo Kim ◽  
Hee Man Kim
Keyword(s):  
Colorectal Cancer ◽  
Cell Carcinoma ◽  
Cancer Registry ◽  
Survival Rates ◽  
Relative Survival ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Signet Ring ◽  
Ring Cell ◽  
Central Cancer Registry

Objective: Signet-ring cell carcinoma (SRCC) is a rare histopathological subtype of colorectal cancer (CRC) constituting approximately 1% of CRC cases. This study analyzed the incidence and survival rates of colorectal SRCC. Methods: We analyzed the incidence and survival rates of colorectal SRCCs based on patients’ data of the Korea Central Cancer Registry. Results: The age-standardized incidence rates of colon and rectum SRCC in 2017 were 0.17 and 0.07 individuals per 100,000, respectively. Between 1993 and 2017, the 1-, 2-, 3-, 4-, and 5-year relative survival rates of patients with colon SRCC were 65.6%, 49.0%, 38.9%, 34.9%, and 33.0%, respectively, while those of patients with rectum SRCC were 69.6%, 47.8%, 38.5%, 32.8%, and 29.4%, respectively. According to the Surveillance, Epidemiology, and End Results summary stages, the 5-year relative survival rates of colon SRCC between 1993 and 2017 were 70.4% for the localized stage, 41.0% for the regional stage, and 7.0% for the distant stage, while those for rectum SRCC were 60.7%, 34.4, and 3.3%, respectively. Conclusions: Although the incidence of colorectal SRCC is extremely low in South Korea, it has been increasing in recent decades. As the prognosis of colorectal SRCC is extremely poor; clinicians should be aware of the differential diagnosis of SRCC in colorectal cancer cases.

scholarly journals Adenocarcinoma with mixed subtypes is a rare but aggressive histologic subtype in colorectal cancer

2019 ◽  
Author(s):  
Hui Sheng ◽  
Xiaoli Wei ◽  
Minjie Mao ◽  
Jincan He ◽  
Tianqi Luo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Markers ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Seer Database ◽  
Histologic Subtype ◽  
Prognostic Relevance ◽  
Signet Ring ◽  
Study Population ◽  
Ring Cell

Abstract Background: Though there have been studies investigating the clinicopathologic and prognostic relevance of mucinous adenocarcinoma (MAC) and signet-ring cell carcinoma (SRCC) compared with classic adenocarcinoma (CA), little is known about the prognosis of adenocarcinoma with mixed subtypes (AM) and the differences among these four subtypes. Methods: The statistics of colorectal cancer registered in the Surveillance, Epidemiology and End Results (SEER) database were retrieved and analyzed. We also compared the clinicopathologic and prognostic relevance between CA, SRCC, MAC and AM. Results: The frequencies of these four subtypes were 69.9% (CA, n=15,812), 25.1% (MAC, n=5,689), 3.6% (SRCC, n=814) and 1.4% (AM, n=321). All of MAC, SRCC and AM were significantly related with aggressive features. Only SRCC and AM were independent poor prognostic markers for overall survival by multivariate analysis. The malignancy degree of AM was between MAC and SRCC according to the clinicopathologic associations. The prognosis of AM was significantly worse than MAC but comparable with SRCC. Conclusions: We confirmed the clinicopathologic relevance with aggressive features of MAC and SRCC, as well as the poor prognostic relevance of SRCC by analyzing a large study population. Furthermore, we identified AM as a rare but aggressive histologic subtype in colorectal cancer, which particular attention should be given in clinical practice.

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