scholarly journals High-density information storage in an absolutely defined aperiodic sequence of monodisperse copolyester

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Jung Min Lee ◽  
Mo Beom Koo ◽  
Seul Woo Lee ◽  
Heelim Lee ◽  
Junho Kwon ◽  
...  

AbstractSynthesis of a polymer composed of a large discrete number of chemically distinct monomers in an absolutely defined aperiodic sequence remains a challenge in polymer chemistry. The synthesis has largely been limited to oligomers having a limited number of repeating units due to the difficulties associated with the step-by-step addition of individual monomers to achieve high molecular weights. Here we report the copolymers of α-hydroxy acids, poly(phenyllactic-co-lactic acid) (PcL) built via the cross-convergent method from four dyads of monomers as constituent units. Our proposed method allows scalable synthesis of sequence-defined PcL in a minimal number of coupling steps from reagents in stoichiometric amounts. Digital information can be stored in an aperiodic sequence of PcL, which can be fully retrieved as binary code by mass spectrometry sequencing. The information storage density (bit/Da) of PcL is 50% higher than DNA, and the storage capacity of PcL can also be increased by adjusting the molecular weight (~38 kDa).

Author(s):  
Robert A. Schultz

In Chapter I, I observed that new uses of IT will be built on four basic features of information technology: • Speed of information processing • Unlimited size of information storage capacity • Availability of information at any location (connectivity) • Easy reproduction of digital information These features combine in many different ways to produce the various applications of IT that give rise both to new benefits and to new ethical problems. But, just as new and unpredictable uses of information technology arise with some regularity, so do new and unpredictable ethical problems. I will define an e-problem as an ethical problem that arises as a result of one of the four features of IT listed above. In this chapter, I will examine five unexpected and difficult e-problems:


2019 ◽  
Vol 15 (01) ◽  
pp. 1-8
Author(s):  
Ashish C Patel ◽  
C G Joshi

Current data storage technologies cannot keep pace longer with exponentially growing amounts of data through the extensive use of social networking photos and media, etc. The "digital world” with 4.4 zettabytes in 2013 has predicted it to reach 44 zettabytes by 2020. From the past 30 years, scientists and researchers have been trying to develop a robust way of storing data on a medium which is dense and ever-lasting and found DNA as the most promising storage medium. Unlike existing storage devices, DNA requires no maintenance, except the need to store at a cool and dark place. DNA has a small size with high density; just 1 gram of dry DNA can store about 455 exabytes of data. DNA stores the informations using four bases, viz., A, T, G, and C, while CDs, hard disks and other devices stores the information using 0’s and 1’s on the spiral tracks. In the DNA based storage, after binarization of digital file into the binary codes, encoding and decoding are important steps in DNA based storage system. Once the digital file is encoded, the next step is to synthesize arbitrary single-strand DNA sequences and that can be stored in the deep freeze until use.When there is a need for information to be recovered, it can be done using DNA sequencing. New generation sequencing (NGS) capable of producing sequences with very high throughput at a much lower cost about less than 0.1 USD for one MB of data than the first sequencing technologies. Post-sequencing processing includes alignment of all reads using multiple sequence alignment (MSA) algorithms to obtain different consensus sequences. The consensus sequence is decoded as the reversal of the encoding process. Most prior DNA data storage efforts sequenced and decoded the entire amount of stored digital information with no random access, but nowadays it has become possible to extract selective files (e.g., retrieving only required image from a collection) from a DNA pool using PCR-based random access. Various scientists successfully stored up to 110 zettabytes data in one gram of DNA. In the future, with an efficient encoding, error corrections, cheaper DNA synthesis,and sequencing, DNA based storage will become a practical solution for storage of exponentially growing digital data.


2021 ◽  
Vol 23 (4) ◽  
pp. 796-815
Author(s):  
Yang Wang ◽  
Sun Sun Lim

People are today located in media ecosystems in which a variety of ICT devices and platforms coexist and complement each other to fulfil users’ heterogeneous requirements. These multi-media affordances promote a highly hyperlinked and nomadic habit of digital data management which blurs the long-standing boundaries between information storage, sharing and exchange. Specifically, during the pervasive sharing and browsing of fragmentary digital information (e.g. photos, videos, online diaries, news articles) across various platforms, life experiences and knowledge involved are meanwhile classified and stored for future retrieval and collective memory construction. For international migrants who straddle different geographical and cultural contexts, management of various digital materials is particularly complicated as they have to be familiar with and appropriately navigate technological infrastructures of both home and host countries. Drawing on ethnographic observations of 40 Chinese migrant mothers in Singapore, this article delves into their quotidian routines of acquiring, storing, sharing and exchanging digital information across a range of ICT devices and platforms, as well as cultural and emotional implications of these mediated behaviours for their everyday life experiences. A multi-layer and multi-sited repertoire of ‘life archiving’ was identified among these migrant mothers in which they leave footprints of everyday life through a tactical combination of interactive sharing, pervasive tagging and backup storage of diverse digital content.


2021 ◽  
Vol 118 (45) ◽  
pp. e2024890118
Author(s):  
Shu Ho ◽  
Rebecca Lajaunie ◽  
Marion Lerat ◽  
Mickaël Le ◽  
Valérie Crépel ◽  
...  

Cerebellar Purkinje neurons integrate information transmitted at excitatory synapses formed by granule cells. Although these synapses are considered essential sites for learning, most of them appear not to transmit any detectable electrical information and have been defined as silent. It has been proposed that silent synapses are required to maximize information storage capacity and ensure its reliability, and hence to optimize cerebellar operation. Such optimization is expected to occur once the cerebellar circuitry is in place, during its maturation and the natural and steady improvement of animal agility. We therefore investigated whether the proportion of silent synapses varies over this period, from the third to the sixth postnatal week in mice. Selective expression of a calcium indicator in granule cells enabled quantitative mapping of presynaptic activity, while postsynaptic responses were recorded by patch clamp in acute slices. Through this approach and the assessment of two anatomical features (the distance that separates adjacent planar Purkinje dendritic trees and the synapse density), we determined the average excitatory postsynaptic potential per synapse. Its value was four to eight times smaller than responses from paired recorded detectable connections, consistent with over 70% of synapses being silent. These figures remained remarkably stable across maturation stages. According to the proposed role for silent synapses, our results suggest that information storage capacity and reliability are optimized early during cerebellar maturation. Alternatively, silent synapses may have roles other than adjusting the information storage capacity and reliability.


3 Biotech ◽  
2019 ◽  
Vol 9 (9) ◽  
Author(s):  
Shufang Zhang ◽  
Beibei Huang ◽  
Xiangming Song ◽  
Tao Zhang ◽  
Hanjie Wang ◽  
...  

2020 ◽  
Vol 117 (46) ◽  
pp. 28589-28595 ◽  
Author(s):  
Chiara Gattinoni ◽  
Nives Strkalj ◽  
Rea Härdi ◽  
Manfred Fiebig ◽  
Morgan Trassin ◽  
...  

Ferroelectric perovskites present a switchable spontaneous polarization and are promising energy-efficient device components for digital information storage. Full control of the ferroelectric polarization in ultrathin films of ferroelectric perovskites needs to be achieved in order to apply this class of materials in modern devices. However, ferroelectricity itself is not well understood in this nanoscale form, where interface and surface effects become particularly relevant and where loss of net polarization is often observed. In this work, we show that the precise control of the structure of the top surface and bottom interface of the thin film is crucial toward this aim. We explore the properties of thin films of the prototypical ferroelectric lead titanate (PbTiO3) on a metallic strontium ruthenate (SrRuO3) buffer using a combination of computational (density functional theory) and experimental (optical second harmonic generation) methods. We find that the polarization direction and strength are influenced by chemical and electronic processes occurring at the epitaxial interface and at the surface. The polarization is particularly sensitive to adsorbates and to surface and interface defects. These results point to the possibility of controlling the polarization direction and magnitude by engineering specific interface and surface chemistries.


1997 ◽  
Vol 1997 (1) ◽  
pp. 973-975
Author(s):  
Carl G. Kitz ◽  
Michael J. Szerlog ◽  
Sean M. Hyde

ABSTRACT EPA Region X has combined the immense storage capacity of CD-ROMs with interactive software to develop a user-friendly tool to provide quick and easy access to digital information for use by oil spill response teams. These CD-ROMs, created specifically for spill planning and response, provide responders with hypertext links and powerful search capabilities allowing uncomplicated access to response information, regulations, nationally recognized standards, and area maps. This format enhances response time by reducing the time needed to access critical information and the volume of materials carried to the site by responders.


2013 ◽  
Vol 756-759 ◽  
pp. 1210-1214
Author(s):  
Chuan Jin Wang

Cloud storage is a new type of concept of digital information storage. In view of its advantages in distributed storage, collaborative storage, dynamic allocation storage space, smooth migration and backup, on the basis of the introduction of related concepts and unique advantages of cloud storage, the present essay introduced cloud storage into the data bank of plane design materials, and constructed a scheme of cloud storage of the data bank of the plane design materials from the three aspects of system structure, topological structure and function module.


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