The effects of fish oil consumption on cardiovascular remodeling in ApoE deficient mice

2013 ◽  
Vol 91 (11) ◽  
pp. 960-965 ◽  
Author(s):  
Kelby Cleverley ◽  
Xiaozhou Du ◽  
Sheena Premecz ◽  
Khuong Le ◽  
Matthew Zeglinski ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Fatty Acid ◽  
Fish Oil ◽  
High Fat Diet ◽  
Cardiovascular Effects ◽  
Left Ventricular ◽  
Omega 3 ◽  
High Fat ◽  
Omega 3 Fatty Acid ◽  
Deficient Mice

Owing to their spontaneous development of atherosclerosis, apolipoprotein E knockout mice (ApoEKO) are one of the best studied animal models for this disease. Little is known about the utility of various omega-3 fatty acid regimens, in particular fish oils, in preventing cardiac disease in ApoEKO mice. The purpose of this study was to determine the cardiovascular effects of omega-3 fatty acid supplementation with either safflower oil (control), fish oil, flaxseed oil, or designed oil in ApoEKO mice fed a high-fat diet for a total of 16 weeks. In-vivo cardiac function was assessed weekly using murine echocardiography. Blood pressure, plasma lipid levels, and brain natriuretic peptide (BNP) were serially measured. The results show that ApoEKO mice fed fish oil demonstrated an increase in left ventricular wall thickness as a result of increased afterload. Despite chronic treatment with fish oil over 16 weeks, blood pressure increased in ApoEKO mice by 20% compared with the baseline. Both echocardiographic evidence of left ventricular hypertrophy and biochemical increase in BNP levels confirmed diastolic dysfunction in ApoEKO mice fed fish oil. This suggests that high-fat diet supplemented with fish oil may lead to adverse cardiovascular effects in ApoE deficient mice.

scholarly journals OMEGA-3 FATTY ACID IMPROVE NON ALCOHOLIC FATTY LIVER INDUCED BY HIGH FAT DIET IN RATS.

2017 ◽  
Vol 5 (3) ◽  
pp. 505-512
Author(s):  
ReemM. Hashem ◽  
◽  
LailaA. Rashed ◽  
GhadaM. Safwat ◽  
IbrahimT. Ibrahim. ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Liver ◽  
High Fat Diet ◽  
Omega 3 ◽  
High Fat ◽  
Alcoholic Fatty Liver ◽  
Omega 3 Fatty Acid

scholarly journals High-fat diet-induced dysregulation of ovarian gene expression is restored with chronic omega-3 fatty acid supplementation

2020 ◽  
Vol 499 ◽  
pp. 110615 ◽  
Author(s):  
Natalie M. Hohos ◽  
Emily M. Elliott ◽  
Kirstin J. Cho ◽  
Ivy S. Lin ◽  
Michael C. Rudolph ◽  
...  
Keyword(s):  
Gene Expression ◽  
Fatty Acid ◽  
High Fat Diet ◽  
Omega 3 ◽  
High Fat ◽  
Fatty Acid Supplementation ◽  
Acid Supplementation ◽  
Omega 3 Fatty Acid

scholarly journals Reduced Dietary Omega-6 to Omega-3 Fatty Acid Ratio and 12/15-Lipoxygenase Deficiency Are Protective against Chronic High Fat Diet-Induced Steatohepatitis

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e107658 ◽  
Author(s):  
Milos Lazic ◽  
Maria Eugenia Inzaugarat ◽  
Davide Povero ◽  
Iris C. Zhao ◽  
Mark Chen ◽  
...  
Keyword(s):  
Fatty Acid ◽  
High Fat Diet ◽  
Fatty Acid Ratio ◽  
Omega 3 ◽  
High Fat ◽  
Omega 3 Fatty Acid ◽  
Acid Ratio ◽  
Omega 6

scholarly journals Synergistic Effect of Omega-3 Fatty Acids and Oral-Hypoglycemic Drug on Lipid Normalization through Modulation of Hepatic Gene Expression in High Fat Diet with Low Streptozotocin-Induced Diabetic Rats

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3652
Author(s):  
Suresh Khadke ◽  
Pallavi Mandave ◽  
Aniket Kuvalekar ◽  
Vijaya Pandit ◽  
Manjiri Karandikar ◽  
...  
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Fish Oil ◽  
High Fat Diet ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
High Fat

Type 2 diabetes mellitus, which an outcome of impaired insulin action and its secretion, is concomitantly associated with lipid abnormalities. The study was designed to evaluate the combinational effect of omega-3 fatty acids (flax and fish oil) and glibenclamide on abnormal lipid profiles, increased blood glucose, and impaired liver and kidney functions in a high fat diet with low streptozotocin (STZ)-induced diabetic rats, including its probable mechanism of action. The male Wistar rats (n = 48) were distributed into eight groups. All animal groups except the healthy received a high fat diet (HFD) for 90 days. Further, diabetes was developed by low dose STZ (35 mg/kg). Diabetic animals received, omega-3 fatty acids (500 mg/kg), along with glibenclamide (0.25 mg/kg). Both flax and fish oil intervention decreased (p ≤ 0.001) serum triglycerides and very low density lipoprotein and elevated (p ≤ 0.001) high density lipoprotein levels in diabetic rats. Total cholesterol and low-density lipoprotein level was decreased (p ≤ 0.001) in fish oil-treated rats. However, it remained unaffected in the flax oil treatment group. Both flax and fish oil intervention downregulate the expression of fatty acid metabolism genes, transcription factors (sterol regulatory element-binding proteins-1c and nuclear factor-κβ), and their regulatory genes i.e., acetyl-coA carboxylase alpha, fatty acid synthase, and tumor necrosis factors-α. The peroxisome proliferator-activated receptor gamma gene expression was upregulated (p ≤ 0.001) in the fish oil treatment group. Whereas, carnitine palmitoyltransferase 1 and fatty acid binding protein gene expression were upregulated (p ≤ 0.001) in both flax and fish oil intervention group.

scholarly journals META060 activates omega‐3 fatty acid receptor GPR120, reduces weight gain, and increases insulin sensitivity in high‐fat diet fed mice

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Veera R. Konda ◽  
Anuradha Desai ◽  
Gary Darland ◽  
Irene O.C.M. Vroegrijk ◽  
Janna A. Diepen ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Weight Gain ◽  
Insulin Sensitivity ◽  
High Fat Diet ◽  
Omega 3 ◽  
High Fat ◽  
Acid Receptor ◽  
Omega 3 Fatty Acid ◽  
Fatty Acid Receptor

scholarly journals Omega-3 fatty acid blood levels are inversely associated with cardiometabolic risk factors in HFpEF patients: the Aldo-DHF randomized controlled trial

2021 ◽  
Author(s):  
Katharina Lechner ◽  
Johannes Scherr ◽  
Elke Lorenz ◽  
Benjamin Lechner ◽  
Bernhard Haller ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Aerobic Capacity ◽  
Cardiometabolic Risk ◽  
Left Ventricular Diastolic Function ◽  
Left Ventricular ◽  
Blood Levels ◽  
Omega 3 ◽  
Maximal Aerobic Capacity ◽  
Omega 3 Fatty Acid ◽  
Neurohumoral Activation

Abstract Objectives To evaluate associations of omega-3 fatty acid (O3-FA) blood levels with cardiometabolic risk markers, functional capacity and cardiac function/morphology in patients with heart failure with preserved ejection fraction (HFpEF). Background O3-FA have been linked to reduced risk for HF and associated phenotypic traits in experimental/clinical studies. Methods This is a cross-sectional analysis of data from the Aldo-DHF-RCT. From 422 patients, the omega-3-index (O3I = EPA + DHA) was analyzed at baseline in n = 404 using the HS-Omega-3-Index® methodology. Patient characteristics were; 67 ± 8 years, 53% female, NYHA II/III (87/13%), ejection fraction ≥ 50%, E/e′ 7.1 ± 1.5; median NT-proBNP 158 ng/L (IQR 82–298). Pearson’s correlation coefficient and multiple linear regression analyses, using sex and age as covariates, were used to describe associations of the O3I with metabolic phenotype, functional capacity, echocardiographic markers for LVDF, and neurohumoral activation at baseline/12 months. Results The O3I was below (< 8%), within (8–11%), and higher (> 11%) than the target range in 374 (93%), 29 (7%), and 1 (0.2%) patients, respectively. Mean O3I was 5.7 ± 1.7%. The O3I was inversely associated with HbA1c (r = − 0.139, p = 0.006), triglycerides-to-HDL-C ratio (r = − 0.12, p = 0.017), triglycerides (r = − 0.117, p = 0.02), non-HDL-C (r = − 0.101, p = 0.044), body-mass-index (r = − 0.149, p = 0.003), waist circumference (r = − 0.121, p = 0.015), waist-to-height ratio (r = − 0.141, p = 0.005), and positively associated with submaximal aerobic capacity (r = 0.113, p = 0.023) and LVEF (r = 0.211, p < 0.001) at baseline. Higher O3I at baseline was predictive of submaximal aerobic capacity (β = 15.614, p < 0,001), maximal aerobic capacity (β = 0.399, p = 0.005) and LVEF (β = 0.698, p = 0.007) at 12 months. Conclusions Higher O3I was associated with a more favorable cardiometabolic risk profile and predictive of higher submaximal/maximal aerobic capacity and lower BMI/truncal adiposity in HFpEF patients. Graphic abstract Omega-3 fatty acid blood levels are inversely associated with cardiometabolic risk factors in HFpEF patients. Higher O3I was associated with a more favorable cardiometabolic risk profile and aerobic capacity (left) but did not correlate with echocardiographic markers for left ventricular diastolic function or neurohumoral activation (right). An O3I-driven intervention trial might be warranted to answer the question whether O3-FA in therapeutic doses (with the target O3I 8–11%) impact on echocardiographic markers for left ventricular diastolic function and neurohumoral activation in patients with HFpEF. This figure contains modified images from Servier Medical Art (https://smart.servier.com) licensed by a Creative Commons Attribution 3.0 Unported License.

Sign in / Sign up

Export Citation Format

Share Document