scholarly journals Oral antibiotic use and early-onset colorectal cancer: findings from a case-control study using a national clinical database

2021 ◽  
Author(s):  
Ronald McDowell ◽  
Sarah Perrott ◽  
Peter Murchie ◽  
Christopher Cardwell ◽  
Carmel Hughes ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Early Onset ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Age Groups ◽  
Antibiotic Consumption ◽  
Case Control ◽  
Oral Antibiotic ◽  
Early Onset Colorectal Cancer ◽  
Control Study

Abstract Background Antibiotic-induced gut dysbiosis has been associated with colorectal cancer (CRC) in older adults. This study will investigate whether an association exists between antibiotic usage and early-onset colorectal cancer (CRC), and also evaluate this in later-onset CRC for comparison. Methods A case-control study was conducted using primary care data from 1999–2011. Analysis were conducted separately in early-onset CRC cases (diagnosed < 50 years) and later-onset cases (diagnosed ≥ 50 years). Conditional logistic regression was used to calculate odds ratios and 95% confidence intervals (CI) for the associations between antibiotic exposure and CRC by tumour location, adjusting for comorbidities. Results Seven thousands nine hundred and three CRC cases (445 aged <50 years) and 30,418 controls were identified. Antibiotic consumption was associated with colon cancer in both age-groups, particularly in the early-onset CRC cohort (<50 years: adjusted Odds Ratio (ORadj) 1.49 (95% CI 1.07, 2.07), p = 0·018; ≥50 years (ORadj (95% CI) 1.09 (1.01, 1.18), p = 0·029). Antibiotics were not associated with rectal cancer (<50 years: ORadj (95% CI) 1.17 (0.75, 1.84), p = 0.493; ≥50 years: ORadj (95% CI) 1.07 (0.96, 1.19), p = 0.238). Conclusion Our findings suggest antibiotics may have a role in colon tumour formation across all age-groups.

scholarly journals Dietary Practices, Addictive Behavior and Bowel Habits and Risk of Early Onset Colorectal Cancer: a Case Control Study

2015 ◽  
Vol 16 (17) ◽  
pp. 7967-7973 ◽  
Author(s):  
Naveed Ali Khan ◽  
Mehwish Hussain ◽  
Ata ur Rahman ◽  
Waqas Ahmed Farooqui ◽  
Abdur Rasheed ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Early Onset ◽  
Case Control Study ◽  
Case Control ◽  
Addictive Behavior ◽  
Dietary Practices ◽  
Bowel Habits ◽  
Early Onset Colorectal Cancer ◽  
Control Study

OC.07.6 DIET AND LIFESTYLE HABITS IN EARLY-ONSET COLORECTAL CANCER: A PILOT CASE CONTROL STUDY

2021 ◽  
Vol 53 ◽  
pp. S121
Author(s):  
M. Puzzono ◽  
M. Di Leo ◽  
R.A. Zuppardo ◽  
A. Mannucci ◽  
M. Russo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Early Onset ◽  
Case Control Study ◽  
Case Control ◽  
Lifestyle Habits ◽  
Diet And Lifestyle ◽  
Early Onset Colorectal Cancer ◽  
Control Study

scholarly journals Antibiotic Therapy and Risk of Early-Onset Colorectal Cancer: A National Case-Control Study

2022 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Long H. Nguyen ◽  
Yin Cao ◽  
Nurgul Batyrbekova ◽  
Bjorn Roelstraete ◽  
Wenjie Ma ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Antibiotic Therapy ◽  
Early Onset ◽  
Case Control Study ◽  
Case Control ◽  
Early Onset Colorectal Cancer ◽  
Control Study

Tu1800 RISK FACTORS FOR EARLY ONSET SPORADIC COLORECTAL CANCER (EOCRC) IN FEMALE VETERANS: PRELIMINARY ANALYSES OF A RETROSEPCTVIE CASE-CONTROL STUDY

2020 ◽  
Vol 158 (6) ◽  
pp. S-1166-S-1167
Author(s):  
Thomas F. Imperiale ◽  
Laura Myers ◽  
Barry C. Barker ◽  
Jason C. Larson ◽  
Timothy E. Stump ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Early Onset ◽  
Case Control Study ◽  
Case Control ◽  
Sporadic Colorectal Cancer ◽  
Female Veterans ◽  
Control Study

scholarly journals Use of antibiotics and colorectal cancer risk: a primary care nested case–control study in Belgium

BMJ Open ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. e053511
Author(s):  
Johannes Van der Meer ◽  
Pavlos Mamouris ◽  
Vahid Nassiri ◽  
Bert Vaes ◽  
Marjan van den Akker
Keyword(s):  
Colorectal Cancer ◽  
General Practice ◽  
Cancer Risk ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Case Control ◽  
Colorectal Cancer Risk ◽  
Oral Antibiotics ◽  
Increased Risk ◽  
Control Study

ObjectivesTo examine the association between the use of oral antibiotics and subsequent colorectal cancer risk.DesignMatched case–control study.SettingGeneral practice centres participating in the Integrated Computerised Network database in Flanders, Belgium.ParticipantsIn total, 1705 cases of colorectal cancer diagnosed between 01 January 2010 and 31 December 2015 were matched to 6749 controls by age, sex, comorbidity and general practice centre.Primary outcome measureThe association between the number of prescriptions for oral antibiotics and the incidence of colorectal cancer over a period of 1–10 years, estimated by a conditional logistic regression model.ResultsA significantly increased risk of colorectal cancer (OR 1.25, 95% CI 1.10 to 1.44) was found in subjects with one or more prescriptions compared with those with none after correction for diabetes mellitus. No dose-response relationship was found.ConclusionsThis study resulted in a modestly higher risk of having colorectal cancer diagnosed after antibiotic exposure. The main limitation was missing data on known risk factors, in particular smoking behaviour. This study did not allow us to examine the causality of the relationship, indicating the need of further investigation.

scholarly journals Risk factors for early-onset colorectal cancer: a population-based case–control study in Ontario, Canada

2021 ◽  
Author(s):  
Vicky C. Chang ◽  
Michelle Cotterchio ◽  
Prithwish De ◽  
Jill Tinmouth
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Early Onset ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Dietary Factors ◽  
Supplement Use ◽  
History Of ◽  
Control Study

Abstract Purpose There has been an alarming increase in colorectal cancer (CRC) incidence among young adults aged < 50 years, and factors driving this upward trend are unknown. This study investigated associations between various medical, lifestyle, and dietary factors and risk of early-onset CRC (EO-CRC). Methods A population-based case–control study was conducted in Ontario, Canada during 2018–2019. EO-CRC cases aged 20–49 years (n = 175) were identified from the Ontario Cancer Registry; sex- and age group-matched controls (n = 253) were recruited through random digit dialing. Data on potential a priori risk factors were collected using a web-based self-reported questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable logistic regression. Results Family history of CRC in a first- or second-degree relative (OR 2.37; 95% CI 1.47–3.84), longer sedentary time (≥ 10 vs. < 5 h/day, OR 1.93; 95% CI 1.02–3.65), greater consumption of sugary drinks (≥ 7 vs. < 1 drinks/week, OR 2.99; 95% CI 1.57–5.68), and a more Westernized dietary pattern (quartile 4 vs. 1, OR 1.92; 95% CI 1.01–3.66) were each associated with an increased risk of EO-CRC. Conversely, calcium supplement use (OR 0.53; 95% CI 0.31–0.92), history of allergy or asthma (OR 0.62; 95% CI 0.39–0.98), and greater parity in females (≥ 3 vs. nulliparity, OR 0.29; 95% CI 0.11–0.76) were each associated with a reduced risk. Conclusion Modifiable factors, particularly sedentary behavior and unhealthy diet including sugary drink consumption, may be associated with EO-CRC risk. Our findings, if replicated, may help inform prevention strategies targeted at younger persons.

scholarly journals Risk of early-onset dementia among persons with tinnitus: a retrospective case–control study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yen-Fu Cheng ◽  
Sudha Xirasagar ◽  
Tzong-Han Yang ◽  
Chuan-Song Wu ◽  
Yi-Wei Kao ◽  
...  
Keyword(s):  
Early Onset ◽  
Case Control Study ◽  
Age Groups ◽  
Case Control ◽  
Research Database ◽  
Retrospective Case ◽  
Early Onset Dementia ◽  
Increased Risk ◽  
Taiwan National Health Insurance ◽  
Control Study

AbstractHigher rates of poor cognitive performance are known to prevail among persons with tinnitus in all age groups. However, no study has explored the association between tinnitus and early-onset dementia. We hypothesize that tinnitus may precede or occur concurrently with subclinical or early onset dementia in adults younger than 65 years of age. This case–control study used data from the Taiwan National Health Insurance Research Database, identifying 1308 patients with early-onset dementia (dementia diagnosed before 65 years of age) and 1308 matched controls. We used multivariable logistic regressions to estimate odds ratios (ORs) for prior tinnitus among patients with dementia versus controls. Among total 2616 sample participants, the prevalence of prior tinnitus was 18%, 21.5% among cases and 14.5% among controls (p < 0.001). Multivariable logistic regression showed and adjusted OR for prior tinnitus of 1.6 for cases versus controls (95% CI: 1.3 ~ 2.0). After adjusting for sociodemographic characteristics and medical co-morbidities, patients with early-onset dementia had a 67% higher likelihood of having prior tinnitus (OR = 1.628; 95% CI = 1.321–2.006). Our findings showed that pre-existing tinnitus was associated with a 68% increased risk of developing early-onset dementia among young and middle-aged adults. The results call for greater awareness of tinnitus as a potential harbinger of future dementia in this population.

scholarly journals Solanaceous Vegetables and Colorectal Cancer Risk: A Hospital-Based Matched Case-Control Study in Northeast China

2021 ◽  
Vol 8 ◽  
Author(s):  
Yang Liu ◽  
Simin Li ◽  
Liqing Jiang ◽  
Yuchong Zhang ◽  
Zhi Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Northeast China ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Case Control ◽  
Dietary Factors ◽  
Colorectal Cancer Risk ◽  
Inverse Association ◽  
Control Study

Background: Dietary factors are regarded as an essential influence in changing colorectal cancer (CRC) risk. However, there is no clear conclusion of the relationship between solanaceous vegetables and colorectal cancer at present. The study aimed to evaluate the intake of solanaceous vegetables in relation to colorectal cancer risk among the Northeast Chinese population.Methods: We carried out a hospital-based case-control study in three hospitals in Northeast China from 2009 to 2011. The study finally included 833 patients with CRC and 833 controls matched separately according to age, gender, and city of residence. We applied a structural questionnaire to collect demographic characteristics and dietary information by face-to-face interview and adopted conditional logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Stratified analyses were conducted by sex and subsites.Results: There was no obvious correlation between total intake of solanaceous plants and CRC risk. The adjusted OR for the highest quartile and the lowest quartile was 1 (95% CI: 0.68–1.5). Certain types of solanaceous vegetables were negatively associated with the risk of CRC, such as eggplant (OR = 0.42; 95% CI:0.29–0.62) and sweet pepper (OR = 0.48; 95%CI: 0.33–0.7). Potato was found to have a positive correlation with CRC (OR = 1.76; 95% CI: 1.26–2.47). In the stratified analyses by gender, total solanaceous vegetables intake was inversely associated with CRC risk only in men. In the stratified analyses of cancer subsites, no significant association between total solanaceous vegetables intake and CRC risk was found.Conclusion: No findings showed that the intake of total solanaceous vegetables was related to the reduction of CRC risk. However, specific types of solanaceous vegetables indicated an inverse association with CRC risk.

scholarly journals Association Between Colonoscopy and Colorectal Cancer Mortality in a US Cohort According to Site of Cancer and Colonoscopist Specialty

2012 ◽  
Vol 30 (21) ◽  
pp. 2664-2669 ◽  
Author(s):  
Nancy N. Baxter ◽  
Joan L. Warren ◽  
Michael J. Barrett ◽  
Therese A. Stukel ◽  
V. Paul Doria-Rose
Keyword(s):  
Colorectal Cancer ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
The United States ◽  
Case Control ◽  
Risk Of Death ◽  
Medicare Data ◽  
Colorectal Cancer Mortality ◽  
Control Study ◽  
Reduced Risk

Purpose We designed this study to evaluate the association of colonoscopy with colorectal cancer (CRC) death in the United States by site of CRC and endoscopist specialty. Methods We designed a case-control study using Surveillance, Epidemiology, and End Results (SEER)–Medicare data. We identified patients (cases) diagnosed with CRC age 70 to 89 years from January 1998 through December 2002 who died as a result of CRC by 2007. We selected three matched controls without cancer for each case. Controls were assigned a referent date (date of diagnosis of the case). Colonoscopy performed from January 1991 through 6 months before the diagnosis/referent date was our primary exposure. We compared exposure to colonoscopy in cases and controls by using conditional logistic regression controlling for covariates, stratified by site of CRC. We determined endoscopist specialty by linkage to the American Medical Association (AMA) Masterfile. We assessed whether the association between colonoscopy and CRC death varied with endoscopist specialty. Results We identified 9,458 cases (3,963 proximal [41.9%], 4,685 distal [49.5%], and 810 unknown site [8.6%]) and 27,641 controls. In all, 11.3% of cases and 23.7% of controls underwent colonoscopy more than 6 months before diagnosis. Compared with controls, cases were less likely to have undergone colonoscopy (odds ratio [OR], 0.40; 95% CI, 0.37 to 0.43); the association was stronger for distal (OR, 0.24; 95% CI, 0.21 to 0.27) than proximal (OR, 0.58; 95% CI, 0.53 to 0.64) CRC. The strength of the association varied with endoscopist specialty. Conclusion Colonoscopy is associated with a reduced risk of death from CRC, with the association considerably and consistently stronger for distal versus proximal CRC. The overall association was strongest if colonoscopy was performed by a gastroenterologist.

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