scholarly journals An independent assessment of an artificial intelligence system for prostate cancer detection shows strong diagnostic accuracy

2021 ◽  
Author(s):  
Sudhir Perincheri ◽  
Angelique Wolf Levi ◽  
Romulo Celli ◽  
Peter Gershkovich ◽  
David Rimm ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Machine Learning ◽  
Diagnostic Accuracy ◽  
Cancer Detection ◽  
Predictive Value ◽  
Core Biopsy ◽  
Learning Algorithm ◽  
Machine Learning Algorithms ◽  
Cancer Center ◽  
Data Set

AbstractProstate cancer is a leading cause of morbidity and mortality for adult males in the US. The diagnosis of prostate carcinoma is usually made on prostate core needle biopsies obtained through a transrectal approach. These biopsies may account for a significant portion of the pathologists’ workload, yet variability in the experience and expertise, as well as fatigue of the pathologist may adversely affect the reliability of cancer detection. Machine-learning algorithms are increasingly being developed as tools to aid and improve diagnostic accuracy in anatomic pathology. The Paige Prostate AI-based digital diagnostic is one such tool trained on the digital slide archive of New York’s Memorial Sloan Kettering Cancer Center (MSKCC) that categorizes a prostate biopsy whole-slide image as either “Suspicious” or “Not Suspicious” for prostatic adenocarcinoma. To evaluate the performance of this program on prostate biopsies secured, processed, and independently diagnosed at an unrelated institution, we used Paige Prostate to review 1876 prostate core biopsy whole-slide images (WSIs) from our practice at Yale Medicine. Paige Prostate categorizations were compared to the pathology diagnosis originally rendered on the glass slides for each core biopsy. Discrepancies between the rendered diagnosis and categorization by Paige Prostate were each manually reviewed by pathologists with specialized genitourinary pathology expertise. Paige Prostate showed a sensitivity of 97.7% and positive predictive value of 97.9%, and a specificity of 99.3% and negative predictive value of 99.2% in identifying core biopsies with cancer in a data set derived from an independent institution. Areas for improvement were identified in Paige Prostate’s handling of poor quality scans. Overall, these results demonstrate the feasibility of porting a machine-learning algorithm to an institution remote from its training set, and highlight the potential of such algorithms as a powerful workflow tool for the evaluation of prostate core biopsies in surgical pathology practices.

A Surveillance on Machine Learning Algorithms and Its Applications

2020 ◽  
Vol 17 (9) ◽  
pp. 4294-4298
Author(s):  
B. R. Sunil Kumar ◽  
B. S. Siddhartha ◽  
S. N. Shwetha ◽  
K. Arpitha
Keyword(s):  
Machine Learning ◽  
Health Care ◽  
Sentiment Analysis ◽  
Learning Algorithm ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Machine Learning Algorithm ◽  
Data Set ◽  
Pros And Cons ◽  
Primary Advantage

This paper intends to use distinct machine learning algorithms and exploring its multi-features. The primary advantage of machine learning is, a machine learning algorithm can predict its work automatically by learning what to do with information. This paper reveals the concept of machine learning and its algorithms which can be used for different applications such as health care, sentiment analysis and many more. Sometimes the programmers will get confused which algorithm to apply for their applications. This paper provides an idea related to the algorithm used on the basis of how accurately it fits. Based on the collected data, one of the algorithms can be selected based upon its pros and cons. By considering the data set, the base model is developed, trained and tested. Then the trained model is ready for prediction and can be deployed on the basis of feasibility.

scholarly journals Bees Assorter

2020 ◽  
Vol 6 (12) ◽  
pp. 61-65
Author(s):  
Himanshu Verma
Keyword(s):  
Machine Learning ◽  
Learning Algorithm ◽  
Machine Learning Algorithms ◽  
Bumble Bee ◽  
Wing Size ◽  
Qualitative And Quantitative Analysis ◽  
Data Set ◽  
Qualitative And Quantitative ◽  
The Difference

Many attempts were made to classify the bees that is bumble bee or honey bee , there have been such a large amount of researches which were made to seek out the difference between them on the premise of various features like wing size , size of bee , color, life cycle and many more. But altogether the analysis there have been either that specialize in qualitative or quantitative , but to beat this issue , thus researchers came up with an answer which might be both qualitative and quantitative analysis made to classify them. And making use of machine learning algorithm to classify them gives a lift . Now the classification would take less time as these algorithms are pretty fast and accurate . By using machine learning work is made easy . Lots of photographs had to be collected and stored for data set. And by using these machine learning algorithms we would be getting information about the bees which might be employed by researchers in further classification of bees. Manipulation of images had to be done so as on prepare them in such a way that they will be applied to the algorithms and have feature extraction done. As there have been a lot of photographs(data set) which take a lot of space and also the area in which bees were present in these photographs were too small so to accommodate it dimension reduction was done , it might not consider other images like trees , leaves , flowers which were there present in the photograph which we elect as a data set.

scholarly journals Predicting the Grade of Prostate Cancer Based on a Biparametric MRI Radiomics Signature

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Li Zhang ◽  
Xia Zhe ◽  
Min Tang ◽  
Jing Zhang ◽  
Jialiang Ren ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Machine Learning ◽  
Logistic Regression ◽  
Learning Algorithm ◽  
Area Under The Curve ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Low Grade ◽  
High Grade ◽  
Random Forest Tree

Purpose. This study aimed to investigate the value of biparametric magnetic resonance imaging (bp-MRI)-based radiomics signatures for the preoperative prediction of prostate cancer (PCa) grade compared with visual assessments by radiologists based on the Prostate Imaging Reporting and Data System Version 2.1 (PI-RADS V2.1) scores of multiparametric MRI (mp-MRI). Methods. This retrospective study included 142 consecutive patients with histologically confirmed PCa who were undergoing mp-MRI before surgery. MRI images were scored and evaluated by two independent radiologists using PI-RADS V2.1. The radiomics workflow was divided into five steps: (a) image selection and segmentation, (b) feature extraction, (c) feature selection, (d) model establishment, and (e) model evaluation. Three machine learning algorithms (random forest tree (RF), logistic regression, and support vector machine (SVM)) were constructed to differentiate high-grade from low-grade PCa. Receiver operating characteristic (ROC) analysis was used to compare the machine learning-based analysis of bp-MRI radiomics models with PI-RADS V2.1. Results. In all, 8 stable radiomics features out of 804 extracted features based on T2-weighted imaging (T2WI) and ADC sequences were selected. Radiomics signatures successfully categorized high-grade and low-grade PCa cases ( P < 0.05 ) in both the training and test datasets. The radiomics model-based RF method (area under the curve, AUC: 0.982; 0.918), logistic regression (AUC: 0.886; 0.886), and SVM (AUC: 0.943; 0.913) in both the training and test cohorts had better diagnostic performance than PI-RADS V2.1 (AUC: 0.767; 0.813) when predicting PCa grade. Conclusions. The results of this clinical study indicate that machine learning-based analysis of bp-MRI radiomic models may be helpful for distinguishing high-grade and low-grade PCa that outperformed the PI-RADS V2.1 scores based on mp-MRI. The machine learning algorithm RF model was slightly better.

scholarly journals Breast Cancer Detection Using Machine Learning Algorithms

2021 ◽  
Vol 10 (11) ◽  
pp. 4-11
Author(s):  
Samer Hamed ◽  
Abdelwadood Mesleh ◽  
Abdullah Arabiyyat
Keyword(s):  
Machine Learning ◽  
Random Forest ◽  
Cancer Detection ◽  
Computer Aided Design ◽  
Machine Learning Algorithms ◽  
Breast Cancers ◽  
Data Set ◽  
Cad System ◽  
Aided Design ◽  
F Measure

This paper presents a computer-aided design (CAD) system that detects breast cancers (BCs). BC detection uses random forest, AdaBoost, logistic regression, decision trees, naïve Bayes and conventional neural networks (CNNs) classifiers, these machine learning (ML) based algorithms are trained to predicting BCs (malignant or benign) on BC Wisconsin data-set from the UCI repository, in which attribute clump thickness is used as evaluation class. The effectiveness of these ML algorithms are evaluated in terms of accuracy and F-measure; random forest outperformed the other classifiers and achieved 99% accuracy and 99% F-measure.

scholarly journals A Self-Supervised Machine Learning Approach for Objective Live Cell Segmentation and Analysis

2021 ◽  
Author(s):  
Marc Raphael ◽  
Michael Robitaille ◽  
Jeff Byers ◽  
Joseph Christodoulides
Keyword(s):  
Machine Learning ◽  
Learning Algorithm ◽  
Learning Algorithms ◽  
Label Cell ◽  
Live Cell ◽  
Machine Learning Algorithms ◽  
Classification Model ◽  
Supervised Machine Learning ◽  
Cell Segmentation ◽  
Data Set

Abstract Machine learning algorithms hold the promise of greatly improving live cell image analysis by way of (1) analyzing far more imagery than can be achieved by more traditional manual approaches and (2) by eliminating the subjective nature of researchers and diagnosticians selecting the cells or cell features to be included in the analyzed data set. Currently, however, even the most sophisticated model based or machine learning algorithms require user supervision, meaning the subjectivity problem is not removed but rather incorporated into the algorithm’s initial training steps and then repeatedly applied to the imagery. To address this roadblock, we have developed a self-supervised machine learning algorithm that recursively trains itself directly from the live cell imagery data, thus providing objective segmentation and quantification. The approach incorporates an optical flow algorithm component to self-label cell and background pixels for training, followed by the extraction of additional feature vectors for the automated generation of a cell/background classification model. Because it is self-trained, the software has no user-adjustable parameters and does not require curated training imagery. The algorithm was applied to automatically segment cells from their background for a variety of cell types and five commonly used imaging modalities - fluorescence, phase contrast, differential interference contrast (DIC), transmitted light and interference reflection microscopy (IRM). The approach is broadly applicable in that it enables completely automated cell segmentation for long-term live cell phenotyping applications, regardless of the input imagery’s optical modality, magnification or cell type.

scholarly journals A Self-Supervised Machine Learning Approach for Objective Live Cell Segmentation and Analysis

2021 ◽  
Author(s):  
Michael C. Robitaille ◽  
Jeff M. Byers ◽  
Joseph A. Christodoulides ◽  
Marc P. Raphael
Keyword(s):  
Machine Learning ◽  
Learning Algorithm ◽  
Learning Algorithms ◽  
Label Cell ◽  
Live Cell ◽  
Machine Learning Algorithms ◽  
Classification Model ◽  
Supervised Machine Learning ◽  
Cell Segmentation ◽  
Data Set

Machine learning algorithms hold the promise of greatly improving live cell image analysis by way of (1) analyzing far more imagery than can be achieved by more traditional manual approaches and (2) by eliminating the subjective nature of researchers and diagnosticians selecting the cells or cell features to be included in the analyzed data set. Currently, however, even the most sophisticated model based or machine learning algorithms require user supervision, meaning the subjectivity problem is not removed but rather incorporated into the algorithm's initial training steps and then repeatedly applied to the imagery. To address this roadblock, we have developed a self-supervised machine learning algorithm that recursively trains itself directly from the live cell imagery data, thus providing objective segmentation and quantification. The approach incorporates an optical flow algorithm component to self-label cell and background pixels for training, followed by the extraction of additional feature vectors for the automated generation of a cell/background classification model. Because it is self-trained, the software has no user-adjustable parameters and does not require curated training imagery. The algorithm was applied to automatically segment cells from their background for a variety of cell types and five commonly used imaging modalities - fluorescence, phase contrast, differential interference contrast (DIC), transmitted light and interference reflection microscopy (IRM). The approach is broadly applicable in that it enables completely automated cell segmentation for long-term live cell phenotyping applications, regardless of the input imagery's optical modality, magnification or cell type.

scholarly journals Exploring Similarities and Differences of Non-European Migrants among Forensic Patients with Schizophrenia

2020 ◽  
Vol 17 (21) ◽  
pp. 7922
Author(s):  
David A. Huber ◽  
Steffen Lau ◽  
Martina Sonnweber ◽  
Moritz P. Günther ◽  
Johannes Kirchebner
Keyword(s):  
Machine Learning ◽  
Learning Algorithm ◽  
Criminal History ◽  
Machine Learning Algorithms ◽  
Supervised Machine Learning ◽  
Psychiatric Clinic ◽  
Schizophrenia Spectrum Disorders ◽  
Related Factors ◽  
Data Set ◽  
Forensic Psychiatric

Migrants diagnosed with schizophrenia are overrepresented in forensic-psychiatric clinics. A comprehensive characterization of this offender subgroup remains to be conducted. The present exploratory study aims at closing this research gap. In a sample of 370 inpatients with schizophrenia spectrum disorders who were detained in a Swiss forensic-psychiatric clinic, 653 different variables were analyzed to identify possible differences between native Europeans and non-European migrants. The exploratory data analysis was conducted by means of supervised machine learning. In order to minimize the multiple testing problem, the detected group differences were cross-validated by applying six different machine learning algorithms on the data set. Subsequently, the variables identified as most influential were used for machine learning algorithm building and evaluation. The combination of two childhood-related factors and three therapy-related factors allowed to differentiate native Europeans and non-European migrants with an accuracy of 74.5% and a predictive power of AUC = 0.75 (area under the curve). The AUC could not be enhanced by any of the investigated criminal history factors or psychiatric history factors. Overall, it was found that the migrant subgroup was quite similar to the rest of offender patients with schizophrenia, which may help to reduce the stigmatization of migrants in forensic-psychiatric clinics. Some of the predictor variables identified may serve as starting points for studies aimed at developing crime prevention approaches in the community setting and risk management strategies tailored to subgroups of offenders with schizophrenia.

scholarly journals Exploring the Efficiency of Various Supervised Machine Learning Techniques to Predict the Heart Disease using Risk Factors

2019 ◽  
Vol 9 (1S) ◽  
pp. 309-312
Keyword(s):  
Machine Learning ◽  
Health Care ◽  
Heart Disease ◽  
Major Part ◽  
Data Science ◽  
Learning Algorithm ◽  
Machine Learning Algorithms ◽  
Supervised Machine Learning ◽  
Machine Learning Techniques ◽  
Data Set

Data Science in healthcare is a innovative and capable for industry implementing the data science applications. Data analytics is recent science in to discover the medical data set to explore and discover the disease. It’s a beginning attempt to identify the disease with the help of large amount of medical dataset. Using this data science methodology, it makes the user to find their disease without the help of health care centres. Healthcare and data science are often linked through finances as the industry attempts to reduce its expenses with the help of large amounts of data. Data science and medicine are rapidly developing, and it is important that they advance together. Health care information is very effective in the society. In a human life day to day heart disease had increased. Based on the heart disease to monitor different factors in human body to analyse and prevent the heart disease. To classify the factors using the machine learning algorithms and to predict the disease is major part. Major part of involves machine level based supervised learning algorithm such as SVM, Naviebayes, Decision Trees and Random forest.

scholarly journals Earthquake Prediction using Machine Learning Algorithm

2020 ◽  
Vol 8 (6) ◽  
pp. 4684-4688
Keyword(s):  
Machine Learning ◽  
Structural Damage ◽  
Data Science ◽  
Learning Algorithm ◽  
Economic Loss ◽  
Machine Learning Algorithms ◽  
Training Data ◽  
Support Vector ◽  
Science Data ◽  
Data Set

Per the statistics received from BBC, data varies for every earthquake occurred till date. Approximately, up to thousands are dead, about 50,000 are injured, around 1-3 Million are dislocated, while a significant amount go missing and homeless. Almost 100% structural damage is experienced. It also affects the economic loss, varying from 10 to 16 million dollars. A magnitude corresponding to 5 and above is classified as deadliest. The most life-threatening earthquake occurred till date took place in Indonesia where about 3 million were dead, 1-2 million were injured and the structural damage accounted to 100%. Hence, the consequences of earthquake are devastating and are not limited to loss and damage of living as well as nonliving, but it also causes significant amount of change-from surrounding and lifestyle to economic. Every such parameter desiderates into forecasting earthquake. A couple of minutes’ notice and individuals can act to shield themselves from damage and demise; can decrease harm and monetary misfortunes, and property, characteristic assets can be secured. In current scenario, an accurate forecaster is designed and developed, a system that will forecast the catastrophe. It focuses on detecting early signs of earthquake by using machine learning algorithms. System is entitled to basic steps of developing learning systems along with life cycle of data science. Data-sets for Indian sub-continental along with rest of the World are collected from government sources. Pre-processing of data is followed by construction of stacking model that combines Random Forest and Support Vector Machine Algorithms. Algorithms develop this mathematical model reliant on “training data-set”. Model looks for pattern that leads to catastrophe and adapt to it in its building, so as to settle on choices and forecasts without being expressly customized to play out the task. After forecast, we broadcast the message to government officials and across various platforms. The focus of information to obtain is keenly represented by the 3 factors – Time, Locality and Magnitude.

scholarly journals Deducing of Optimal Machine Learning Algorithms for Heterogeneity

2021 ◽  
Author(s):  
Omar Alfarisi ◽  
Zeyar Aung ◽  
Mohamed Sassi
Keyword(s):  
Machine Learning ◽  
Random Forest ◽  
Learning Algorithm ◽  
Learning Algorithms ◽  
Synthetic Data ◽  
Machine Learning Algorithms ◽  
Supervised Machine Learning ◽  
Machine Learning Algorithm ◽  
Data Set ◽  
Optimal Machine

For defining the optimal machine learning algorithm, the decision was not easy for which we shall choose. To help future researchers, we describe in this paper the optimal among the best of the algorithms. We built a synthetic data set and performed the supervised machine learning runs for five different algorithms. For heterogeneity, we identified Random Forest, among others, to be the best algorithm.

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