scholarly journals DNA damage signaling guards against perturbation of cyclin D1 expression triggered by low-dose long-term fractionated radiation

Oncogenesis ◽  
2014 ◽  
Vol 3 (12) ◽  
pp. e132-e132 ◽  
Author(s):  
T Shimura ◽  
J Kobayashi ◽  
K Komatsu ◽  
N Kunugita
Keyword(s):  
Dna Damage ◽  
Cyclin D1 ◽  
Low Dose ◽  
Dna Damage Signaling ◽  
Fractionated Radiation

scholarly journals Nuclear accumulation of cyclin D1 following long-term fractionated exposures to low-dose ionizing radiation in normal human diploid cells

Cell Cycle ◽  
2014 ◽  
Vol 13 (8) ◽  
pp. 1248-1255 ◽  
Author(s):  
Tsutomu Shimura ◽  
Nobuyuki Hamada ◽  
Megumi Sasatani ◽  
Kenji Kamiya ◽  
Naoki Kunugita
Keyword(s):  
Ionizing Radiation ◽  
Cyclin D1 ◽  
Low Dose ◽  
Nuclear Accumulation ◽  
Normal Human ◽  
Human Diploid Cells ◽  
Diploid Cells

Effects of Melissa officinalis L. on oxidative status and DNA damage in subjects exposed to long-term low-dose ionizing radiation

2010 ◽  
Vol 27 (3) ◽  
pp. 205-212 ◽  
Author(s):  
Akbar Zeraatpishe ◽  
Shahrbano Oryan ◽  
Mohammad Hadi Bagheri ◽  
Ali Asghar Pilevarian ◽  
Ali Akbar Malekirad ◽  
...  
Keyword(s):  
Dna Damage ◽  
Ionizing Radiation ◽  
Low Dose ◽  
Oxidative Status ◽  
Melissa Officinalis

scholarly journals Exposure of Breast and Lung Cancer Cells to a Novel Estrone Analog Prior to Radiation Enhances Bcl-2-Mediated Cell Death

2018 ◽  
Vol 19 (10) ◽  
pp. 2887 ◽  
Author(s):  
Elsie Nolte ◽  
Anna Joubert ◽  
Roy Lakier ◽  
Ado van Rensburg ◽  
Anne Mercier
Keyword(s):  
Lung Cancer ◽  
Dna Damage ◽  
Cancer Cells ◽  
Low Dose ◽  
A549 Cells ◽  
Lung Cancer Cells ◽  
Term Survival ◽  
Dna Damage And Repair ◽  
Mcf 7

Following exposure of cells to gamma-radiation, a cascade of intracellular consequences may be observed in a semitemporal manner. This includes deoxyribonucleic acid (DNA) damage and reactive oxygen species (ROS) accumulation initially, with consequent signaling for DNA repair and facilitative regulation of the cell cycle. Failure to rectify the damage or ROS levels leads to induction of senescence or apoptosis. 2-Ethyl-3-O-sulfamoyl-estra-1,3,5(10),15-tetraen-17-ol (ESE-15-ol), a 2-methoxyestradiole analog designed in silico for superior pharmacokinetics, was investigated for its potential to enhance apoptotic signaling and decrease the long-term survival of cells exposed to radiation. Sequential early intracellular effects within radiation-treated MCF-7 breast- and A549 lung cancer cells pre-exposed to low-dose ESE-15-ol were investigated using various flow cytometric protocols, spectrophotometry, and microscopy. Long-term cellular survival and proliferation was examined using clonogenic studies, which demonstrated a significant decrease in the presensitized cells. Combination-treated cells exhibited increased superoxide formation, and decreased Bcl-2 expression and -phosphorylation. Induction of apoptosis and elevation of the sub-G1 phase was evident in the pre-exposed MCF-7 cells, although only minimally in the A549 cells at 48-h. These results indicate that low-dose ESE-15-ol may increase tumor response to radiation. Future studies will investigate the effect of ESE-15-ol pre-exposure on radiation-induced DNA damage and repair mechanisms.

scholarly journals γ-H2AX responds to DNA damage induced by long-term exposure to combined low-dose-rate neutron and γ-ray radiation

2016 ◽  
Vol 795 ◽  
pp. 36-40 ◽  
Author(s):  
Junlin Zhang ◽  
Ying He ◽  
Xianrong Shen ◽  
Dingwen Jiang ◽  
Qingrong Wang ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dose Rate ◽  
Low Dose ◽  
Low Dose Rate ◽  
Γ Ray

Ovarian Dysfunction in Fetally Irradiated Beagles

1977 ◽  
Vol 35 ◽  
pp. 658-659
Author(s):  
T. M. Seed ◽  
M. H. Sanderson ◽  
D. L. Gutzeit ◽  
T. E. Fritz ◽  
D. V. Tolle ◽  
...  
Keyword(s):  
Gamma Rays ◽  
Low Dose ◽  
Long Term Effects ◽  
Ovarian Dysfunction ◽  
Dose Rates ◽  
Highly Sensitive ◽  
Microscopic Evaluation ◽  
Ovarian Pathology ◽  
Normal Offspring

The developing mammalian fetus is thought to be highly sensitive to ionizing radiation. However, dose, dose-rate relationships are not well established, especially the long term effects of protracted, low-dose exposure. A previous report (1) has indicated that bred beagle bitches exposed to daily doses of 5 to 35 R 60Co gamma rays throughout gestation can produce viable, seemingly normal offspring. Puppies irradiated in utero are distinguishable from controls only by their smaller size, dental abnormalities, and, in adulthood, by their inability to bear young.We report here our preliminary microscopic evaluation of ovarian pathology in young pups continuously irradiated throughout gestation at daily (22 h/day) dose rates of either 0.4, 1.0, 2.5, or 5.0 R/day of gamma rays from an attenuated 60Co source. Pups from non-irradiated bitches served as controls. Experimental animals were evaluated clinically and hematologically (control + 5.0 R/day pups) at regular intervals.

The Acute Effect of Alcohol on Various Memory Processes

2010 ◽  
Vol 24 (4) ◽  
pp. 249-252 ◽  
Author(s):  
Márk Molnár ◽  
Roland Boha ◽  
Balázs Czigler ◽  
Zsófia Anna Gaál
Keyword(s):  
Low Dose ◽  
Short Term Memory ◽  
Acute Effect ◽  
Long Term Memory ◽  
Term Memory ◽  
Memory Processes ◽  
Different Types ◽  
The Brain ◽  
Legal Consequences

This review surveys relevant and recent data of the pertinent literature regarding the acute effect of alcohol on various kinds of memory processes with special emphasis on working memory. The characteristics of different types of long-term memory (LTM) and short-term memory (STM) processes are summarized with an attempt to relate these to various structures in the brain. LTM is typically impaired by chronic alcohol intake but according to some data a single dose of ethanol may have long lasting effects if administered at a critically important age. The most commonly seen deleterious acute effect of alcohol to STM appears following large doses of ethanol in conditions of “binge drinking” causing the “blackout” phenomenon. However, with the application of various techniques and well-structured behavioral paradigms it is possible to detect, albeit occasionally, subtle changes of cognitive processes even as a result of a low dose of alcohol. These data may be important for the consideration of legal consequences of low-dose ethanol intake in conditions such as driving, etc.

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