scholarly journals Diet transition to a high-fat diet for 3 weeks reduces brain omega-3-fatty acid levels, alters BDNF signaling and induces anxiety & depression-like behavior in adult rats

2012 ◽  
Author(s):  
Sandeep Sharma ◽  
Yumei Zhuang ◽  
Fernando Gomez-Pinilla
Keyword(s):  
Fatty Acid ◽  
High Fat Diet ◽  
Omega 3 ◽  
High Fat ◽  
Adult Rats ◽  
Omega 3 Fatty Acid ◽  
Bdnf Signaling ◽  
Anxiety Depression

The effects of fish oil consumption on cardiovascular remodeling in ApoE deficient mice

2013 ◽  
Vol 91 (11) ◽  
pp. 960-965 ◽  
Author(s):  
Kelby Cleverley ◽  
Xiaozhou Du ◽  
Sheena Premecz ◽  
Khuong Le ◽  
Matthew Zeglinski ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Fatty Acid ◽  
Fish Oil ◽  
High Fat Diet ◽  
Cardiovascular Effects ◽  
Left Ventricular ◽  
Omega 3 ◽  
High Fat ◽  
Omega 3 Fatty Acid ◽  
Deficient Mice

Owing to their spontaneous development of atherosclerosis, apolipoprotein E knockout mice (ApoEKO) are one of the best studied animal models for this disease. Little is known about the utility of various omega-3 fatty acid regimens, in particular fish oils, in preventing cardiac disease in ApoEKO mice. The purpose of this study was to determine the cardiovascular effects of omega-3 fatty acid supplementation with either safflower oil (control), fish oil, flaxseed oil, or designed oil in ApoEKO mice fed a high-fat diet for a total of 16 weeks. In-vivo cardiac function was assessed weekly using murine echocardiography. Blood pressure, plasma lipid levels, and brain natriuretic peptide (BNP) were serially measured. The results show that ApoEKO mice fed fish oil demonstrated an increase in left ventricular wall thickness as a result of increased afterload. Despite chronic treatment with fish oil over 16 weeks, blood pressure increased in ApoEKO mice by 20% compared with the baseline. Both echocardiographic evidence of left ventricular hypertrophy and biochemical increase in BNP levels confirmed diastolic dysfunction in ApoEKO mice fed fish oil. This suggests that high-fat diet supplemented with fish oil may lead to adverse cardiovascular effects in ApoE deficient mice.

scholarly journals OMEGA-3 FATTY ACID IMPROVE NON ALCOHOLIC FATTY LIVER INDUCED BY HIGH FAT DIET IN RATS.

2017 ◽  
Vol 5 (3) ◽  
pp. 505-512
Author(s):  
ReemM. Hashem ◽  
◽  
LailaA. Rashed ◽  
GhadaM. Safwat ◽  
IbrahimT. Ibrahim. ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Liver ◽  
High Fat Diet ◽  
Omega 3 ◽  
High Fat ◽  
Alcoholic Fatty Liver ◽  
Omega 3 Fatty Acid

scholarly journals High-fat diet-induced dysregulation of ovarian gene expression is restored with chronic omega-3 fatty acid supplementation

2020 ◽  
Vol 499 ◽  
pp. 110615 ◽  
Author(s):  
Natalie M. Hohos ◽  
Emily M. Elliott ◽  
Kirstin J. Cho ◽  
Ivy S. Lin ◽  
Michael C. Rudolph ◽  
...  
Keyword(s):  
Gene Expression ◽  
Fatty Acid ◽  
High Fat Diet ◽  
Omega 3 ◽  
High Fat ◽  
Fatty Acid Supplementation ◽  
Acid Supplementation ◽  
Omega 3 Fatty Acid

scholarly journals Reduced Dietary Omega-6 to Omega-3 Fatty Acid Ratio and 12/15-Lipoxygenase Deficiency Are Protective against Chronic High Fat Diet-Induced Steatohepatitis

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e107658 ◽  
Author(s):  
Milos Lazic ◽  
Maria Eugenia Inzaugarat ◽  
Davide Povero ◽  
Iris C. Zhao ◽  
Mark Chen ◽  
...  
Keyword(s):  
Fatty Acid ◽  
High Fat Diet ◽  
Fatty Acid Ratio ◽  
Omega 3 ◽  
High Fat ◽  
Omega 3 Fatty Acid ◽  
Acid Ratio ◽  
Omega 6

scholarly journals META060 activates omega‐3 fatty acid receptor GPR120, reduces weight gain, and increases insulin sensitivity in high‐fat diet fed mice

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Veera R. Konda ◽  
Anuradha Desai ◽  
Gary Darland ◽  
Irene O.C.M. Vroegrijk ◽  
Janna A. Diepen ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Weight Gain ◽  
Insulin Sensitivity ◽  
High Fat Diet ◽  
Omega 3 ◽  
High Fat ◽  
Acid Receptor ◽  
Omega 3 Fatty Acid ◽  
Fatty Acid Receptor

scholarly journals Omega-3 Phospholipids from Krill Oil Enhance Intestinal Fatty Acid Oxidation More Effectively than Omega-3 Triacylglycerols in High-Fat Diet-Fed Obese Mice

Nutrients ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 2037 ◽  
Author(s):  
Petra Kroupova ◽  
Evert M. van Schothorst ◽  
Jaap Keijer ◽  
Annelies Bunschoten ◽  
Martin Vodicka ◽  
...  
Keyword(s):  
Gene Expression ◽  
Fatty Acid ◽  
High Fat Diet ◽  
Body Weight Gain ◽  
Acid Oxidation ◽  
Obese Mice ◽  
Krill Oil ◽  
Omega 3 ◽  
High Fat ◽  
Lower Body Weight

Antisteatotic effects of omega-3 fatty acids (Omega-3) in obese rodents seem to vary depending on the lipid form of their administration. Whether these effects could reflect changes in intestinal metabolism is unknown. Here, we compare Omega-3-containing phospholipids (krill oil; ω3PL-H) and triacylglycerols (ω3TG) in terms of their effects on morphology, gene expression and fatty acid (FA) oxidation in the small intestine. Male C57BL/6N mice were fed for 8 weeks with a high-fat diet (HFD) alone or supplemented with 30 mg/g diet of ω3TG or ω3PL-H. Omega-3 index, reflecting the bioavailability of Omega-3, reached 12.5% and 7.5% in the ω3PL-H and ω3TG groups, respectively. Compared to HFD mice, ω3PL-H but not ω3TG animals had lower body weight gain (−40%), mesenteric adipose tissue (−43%), and hepatic lipid content (−64%). The highest number and expression level of regulated intestinal genes was observed in ω3PL-H mice. The expression of FA ω-oxidation genes was enhanced in both Omega-3-supplemented groups, but gene expression within the FA β-oxidation pathway and functional palmitate oxidation in the proximal ileum was significantly increased only in ω3PL-H mice. In conclusion, enhanced intestinal FA oxidation could contribute to the strong antisteatotic effects of Omega-3 when administered as phospholipids to dietary obese mice.

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