Clinic and ambulatory blood pressure in relation to the interaction between plasma advanced glycation end products and sodium dietary intake and renal handling

2021 ◽  
Author(s):  
Qi-Fang Huang ◽  
Yi-Bang Cheng ◽  
Qian-Hui Guo ◽  
Chang-Yuan Liu ◽  
Yuan-Yuan Kang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Dietary Intake ◽  
Advanced Glycation End Products ◽  
Ambulatory Blood Pressure ◽  
Advanced Glycation ◽  
Renal Handling ◽  
Glycation End Products ◽  
End Products

scholarly journals Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans

Hypertension ◽  
2021 ◽  
Author(s):  
Vienna E. Brunt ◽  
Abigail G. Casso ◽  
Rachel A. Gioscia-Ryan ◽  
Zachary J. Sapinsley ◽  
Brian P. Ziemba ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Advanced Glycation End Products ◽  
Gut Microbiome ◽  
Disease Risk ◽  
Advanced Glycation ◽  
Wall Stiffness ◽  
Glycation End Products ◽  
End Products ◽  
Aortic Stiffening

Aging is associated with stiffening of the large elastic arteries and consequent increases in systolic blood pressure (SBP), which together increase cardiovascular disease risk; however, the upstream mechanisms are incompletely understood. Using complementary translational approaches in mice and humans, we investigated the role of the gut microbiome-derived metabolite trimethylamine N-oxide (TMAO) in age-related aortic stiffening and increased SBP. Aortic stiffness was measured using carotid-femoral or aortic pulse wave velocity (PWV) in humans and mice, respectively. Study 1: Plasma TMAO concentrations were elevated ( P <0.001) in healthy middle-aged to older (6.3±5.8 µmol/L) versus young (1.8±1.4 µmol/L) humans and positively related to carotid-femoral PWV ( r 2 =0.15, P <0.0001) and SBP ( r 2 =0.09, P <0.001), independent of traditional cardiovascular risk factors. Study 2: Dietary supplementation with TMAO increased aPWV in young mice and exacerbated the already elevated aPWV of old mice, accompanied by increases in SBP of ≈10 mm Hg in both groups. TMAO-supplemented versus control-fed mice also had higher intrinsic mechanical stiffness of the aorta (stress-strain testing) associated with higher aortic abundance of advanced glycation end-products, which form crosslinks between structural proteins to promote aortic stiffening. Study 3: Ex vivo incubation of aortic rings with TMAO increased intrinsic stiffness, which was attenuated by the advanced glycation end-products crosslink breaker alagebrium and prevented by inhibition of superoxide signaling. TMAO induces aortic stiffening and increases SBP via formation of advanced glycation end-products and superoxide-stimulated oxidative stress, which together increase intrinsic wall stiffness. Increases in circulating TMAO with aging represent a novel therapeutic target for reducing risk of aortic stiffening-related clinical disorders.

scholarly journals Relationship Between Advanced Glycation End Products and Their Receptor, sRAGE and Cardiovascular Diseases Risk in Adults with T2D and Vitamin D Insufficiency/deficiency (FS12-08-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Justina Owusu ◽  
Fatma Huffman ◽  
Juan Liuzzi ◽  
Tan Li ◽  
Vijaya Narayanan
Keyword(s):  
Blood Pressure ◽  
Vitamin D ◽  
Cardiovascular Diseases ◽  
Advanced Glycation End Products ◽  
Serum Levels ◽  
Vitamin D Insufficiency ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
The Relationship

Abstract Objectives Advanced Glycation End Products, (AGEs) and their soluble receptor (sRAGE) have been implicated in the development of complications and mortality among individuals with type 2 diabetes (T2D). There is limited information on the relationship between AGEs and sRAGE and risk of cardiovascular diseases (CVD) in minority groups, who have a higher burden of T2D. The relationship between AGEs and sRAGE and CVD risks in adults with T2D and vitamin D insufficiency/deficiency was assessed in a minority population. Methods A cross sectional study of Hispanics and African Americans with T2D (n = 64, 41 women and 23 men, mean age = 54 ± 9) recruited from two clinics in Miami Dade. Systolic (SBP) and diastolic blood pressure (DBP), weight and height measurement and serum lipid profile were completed. ELISA kits were used to assess serum levels of AGEs (Biotang Inc/TSZ Elisa, Waltham, MA, USA) and sRAGE (Biotang Inc/TSZ Elisa, Waltham, MA, USA). Multiple linear regression was used to assess association between AGEs, sRAGE and CVD risks. Results A negative and significant association between AGEs and high-density lipoprotein cholesterol (HDL-C)(B = −0.551, P = 0.029) was found. The relationship between AGEs and HDL-C persisted after adjusting for covariates (P < 0.05). sRAGE was significantly associated with SBP (B = 0.015, P = 0.025) and diastolic blood pressure DBP (B = 0.0271, P = 0.037). Results loss significance when association between sRAGE and DBP and SBP were adjusted for covariates such as age, body mass index (BMI), smoking and alcohol intake. Conclusions Our results suggest that AGEs and sRAGE are related to markers of cardiovascular risk such as HDL-C, SBP and DBP in the study population of African Americans and Hispanics with T2D and vitamin D insufficiency/deficiency. Measures on reducing serum levels of AGEs and improving sRAGE and vitamin D are warranted in these populations for risk reduction of CVD. Funding Sources Partial funding for this research was provided through an NIH/NIDDK sponsored grant.

scholarly journals Effect of Vaccinium Myrtillus Extract Supplement on Advanced Glycation End-products: A Pilot Study (P06-098-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Liangkai Chen ◽  
Xuguang Zhang ◽  
Qiang Wang ◽  
Wanyi Li ◽  
Liegang Liu
Keyword(s):  
Placebo Group ◽  
Dietary Intake ◽  
Advanced Glycation End Products ◽  
Mental State ◽  
Intervention Group ◽  
Vaccinium Myrtillus ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
Anthropometric Characteristics

Abstract Objectives Excessive consumption of advanced glycation end products (AGEs) with western-style diet in vogue is increasingly seen as a potential cause of aging and metabolic diseases. Several berries contain appreciable quantities of bioactive phytonutrients, including phenolic compounds, which are potentially good candidates as AGE inhibitors. This parallel double-blind intervention study investigated whether the Vaccinium Myrtillus extract supplement is able to reduce the AGEs levels in humans. (clinicaltrials.gov NCT03316612) Methods Seventy-four healthy subjects were randomly assigned to an intervention group (4 tablets per day, containing 600 mg Vaccinium Myrtillus extract, n = 39) versus placebo group (tablets with the same appearance but without the berry extract, n = 35). We evaluated dietary intake, sleep, exercise, mental state, and anthropometric characteristics over the 3 months of intervention. Plasma soluble receptor for AGE (sRAGE) levels were determined by ELISA (R&D). Plasma protein-bound AGEs, including Nε-(carboxymethyl)lysine (CML) and Nε-(carboxyethyl)lysine (CEL), were determined by ultra-high performance liquid chromatography-tandem mass spectrometry. Results Dietary intake, sleep, exercise, mental state, anthropometric characteristics, and plasma sRAGE levels were not changed during the intervention in two groups. CML levels [1137.5 (918.5–1493.0) vs. 840.9 (757.4–953.8) μg/L, P < 0.001] decreased significantly in the intervention group compared with the placebo group. However, we did not observe a significant change of CEL levels [201.9 (168.5–236.3) vs.176.8 (147.1–212.6) μg/L, P = 0.067] in the intervention group. Conclusions Our results suggest that plasma protein-bound AGEs can be reduced partly by Vaccinium Myrtillus extract supplement. As widely available, safe and nutritious foods, berries with rich phenolic metabolites (particularly anthocyanins) represent a promising dietary intervention worthy of further investigation. Funding Sources Nutrition Scientific Research Foundation of BY-HEALTH. Supporting Tables, Images and/or Graphs

Effects of Combined Lipoic Acid and Pyridoxine on Albuminuria, Advanced Glycation End-Products, and Blood Pressure in Diabetic Nephropathy

2013 ◽  
Vol 83 (2) ◽  
pp. 77-85 ◽  
Author(s):  
Nazanin Noori ◽  
Hadi Tabibi ◽  
Farhad Hosseinpanah ◽  
Mehdi Hedayati ◽  
Mohsen Nafar
Keyword(s):  
Blood Pressure ◽  
Diabetic Nephropathy ◽  
Placebo Group ◽  
Advanced Glycation End Products ◽  
Lipoic Acid ◽  
Advanced Glycation ◽  
Supplement Group ◽  
Glycation End Products ◽  
End Products ◽  
Combined Administration

This study was designed to investigate the effects of combined administration of lipoic acid and pyridoxine on albuminuria, oxidative stress, blood pressure, serum advanced glycation end-products, nitric oxide (NO), and endothelin-1 in patients with diabetic nephropathy. Thirty-four patients were randomly assigned to either a supplement group or a placebo group. The patients in the supplement group received 800 mg lipoic acid and 80 mg pyridoxine daily for 12 weeks, whereas the placebo group received corresponding placebos. Urinary albumin, serum malondialdehyde (MDA), and systolic blood pressure decreased significantly in the supplement group compared to the placebo group (p < 0.05). Serum NO increased in the supplement group compared to the placebo group (p < 0.05). Serum pentosidine and carboxymethyl lysine decreased significantly in the supplement group at the end of week 12 compared to baseline (p < 0.05). No statistically significant differences were observed between the two groups in mean changes of serum endothelin-1, glucose, and diastolic blood pressure. The present study indicates that combined administration of lipoic acid and pyridoxine improves albuminuria in patients with diabetic nephropathy by reducing oxidative stress, advanced glycation end-products, and systolic blood pressure. The reduction in microalbuminuria may be of benefit in retarding the progression of diabetic nephropathy.

scholarly journals Dietary intake of advanced glycation end products (AGEs) and changes in body weight in European adults

2019 ◽  
Vol 59 (7) ◽  
pp. 2893-2904 ◽  
Author(s):  
R. Cordova ◽  
V. Knaze ◽  
V. Viallon ◽  
P. Rust ◽  
C. G. Schalkwijk ◽  
...  
Keyword(s):  
Body Weight ◽  
Dietary Intake ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

scholarly journals Dietary Intake of Advanced Glycation End Products (AGEs) and Mortality Among Individuals with Colorectal Cancer

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4435
Author(s):  
Ziling Mao ◽  
Elom K. Aglago ◽  
Zhiwei Zhao ◽  
Casper Schalkwijk ◽  
Li Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dietary Intake ◽  
Advanced Glycation End Products ◽  
Dietary Intakes ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
All Cause Mortality ◽  
Specific Mortality

Advanced glycation end-products (AGEs) may promote oxidative stress and inflammation and have been linked to multiple chronic diseases, including cancer. However, the association of AGEs with mortality after colorectal cancer (CRC) diagnosis has not been previously investigated. Multivariable Cox proportional hazards models were used to calculate hazard ratios and corresponding 95% confidence intervals for associations between dietary intake of AGEs with CRC-specific and all-cause mortality among 5801 participant cases diagnosed with CRC in the European Prospective Investigation into Cancer and Nutrition study between 1993 and 2013. Dietary intakes of AGEs were estimated using country-specific dietary questionnaires, linked to an AGE database, that accounted for food preparation and processing. During a median of 58 months of follow-up, 2421 cases died (1841 from CRC). Individually or combined, dietary intakes of AGEs were not associated with all-cause and CRC-specific mortality among cases. However, there was a suggestion for a positive association between AGEs and all-cause or CRC-specific mortality among CRC cases without type II diabetes (all-cause, Pinteraction = 0.05) and CRC cases with the longest follow-up between recruitment and cancer diagnosis (CRC-specific, Pinteraction = 0.003; all-cause, Pinteraction = 0.01). Our study suggests that pre-diagnostic dietary intakes of AGEs were not associated with CRC-specific or all-cause mortality among CRC patients. Further investigations using biomarkers of AGEs and stratifying by sex, diabetes status, and timing of exposure to AGEs are warranted.

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