scholarly journals Gestational body weight gain and risk of low birth weight or macrosomia in women of Japan: a nationwide cohort study

2021 ◽  
Author(s):  
Hiroyuki Uchinuma ◽  
Kyoichiro Tsuchiya ◽  
Tetsuo Sekine ◽  
Sayaka Horiuchi ◽  
Megumi Kushima ◽  
...  
Keyword(s):  
Cohort Study ◽  
Weight Gain ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Body Weight Gain ◽  
First Trimester ◽  
Second Trimester ◽  
Prepregnancy Bmi ◽  
National Cohort ◽  
The Impact

Abstract Objective Both maternal prepregnancy body mass index (BMI) and gestational weight gain (GWG) influence maternal and pediatric outcomes. We sought to clarify the impact of prepregnancy BMI-specific GWG and its patterns on the risk of low birth weight (LBW) or macrosomia using data from a large nationwide study in Japan. Methods This cohort study (n = 98,052) used data from the Japan Environment and Children’s Study (JECS). The outcome variables in this study were LBW and macrosomia. We stratified the subjects into groups according to prepregnancy BMI. Results GWG from pre-pregnancy to the first trimester had a small effect on the risk of LBW and macrosomia. From the first to second trimesters, insufficient GWG was associated with the risk of LBW, and from the second trimester to delivery, a GWG of less than 2 kg was associated with the risk of LBW. These associations were commonly observed in all prepregnancy BMI categories. Irrespective of the GWG from pre-pregnancy to the first trimester, GWG from the first to second trimesters affects LBW and/or macrosomia. Irrespective of the GWG from the first to second trimesters, GWG from the second trimester to delivery affects LBW and/or macrosomia. LBW or macrosomia was associated with the prevalence of a sustained low or high BMI percentile until three years of age, respectively. Conclusions The present large national cohort study indicates that the risk of LBW or macrosomia is associated with GWG in women in Japan; the significance of this risk depends on the GWG patterns.

scholarly journals Relationship between birth order, birth weight, colostrum intake, acquisition of passive immunity and pre-weaning mortality of piglets

2017 ◽  
Vol 15 (2) ◽  
pp. e0603 ◽  
Author(s):  
Jean Le Dividich ◽  
Rui Charneca ◽  
Françoise Thomas
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Birth Order ◽  
Body Weight Gain ◽  
Passive Immunity ◽  
Large White ◽  
Serum Igg ◽  
Causes Of Mortality

This study investigates the relation between birth order (BO), birth weight (BW0), colostrum intake (CI), level of passive immunity and pre-weaning mortality of piglets. The animals used were 551 cross-bred piglets [Piétrain × (Large-White × Landrace)] born from 40 sows. Colostrum immunoglobulins G (IgG) determinations were made from 17 sows. Colostrum samples were obtained at birth of the first piglet then at 3, 6, 12, 24, and 36 h later, and on the first-two and the last-two piglets born. Serum IgG determinations from 68 piglets were made at 2d of age and at weaning. Individual CI was estimated from body weight gain. Relative birth order (RBO) and BW0 within-litter were weakly (R2<0.05) but positively correlated (p<0.01). Colostrum intake of piglets was independent from RBO (p>0.10) but increased by 26 ± 1.6 g per 100 g increase in BW0 (p<0.001). Serum IgG concentrations of the last two born piglets were 29.5% lower (p<0.01) than the first two born at 2 d of age, and 25% (p<0.05) at weaning. They were also lower at weaning than at 2 d of age (p<0.001). Serum IgG concentrations of piglets at weaning and at 2 d of age were positively correlated (R2=0.50, p<0.001). Within-litter, CI explained 11% (p<0.01) of the variation observed in piglets’ IgG at 2d of age. Mortality of piglets was irrespective of RBO (p>0.10). It was concluded that despite last-born piglets obtained less passive immunity than first-born, they were not at higher risk of dying before weaning. Major causes of mortality were low birth weight and insufficient colostrum (energy) intake.

A Comparative Study on Serum Levels of Iron, Magnesium, Calcium and Phosphorus during First & Second Trimesters of Pregnancy at a Tertiary Referral Hospital in South India

2021 ◽  
Vol 8 (29) ◽  
pp. 2609-2614
Author(s):  
Pradeep Kumar M ◽  
Mayadevi Brahmanandan ◽  
Dini S.B
Keyword(s):  
Body Mass Index ◽  
Birth Weight ◽  
Preterm Birth ◽  
Low Birth Weight ◽  
Serum Levels ◽  
First Trimester ◽  
Second Trimester ◽  
Mean Values ◽  
Calcium And Phosphorus ◽  
In Pregnancy

BACKGROUND Multiple micronutrient deficiencies commonly coexist in pregnancy and may play a role in the pathogenesis of many high-risk events in pregnancy. Mineral estimation during the first and second trimester may help in the identification of high-risk pregnancies predisposed to pre-eclampsia, preterm birth or low birth weight. Body mass index (BMI) is an independent risk factor influencing the serum levels of micronutrients like iron, calcium, phosphorous and magnesium. The purpose of this study was to compare the serum levels of iron, magnesium, calcium and phosphorus during first & second trimesters of pregnancy and their correlation with body mass index and adverse pregnancy outcomes. METHODS This was a longitudinal descriptive study, done over a period of twelve months, from April 2017 to March 2018. 94 low risk pregnant women were selected in the first trimester, and they were followed up for the entire duration of pregnancy. 2 ml of blood is collected at first and second trimester and analysed for the serum levels of iron (µg/dl), magnesium (mg/dl), calcium (mg/dl) and inorganic phosphorus (mg/dl). Mean values of these elements were noted and BMI was measured. Patients were followed up to observe the pregnancy outcome, especially development of hypertension, preterm birth and low birth weight. The data were subjected to suitable statistical analyses. P value less than 0.05 is considered as statistically significant. RESULTS Mean values of Ca, Mg, inorganic P and Fe were 9.3 mg/dl ± 0.52, 1.79 mg/dl ± 0.28, 3.59 mg/dl ± 0.54 and 83.7 µg/dl ± 25.36 respectively in first trimester and 8.9 mg/dl ± 0.47, 1.62 mg/dl ± 0.16, 3.17 mg/dl ± 0.44 and 76.17 µg/dl ± 21. 69 respectively in the second trimester. Hypocalcaemia was noted in 12.7 % and 38.3 % in the first and second trimester respectively. Hypomagnesaemia was seen in 51.1 % and 80.9 % in the first and second trimester respectively. Hypophosphatemia was seen in 3.2 % and 14.8 % in the first and second trimester respectively. These findings were statistically significant. There was no significant change in the iron levels in the present study. 19.1 % were underweight. 56.4 % had normal BMI. 19.2 % were overweight. 5.3 % were obese. CONCLUSIONS There is no correlation between serum values of trace elements and the BMI of study subjects. Even though significant hypocalcaemia, hypophosphatemia and hypomagnesaemia was noted in second trimester compared to first, there was no predisposition to the development of adverse outcomes like pre-eclampsia, preterm birth or low birth weight. This may be the effect of dietary and pharmacological supplementation during pregnancy. KEYWORDS Micronutrients, Pregnancy Complications, Calcium, Phosphorus, Magnesium, Iron

scholarly journals Late-Onset Sepsis as a Risk Factor for Bronchopulmonary Dysplasia in Extremely Low Birth Weight Infants: A Nationwide Cohort Study

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Euiseok Jung ◽  
Byong Sop Lee
Keyword(s):  
Risk Factor ◽  
Cohort Study ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Bronchopulmonary Dysplasia ◽  
Late Onset ◽  
Extremely Low Birth Weight ◽  
Late Onset Sepsis ◽  
The Impact ◽  
Multiple Episodes

Abstract This study aimed to determine the effect of late-onset sepsis (LOS) on the development of bronchopulmonary dysplasia (BPD) in extremely low birth weight (ELBW) infants. A prospective cohort study was performed using data collected from 64 centres registered in the Korean national registry. LOS was defined as a positive blood culture and antibiotics treatment after 72 hours of life and prior to 36 weeks postmenstrual age (PMA). Data on the causative organisms were collected and analysed for respiratory outcomes. Among the 1,434 ELBW infants who survived to 36 weeks PMA, 481 (34%) developed LOS caused by bacteria (n = 405), fungi (n = 28), or both (n = 48). The incidence of BPD was significantly associated with LOS in both the entire cohort and the propensity score-matched cohort. Two or more LOS episodes were a risk factor for BPD. The impact of multiple episodes of LOS on BPD was prominent in infants who received mechanical ventilation for two weeks or less. The estimated odds ratios for BPD and severe BPD were greater with fungal LOS than with bacterial LOS. In conclusion, LOS, particularly complicated by multiple episodes and/or fungi, was a risk factor for BPD in ELBW infants.

scholarly journals Effects of maternal smoking on body size and proportions at birth: a register-based cohort study of 1.4 million births

BMJ Open ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. e033465 ◽  
Author(s):  
Isabell Rumrich ◽  
Kirsi Vähäkangas ◽  
Matti Viluksela ◽  
Mika Gissler ◽  
Hanna de Ruyter ◽  
...  
Keyword(s):  
Cohort Study ◽  
Body Size ◽  
Birth Weight ◽  
Preterm Birth ◽  
Low Birth Weight ◽  
Head Circumference ◽  
Maternal Smoking ◽  
First Trimester ◽  
Body Proportions ◽  
High Head

ObjectivesThe aim of our work was to analyse the effect of maternal smoking on body size and body proportions of newborns when the mother had smoked only during the first trimester, in comparison with continued smoking after the first trimester. Furthermore, we have evaluated how growth restriction associated with maternal smoking contributes to changes in body proportions.DesignRegister-based cohort studySettingMaternal Exposure (MATEX) cohort identified from the Finnish Medical Birth Register.ParticipantsSingleton births without congenital anomalies and missing data (1.38 million) from 1 January 1991 to 31 December 2016.MethodsLogistic regression was used to quantify the effect of maternal smoking, stratified by the maternal smoking status.Outcome measuresBody proportions indicated by low brain-to-body ratio (defined as <10th percentile); high ponderal index and high head-to-length ratio (defined as >90th percentile); small body size for gestational age at birth (defined as weight, length or head circumference <10th percentile) and preterm birth (<37 weeks) and low birth weight (2500 g).ResultsContinued smoking after the first trimester was associated with high ponderal index (OR 1.26, 95% CI 1.23 to 1.28), low brain-to-body ratio (1.11, 1.07–1.15) and high head-to-length ratio (1.22, 1.19–1.26), corresponding with absolute risks of 22%, 10% and 19%, respectively). The effects were slightly lower when smoking had been quit during the first trimester. Similar effects were seen for the body size variables and low birth weight. Preterm birth was not associated with smoking only during first trimester.ConclusionsMaternal smoking, independent of smoking duration during pregnancy, was associated with abnormal body proportions resulting from larger reduction of length and head circumference in comparison to weight. The effects of having quit smoking during the first trimester and having continued smoking after the first trimester were similar, suggesting the importance of early pregnancy as a sensitive exposure window.

scholarly journals Weight gain during pregnancy and low birth weight babies: a retrospective cohort study in Gianyar District, Bali

2019 ◽  
Vol 7 (1) ◽  
pp. 49
Author(s):  
Putu Riza Kurnia Indriana ◽  
Luh Putu Suariyani ◽  
Ni Ketut Sutiari
Keyword(s):  
Weight Gain ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Pregnant Women ◽  
Medical Record ◽  
Retrospective Cohort ◽  
First Trimester ◽  
Institute Of Medicine ◽  
Anemia Group ◽  
Weight Gain During Pregnancy

Background and purpose: Low birth weight (LBW) is a major causal factor for neonatal and perinatal mortality. The aim of this study is to determine the risk of LBW incidence in pregnant women with weight gain not in accordance with the Institute of Medicine (IOM) standards.Methods: This study used a retrospective cohort design with data obtained from three Public Health Centres (PHCs) in Gianyar District over the period of January-December 2017. Samples in this study were 186 pregnant women with the following criteria: complete data on the mother’s medical record, had an antenatal care visit in the first trimester and at the end of the third trimester, at term delivery, not giving birth to twins and no complications during pregnancy. The sample size was determined with 95% confidence level, 80% power, the proportion of LBW in the group of inadequate weight gain of 26%, the proportion of LBW in the group of adequate weight gain of 9% and a relative risk (RR) estimate of 3.0. Data extracted from medical record consisted of weight gain, pre-pregnancy weight, height, upper arm circumference, hemoglobin level, employment, age, parity and birth weight. The cumulative incidence of LBW was calculated to determine the RR. Multivariate analysis with binary logistic regression was conducted to determine the adjusted RR (ARR).Results: The incidence of LBW in the group whose weight gain during pregnancy not in accordance with IOM standards was 59%, while those in accordance with the standards were 8.2% with RR=7.22 (95%CI: 3.96–13.19). The ARR for those with weight gain during pregnancy not in accordance with IOM standards was 15.33 (95%CI: 5.82-40.38). The incidence of LBW in the anemia group was 49% and not anemia group was 10%. The RR and ARR values for LBW in the anemia group were 4.72 (95%CI: 2.66-8.36) and 6.66 (95%CI: 2.53-17.53) respectively.Conclusion: Mothers experiencing weight gain during pregnancy that was not in accordance with IOM standards and anemia were found to increase the risk of LBW. Monitoring of weight gain during pregnancy should be implemented using the IOM standards and anemia prevention among pregnant mothers should be enhanced.

scholarly journals Performance of low birth-weight piglets upon protein-energy and/or colostrum supplementation

2018 ◽  
Vol 70 (4) ◽  
pp. 1293-1300 ◽  
Author(s):  
R.C. Viott ◽  
T.A. Menezes ◽  
A.P.G. Mellagi ◽  
M.L. Bernardi ◽  
I. Wentz ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Body Weight Gain ◽  
Post Partum ◽  
Daily Weight Gain ◽  
Control Group ◽  
Suckling Period ◽  
Protein Energy

ABSTRACT The study aimed to investigate the effect of oral protein-energy supplement (OPES) and/or extra colostrum within the first few hours of life on the survival and growth performance of low birth-weight piglets during the suckling period. Based upon nutritional strategy, low-birth-weight piglets (804−1309g) were randomly allocated into four groups: C0S0 (control group, n= 300) - no supplementation; C1S0 (n= 299) - supplementation with 50mL of a colostrum pool through an orogastric tube; C0S1 (n= 298) - oral supplementation with 8mL oral OPES; C1S1 (n= 297) - supplementation with both 50mL of colostrum and 8mL of OPES. The piglets’ body weight was monitored at birth, 24h after birth, on day 7, day 14 and day 20 post-partum. Both colostrum and protein-energy supplementations did not affect (P>0.05) colostrum intake (253.6g; 259.4g; 259.4g; 263.8g for C0S0, C1S0, C0S1, C1S1, respectively), weight gain during the first 24h (62.6g; 68.3g; 67.1g and 69.8g for C0S0, C1S0, C0S1, C1S1, respectively) and pre-weaning mortality (11.3%, 11.4%, 12.4% and 9.4% for C0S0, C1S0, C0S1, C1S1, respectively). Administration of OPES increased (P= 0.032) the average daily weight gain from birth till weaning (189.1 vs. 182.3g) and tended to increase the weight of the piglets (P= 0.060) at weaning (4893.1 vs. 4746.4g for OPES and no OPES, respectively). In conclusion, nutritional manipulation does not affect colostrum intake and pre-weaning mortality of low birth-weight piglets. However, body weight gain during the suckling period and the weight at weaning were observed to be marginally improved by administration of OPES.

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